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PENGARUH TINGKAT PENYANGRAIAN EKSTRAK BIJI KOPI ROBUSTA (Coffea canephora) TERHADAP GAMBARAN HISTOPATOLOGI HEPAR TIKUS PUTIH JANTAN (Rattus norvegicus) GALUR SPRAGUE DAWLEY YANG DIINDUKSI ASPIRIN ananti, anggini tasyakurillah; Rudiyanto, Waluyo; Ratna, Maya Ganda; Windarti, Indri
E-Jurnal Medika Udayana Vol 13 No 8 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i08.P03

Abstract

Abstract Background: Coffee is a plant that widely consumed by the community. It contains antioxidant-rich compounds such as caffeine, chlorogenic acid, trigonelin, kafestol, and kahweol. Coffee quality related to the roasting process. This study aimed to determine the effect of different roasting level of robusta coffee extract (Coffea canephora) on liver histopathology of male Sprague Dawley strain white rats (Rattus norvegicus) induced by aspirin. Methods: This research is an experimental study with Post-Test Only Control Group design for 15 days. This research used 30 rats in 5 groups, K(-) (aquadest); K(+) (aspirin 90mg/day); P1 (aspirin and robusta coffee extract Light roast 25mg/kgBW/day); P2 (aspirin and robusta coffee extract Medium roast 25mg/kgBW/day); and P3 (aspirin and robusta coffee extract Dark roast 25mg/kgBW/day). Assessment of liver cell damage using modified Suzuki scoring. Results: Mean score of hepatocyte damage on the histopathological findings was K(-)=0,44; K(+)=1,92; P1=1,28; P2=1,20; and P3=1,68. Data analysis performed using One-Way ANOVA test followed by Post-Hoc LSD and obtained significant results between all groups. Conclusion: There is an effect of roasting level of robusta coffee extract (Coffea canephora) with the roasting level is Medium Roast on liver histopathology of male Sprague Dawley strain white rats (Rattus norvegicus) induced by aspirin. Key Words: aspirin, coffee roasting, liver histopathology, robusta coffee extract.
Hubungan Durasi Bermain Game Online dengan Kecemasan pada Remaja Rudiyanto, Waluyo
Jurnal Keperawatan Jiwa Vol 12, No 3 (2024): Agustus 2024
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jkj.12.3.2024.507-512

Abstract

Kecanduan game online dapat berdampak pada kesehatan fisik, mental dan sosial. Tujuan penelitian ini adalah mengetahui hubungan hubungan durasi bermain game online dengan kecemasan pada remaja. Penelitian ini menggunakan jenis penelitian analitik observasional. Penelitian ini dilaksanakan pada bulan Mei-Juni 2024 di Desa Marga Agung Lampung Selatan. Variabel independen adalah durasi bermain game online dan variabel dependennya kecemasan. Populasi dalam penelitian adalah remaja dengan jumlah sampel berjumlah 346 orang. Sampel dalam penelitian ini diambil menggunakan teknik simple random sampling. Instrumen penelitian menggunakan kuesioner yang telah diuji validitas dan reliabilitas dengan nilai alpha Cronbach 0,78-0,96. Pengolahan data melalui tahapan editing, coding, tabulating, entry dan cleaning. Analisis data menggunakan distribusi frekuensi  dan uji Chi-Square. Durasi bermain game online yang <6 jam sebanyak 81 orang (23,4%) dan ≥6 jam sebanyak 265 orang (76,6%). Kecemasan ringan sebanyak 85 orang (24,6%) dan kecemasan sedang sebanyak 261 orang (75,4%). Sebagian besar yang keluhan ringan adalah yang bermain dengan durasi <6 jam (33,3%) dan keluhan sedang adalah yang bermain dengan durasi ≥6 jam (78,1%). Ada hubungan durasi bermain game online dengan kecemasan pada remaja (p=0,036).
Obstructive Sleep Apnea (OSA) pada Usia Produktif Annisarahma, Lyvia; Karima, Nisa; Sangging, Putu Ristyaning Ayu; Rudiyanto, Waluyo
Medula Vol 14 No 1 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i1.951

