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Basmiati, Basmiati
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Aktivitas Antibakteri Ekstrak Metanol Buah Pare (Momordica charantia L.) Terhadap Pertumbuhan Methicillin Resistant Staphylococcus aureus (MRSA) Basmiati, Basmiati; Taufiq, Nuramaniyah; Firdaus, Sirajul
INHEALTH : INDONESIAN HEALTH JOURNAL Vol. 4 No. 1 (2025): INHEALTH JOURNAL
Publisher : CV. Eureka Murakabi Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56314/inhealth.v4i1.294

Abstract

Obat tradisional adalah bahan atau ramuan bahan yang berupa bahan tumbuhan, bahan hewan, bahan mineral, sediaan sarian atau campuran dari bahan tersebut yang secara turun temurun telah digunakan untuk pengobatan, dan dapat diterapkan sesuai dengan norma yang berlaku di masyarakat. Salah satu dari obat tradisional tersebut adalah buah pare. Buah pare merupakan anggota keluarga Cucurbitaceae yaitu tanaman tropis yang saat ini didistribusikan di seluruh dunia dan memiliki sifat terapeutik seperti antibakteri, anti diabetes, antioksidan, antiviral dan aktivitas antineoplastik. Kandungan kimia ekstrak buah pare adalah flavonoid, alkaloid, saponin, streoid/terpenoid, dan glikosida. Salah satu zat kimia yang berfungsi sebagai antibakteri adalah flavonoid. Senyawa flavonoid berkerja sebagai antibakteri dengan cara membentuk senyawa kompleks terhadap protein extraseluler yang mengganggu intergritas membran sel bakteri Penelitian ini bertujuan untuk mengetahui daya antibakteri ekstrak metanol buah pare terhadap MRSA dan untuk mengetahui Kadar Hambat Minimum (KHM) dan Kadar Bunuh Minimum (KBM) ekstrak metanol buah pare terhadap MRSA. Metode yang digunakan pada penelitian ini adalah metode dilusi. Hasil penelitian menunjukkan bahwa ekstrak metanol buah pare (Momordica charantia L.) memiliki aktivitas antibakteri terhadap bakteri Methicillin Resistant Stapylococcus aureus (MRSA) dengan KHM pada konsentrasi 2% dan KBM pada konsentrasi 4%.
Metagenomic Analysis of Intestinal Microbiota Derived from Stool Samples of Third-Trimester Pregnant Women Kamaruddin, Mudyawati; Zamzam, Miftahul Khairiyah; Pratama, Rahadian; Nur, AbdurRahman Shakhr; Muthiadin, Cut; Sembiring, Christine; Triananinsi, Nurhidayat; Nurisyah, Nurisyah; Dewi, Ratnasari; Fatmawati, Fatmawati; Erniawati, Erniawati; Jusni, Jusni; Basmiati, Basmiati
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol. 14 No. 1 (2025): MARET 2025
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v14i1.4173

Abstract

Background: The human gut microbiota plays a unique role in metabolism, immunity, and nutrient absorption.  Various studies on the gut microbiota have identified a link between changes in bacterial abundance in the gut known as dysbiosis (imbalance) and the pathogenesis of certain disorders. It is known that an imbalance in the ratio of the phyla Firmicutes and Bacteroidetes has been associated with various chronic diseases, including inflammatory bowel disease and metabolic disorders. The Firmicutes/Bacteroidetes (F/B) ratio is a measure used to assess gut microbiota composition, which is believed to play a significant role in intestinal health and metabolism. Studies suggest that a higher F/B ratio is often associated with obesity and other metabolic conditions. Objective: This study aims to carry out metagenomic analysis of third-trimester pregnant women's faecal samples to predict degenerative diseases using third-generation whole genome sequencing, namely PromethION nanopore technology.  Method: Nanopore Technology: DNA sequencing of faecal samples from pregnant women in the third trimester was performed using the Oxford Nanopore Technology (ONT) device based on the Ligation Sequencing gDNA - Native Barcoding Kit 24 V14 and following its guidelines. Result: Based on the quality and quantity of total DNA reads from 20 stool samples from pregnant women, only 4 samples were continued for analysis (1A, 2A, 3A and 4A). The results of the abundance of intestinal microbiota based on the most abundant phylum are Proteobacteria, Bacteriodetes, and Firmicutes. Conclusion: Meanwhile, based on species abundance, it shows that Prevotella copri (phylum Bacteriodetes) is abundant in samples 2A, 3A and 4A, while in sample 1A the most abundant species is Succinivirio dextrinosolvens (phylum Proteobacteria). Bacteroidetes are a group of Gram-negative bacteria that are often found to increase in individuals with type 2 diabetes and obesity
Co-Authors Cut Muthiadin Dewi Ratnasari Erniawati, Erniawati Fatmawati, Fatmawati Jusni, Jusni Mudyawati Kamaruddin Nur, AbdurRahman Shakhr Nurisyah, Nurisyah Rahadian Pratama Sembiring, Christine Sirajul Firdaus, Sirajul Taufiq, Nuramaniyah Triananinsi, Nurhidayat Zamzam, Miftahul Khairiyah