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Sunscreen Cream Formulation of Noni Leaf Extract (Morinda citrifolia L.) with Emulsifier Combination of Tween 80 and Lecithin Bianca Levie Tania; Rini Dwiastuti; Agatha Budi Susiana Lestari; Dewi Setyaningsih
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 3 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i32022.262-271

Background: Noni leaf (Morinda citrifolia L.) extract is a natural product that can be used as a sunscreen. The extract contains flavonoids which function act as an antioxidant. In this work, sunscreen cream formulated with noni leaf extract was prepared using a combination of tween 80 and lecithin. Objective: The purpose of this study is to evaluate how the combination of tween 80 and lecithin affects the physical qualities of the cream, such as organoleptic, homogeneity, emulsion type, spreadability, adhesion, pH, and stability over 28 days of storage at room temperature, and to find the best formula. Methods: This study used 10% of noni leaf extract in the cream formulation. The Simplex Lattice Design (SLD) method was used to determine the effect of different concentrations of the two emulsifiers on the cream's spreadability, adhesion, and pH. Furthermore, the SLD was used to find the best formula. Results: The results showed that different concentrations of the emulsifier, which are the tween 80 and lecithin combination, affected the physical properties and storage stability of cream preparations. The interaction of tween 80 and lecithin is having a significant impact on the cream's adhesion and spreadability; however, the effect of the interaction on the pH value was not significant. Conclusion: The formula containing 2.5 % tween 80 and 2.5 percent lecithin was found to be the most effective in fulfilling the cream physical properties while remaining stable during storage.

Optimasi CMC-Na dan Gliserin dalam Sediaan Gel Ekstrak Lidah Buaya secara Simplex Lattice Design Martina Indah Anita; Agatha Budi Susiana lestari
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 1 (2023): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i1.1226

Aloe vera (Aloe barbandesis Mill.) is a plant with many benefits, such as an antibacterial agent. A gel dosage form has many advantages, such as being easy to use, not sticky, and quickly washed with water. This pure experimental study aims to obtain the optimal composition of CMCNa as a gelling agent and glycerin as a humectant to produce a gel with good physical properties and physical stability using the Simplex Lattice Design. The results of the responses of spreadability, viscosity, viscosity shift, and spreadability shift were used to determine the optimum formula and were analyzed using Software Design Expert. The results of the research found that the optimum formulas were formulas 1, 2, and 3 with a concentration of CMC-Na and glycerin, respectively, which were 1.500 g and 1.750 g; 1.563 g and 1.688 g; and 1.625 g. In addition, formulas 1, 2, and 3 fulfill the gel's physical properties and stability parameters.

The effect of recompression and concentration of polyvinylpyrrolidone (PVP) K-30 on the quality of paracetamol tablets Lestari, Agatha Budi Susiana; Angelina, Desak Made Rachel
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.28399

Quality control during production is a critical process that ensures the quality of the tablets until it reaches the consumer. In the pharmaceutical industry, there is a possibility of reworking, including tablet recompression. Nevertheless, the recompression process may have affected the potential of PVP K-30 as a binder to reunite the particles of tablet ingredients. However, the difference of PVP K-30 concentration might be resulting in the differences of granule and tablet characteristics. This study aims to determine whether there is an effect of recompression and the difference of PVP K-30 on the quality of paracetamol tablets. The effect of recompression and the difference of PVP K-30 was seen based on whether there is a significant different on physical properties of the mixture of tablet ingredients (mixture’s flow rate and compressibility) and the tablets (compatibility and tablet’s hardness, friability, and disintegration time) from the formula with a concentration of 2% w/w and 4% w/w PVP K-30 after experiencing 2 times of recompression. Paracetamol tablets were made by wet granulation method through the stages of granulation, lubrication, physical properties testing of the mixture, tablet compression, physical properties testing of tablets, crushing, and recompression. Data analysis was performed statistically using the Shapiro-Wilk normality test, followed by two-way Analysis of Variance (ANOVA) or Kruskal-Wallis test and Post Hoc Mann Whitney test. The results showed there was an effect of recompression and different concentration of PVP K-30 on the potential of PVP K-30 as a binder as seen from significant differences in the physical properties of the mixture and tablets in each test group.