Abstract

Obstructive sleep apnea (OSA) is a sleep disorder which characterized by cessation of breathing for more than 10 seconds. A blockage in the upper respiratory tract may be the cause of OSA. One known risk factor for OSA is smoking. Moreover, the degree of physical activity might also influence OSA risk. This article is a literature review with a variety of the latest sources that are relevant to the topic. The sources used were obtained from the search engine for health journals. The prevalence of OSA in the productive age community in Asia is 4.1 - 7.5%. Some factors that affect the symptoms of OSA, especially in productive age, namely obesity, male sex, old age, genetic, smoking habits, and small upper airway diameter. OSA is characterized by snoring, periodic apnea, hypoxemia during sleep and hypersomnolence during the day. Some symptoms of OSA are snoring hard and annoying, stopping repeated breathing during sleep at night, insomnia, fatigue, and drowsiness during the day. Death from OSA in productive age is usually caused by complications after having OSA in the long period ahead.
Anatomi dan Fisiologi Ginjal: Tinjauan Pustaka Alwiyah, Fadilah; Rudiyanto, Waluyo; Anggraini, Dwi Indria; Windarti, Indri
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.977

Abstract

The kidneys are retroperitoneal organs located at the top on both sides of the III lumbar vertebra and attached directly to the abdominal or ventral wall of the M. psoas major and M. quadratus lumborum. The kidneys function to regulate the amount and concentration of ECF electrolytes and maintain nerve and muscle excitability, activating vitamin D which is important for calcium absorption in the digestive tract and producing erythropoietin which is a hormone to stimulate the bone marrow to form red blood cells. The main function of the kidneys is to filter and excrete metabolic waste products in the urine so that administration of toxic compounds or irritating compounds can cause degenerative changes such as fatty degeneration to necrosis of the kidneys. Disorders of the kidneys can disrupt kidney function. Chronic Kidney Disease (CKD) sufferers have several complications such as overhydration, hyperkalemia, metabolic acidosis, mineral and bone disorders, hypertension, anemia and dyslipidemia. The most common etiologies of CKD in adult patients are diabetes mellitus and hypertension. In children, the most common primary cause of PGTA is congenital abnormalities of the kidneys and urinary tract (such as obstructive uropathy, vesicoureteral reflux, renal dysplasia). Indonesian Nephrology Association (PERNEFRI) in 2006, which found that the prevalence of Chronic Kidney Disease (CKD) was 12.5%. Meanwhile, data according to the 2019 Health Insurance Administration (BPJS) shows that there were 1.93 million cases of kidney failure and 1.79 million cases in 2020. With this data, the author is interested in discussing the kidneys in more depth.
Kerusakan, alkohol, kesehatan Kerusakan Lambung Akibat Konsumsi Alkohol: Dampak dan Penanganannya Madina Ghassan Nebraska; Jausal, Annisa Nuraisa; Wulan, Anggraeni Janar; Rudiyanto, Waluyo
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.984

Abstract

Alcohol consumption has spread across various social strata of society, especially among teenagers. Health issues caused by alcohol are often overlooked. This article delves into the damage to the stomach caused by alcohol consumption. Alcohol can damage the gastric mucosa layer and disrupt the balance of stomach acid, leading to various conditions such as gastritis, gastric ulcers, and even gastric cancer. Additionally, alcohol can affect the movement of food and fluids in the digestive tract, increasing the risk of acid reflux, which can worsen stomach conditions. The mechanisms of stomach damage by alcohol involve the direct toxic effects of alcohol itself and the chronic inflammation it induces. Although this damage is often not immediately felt, its long-term effects can lead to serious complications. Management of alcohol-induced stomach damage involves lifestyle modifications, such as reducing or ceasing alcohol consumption, and medical treatment to alleviate symptoms and accelerate healing. To prevent further damage, it is important to raise awareness of the risks of alcohol to stomach health and promote a healthy lifestyle. Understanding the impact and management of stomach damage caused by alcohol consumption is crucial in preventing more serious complications.
Tinjuan Pustaka: Hubungan Jenis Kelamin dan Hormon Androgen dengan Kejadian Dry-Eye Disease Fairuz Hanan, Sifa’Syaharani; Rengganis Wardani, Dyah Wulan Sumekar; Rudiyanto, Waluyo; Himayani, Rani
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.992

