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All Journal E-Jurnal Medika Udayana Medula JURNAL PENELITIAN PERAWAT PROFESIONAL Journal of Innovative and Creativity JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Ratna, Maya Ganda
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Dentistry Education Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Medula

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Literature Review: Gagal Ginjal Akut Akibat Nefrotoksisitas Gentamisin Akbar, Dafa Rafiqi; Yonata, Ade; Ratna, Maya Ganda; Darwis, Iswandi
Medula Vol 14 No 9 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i9.1312

Abstract

Acute kidney failure or Acute Kidney Injury (AKI) is a sudden decline in kidney function that is often caused by various factors such as sepsis, ischemia, and nephrotoxicity. One of the significant causes of nephrotoxicity is gentamicin, an aminoglycoside antibiotic commonly used to treat Gram-negative bacterial infections. Although effective, gentamicin has nephrotoxic side effects, especially at high doses or long-term use, which can cause damage to the renal tubular epithelium and trigger AKI. This literature review aims to describe and study more deeply the relationship between gentamicin consumption and the incidence of acute kidney failure. Gentamicin works by inhibiting bacterial protein synthesis on the 30S ribosome. Still, its mechanism of action also has the potential to cause nephrotoxicity through drug accumulation in kidney cells, impaired mitochondrial function, increased production of reactive oxygen species (ROS), and mesangial contractions that reduce the glomerular filtration rate. Signs of gentamicin nephrotoxicity include increased serum creatinine levels, blood urea nitrogen, albuminuria, and decreased glomerular filtration rate, accompanied by structural damage such as tubular necrosis and edema in the proximal tubular epithelium. Previous studies have shown that high doses of gentamicin can increase the number of necrotic cells in the kidney and cause renal fibrosis in test animals. In humans, the incidence of gentamicin-induced nephrotoxicity has been reported to reach 10-25% of therapeutic use, with an estimated incidence of AKI of around 15% of total AKI cases. The importance of proper monitoring and management for patients using gentamicin to reduce the risk of nephrotoxicity. Prevention strategies include monitoring kidney function, dose adjustment, adequate hydration, and considering various alternative antibiotic therapies for patients at high risk of nephrotoxicity.
Penggunaan Dinamometer Tangan Sebagai Instrumen Asesmen Klinis Ilhamy, Satria Rizqi; Setiorini, Anggi; Ratna, Maya Ganda; Ismunandar, Helmi
Medula Vol 14 No 8 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i8.1254

Abstract

Hand is one of the system organs in the human bodies consisting of bones, muscles, and nerves that works in unison in order to function well. Hand plays a crucial role in daily activities hence it needs to have a good function. One of the main method to assess one’s hand function is by their handgrip strength measured by a hand dynamometer. Hand grip strength measured by a hand dynamometer can be used as a certain health indicator in clinical settings either as a diagnostic tool or as a prognostic predictor for some diseases. One of the use of hand grip strength measured by a hand dynamometer is to diagnose sarcopenia, a musculoskeletal degenerative disease that affects the elderly because of their aging process. Research showed a relationship between a low results of hand grip measurement with an increase of the risk of death in pneumonia patients caused by COVID-19. The results from the dynamometer can also be used as a predictor of success for weaning off a ventilator. Other research also found a correlation between the hand grip measurement with the degree of severity in type 3 spinocerebellar ataxia. Hand grip measurement is relevant for assessing clinical outcomes in patients with incurable cancer. Another study found that hand grip strength measurement can be used to assess chronic kidney disease patient’s vascular diameter for their vascular access in order to continue their hemodialysis. Therefore, dynamometer has a potential as a clinical assessment instrument to support diagnostic and prognostic accuracy.
Dermatitis Seboroik: Etiologi & Faktor Risiko, Patofisiologi, Diagnosis, dan Tatalaksana Sudarmanto, Syifa Hasna; Sibero, Hendra Tarigan; Ratna, Maya Ganda; Darwis, Iswandi
Medula Vol 14 No 11 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i11.1327

