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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Media Farmasi Jurnal Mandala Pharmacon Indonesia Jurnal Pengabdian Kefarmasian FASKES : Jurnal Farmasi, Kesehatan, dan Sains Media Farmasi Jurnal Media Analis Kesehatan
Nurisyah, Nurisyah
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Kadar Gula Pereduksi Dan Kadar Air Pada Madu Yang Beredar Di Kota Makassar Abdullah, Tajuddin; Nurisyah, Nurisyah; Asyikin, Asyhari
Media Farmasi XXX Vol 19, No 1 (2023)
Publisher : Jurusan Farmasi Politeknik Kesehatan Makassar, Kementerian Kesehatan RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v19i1.3006

Abstract

Reducing Sugar Levels and Water Content Of Honey Circulating In Makassar CityHoney has many benefits that people can use to improve their health, but the presence of fake honey can have an unwanted impact. This study aims to determine how much-reduced sugar and water content are contained in honey samples circulating in Makassar City. Sample testing was carried out with a qualitative test and a quantitative test. Qualitative testing used the Mollish reagent, Seliwanof reagent, and Fehling reagent and showed positive results for containing reducing sugars. Quantitative testing was carried out using the Luff School method. While testing the water content of honey is done by drying method using an oven. The results showed that the reducing sugar content of the three samples, namely the Honey A sample was 77.11%, the Honey B sample was 69.52%, and the Honey C sample was 85.17%. Meanwhile, the water content obtained by honey sample A was 25.39%, honey sample B was 21.21%, and honey sample C was 19.83%. Thus, it can be concluded that honey samples A, B, and C met the requirements for honey-reducing sugar content in SNI-01-3545-2004, namely at least 65% w/w. While the water content in Honey A does not meet SNI-01-3545-2004 honey quality standards: a maximum of 22% w/w and those that meet the requirements are Honey B and C samples with a water content of less than 22% w/w.Keywords: Honey, Reducing Sugar, Moisture Content, Luff Schrool Method, Gravimetric MethodMadu memiliki banyak manfaat yang dapat digunakan oleh masyarakat untuk meningkatkan Kesehatan, namun adanya madu yang palsu malahan dapat memberikan dampak yang tidak diinginkan. Penelitian ini bertujuan untuk mengetahui berapa besar kadar gula reduksi dan kadar air yang terdapat pada sampel madu yang beredar di Kota Makassar. Pengujian sampel dilakukan dengan Uji Kualitatif dan Uji Kuantitatif. Pengujian secara kualitatif menggunakan Pereaksi Mollish, Pereaksi Seliwanof, dan Pereaksi Fehling dan menunjukkan hasil positif mengandung gula pereduksi. Pengujian secara kuantitatif dilakukan dengan metode Luff Schrool. Sedangkan pada pengujian kadar air madu dilakukan dengan metode pengeringan dengan menggunakan oven. Hasil penelitian diperoleh kadar gula reduksi dari tiga sampel yaitu sampel Madu A sebesar 77,11 %, sampel Madu B sebesar 69,52 %, dan sampel Madu C sebesar 85,17 %. Sedangkan kadar air yang diperoleh sampel madu A sebesar 25,39 %, sampel madu B sebesar 21,21 %, dan sampel madu C sebesar 19,83 %. Dengan demikian dapat disimpulkan bahwa sampel madu A, B, dan C memenuhi syarat kadar gula reduksi madu pada SNI-01-3545-2004 yaitu minimal 65% b/b. Sedangkan kadar air pada Madu A tidak memenuhi SNI-01-3545-2004 standar kualitas madu : maksimal 22 % b/b dan yang memenuhi syarat yaitu sampel Madu B dan C dengan kadar air kurang dari 22 % b/b.Kata Kunci : Madu, Gula Pereduksi, Kadar Air, Metode Luff Schrool, Metode Gravimetri
Kesesuaian Penggunaan Obat Pada Pasien Diabetes Melitus Berdasarkan Algoritma Terapi Di Wilayah Kerja Puskesmas Andalas Dan Puskesmas Tarakan Kota Makassar Rusli, Rusli; Nurisyah, Nurisyah; dewi, ratnasari; Rianti, A.Elmi; Khafifah, Khafifah
Jurnal Media Analis Kesehatan Vol 15 No 2 (2024): JURNAL MEDIA ANALIS KESEHATAN
Publisher : Potekkes Kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/jmak.v15i2.1074

