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All Journal Jurnal Dedikasi Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Acta Pharmaceutica Indonesia UNEJ e-Proceeding Martabe : Jurnal Pengabdian Kepada Masyarakat Food Science and Technology Journal (Foodscitech) Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Jurnal Kesehatan Tambusai Jurnal EduHealth Borneo Journal of Pharmacy
Engrid Juni Astuti
Program Studi Farmasi Fakultas Ilmu Kesehatan Universitas Muhammadiyah Malang
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Journal : Borneo Journal of Pharmacy

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Integrative Network Pharmacology Unveils Limonia acidissima as a Potential Natural Product for Targeting Cancer Wahyuni, Reni Sri; Muchlisin, M. Artabah; Jamil, Ahmad Shobrun; Astuti, Engrid Juni; Rafikayanti, Agustin
Borneo Journal of Pharmacy Vol. 7 No. 3 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i3.6988

Abstract

Cancer remains a formidable health challenge worldwide, with complex molecular mechanisms driving its initiation, progression, and therapeutic resistance. In this study, we employed bioinformatics analyses to elucidate the molecular underpinnings of cancer biology, focusing on Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. Our GO analysis revealed the enrichment of key biological processes such as protein phosphorylation, regulation of programmed cell death, and transmembrane receptor signaling pathways, underscoring the critical roles of signaling cascades and regulatory mechanisms in tumorigenesis. Similarly, molecular functions such as protein kinase activity and ATP binding were identified as significantly enriched, highlighting the importance of protein kinases and molecular interactions in cancer development and progression. The KEGG pathway analysis further delineated dysregulated signaling pathways associated with cancer, including the MAPK and PI3K-Akt signaling pathways, implicating these pathways as central regulators of cancer progression. These findings deepen our understanding of cancer biology and offer potential targets for therapeutic intervention. Integrating multi-omics data and systems biology approaches may provide deeper insights into the intricate networks underlying cancer pathogenesis, paving the way for developing more effective treatments for cancer patients.
Co-Authors Ahmad Shobrun Jamil Akhmad Aminur Rizqia Bambang Tri Purwanto Bilgis Nurfatiyah, Rize Cahyanang Putria Widianto, Regita Dian Ermawati Dina Siti Rahma M. Hentu Dini Fitri Mudhakir, Ainuzahra Dyah Rahmasari Hentu, Dina Siti Rahma M. Hidajah Rachmawati Huda Prastyo, Miftahul Ika Ratna Hidayati Ikka Choirun Nisa, Vasda Ilham, Roha Fakhri Naufal Ismahanisa Ismail, Wan Januar Rahman Juni Ekowati M. Artabah Muchlisin Muchlisin, M. Artabah Muhammad Ali Zulfikar Nailis Syifa Pertiwi, Cinta Junaidi Putri Purwanto, Septiana Tita Puspitasari, Chenchen Rafikayanti, Agustin Rahman, Januar Rahmana Emran Kartasasmita Riesta Prima Harinastitic Rika, Wenni Fista Roha Fakhri Naufal Ilham Rohmaturrizqi, Arvil Slamet Ibrahim Sovia Aprina Basukia Tazkia Azizid, Nala wahyuni, reni sri Yesica, Yeni Zalmi, Syakinatul