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All Journal Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Nusantara Hasana Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research jeti
Hera Novianti
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Penatalaksanaan Polip Antrokoana pada Anak Arif Fahmi; Dolly Irfandy; Bestari Jaka Budiman; Hera Novianti
Majalah Kedokteran Andalas Vol 45, No 3 (2022): Online July 2022
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v45.i3.p443-453.2022

Abstract

Pendahuluan: Polip antrokoanal adalah polip yang berasal dari sinus maksila yang keluar ke kavum nasal menuju ke koana dan nasofaring. Polip antrokoanal sering terjadi pada anak-anak. Diagnosis polip antrokoanal ditegakkan dari gejala klinis , pemeriksaan fisik tampak massa berwarna putih keabuan di kavum nasal sampai ke koana didukung pemeriksaan penunjang tomografi computer (CT Scan) dan histopatologi ditemukan adanya sel respiratoris pada permukaan massa polip. Tatalaksana polip antrokoanal adalah polipektomi dengan Bedah Sinus Endoskopi Fungsional (BSEF).  Laporan Kasus: Dilaporkan satu kasus perempuan usia 12 tahun dengan keluhan utama hidung kiri tersumbat dirasakan semakin memberat dalam 2 bulan ini. Pemeriksaan nasoendoskopi massa pada kavum nasi sinistra berwarna putih keabuan, tidak mudah berdarah. Pemeriksaan CT Scan tampak lesi hiperdens di kavum nasal sinistra sampai ke nasofaring. Pasien di diagnosa dengan suspek polip antrokoanal dan dilakukan ekstirpasi massa dengan BSEF didapatkan massa polip ukuran 3,5 cm x 3 cm x 1 cm. Hasil pemeriksaan histopatologi didapatkan polip antrokoanal dengan sel radang kronik. Kesimpulan:Pilihan utama tatalaksana polip antrokoanal pada anak dengan BSEF. Polip antrokoanal pada anak berkaitan erat dengan variasi anatomi konka paradoksikal dan osteum asesorius sinus maksila
ATYPICAL MICROGLANDULAR ADENOSIS MIMICKING INVASIVE TUBULAR CARCINOMA, A RARE CHALLENGING DIAGNOSIS Hera Novianti; Fitri Nur Handriyani; Aswiyanti Asri; Yenita Yenita; Noza Hilbertina; Pamelia Mayorita; Yessy Setiawati; Zulda Musyarifah; Meta Zulyati Oktora; Maisyah Nelzima
Nusantara Hasana Journal Vol. 4 No. 7 (2024): Nusantara Hasana Journal, December 2024
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i7.1297

Abstract

Background: Microglandular adenosis (MGA) is a rare breast lesion that poses diagnostic challenges due to its resemblance to invasive carcinoma, particularly invasive tubular carcinoma (ITC). Atypical MGA is of clinical concern because of its potential for malignant transformation. Accurate diagnosis relies on histopathological examination and immunohistochemical (IHC) analysis. Case Presentation: A 34-year-old woman presented with a painless lump in her left breast. Intraoperative frozen section analysis revealed small glandular structures with histological features mimicking ITC. Definitive diagnosis required further evaluation. Immunohistochemical analysis demonstrated S100 positivity, consistent with glandular differentiation, and negative p63 staining, indicating the absence of a myoepithelial layer. These findings, in the absence of definitive stromal invasion, supported a diagnosis of atypical MGA. Complete surgical excision was performed to ensure negative margins and exclude associated malignancy. Discussion: This case highlights the diagnostic complexity of atypical MGA, particularly in young patients. Frozen section analysis alone often fails to distinguish MGA from invasive carcinoma due to overlapping histological features. IHC markers, such as S100 and p63, are critical for differentiation. S100 positivity confirms glandular origin, while p63 negativity indicates the lack of a myoepithelial layer, distinguishing MGA from benign proliferative lesions. Accurate diagnosis is essential to avoid overtreatment, such as unnecessary chemotherapy or radical surgery, while ensuring appropriate management to mitigate malignant potential. Conclusion: This report underscores the importance of combining frozen section and IHC findings for rare breast lesions like atypical MGA. Increased awareness and careful evaluation are essential to achieve timely and precise diagnosis, enabling optimal surgical management and long-term outcomes.
CASE REPORT MALIGNANT GLOMUS TUMOR: A RARE CASE Pamelia Mayorita; Mustika Sari; Zulda Musyarifah; Hera Novianti; Yessy Setiawati; Meta Zulyati Oktora
Nusantara Hasana Journal Vol. 4 No. 8 (2025): Nusantara Hasana Journal, January 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i8.1309