Abstract

Seborrheic dermatitis is a type of chronic skin inflammation caused by the fungus Malassezia sp. which is often found among patients. The prevalence reaches 4.38% on a global scale and 2% - 30% in Asia. Often found in infantile (self-limited) and adult (chronic) patients. This disease is considered to reduce the patient's quality of life. The high number of cases and the rate of decline in patient quality of life due to seborrheic dermatitis became the basis for conducting this research. Research was conducted to collect and analyze articles that raise topics related to clinical aspects of seborrheic dermatitis. The research design used was a literature review. Article collection was carried out using relevant article search applications such as Google Scholar, PubMed, and Prospero. The articles used have a range of publication criteria in 2013-2024. Based on the articles collected, results were obtained in the form of risk factors, pathophysiology, diagnosis and management of seborrheic dermatitis. Risk factors that are considered to trigger seborrheic dermatitis include high sebaceous gland activity, low body immunity, physical environmental factors in the form of humidity and temperature, and a history of poor personal hygiene. The appearance of the disease is in the form of reddish lesions covering fine colored scales, sometimes accompanied by oil or white powder. The severity of the disease is determined through the SDASI score or Seborrhoeic Dermatitis Area Severity Index. Healing therapy aims to reduce symptoms and improve skin function. The type of therapy given is based on the lesion severity index and the patient's response to therapy.
Peran Anemia Sebagai Faktor Risiko Hipertensi Resisten pada Penyakit Ginjal Kronik Nasution, Salwa Salsabila; Kurniati, Intanri; Ratna, Maya Ganda; Ramadhian, M. Ricky
Medula Vol 14 No 10 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1354

Abstract

Anemia is one of the most common complications in chronic kidney disease (CKD) that significantly affects quality of life and prognosis. Anemia is a condition where there is a decrease in iron-rich hemoglobin levels, which functions to circulate oxygen throughout the body. Chronic kidney disease is a kidney condition characterized by abnormalities in kidney structure or function. Men have a 2 times higher risk of developing CKD than women due to their generally poorer lifestyle habits. The condition of insufficient oxygen perfusion to tissues leads to activation of the renin-angiotensin-aldosterone system (RAAS). The RAAS system ultimately produces aldosterone and antidiuretic hormones that cause sodium retention in the body and lead to increased blood pressure. Additionally, anemia can cause changes in blood vessels, where there is an increase in vascular resistance, especially in CKD patients. Studies have also shown that erythropoietin therapy can increase the prevalence of hypertension. Resistant hypertension is a condition where someone suffering from hypertension fails to achieve target blood pressure of <140/80 mmHg in normal individuals and <130/80 mmHg in CKD patients despite adhering to a combination dose of three types of antihypertensive medications. Someone suffering from resistant hypertension must comply with the drug dosage prescribed by the doctor and also improve their lifestyle. This article aims to understand how anemia serves as a risk factor for resistant hypertension in CKD patients. Furthermore, the diagnosis and treatment of resistant hypertension are also discussed in this article.
Dampak Stres pada Kesehatan Qonita, Adzrok; Setiorini, Anggi; Ratna, Maya Ganda; Zuraida, Reni
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1404

Abstract

Stress is a bodily response to a stressor, which refers to any condition perceived as threatening or causing pressure. Stress can have both positive (eustress) and negative (distress) effects. Prolonged distress can affect various body systems through the activation of the Hypothalamus-Pituitary-Adrenal (HPA) axis and the Sympathetic-Adreno-Medullary (SAM) axis. Activation of these axes triggers the release of cortisol, epinephrine, and norepinephrine, leading to physiological and behavioral changes. Stress impacts multiple organ systems, including the cardiovascular, respiratory, gastrointestinal, hepatobiliary, urinary, reproductive, musculoskeletal, integumentary, sensory, and immune systems. It also affects sleep quality and mental health. In the cardiovascular system, stress can cause hypertension, atherosclerosis, and an increased risk of heart disease. In the respiratory system, stress worsens asthma and increases the risk of airway infections. In the gastrointestinal system, stress triggers digestive disorders, such as gastritis and peptic ulcers, due to increased stomach acid production and inflammatory mediators. Stress affects the hepatobiliary system by impairing liver function through increased inflammation. In the urinary system, stress can cause dysfunctions such as enuresis and increased urination frequency. In the reproductive system, stress can result in menstrual disorders in women and decreased testosterone levels in men. The musculoskeletal system can be affected by excessive muscle contractions, leading to pain and muscle fatigue. Stress impacts the integumentary system, triggering conditions such as acne, psoriasis, and alopecia areata. It can also cause sensory system disorders, affecting hearing, taste, and vision. In the immune system, stress suppresses immune responses, increasing susceptibility to infections and prolonging wound healing. Prolonged stress negatively impacts both physical and mental health, highlighting the importance of understanding the mechanisms through which stress affects the body to reduce the risk of serious health problems.
The Role of Between Scenario Quality and Prior Knowledge on the Effectiveness of Tutorial Discussions in Problem-Based Learning (PBL): Literature Review Mu'izabby, Iffah Salma; Oktafany, Oktafany; Ratna, Maya Ganda; Lisiswanti, Rika
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1460

