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All Journal Jurnal Dedikasi Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Acta Pharmaceutica Indonesia UNEJ e-Proceeding Martabe : Jurnal Pengabdian Kepada Masyarakat Food Science and Technology Journal (Foodscitech) Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Jurnal Kesehatan Tambusai Jurnal EduHealth Borneo Journal of Pharmacy
Engrid Juni Astuti
Program Studi Farmasi Fakultas Ilmu Kesehatan Universitas Muhammadiyah Malang
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Journal : Acta Pharmaceutica Indonesia

 1 
PEGEMBANGAN DAN VALIDASI METODE HEPARIN ATAU ENOKSAPARIN MENGGUNAKAN KROMATOGRAFI CAIR KINERJA TINGGI PASANGAN ION Astuti, Engrid Juni; Hidayati, Ika Ratna; Ibrahim, Slamet; Zulfikar, Muhammad Ali
Acta Pharmaceutica Indonesia Vol. 50 No. 1 (2025)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v50i1.24659

Abstract

One of the drugs used to treats and prevents COVID-19 thromboembolic problems is heparin or enoxaparin sodium. Heparin and enoxaparin have the side effect of bleeding when used, so monitoring of therapy is necessary. This present study aims to validate an ion pair high-performance liquid chromatography (HPLC) condition to analyse the adsorption of heparin or enoxaparin at molecularly imprinted polymer (MIP) after synthesis. The chromatographic system consists of a C8 column with a Diode Array Detector (DAD). The optimal chromatographic condition was obtained using mobile phase A (300mM NaCl + 10mM tetra n-butyl ammonium hydroxide) and mobile phase B (acetonitrile) under gradient elution, and 100 µl injection volume. The heparin or enox was detected at 231 nm, generating symmetrical peaks and good separation in 4.1 minutes after injection. The method indicated good selectivity with a resolution of 3.49 for heparin and 3.74 for enox. A linear detector response with R2 of 0.9965 and 0.9994 for heparin and enox. The method yields good precision and good accuracy. The proposed method has met the method validation requirements for adsorption heparin or enox analysis before using validation in biological samples.
Co-Authors Ahmad Shobrun Jamil Akhmad Aminur Rizqia Bambang Tri Purwanto Bilgis Nurfatiyah, Rize Cahyanang Putria Widianto, Regita Dian Ermawati Dina Siti Rahma M. Hentu Dini Fitri Mudhakir, Ainuzahra Dyah Rahmasari Hentu, Dina Siti Rahma M. Hidajah Rachmawati Huda Prastyo, Miftahul Ika Ratna Hidayati Ikka Choirun Nisa, Vasda Ilham, Roha Fakhri Naufal Ismahanisa Ismail, Wan Januar Rahman Juni Ekowati M. Artabah Muchlisin Muchlisin, M. Artabah Muhammad Ali Zulfikar Nailis Syifa Pertiwi, Cinta Junaidi Putri Purwanto, Septiana Tita Puspitasari, Chenchen Rafikayanti, Agustin Rahman, Januar Rahmana Emran Kartasasmita Riesta Prima Harinastitic Rika, Wenni Fista Roha Fakhri Naufal Ilham Rohmaturrizqi, Arvil Slamet Ibrahim Sovia Aprina Basukia Tazkia Azizid, Nala wahyuni, reni sri Yesica, Yeni Zalmi, Syakinatul