Abstract

Dry eye disease (DED) is a multifactorial condition on the surface of the eye that occurs due to disruption of tear film homeostasis with manifestations of symptoms such as tear film instability, hyperosmolarity, inflammation, eye surface damage, and neurosensory abnormalities. DED can occur due to decreased eye fluid production or increased tear evaporation which is generally caused by meibomian gland dysfunction. The global prevalence of DED ranges from 5-50%, with women having a higher risk than men. The prevalence of dry eye in women (3.2 million) is higher than in men (1.6 million) aged over 50 years. Asian ethnicity is the most consistent risk factor for DED. The female gender factor is a risk in the development of DED with increasing age. The pathophysiological mechanisms of DED can be influenced by differences in endocrine function related to sex, especially androgen, estrogen and other hormones. The meibomian and lacrimal glands are target organs for androgen hormones, and low androgen activity can cause meibomian gland dysfunction and inflammation of the lacrimal glands, contributing to the occurrence of DED. In addition, differences in gene expression affect mucin production by the cornea and conjunctiva, as well as other hormonal involvement can also affect eye health and cause dry eye symptoms. Further understanding of the relationship between gender, hormones, and pathophysiological mechanisms of DED may aid the development of more effective treatment strategies.
Hubungan Konsumsi Kopi dengan Kejadian Gastroesophageal Reflux Disease (GERD) pada Remaja Kanzulli, Mohammad Haidar; Suharmanto, Suharmanto; Rudiyanto, Waluyo
Journal of Language and Health Vol 5 No 3 (2024): Journal of Language and Health
Publisher : CV. Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/jlh.v5i3.5036

Abstract

Gastroesophageal Reflux Disease (GERD) merupakan gangguan pencernaan umum yang disebabkan oleh aliran balik asam lambung ke esofagus, yang dapat mengakibatkan berbagai gejala klinis seperti nyeri ulu hati, nyeri epigastrium, dan mual. ​​Konsumsi kopi yang tinggi pada remaja diduga berkontribusi terhadap peningkatan kejadian GERD. Penelitian ini bertujuan untuk menganalisis hubungan antara konsumsi kopi dan kejadian GERD pada remaja di SMAN 5 Bandar Lampung. Penelitian ini menggunakan desain cross-sectional dengan pendekatan analisis observasional. Sampel penelitian sebanyak 293 siswa yang dipilih melalui stratified random sampling. Data dikumpulkan menggunakan kuesioner yang tervalidasi dan reliabel. Variabel bebasnya adalah konsumsi kopi, sedangkan variabel terikatnya adalah kejadian GERD yang diukur menggunakan GERD-Q. Analisis data dilakukan dengan menggunakan uji Chi-Square. Hasil penelitian menunjukkan adanya hubungan yang signifikan antara konsumsi kopi dan kejadian GERD (p=0,002). Sebagai kesimpulan, konsumsi kopi ringan hingga sedang dapat meningkatkan risiko GERD pada remaja.
Insomnia pada Mahasiswa Kedokteran: Sebuah Tinjauan Pustaka Fuad Fadillah; Lisiswanti, Rika; Rudiyanto, Waluyo; Oktafany, Oktafany
Medula Vol 14 No 9 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i9.1416