Abstract

Diabetes melitus adalah penyakit kronis yang disebabkan oleh peningkatan kadar gula darah. Salah satu strategi pengendalian kadar gula darah pada pasien diabetes melitus adalah penggunaan obat secara rasional. Penelitian ini bertujuan untuk menganalisis kesesuaian penggunaan obat pada pasien diabetes melitus berdasarkan algoritma terapi di wilayah kerja puskesmas Andalas dan Puskesmas Tarakan kota Makassar. Penelitian ini merupakan penelitian deskriptif yang bersifat non eksperimental yang dilakukan dengan mengumpulkan data rekam medis pasien diabetes melitus. Sampel dalam penelitian ini adalah pasien diabetes melitus yang mendapatkan pengobatan di puskesmas Andalas di tahun 2023 yaitu sebanyak 56 catatan rekam medis pasien yang terdiri dari 26 orang laki-laki dan 30 orang perempuan sedangkan di puskesmas Tarakan sebanyak 33 catatan rekam medis pasien yang terdiri dari 9 orang laki-laki dan 24 orang perempuan, penggunaan obat yang diberikan kepada pasien dibandingkan dengan standar PERKENI 2021. Hasil penelitian menunjukkan bahwa penggunaan obat antidiabetes terapi tunggal yang paling banyak digunakan di Puskesmas Andalas dan Puskesmas Tarakan berturut-turut adalah golongan biguanide yaitu metformin (76,67%) dan (48,48%) dan terapi kombinasi yang paling banyak adalah golongan biguanide + sulfonilurea yaitu metformin + glimepiride (53,84%) dan (70,37%). Evaluasi menunjukkan pasien yang tepat indikasi (100%), tepat obat di Puskesmas Andalas (96,43%) dan Pukesmas Tarakan (87,88%), tepat dosis di Puskesmas Andalas (87,5%) dan Pukesmas Tarakan (97%), dan tepat pasien (100%). Berdasarkan hasil penelitian tersebut dapat disimpulkan bahwa 96,43% penggunaan obat pada pasien diabetes melitus di Puskesmas Andalas kota Makassar sudah sesuai dengan Algoritma Persatuan Endokrinologi Indonesia tahun 2021 (PERKENI 2021) dan penggunaan obat diabetes melitus di Puskesmas Tarakan yang sesuai dengan Algoritma sebanyak 87,88%.
Aktivitas Antioksidan Ekstrak Etanol, Etil Asetat, Dan n-Heksan Biji Mengkudu (Morinda Citrifolia L.) Dengan Metode DPPH Nurisyah, Nurisyah; Irawati, Irawati; Salasa, Alfrida Monica; Asyikin, Asyhari
Media Farmasi Vol 20 No 2 (2024): Media Farmasi Edisi Oktober 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i2.686

Abstract

Antioxidants are compounds that can reduce the negative impact of free radicals. Noni seeds (Morinda citrifolia L.) contain these compounds as secondary metabolites. This research is a laboratory observational study to determine and compare the antioxidant activity of ethanol extract, ethyl acetate extract, and n-hexane extract noni seeds (Morinda citrifolia L.) using the 1,1-diphenyl-2- picrylhydrazyl method using a UV-Vis Spectrophotometer at a wavelength of 516 nm. The results showed that the IC50 value of the ethanol extract of noni fruit seeds was 507.75 ppm and the IC50 value of the ethyl acetate extract of noni fruit seeds was 43.18 ppm, while the n-hexane extract of noni fruit seeds had inactive antioxidant activity. The antioxidant activity of the ethanol extract of noni seeds is in the weak category and the antioxidant activity of the ethyl acetate extract is in the very strong category. The extracting solution that produces noni seed extract with the highest antioxidant activity is ethyl acetate solvent
Studi Molecular Docking Senyawa Ircinianin Terhadap Reseptor Sodium-Glukose Co-Transporter 2 (SGLT-2) ramadhan, dwi syah fitra; Dewi, Ratnasari; Ibrahim, Ismail; Rachmawati Daswi, Dwi; Nurisyah, Nurisyah; Asyikin, Asyhari; Abdullah, Tajuddin
FASKES : Jurnal Farmasi, Kesehatan, dan Sains Vol. 2 No. 2 (2024): Bulan November 2024 Faskes : Jurnal Farmasi, Kesehatan, dan Sains
Publisher : Program Studi Farmasi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32665/faskes.v2i2.3514

