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. Vera Dewi Mulia, Troef Soemarno
Bagian Patologi Anatomi, Fakultas Kedokteran, Universitas Syiah Kuala
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Journal : Jurnal Natural

 1 
TRIGONELLA FOENUM : A REVIEW OF HYPOGLYCEMIC ACTIVITY Suryawati Suryawati; Safrida Safrida; Firdausa Sarah; Azizah Vonna; Vera Dewi Mulia
Jurnal Natural Volume 19 Number 3, October 2019
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (487.553 KB) | DOI: 10.24815/jn.v19i3.13405

Abstract

Treatment of diabetes mellitus is intended to reduce the risk of blindness, kidney failure, neuropathy and heart disease that can develop due to the chronic increase in the blood glucose level. The selected hypoglycemic agents should be effective, safe and readily available. The widely used agents work by interrupting enzymes responsible for glucose regulation. Those enzymes are α-amilase, α-glucosidase, dipeptidyl peptidase-IV, aldose reductase and angiotensin converting enzyme. A medicinal plant, fenugreek (Trigonella foenum-graecum) has been used as an antidiabetic folk medicine. This review provides information related to in vitro studies showing antihyperglycemic activity of fenugreek along with an in vivo study in animals. In addition, potential phytochemicals that have been isolated from this plant are described and play a role in the searching for the most potent agents for diabetes mellitus therapy.
Acute toxicity evaluation of ethanolic extract of the leaves of Anredera cordifolia in wistar rats (Rattus Norvegicus) SURYAWATI SURYAWATI; NISSA SEURUNIE; DAMAR DITA KIRANA; VERA DEWI MULIA; HIJRA NOVIA SUARDI
Jurnal Natural Volume 22 Number 2, June 2022
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3129.595 KB) | DOI: 10.24815/jn.v22i2.22285

Abstract

Anredera cordifolia (Binahong) is one of the medicinal plants that has been widely used for its properties of inhibiting the growth of microorganisms, decreasing blood uric acid, and healing wounds. This study was conducted to evaluate the acute toxicity effects of ethanolic extract of binahong to support its use as a medicinal plant. Ethanolic extracts of binahong leaves were prepared. Twenty-five white male rats (Rattus norvegicus) were divided into 5 groups and administered with a single dose of Na-CMC suspension or a dose of 300, 600, 1200, or 2400 mg/kg BW of binahong ethanolic leaf extract, respectively. Toxicity symptoms were monitored at three-time intervals: ½-1, 1½-2, and 3-6 hours after the administration. A macroscopic evaluation of the rat’s liver was carried out to identify any lesion. The rat’s liver and whole-body weights were determined to assess the weight reduction. The results showed that there was no dead rat in any of the groups, indicating that no LD50 was identified. Also, there were several toxic effects observed including a decrease in movements, somatic response, insensitivity, and stool consistency. There was no evidence of a lesion on liver macroscopy. However, the weights of rats’ livers increased in tandem with the reduction in their body weights. The findings from this study reveal that single dose of binahong ethanolic extract ranging from 300 to 2400 mg/kg BW are safe, while minimal toxic effects were observed.
Acute toxicity evaluation of ethanolic extract of the leaves of Anredera cordifolia in wistar rats (Rattus Norvegicus) SURYAWATI SURYAWATI; NISSA SEURUNIE; DAMAR DITA KIRANA; VERA DEWI MULIA; HIJRA NOVIA SUARDI
Jurnal Natural Volume 22 Number 2, June 2022
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v22i2.22285

Abstract

Anredera cordifolia (Binahong) is one of the medicinal plants that has been widely used for its properties of inhibiting the growth of microorganisms, decreasing blood uric acid, and healing wounds. This study was conducted to evaluate the acute toxicity effects of ethanolic extract of binahong to support its use as a medicinal plant. Ethanolic extracts of binahong leaves were prepared. Twenty-five white male rats (Rattus norvegicus) were divided into 5 groups and administered with a single dose of Na-CMC suspension or a dose of 300, 600, 1200, or 2400 mg/kg BW of binahong ethanolic leaf extract, respectively. Toxicity symptoms were monitored at three-time intervals: ½-1, 1½-2, and 3-6 hours after the administration. A macroscopic evaluation of the rat’s liver was carried out to identify any lesion. The rat’s liver and whole-body weights were determined to assess the weight reduction. The results showed that there was no dead rat in any of the groups, indicating that no LD50 was identified. Also, there were several toxic effects observed including a decrease in movements, somatic response, insensitivity, and stool consistency. There was no evidence of a lesion on liver macroscopy. However, the weights of rats’ livers increased in tandem with the reduction in their body weights. The findings from this study reveal that single dose of binahong ethanolic extract ranging from 300 to 2400 mg/kg BW are safe, while minimal toxic effects were observed.
TRIGONELLA FOENUM : A REVIEW OF HYPOGLYCEMIC ACTIVITY Suryawati Suryawati; Safrida Safrida; Firdausa Sarah; Azizah Vonna; Vera Dewi Mulia
Jurnal Natural Volume 19 Number 3, October 2019
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v19i3.13405

Abstract

Treatment of diabetes mellitus is intended to reduce the risk of blindness, kidney failure, neuropathy and heart disease that can develop due to the chronic increase in the blood glucose level. The selected hypoglycemic agents should be effective, safe and readily available. The widely used agents work by interrupting enzymes responsible for glucose regulation. Those enzymes are α-amilase, α-glucosidase, dipeptidyl peptidase-IV, aldose reductase and angiotensin converting enzyme. A medicinal plant, fenugreek (Trigonella foenum-graecum) has been used as an antidiabetic folk medicine. This review provides information related to in vitro studies showing antihyperglycemic activity of fenugreek along with an in vivo study in animals. In addition, potential phytochemicals that have been isolated from this plant are described and play a role in the searching for the most potent agents for diabetes mellitus therapy.
Co-Authors Aini, Zahratul Amida Jannatus Saleha Anak Agung Gede Sugianthara Azizah Vonna Benny Kurnia DAMAR DITA KIRANA Dina Alia Fauzul Husna Firdausa, Sarah Ghina Raudathul Jannah Hafni Andayani Hanifah Yusuf Hijra Novia Suardi Hijra Novia Suardi Indra Gunawan Mirfandi Amirsyah MUHAMMAD AGUS SUPRAYUDI Muhammad Jailani NISSA SEURUNIE Nurrahmah Latifa Reno Keumalazia Kamarlis Safrida Safrida Suryawati Suryawati Suryawati Suryawati Suryawati Suryawati Suryawati Suryawati T. Hidayat Syah Zahratul Aini