Abstract

A person who struggles to fall asleep and/or stay asleep is said to have insomnia. In Southeast Asia, 67% of 1,508 persons suffer from insomnia worldwide, and 7.3% of those who suffer from it are students. About 67% of Indonesians suffer from insomnia, with mild insomnia accounting for 55.8% and moderate insomnia for 23.3% of cases. Students who suffer from insomnia suffer, particularly those studying medicine. Medical students' usage of devices and the stress that comes with learning are linked to insomnia. By interfering with the body's sleep and wake cycle and blocking the melatonin hormone's function, using electronics at night, particularly shortly before bed, can make it difficult for the body to regulate and manage the ideal time to go to sleep and the time to be awake. Through the HPA-axis mechanism, which is triggered by corticosteroid releasing factor (CRF) and arginine vasopressin (AVP), anxiety can result in sleeplessness. This may lead the body to produce more cortisol, which would raise the wakefulness system and result in insomnia. Those who suffer from insomnia, particularly the medical students in this piece, incur unpleasant consequences. Fatigue, memory loss, and concentration issues are some of the issues that cause insomnia and impact a person's performance during the day. Disrupting concentration makes learning ineffective, which can ultimately impact medical students' performance and the quality of graduates.
SKRINING FUNGSI KOGNITIF DAN KADAR ASAM URAT PADA PESERTA PROLANIS KLINIK DOKTER KELUARGA Purwoko, Mitayani; Heriyanto, Mochammad Junaidy; Sulistiyani, Sulistiyani; Sriningsih, Solikah; Putra, Chendra Perdana; Gani, Rima January Putri Ridwan; Prakoso, Denny Anggoro; Novitasari, Erlina Krisdianita; Tubarad, Gladys Dwiani Tinovella; Sukarno, Rizky Triutami; Rudiyanto, Waluyo; Pandhita, Gea; Aziza, Nurita; Tursinawati, Yanuarita; Airlangga, Muhammad Perdana; Setiawan, Meddy; Romi, M. Mansyur
Jurnal Pengabdian Masyarakat Medika Vol 5. No. 2, September 2025
Publisher : Universitas Muhamamdiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jpmmedika.v5i2.12547

Abstract

ABSTRAK Fungsi kognitif dan kadar asam urat darah lansia tidak termasuk dalam pemeriksaan wajib dalam program Prolanis. Fungsi kognitif perlu dinilai untuk memastikan bahwa peserta Prolanis tidak mengalami kemunduran fungsi kognitif. Tujuan kegiatan ini adalah untuk melakukan skrining tingkat fungsi kognitif dan kadar asam urat darah peserta Prolanis di Klinik Dokter Keluarga Fakultas Kedokteran Universitas Muhammadiyah Palembang. Kegiatan dilaksanakan dalam satu hari selama 2 jam 30 menit. Pemeriksaan fungsi kognitif dilakukan menggunakan kuesioner Mini Mental State Examination (MMSE) berbahasa Indonesia. Pemeriksaan kadar asam urat darah dilakukan menggunakan darah dari ujung jari dengan alat pemeriksa asam urat dan strip khusus. Hasil skrining menunjukkan bahwa 80,4% peserta Prolanis memiliki fungsi kognitif yang normal dan 66,7% memiliki kadar asam urat darah yang normal.   ABSTRACT Cognitive function and blood uric acid levels in the elderly are not included in the mandatory screening in the Prolanis program. Cognitive function needs to be assessed to ensure that Prolanis participants do not experience cognitive decline. The purpose of this activity was to screen the cognitive function and blood uric acid levels of Prolanis participants at the Family Physician Clinic, Faculty of Medicine, Muhammadiyah University of Palembang. The activity was carried out in one day for 2 hours and 30 minutes. Cognitive function testing was conducted using the Indonesian language Mini Mental State Examination (MMSE) questionnaire. Blood uric acid testing was performed using fingertip blood with a uric acid tester and special strips. The screening results showed that 80.4% of Prolanis participants had normal cognitive function and 66.7% had normal blood uric acid levels.