Abstract

Latar Belakang: Sodium-glucose cotransporter 2 (SGLT-2) merupakan target potensial dalam pengobatan diabetes tipe 2, dengan inhibitor SGLT-2 yang bekerja menghambat reabsorpsi glukosa di ginjal. Penelitian ini bertujuan untuk mengevaluasi potensi ircinianin, senyawa alami yang diisolasi dari spons Ircinia sp., sebagai inhibitor SGLT-2 menggunakan pendekatan molecular docking. Tujuan: Penelitian ini bertujuan untuk menganalisis interaksi antara ircinianin dan protein SGLT-2 serta mengevaluasi potensi penghambatan ircinianin terhadap reseptor SGLT-2. Metode: Metode yang digunakan adalah molecular docking dengan perangkat lunak AutoDock4. Prosedur dilakukan dengan docking ligan pada situs aktif SGLT-2. Ligan didocking dengan 100 iterasi untuk memperoleh konformasi ikatan yang optimal. Interaksi dianalisis berdasarkan energi ikatan dan visualisasi dilakukan menggunakan Discovery Studio. Hasil: Ircinianin menunjukkan energi ikatan sebesar -10,76 kcal/mol, sedikit lebih tinggi dibandingkan native ligand (-11,46 kcal/mol). Ircinianin membentuk dua ikatan hidrogen dengan residu PHE:98 dan TRP:291. Kesimpulan dan Saran: Ircinianin memiliki potensi sebagai inhibitor SGLT-2, meskipun ikatan hidrogennya lebih sedikit dibandingkan ligan asli. Penelitian lebih lanjut diperlukan untuk mengeksplorasi potensi terapeutik ircinianin dalam pengobatan diabetes tipe 2.
Edukasi dan Pelatihan Pembuatan Serbuk Sari Buah Mengkudu (Morinda Citrifolia L.) Untuk Pengendalian Hipertensi Asyikin, Asyhari; Nurisyah, Nurisyah
Jurnal Pengabdian Kefarmasian Vol 6, No 1 (2025): JURNAL PENGABDIAN KEFARMASIAN
Publisher : Jurusan Farmasi Politeknik Kesehatan Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/jpk.v16i1.3481

Abstract

Education and Training on Producing Noni Fruit (Morinda citrifolia L.) For Hypertension ControlBackground Hypertension is a serious problem because one in three adults worldwide suffers from hypertension and is currently a trending urban health problem. In 2025, it is predicted that 29% of adults worldwide will suffer from hypertension. The proportion of hypertension in Indonesia has increased in 2018, which was 34.1%. Hypertension sufferers in Makassar City have increased every year. In 2020, the number of hypertension cases in Makassar City reached 40,288 cases. In overcoming the incidence of hypertension, some people in Pa'baeng-baeng Village, Tamalate District, Makassar City have never been exposed to counseling related to hypertension so that most of them check their blood pressure if they already have hypertension. The purpose of the activity is to provide counseling on hypertension, create a module on how to make instant herbal powder from noni fruit, red ginger, cinnamon, and cloves (MORIZYA instant powder) to control hypertension. Method This activity was carried out in the Pa'baeng-baeng Village area, Tamalate District, Makassar City. Tamalate Makassar City in the form of counseling and training on making instant herbal powder MORIZYA for controlling hypertension and to measure the success and effectiveness of education in this community service activity, an evaluation was carried out through a pre-test and post-test. The results of the activity showed that there were 30 people who participated in the activity and the results of the post-test showed that after the education, the participants' knowledge increased by 4.2 points (42%). The conclusion is that there is an increase in public knowledge about hypertension and they are able to make instant powder MORIZYA for controlling hypertensionLatar Belakang Hipertensi menjadi masalah serius karena satu dari tiga orang dewasa diseluruh dunia menderita hipertensi dan menjadi tren masalah kesehatan perkotaan saat ini. Pada tahun 2025, diprediksi 29% orang dewasa di seluruh dunia menderita hipertensi. Proporsi penyakit hipertensi di Indonesia semakin meningkat pada tahun 2018, yaitu 34,1%. Penderita hipertensi di Kota Makassar mengalami peningkatan setiap tahunnya. Pada tahun 2020 jumlah kasus hipertensi di Kota Makassar mencapai 40.288 kasus. Dalam penanggulangan kejadian penyakit hipertensi, sebagian masyarakat di Kelurahan Pa’baeng-baeng Kecamatan Tamalate Kota Makassar belum pernah terpapar penyuluhan terkait hipertensi sehingga kebanyakan dari mereka, memeriksakan tekanan darahnya apabila sudah mengalami hipertensi. Tujuan Kegiatan untuk melakukan penyuluhan tentang hipertensi, pembuatan modul tentang cara pembuatan serbuk instan herbal dari buah mengkudu, jahe merah, kayu manis, dan cengkeh (sebuk instan MORIZYA) untuk pengendalian hipertensi. Metode Kegiatan ini dilakukan di wilayah Kelurahan Pa’baeng-baeng Kec. Tamalate Kota Makassar dalam bentuk penyuluhan dan pelatihan pembuatan herbal serbuk instan MORIZYA untuk pengendalian Hipertensi dan untuk mengukur keberhasilan dan efektivitas edukasi dalam kegiatan pengabmas ini maka dilakukan evaluasi melalui pre-test dan post-test. Hasil kegiatan menunjukan terdapat 30 orang yang mengikuti kegiatan dan hasil post test menunjukkan bahwa setelah edukasi pengetahuan peserta naik sebesar 4,2 point (42%). Kesimpulan terdapat peningkatan pengetahuan masyarakat tentang penyakit hipertensi dan mampu membuat serbuk instan MORIZYA untuk pengendalian Hipertensi.
Review: Medication Error in Prescribing and Dispensing Phases on Outpatient: Review: Medication error dalam fase peresepan dan dispensing pada Pasien Rawat Jalan Anwar, Ismail; Sinala, Santi; Nurisyah, Nurisyah; Adhayanti, Ida; Dewi, Sisilia Teresia Rosmala
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 8 No. 1 (2022): (March 2022)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2022.v8.i1.15800

