Article Per Year (5 Year)
p-Index From 2021 - 2026
1.347
P-Index
This Author published in this journals
All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Journal of Medicine and Health Berkala Ilmiah Kedokteran Duta Wacana Majalah Patologi Indonesia Jurnal Biomedika dan Kesehatan Jurnal Kedokteran Meditek
Tejo Jayadi
Fakultas Kedokteran Universitas Kristen Duta Wacana, Yogyakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Published : 14 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 14 Documents
Search

 1   2 
EDITORIAL Role of Obesity in Breast Cancer Metastasis and Relapse Tejo Jayadi
Berkala Ilmiah Kedokteran Duta Wacana Vol. 7 No. 2 (2022): BERKALA ILMIAH KEDOKTERAN DUTA WACANA
Publisher : Faculty of Medicine Universitas Kristen Duta Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21460/bikdw.v7i2.576

Abstract

The breast cancer patients survivors expected to be increased, because of better early cancer detection and better treatment. Although the survivorship should be celebrated, but there are common late effect of cancer and its treatment. So, it need to be better health care treatment provided to the survivor to give them better quality of life.
Hubungan antara Obesitas dengan Kanker Ovarium di Rumah Sakit Bethesda Yogyakarta Anglicia Lovelin Handoko; Tejo Jayadi; Eduardus Raditya Kusuma Putra; Theresia Avilla Ririel Kusumosih
Jurnal Kedokteran Meditek Vol 29 No 1 (2023): JANUARI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v29i1.2544

Abstract

Kanker ovarium merupakan keganasan yang terjadi pada organ ovarium. Gambaran yang umum terlihat adalah gambaran sel invasif, merusak struktur disekitarnya, dan dapat bermetastasis. Penyebab kanker ovarium bersifat multifaktoral, seperti faktor genetik, riwayat penyakit kanker, riwayat kehamilan, dan lain-lain. Obesitas menjadi salah satu faktor risiko kanker ovarium. Pada wanita obesitas, dapat terjadi peningkatan risiko terkena kanker ovarium 10% lebih tinggi dibandingkan wanita dengan IMT normal. Peningkatan lemak berlebihan dapat menyebabkan perubahan hormonal dan terjadinya inflamasi berkepanjangan sehingga mempermudah kanker berkembang. Melalui tulisan ini, akan dibahas lebih dalam mengenai hubungan antara obesitas dengan kanker ovarium di Rumah Sakit Bethesda Yogyakarta. Data yang digunakan adalah data sekunder berupa rekam medik pasien tumor jinak ovarium dan kanker ovarium di Rumah Sakit Bethesda Yogyakarta tahun 2015-2019. Penelitian menggunakan desain cross-sectional dan sampel terbagi menjadi 2, yaitu penderita kanker ovarium dan penderita tumor jinak ovarium. Pengambilan sampel menggunakan metode random sampling dan total terdapat 118 data yang digunakan. Data dianalisis menggunakan uji chi-square dengan nilai p 0,335 (p >0,05) yang berarti hasil dari penelitian ini menunjukkan bahwa obesitas tidak memiliki hubungan yang signifikan dengan kasus kanker ovarium di Rumah Sakit Bethesda Yogyakarta.
Hubungan Sosiodemografi dan Klinikopatologi dengan Ketahanan Hidup Pasien Kanker Payudara Jayadi Tejo
Jurnal Biomedika dan Kesehatan Vol 5 No 1 (2022)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2022.v5.33-41

