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All Journal journal of internal medicine Indonesian Journal of Cancer The Indonesian Biomedical Journal Molecular and Cellular Biomedical Sciences (MCBS) Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Ami Ashariati
Medical Hematology Oncology Division, Department Of Internal Medicine, Faculty Of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Increased hs-CRP and Sepsis Influence the Occurrence of Thrombocytopenia in Severe and Critically Ill COVID-19 Patients Receiving Anticoagulants Ami Ashariati Prayoga; Siprianus Ugroseno Yudho Bintoro; Pradana Zaky Romadhon; Muhammad Noor Diansyah; Putu Niken Ayu Amrita; Merlyna Savitri; Choirina Windradi; Krisnina Nurul Widiyastuti
The Indonesian Biomedical Journal Vol 15, No 1 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i1.2045

Abstract

BACKGROUND: Despites its benefits, as one of COVID-19 principal treatments, anticoagulant raises a significant concern regarding the anticoagulant-related thrombocytopenia. However, up to date, there is lack of study examining anticoagulantinduced thrombocytopenia during COVID-19, hence this study was conducted to determine the factors inducing anticoagulant-induced thrombocytopenia in COVID-19 patients.METHODS: An observational cross-sectional study of 106 anticoagulant-treated COVID-19 subjects was conducted. Blood serum was drawn from subjects, then platelets, prothrombin time (PT), activated partial thromboplastin (aPPT), international ratio (INR), D-dimer, ferritin, fibrinogen, and high-sensitivity C-reactive protein (hs-CRP), were measured. For thrombocytopenia risk assessment, the 4T score was calculated. To assess the risk of thrombocytopenia. Statistical analysis using Chi-square and Mann-Whitney U test were performed and followed by multivariate analysis to examine the correlation among the thrombocytopenia risk factors.RESULTS: Significant differences were identified in the length of stay (LOS) (p=0.04), disease severity (p=0.021), sepsis (p=0.006), hs-CRP (p=0.003), and mortality rate (p=0.028) between thrombocytopenia and nonthrombocytopenia groups. A multivariate analysis through linear and logistic regression disclosed an increase in hs-CRP (OR=-0.29; p=0.045) and sepsis (OR=4.32; p=0.03) that precipitate the thrombocytopenia events.CONCLUSION: In severe and critically ill COVID-19 patients, the occurrence of thrombocytopenia was followed by an increase in inflammatory parameters such as D-dimer, fibrinogen, ferritin, hs-CRP and prolonged coagulation. The increase in hs-CRP and sepsis may raise the risk of thrombocytopenia, especially in severe and crtically ill cases of COVID-19.KEYWORDS: COVID-19, anticoagulant, thrombocytopenia, inflammation, infectious disease
Co-Authors Abdurachman Abdurachman Adi Mulyono Andi Yasmin Wijaya Andy Purnomo ARIO DJATMIKO, ARIO Bintoro, Siprianus Ugroseno Yudho Boediwarsono - Choirina Windradi Fedik Abdul Rantam I'tishom, Reny ISKANDAR ALI, ISKANDAR Krisnina Nurul Widiyastuti KUSUMASTUTI, ETTY HARY Lukman Hakim Made Putra Sedana Merlyna S Merlyna Savitri Merlyna Savitri Merlyna Savitri Merlyna Savitri Savitri Muhammad Noor Diansyah Muhammad Noor Muhammad Nur Imroatul Mursyidah Putu Niken Ayu Amrita Putu Niken Ayu Amrita Putu Niken Ayu Amrita Putu Niken Ayu Amrita Rizky Amalia Putri Romadhon, Pradana Zaky S.Pd. M Kes I Ketut Sudiana . Soebandiri - Steven Sheng Looi Sugianto - Ugroseno - Ugroseno Yudho Bintoro Ugroseno Yudho Bintoro Wiharjo Hadisuwarno Winona May Hendrata Yudith Annisa Ayu Rezkitha, Yudith Annisa Ayu