Abstract

Background: A medication error is defined as "any preventable event that may cause or lead to inappropriate medication use or patient harm while the medication is in the control of the healthcare professional, patient, or consumer." A medication error might occur at any point during the medication-use process, such as when prescribing the medicines, during dispensing, and when the drug is taken by the patient. Objectives: This review focusing on the types of medication errors (MEs) which commonly occurs during prescribing and dispensing phase on the outpatient in Indonesia. Material and Methods: Articles related to MEs during prescribing and dispensing phase were collected from DOAJ (Directory of Open Access Journals) and google scholar. The articles were reviewed and analyze to draw conclusions about the common type of MEs mostly occured on the outpatients. There were 10 articles (2003-2020) that have been reviewed, covering the types of MEs, MEs incidents and how to reduce the number of MEs incident. Results: Based on the reviewed articles, MEs commonly occured in the prescribing phase were incomplete data of patient's on the prescription include address, born date, weight and gender; unclear information on the prescription including, dosage, route of adminstration, illegible writing; uncomplete data on the doctor's information such as the practise license number wasn't listed, and there were no information on medicine interactions. MEs occured during dispensing phase were uncomplete data on the information about how to use, time of using, indication, the amount of the drug given, the side effects, the storage instruction, the strength or the doses of medicine, error in writing etiquette, error in compounding as well as there was no information related what to do if the patient forgot to take the medicines.
Identifikasi Metabolit Bioaktif pada Asam Jawa (Tamarindus indica L.) menggunakan Komputasi Dinamika Molekuler untuk Penargetan HER-2 Kanker Payudara Ramadhan, Dwi Syah Fitra; Indraswari, Ni Luh Astri; Hakim, Supartina; Rusli, Rusli; Nurisyah, Nurisyah; Asikin, Asyhari; Fakih, Taufik Muhammad; Aksar, M
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 1 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i1.520

Abstract

The HER-2 (Human EGF Receptor-2) receptor is a receptor known to be strongly correlated with carcinogenesis and a worse prognosis in breast cancer patients. One of the native Indonesian plants that has been reported to inhibit breast cancer growth is tamarind (Tamarindus indica L.) which is known to contain various active metabolites. However, until now, the molecular activity of each of these metabolites has not been known. and one of the highly accurate simulation methods commonly used is molecular dynamics simulation. This study aims to understand the binding stability of active metabolites in tamarind computationally using molecular dynamics. The simulation begins with the preparation of 3D structures of ligands and receptors. The ligand of active metabolite from tamarind tree was obtained from KnapSack natural compound database, and the 3D structure of HER-2 receptor was obtained from PDB site with code 3PP0 and resolution of 2.25 Å. Furthermore, molecular tethering was performed using Autodock4 software. A high-performance computer was used for molecular dynamics simulation with Gromacs 2016 software for 100 nanoseconds (ns). Afterwards, molecular affinity analysis was performed, including RMSD (Root Mean Square Deviation) and RMSF (Root Mean Square Fluctuation). The analysis results showed that of the 6 compounds found in tamarind plants, the orientin compound showed the most favorable molecular Tethering activity with a value of -8.41 Kcal/mol. Although still higher than the natural ligand, the value is close to the value of the natural ligand with a difference of 1.8 Kcal/mol, which is -10.21 Kcal/mol. Furthermore, orientin showed very similar stability to the native ligand, as observed from the RMSD and RMSF analysis. In conclusion, the compound orientin found in tamarind has the potential to be a lead compound for inhibiting HER-2 in breast cancer.
Co-Authors Abdullah, Tajuddin Adhayanti, Ida Aksar, M Anwar, Ismail Asikin, Asyhari Asyikin, Asyhari Dewi Ratnasari Dewi, Sisilia Teresia Rosmala Dwi Syah Fitra Ramadhan Hakim, Supartina Indraswari, Ni Luh Astri Irawati Irawati Ismail Ibrahim Khafifah, Khafifah R. Rusli Rachmawati Daswi, Dwi Rianti, A.Elmi Salasa, Alfrida Monica Sinala, Santi Taufik Muhammad Fakih