Abstract

Background: Glomus tumor is a rare mesenchymal neoplasm that accounts for less than 2% of all soft tissue tumors and 1.5% of extremity neoplasms. Malignant glomus tumors are exceptionally rare, comprising only 1-2.9% of all glomus tumors, and are often associated with significant diagnostic and therapeutic challenges. Case Presentation: We report a case of a 62-year-old male presenting with a painful lump on his left thumb, progressively enlarging over six months. Clinical examination revealed a 3x2x1 cm subungual mass with positive cold sensitivity and pin love tests. The patient underwent amputation, and histopathological analysis showed a proliferation of round-to-oval and spindle cells with nuclear atypia, frequent mitotic figures (>5/50 HPF), and atypical mitoses, consistent with malignant glomus tumor grade 2. Surgical margins and bone were free of tumor infiltration. Conclusion: This case highlights the importance of clinical-pathological correlation in diagnosing malignant glomus tumors, which remain a diagnostic challenge due to their rarity. Complete surgical excision with negative margins remains the gold standard for treatment, ensuring favorable outcomes and minimizing recurrence risk.
Primary Malignant Peritoneal Mesothelioma Mimicking Ovarian Carcinoma: A Case Report Highlighting the Importance of Immunohistochemistry Rio Hendra; Tofrizal; Hera Novianti; Yessy Setiawati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 3 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i3.1212

Abstract

Background: Primary malignant peritoneal mesothelioma (PMPM) is an uncommon and aggressive malignancy arising from the mesothelial lining of the peritoneal cavity. The diagnosis of PMPM is often challenging due to its rarity, nonspecific clinical presentation, and histologic similarities to other malignancies, particularly adenocarcinomas. Immunohistochemistry plays a crucial role in differentiating PMPM from metastatic adenocarcinoma, which is essential for accurate diagnosis, appropriate treatment, and prognostication. Case presentation: We present the case of a 43-year-old female who presented with abdominal distension, ascites, and weight loss, initially raising suspicion of ovarian carcinoma. However, histopathological examination of the omental tissue revealed a proliferation of epithelial cells with papillary and glandular-like growth patterns. Immunohistochemical staining demonstrated strong positivity for calretinin, a mesothelial marker, while staining for estrogen receptor (ER) and progesterone receptor (PR) was negative, effectively ruling out an ovarian or endometrial origin. The diagnosis of PMPM, epithelioid subtype, was confirmed. Conclusion: This case underscores the challenges in diagnosing PMPM and highlights the critical role of immunohistochemistry in differentiating it from metastatic adenocarcinoma. Accurate diagnosis is essential for determining appropriate management strategies and providing prognostic information.
Rancang Bangun Sistem Informasi Alumni Fakultas Komputer Dan Multimedia Universitas Islam Kebangsaan Indonesia Kabupaten Bireuen Hera Novianti; Nur Amalia Hasma; T. Irfan Fajri
Jurnal Elektronika dan Teknologi Informasi Vol 5 No 2 (2024): September 2024
Publisher : LPPM-UNIKI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5201/jet.v5i2.493

Abstract

Pengolahan data alumni pada Fakultas Komputer Universitas Islam Kebangsaan Indonesia masih menggunakan cara manual yaitu pendataan masih disimpan di microsoft excel. Dengan cara manual tentu saja banyak menimbulkan kesulitan bagi kasi fasilkom dalam hal pengelolaan data alumni dan penyampaian informasi ke alumni. Oleh karena itu dibangun sistem informasi berbasis Mobile yang lebih efektif dan efisien sehingga mengurangi proses-proses yang masih dilakukan secara manual. Tujuan dari penelitian yang penulis lakukan adalah Mengembangkan sistem informasi Pengolahan data alumni di Fakultas Ilmu Komputer Universitas Islam Kebangsaan Indonesia yang berbasis Mobile, sehingga bisa mempermudah dalam proses pengolahan data alumni dan penyampaian informasi baik berita agenda kegiatan alumni secara tepat dan cepat. Pengumpulan data dilakukan dengan metode wawancara dan metode observasi. Tahapan perancangan yang digunakan meliputi perancangan desain sistem yaitu dengan menggunakan Context Diagram (CD) dan Data Flow Diagram (DFD), Perancangan database yaitu Entity Relationship Diagram (ERD), perancangan desain fisik. Sistem ini dibuat dengan menggunakan bahasa pemrograman JAVA, MySQL dan dengan bantuan aplikasi Android Studio. Hasil penelitian ini adalah Pengembangan Sistem Informasi Alumni Berbasis Android di Fakultas Ilmu Komputer Universitas Islam Kebangsaan Indonesia. Sistem ini mudah digunakan, kecepatan aksesnya cepat, laporannya sesuai dengan yang pengelola/akademk inginkan sehingga diharapkan sistem ini dapat membantu pihak akademik dalam pengelolaan data alumni dan menyampaikan informasi.
Primary Malignant Peritoneal Mesothelioma Mimicking Ovarian Carcinoma: A Case Report Highlighting the Importance of Immunohistochemistry Rio Hendra; Tofrizal; Hera Novianti; Yessy Setiawati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 3 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i3.1212