PENINGKATAN PENGETAHUAN TENTANG PENYALAHGUNAAN DAN PENGGUNASALAHAN OBAT DI KALANGAN PELAJAR SEKOLAH MENENGAH DI YOGYAKARTA Lestari, Agatha Budi Susiana; Gani, Michael Raharja; Christasani, Putu Dyana
ABDIMAS ALTRUIS: Jurnal Pengabdian Kepada Masyarakat Vol 7, No 2 (2024): Oktober 2024
Publisher : Universitas Sanata Dharma

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/aa.v7i2.8172

Drug abuse and misuse among teenagers have been on the rise year after year. These teenagers must have a solid knowledge of drug use. Health education is provided to Yogyakarta high school students in order to improve their understanding of drug abuse and misuse. The health education is being held at SMK Kesehatan Pelita Bangsa Yogyakarta with 92 participants. The activities begin with a pre-test, continue with a presentation about drug abuse and misuse, and conclude with a post-test. Most participants are female (82%) and in the twelfth grade (49%). The average pre-test score of 86.41 increases to 91.41 in the average post-test score, indicating an improvement in respondents' knowledge. The activity hopes to teach students how to use drugs rationally, particularly ones widely abused by teenagers.

Optimization of sodium starch glycolate and maltodextrin in chlorpheniramine maleate Fast Disintegrating Tablet (FDT) by factorial design Sutristio, Kezia Livianthi Kirana Budhi; Lestari, Agatha Budi Susiana
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1493

Chlorpheniramine maleate (CTM) is an antihistamine that is widely available on the market in tablet form. It needs to be formulated in the form of Fast Disintegrating Tablets (FDT) to produce a faster therapeutic effect to treat allergy symptoms, which are often irritating. The FDT contains a super disintegrant to regulate the disintegration speed of tablet and a binder to provide the ability to bind between powders. This research was conducted to obtain the effect of Sodium Starch Glycolate (SSG) as a super disintegrant and maltodextrin as a binder, and their interaction in the chlorpheniramine maleate tablet formulation. This research was categorized as true experimental designs with FDT quality parameters such as organoleptic, hardness, friability, disintegration time, wetting time, water absorption ratio, and content uniformity. The optimization method used is factorial design. Data analysis was performed using Analysis of Variance (ANOVA). Based on the data, it conclude that Sodium Starch glycolate (SSG) affects increasing hardness, increasing friability, extending disintegration time, extending wetting time, and reducing the water absorption ratio. Maltodextrin, has the effect of increasing hardness, reducing friability, extending disintegration time, extending wetting time, and reducing the water absorption ratio. The interaction of SSG and maltodextrin has the effect of reducing hardness, increasing friability, shortening disintegration time, shortening wetting time, and increasing the water absorption ratio.

Optimization of Crospovidone and Copovidone in Fast Disintegrating Tablet (FDT) Diphenhydramine HCl Using Factorial Design Agatha Budi Susiana Lestari; Aldo Christian Jonathan
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 2 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006396

Diphenhydramine HCl is a drug used to treat motion sickness. Treatment of motion sickness needs rapid onset for successful therapy. Fast Disintegrating Tablet (FDT) is one dosage form that provides fast onset. The purpose of this study was to identify the dominant factors of crospovidone and copovidone, their interactions, and discover the optimum composition area to produce a FDT dosage form with optimum parameters involving hardness, friability, disintegration time, wetting time, and water absorption ratio. This study was experimental and used a factorial design. The result showed that copovidone significantly influenced friability, disintegration time, wetting time, and water absorption ratio, while their interactions significantly influenced the hardness of FDT diphenhydramine HCl. At the level studied, the optimum composition area was found, which can be predicted as a diphenhydramine HCl FDT dosage form formula.

Reworking Potential of Polyvinylpyrrolidone K-25 as a Binder in The Production of Paracetamol Tablets Agatha Budi Susiana Lestari; Okana, Lie Dofi Ananda Madelin
Journal of Fundamental and Applied Pharmaceutical Science Vol. 6 No. 1 (2025): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v6i1.27034

Binding agents play an important role in maintaining the bond between active and additional ingredients in tablets, especially when subjected to repeated compression. One commonly used binder is polyvinylpyrrolidone (PVP) K-25. However, issues often arise regarding the binder's potential when undergoing multiple compressions. This research, hence, aims to determine the reworking potential of PVP K-25 with different concentration levels as a binder, focusing on the physical properties of the mixtures and the resulting paracetamol tablets. The study follows a pure experimental design with a two-way completely randomized research design. Tablets were compressed and subsequently crashed again twice. Various tests, including flow properties and compressibility for the mixtures, as well as compatibility, hardness, friability, and disintegration time for the tablets, were conducted to assess their physical properties. The obtained data were subjected to statistical analysis, starting with the Shapiro-Wilk normality test, followed by Kruskal-Wallis and Post-Hoc Mann-Whitney tests. The research findings indicate that PVP K-25 can maintain its potential as a binder, as evidenced by the physical properties of both the mixtures and the resulting paracetamol tablets.