Abstract

Background: The research of breast cancer prognostic factors has been conducting for a long time, but the results still controversial. The research on demography and clinicopathology factors that determine the survival of breast cancer (BC) patients, remains to be done. Methods: The observational analytic with cross-sectional design would be conduct to describe the demographic, clinicopathology, therapy and two years survival of breast cancer patients. The independent variables were age, stage of disease, and molecular subtype. The dependent variable was two years survival. The association between those variables analyzed by bivariate statistic and the significant variables would be analyzed by regression logistic. Results: Most age of breast cancer patients at diagnosis were ≥ 50 years (74.5%). The majority of sociodemographic profiles of BC patients were undergraduate education, private job and married. The main histological type was the invasive ductal carcinoma. More than 50% of the patients were high stage (60.8%) and hormonal receptors molecular subtype (60.7%). Neoadjuvant chemotherapy was given to 40 patients (78.5%), only 9 patients (17.7%) eligible for anti HER-2/neu therapy. There were 42 of patients (82.4%) have two years survival. There weren’t association between age (p=0.586), stage of disease (p=0.223), molecular subtype (p=0.223) with two years survival of breast cancer patients. Conclusions: The common risk factors of breast cancer is increasing age. Most of breast cancer patients presenting high stage and hormone receptors positive of BC. Although there weren’t significance association, the prevalence low stage BC patients had higher two years survival.
Hubungan Ekspresi Protein NM23-H1, Densitas Limfovaskuler Peri-tumoral dan Invasi Limfovaskuler dengan Stadium dan Diferensiasi Histopatologi Adenokarsinoma Kolorektal Tejo Jayadi; Harijadi -; Prijono Tirtoprod
Majalah Patologi Indonesia Vol. 22 No. 2, Mei 2013
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRAK Latar belakang Salah satu penyebab kekambuhan karsinoma kolorektal adalah metastasis locoregional atau metastasis jauh. NM23-H1 salah satu gen penghambat metastasis yang berperan dalam menurunkan potensi metastasis. Hasil penelitian-penelitian tentang peran NM23-H1 dan invasi limfovaskuler terhadap peningkatan derajat histopatologi dan stadium adenokarsinoma hasilnya masih kontroversial. Penelitian ini bertujuan mengetahui hubungan ekspresi protein NM23-H1 dan invasi limfovaskuler dengan derajat histopatologi dan stadium karsinoma kolorektal. Metode Rancangan Penelitian adalah potong lintang dengan menggunakan 50blok parafin dari pasien karsinoma kolorektal yang diagnosisnya ditegakkan secara histopatologis sebagai adenokarsinoma kolorektal stadium Duke B dan C di RSUP. Dr. Sardjito mulai tanggal 1 Januari 2007. Blok parafin dipotong 4 μm diwarnai dengan antibodi poliklonal anti NM23-H1 dan antibodi monoklonal anti D2-40. Korelasi NM23-H1 dengan invasi limfovaskuler dianalisa dengan uji korelasi Spearman; asosiasi NM23-H1 dan invasi limfovaskuler dengan diferensiasi histopatologi dan stadium dianalisa menggunakan uji Chi-square. Hasil Penelitian ini menunjukkan terdapat korelasi antara ekspresi NM23-H1 dan invasi limfovaskuler dengan stadium adenokarsinoma kolorektal Duke B dan C (p= 0,006 dan 0,013). Ekspresi NM23-H1 tidak berhubungan dengan diferensiasi histopatologi (p=0,644). Invasi limfovaskuler berhubungan dengan diferensiasi histopatologi (p=0,018). Densitas limfovaskuler peritumoral tidak berhubungan dengan diferensiasi histopatologi dan stadium (p=0,556 dan p=0,768). Penelitian ini juga menunjukkan tidak adanya akorelasi antara NM23-H1 dengan densitas limfovaskuler peritumoral dan invasi limfovaskuler (p=0,996 dan p=0,176), dengan rasio odds 1,071 dan 2,1. Kesimpulan Ekspresi NM23-H1 dan invasi limfovaskuler berperan dalam perluasan dan metastasis adenokarsinoma kolorektal, sedangkan derajat diferensiasi sel tumor berhubungan dengan invasi limfovaskuler. Kata kunci : adenokarsinoma kolorektal, diferensiasi histopatologi, invasi limfovaskuler, NM23-H1, stadium. ABSTRACT Background One of the causes of colorectal carcinoma recurrence due to locoregional or distant metastasis. NM23-H1 is one of metastasis suppressor gene, and many studies showed that the influence of NM23-H1 expression and lymphovascular invasion to the grading and staging of colorectal carcinoma still controversial. The aim of this study is to determine the correlation of NM23-H1 expression and lymphovascular invasion with the grading and staging of colorectal carcinoma. Methods The study was retrospective cross sectional using 50 paraffin embedded tissue of patients with adenocarcinoma colorectal Duke B and C paraffin block, which diagnosed as adenocarcinoma colorectal Duke B and C by histopathological examination in Dr. Sardjito Central General Hospital since 1 January 2007. Those embeded tissues were cut 4μm and stained by NM23-H1 polyclonal antibody and D2-40 monoclonal antibodi. t. Correlation NM23-H1 with lymphovascular invasion were analyzed using Spearman test. Chi Square test was performed to analyzed the association of NM23-H1 and lymphovascular invasion with grading and staging of the tumor. Results There were correlations between NM23-H1 expression, lymphovascular invasion with adenocarcinoma colorectal stage B and C (p=0.006 and 0.013). There was no correlation between NM23-H1 expression with the grading of tumor (p=0.644). There was correlation between lymphovascular invasion and grading of the tumor (p=0.018). There was no correlation between peripheral lymphovessel density with grading dan staging of the tumor (p=0,556 and p=0,768). This study showed no correlation between NM23-H1 with peripheral lymphovessel density and lymphovascular invasion (p=0.996 and p=0.176), with odds ratio 1.071 and 2.1. Conclusion NM23-H1 expression and lymphovascular invasion may have a role in the adenocarcinoma colorectal expansion and metastasis, while moderate and high grade have relationship with lymphovascular invasion. Key words: adenocarcinoma colorectal, histopathology differentiation, lymphovascular invasion, Nm23-H1, stage.
Co-Authors Agatha MA Putri agatha maheswari adita putri Anglicia Lovelin Handoko Arum Krismi Ayu Anita Rosalia brenda miriane rustam Cindy Tamara Widagdo Eduardus Raditya Kusuma Putra Harijadi - Jonathan W Siagian Maria Anasthasia Tangsilan Maria Chrisna Indrasari Pingkan Naibaho Prijono Tirtoprod Sulanto Saleh Danu Theresia Avilla Ririel Kusumosih Wiwiek Probowati Wiwiek Probowati