Abstract

Background: Primary malignant peritoneal mesothelioma (PMPM) is an uncommon and aggressive malignancy arising from the mesothelial lining of the peritoneal cavity. The diagnosis of PMPM is often challenging due to its rarity, nonspecific clinical presentation, and histologic similarities to other malignancies, particularly adenocarcinomas. Immunohistochemistry plays a crucial role in differentiating PMPM from metastatic adenocarcinoma, which is essential for accurate diagnosis, appropriate treatment, and prognostication. Case presentation: We present the case of a 43-year-old female who presented with abdominal distension, ascites, and weight loss, initially raising suspicion of ovarian carcinoma. However, histopathological examination of the omental tissue revealed a proliferation of epithelial cells with papillary and glandular-like growth patterns. Immunohistochemical staining demonstrated strong positivity for calretinin, a mesothelial marker, while staining for estrogen receptor (ER) and progesterone receptor (PR) was negative, effectively ruling out an ovarian or endometrial origin. The diagnosis of PMPM, epithelioid subtype, was confirmed. Conclusion: This case underscores the challenges in diagnosing PMPM and highlights the critical role of immunohistochemistry in differentiating it from metastatic adenocarcinoma. Accurate diagnosis is essential for determining appropriate management strategies and providing prognostic information.
The Large-Mass Phenotype of Uterine Smooth Muscle Tumor of Uncertain Malignant Potential (STUMP): A Clinicopathological Analysis of 37 Cases in Indonesia Using WHO 2021 and Modified Stanford Criteria Yuliza Ariani; Henny Mulyani; Noza Hilbertina; Yenita; Aswiyanti Asri; Tofrizal; Loli Devianti; Hera Novianti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 4 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i4.1565

Abstract

Background: Uterine smooth muscle tumor of uncertain malignant potential (STUMP) presents a diagnostic dilemma, especially in Southeast Asian populations, where delayed presentation often leads to advanced tumor burden. This study aimed to characterize the clinicopathological profile of STUMP in Indonesia using the 2021 WHO Classification and modified Stanford parameters. Methods: A descriptive study analyzed 37 STUMP cases diagnosed between 2023 and 2025 at a tertiary referral center in West Sumatra. A panel of pathologists re-evaluated archival slides for atypia, mitotic activity, necrosis, and growth patterns, establishing inter-observer reliability. Fisher’s Exact Test was employed to correlate tumor size with morphological markers of aggression. Results: The cohort demonstrated a distinct large-mass phenotype, with 54.1% of tumors exceeding 10 cm and a median diameter of 14.5 cm. Pathological review classified 56.8% of cases into WHO Group 4 (atypia with ambiguous mitosis). A statistically significant correlation was identified between tumor size >10 cm and the presence of infiltrative growth margins (81.1%; p=0.034). Conclusion: Indonesian STUMP cases are distinctively characterized by massive size and high rates of infiltrative growth, likely driven by prolonged natural history. The prevalence of ambiguous mitotic figures underscores the utility of the WHO Group 4 category in resource-limited settings. These findings advocate for aggressive surgical management and wider resection margins in large-mass variants to mitigate local recurrence risk.
The Large-Mass Phenotype of Uterine Smooth Muscle Tumor of Uncertain Malignant Potential (STUMP): A Clinicopathological Analysis of 37 Cases in Indonesia Using WHO 2021 and Modified Stanford Criteria Yuliza Ariani; Henny Mulyani; Noza Hilbertina; Yenita; Aswiyanti Asri; Tofrizal; Loli Devianti; Hera Novianti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 4 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i4.1565

Abstract

Background: Uterine smooth muscle tumor of uncertain malignant potential (STUMP) presents a diagnostic dilemma, especially in Southeast Asian populations, where delayed presentation often leads to advanced tumor burden. This study aimed to characterize the clinicopathological profile of STUMP in Indonesia using the 2021 WHO Classification and modified Stanford parameters. Methods: A descriptive study analyzed 37 STUMP cases diagnosed between 2023 and 2025 at a tertiary referral center in West Sumatra. A panel of pathologists re-evaluated archival slides for atypia, mitotic activity, necrosis, and growth patterns, establishing inter-observer reliability. Fisher’s Exact Test was employed to correlate tumor size with morphological markers of aggression. Results: The cohort demonstrated a distinct large-mass phenotype, with 54.1% of tumors exceeding 10 cm and a median diameter of 14.5 cm. Pathological review classified 56.8% of cases into WHO Group 4 (atypia with ambiguous mitosis). A statistically significant correlation was identified between tumor size >10 cm and the presence of infiltrative growth margins (81.1%; p=0.034). Conclusion: Indonesian STUMP cases are distinctively characterized by massive size and high rates of infiltrative growth, likely driven by prolonged natural history. The prevalence of ambiguous mitotic figures underscores the utility of the WHO Group 4 category in resource-limited settings. These findings advocate for aggressive surgical management and wider resection margins in large-mass variants to mitigate local recurrence risk.
Co-Authors arif fahmi Aswiyanti Asri Bestari Jaka Budiman Dolly Irfandy Fitri Nur Handriyani Henny Mulyani Loli Devianti Maisyah Nelzima Meta Zulyati Oktora Mustika Sari Mutasar Noza Hilbertina Nur Amalia Hasma Pamelia Mayorita Rio Hendra Tofrizal Yenita . Yenita Yenita Yessy Setiawati Yuliza Ariani Zulda Musyarifah