The effect of recompression and concentration of polyvinylpyrrolidone (PVP) K-30 on the quality of paracetamol tablets Lestari, Agatha Budi Susiana; Angelina, Desak Made Rachel
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.28399

Quality control during production is a critical process that ensures the quality of the tablets until it reaches the consumer. In the pharmaceutical industry, there is a possibility of reworking, including tablet recompression. Nevertheless, the recompression process may have affected the potential of PVP K-30 as a binder to reunite the particles of tablet ingredients. However, the difference of PVP K-30 concentration might be resulting in the differences of granule and tablet characteristics. This study aims to determine whether there is an effect of recompression and the difference of PVP K-30 on the quality of paracetamol tablets. The effect of recompression and the difference of PVP K-30 was seen based on whether there is a significant different on physical properties of the mixture of tablet ingredients (mixture’s flow rate and compressibility) and the tablets (compatibility and tablet’s hardness, friability, and disintegration time) from the formula with a concentration of 2% w/w and 4% w/w PVP K-30 after experiencing 2 times of recompression. Paracetamol tablets were made by wet granulation method through the stages of granulation, lubrication, physical properties testing of the mixture, tablet compression, physical properties testing of tablets, crushing, and recompression. Data analysis was performed statistically using the Shapiro-Wilk normality test, followed by two-way Analysis of Variance (ANOVA) or Kruskal-Wallis test and Post Hoc Mann Whitney test. The results showed there was an effect of recompression and different concentration of PVP K-30 on the potential of PVP K-30 as a binder as seen from significant differences in the physical properties of the mixture and tablets in each test group.

Optimasi Formula Gel Hand Sanitizer Minyak Atsiri Daun Jeruk Nipis (Citrus aurantifolia) dengan Variasi CMC-Na dan Gliserin Secara Desain Faktorial Lestari, Agatha Budi Susiana; Winarti, Elisabet
Jurnal Ilmiah Farmasi Vol. 20 No. 1 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss1.art8

Background: Lime leaves (Citrus aurantifolia) contain essential oils that are proven to inhibit the growth of bacteria. Objective: This study aims to formulate the essential oil from lime leaves in an emulgel dosage form that meets the quality requirements, using CMC-Na as a gelling agent and glycerin as a humectant using factorial design. Methods: Antibacterial activity tests are carried out using the diffusion method. The positive control used is ceftazidime, while the negative control is DMSO. The quality parameters used are physical properties (organoleptic, homogeneity, pH, viscosity, and spreadability), and physical stability of the preparation (pH shift, viscosity shift, and spreadability shift) using the freeze and thaw method. Results: Antibacterial test results show that lime leaf essential oil at concentrations of 10, 15, 20, 25, and 50% can inhibit the growth of bacteria that show strong antibacterial activity. Overall, the average test of physical properties and physical stability of the essential oil preparation of lime leaves meets the range of reception, pH 4.5–6.5, viscosity 112.77-180.66 dPa.s., and spreading power 5.55-7.97 cm. Conclusion: The optimum area specified indicates that all four formulas fulfill the criteria of pH, viscosity, spreadability, and pH shift.Keywords: CMC-Na, emulgel, essential oil of lime leaves, factorial design, glycerin Intisari Latar belakang: Daun jeruk nipis (Citrus aurantifolia) memiliki kandungan minyak atsiri yang terbukti dapat menghambat pertumbuhan bakteri. Tujuan: Penelitian ini bertujuan untuk memformulasikan minyak atsiri daun jeruk nipis dalam sediaan emulgel yang memenuhi persyaratan kualitas, dengan CMC-Na sebagai gelling agent dan gliserin sebagai humektan dengan metode desain faktorial. Metode: Uji aktivitas antibakteri dilakukan menggunakan metode difusi sumuran, dengan kontrol positif ceftazidime, sedangkan untuk kontrol negatif digunakan yakni DMSO. Parameter yang digunakan untuk kontrol kualitas sediaan emulgel meliputi uji sifat fisik (organoleptis, homogenitas, pH, viskositas dan daya sebar) dan uji stabilitas fisik (pergeseran terhadap respon pH, respon viskositas, respon daya sebar) dengan metode freeze and thaw. Hasil: Berdasarkan pengujian aktivitas antibakteri minyak atsiri daun jeruk nipis pada konsentrasi 10, 15, 20, 25 dan 50%, semuanya dapat menghambat pertumbuhan bakteri Escherichia coli dan termasuk dalam kategori kuat. Sediaan emulgel yang dihasilkan memenuhi syarat secara organoleptis maupun sifat fisik sediaan, dengan hasil pH 5-7, viskositas 112,77–180,66 dPa.s., dan daya sebar 5,55–7,97 cm. Untuk stabilitas fisik, sediaan emulgel memenuhi persyaratan pergeseran pH. Kesimpulan: Berdasarkan hasil analisis, diperoleh area optimum dari keempat formula memenuhi kriteria pH, viskositas dan daya sebar dan pergeseran pH.Kata kunci: Minyak atsiri daun jeruk nipis, CMC-Na, gliserin, emulgel, desain faktorial

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