Abstract

Problem-Based Learning (PBL) is a learning method that puts students at the centre of the learning process, encouraging them to learn independently through problem solving. One of the main approaches in PBL is tutorial discussion, which plays an important role in promoting deep learning. The effectiveness of tutorial discussions is influenced by three main aspects: the quality of the problem scenario, students' prior knowledge, and tutor performance. The scenario should be authentic, relevant to the students' level of understanding, and able to stimulate independent learning. Students' prior knowledge also affects their contribution to the discussion, as adequate understanding allows for more active engagement. In addition, the tutor's role in facilitating the discussion also influences the success of the PBL method. The quality of the scenario and prior knowledge play an important role in the effectiveness of Problem-Based Learning (PBL) discussions, although their relationship is not always statistically significant. The quality of a well-designed scenario can stimulate meaningful discussions, motivate students, and support the achievement of learning objectives. Prior knowledge, while not necessarily determining the success of the discussion, influences how students integrate new information. Groups with lower prior knowledge can show higher discussion effectiveness through active exploration. Overall, the effectiveness of PBL is influenced by the interaction between the quality of learning design and student characteristics, suggesting the need for a holistic approach in designing PBL scenarios.
Faktor-Faktor yang Memengaruhi Empati pada Mahasiswa Kedokteran Alifah, Rahmah; Lisiswanti, Rika; Ratna, Maya Ganda; Oktafany
Medula Vol 14 No 11 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i11.1468

Abstract

Empathy in medical students is an important aspect that affects how medical students interact with patients and understand their feeling. In the medical world, empathy can enhance the doctor-patient relationship, improve patient satisfaction, and can even affect clinical outcomes. Patients who feel empathy from their doctors are more likely to fully explain their symptoms and actively engage in the doctor-patient relationship. Research shows that empathetic doctors tend to have more satisfied and compliant patients. A number of studies have identified that the level of empathy in medical students varies and is influenced by several factors. The purpose of this literature review is to identify the factors that affect empathy in medical students. The journal were obtained from Google Scholar and Pubmed database with keyword (Empathy) and (Medical Student) for publication in 2015-2024. Journal inclusion criteria used were medical student population, journals that discussed the relationship between several factors with empathy levels, and published between 2015-2024. Exclusion criteria are journals that cannot be accessed completely. The method of analysis carried out in this literature review is a descriptive method, which describes and explains through narratives of the articles found. Based on the results of review from several journals, it was found that factors such as stress, role models, empathy training, mental health, self-control, self-motivation, social awareness, and social skills, perception of learning environment, personality, self-reflection, emotional intelligence, and gratitude.
Co-Authors Ade Yonata, Ade Adnan, Ayu Zahera Akbar, Dafa Rafiqi Alifah, Rahmah Ambarwati, Yuli ananti, anggini tasyakurillah Asep Sukohar Asyifa, Nisa Balqis, Gasela Zalianti Dian Isti Angraini Ety Apriliana Fadli, Muhammad Yogie Giska Tri Putri Helmi Ismunandar Hendra Tarigan Sibero Ilhamy, Satria Rizqi Indri Windarti Intanri Kurniati Irawati, Nur Ayu Virginia Irawati, Nur Bebi Ulfah Iswandi Darwis Jausal, Anisa Nuraisa Jhons Fatriyadi Suwandi Karima, Nisa Khairun Nisa Mu'izabby, Iffah Salma Muhammad Ricky Ramadhian Nasution, Salwa Salsabila Oktafany Oktafany, Oktafany Purnomo, Rizki Agung Putri, Dela Putri, Tiara Triwansa Qhaniya, Mutiara Cheisya Nur Qonita, Adzrok Ramdani, Resti Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Reni Zuraida Rika Lisiswanti Rudiyanto, Waluyo Septia Eva Lusina Septiani, Linda Setiorini, Anggi Shinta Nareswari, Shinta Sudarmanto, Syifa Hasna Susianti, Susianti Sutyarso SYAIFUL BAHRI Utari Gita Mutiara