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All Journal Indonesian Journal of Tropical and Infectious Disease Jurnal Ners Majalah Biomorfologi (Biomorphology Journal) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Folia Medica Indonesiana
Wironegoro, Rio
Department Of Internal Medicine, Faculty Of Medicine, Universitas Airlangga; Indonesian Society Of Internal Medicine (PAPDI)
Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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MATERNAL OBESITY INCREASES RISK OF PREECLAMPSIA AND DIABETES MELLITUS Naura Ega Kahayani; Hermanto Tri Joewono; Rio Wironegoro
Majalah Biomorfologi Vol. 31 No. 2 (2021): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v31i2.2021.44-48

Abstract

Background: Obesity in pregnant women has been linked to negative outcomes for both the mother and the fetus. Gestational diabetes, preeclampsia, and postpartum haemorrhage are all threats for mothers during pregnancy. These may also affect labor outcomes because fat accumulation in the pelvis makes obese pregnant women more likely to have a caesarean section. Objective: To analyze the outcome of maternal obesity in pregnancy in 2017. Materials and Methods: This was an analytic cross-sectional, observational study in pregnant women with obesity in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, within the period of January 1st – December 31st 2017 using medical records. Sample size was determined using cross-sectional sample size calculation with the result of n=162. After receiving approval of ethical clearance, medical records were collected and analyzed. The statistical analysis was done using chi-square test. Results: From a total of 162 subjects, most of the patients were 21-34 y/o (56.8%), under graduate (90.7%) and 58% of the subjects worked. Proportion of grade I, II and III were 60.5%, 22.2%, and 17.3%, and 67% suffered from complications such as PE, DM, PE with DM with percentages as follows: 56.2%, 4.9%, and 6.2%. Neonatal complications were preterm 42.6%, macrosomia 4.3%, stillbirth 4.9%, and low Apgar score 48.1%. No association was identified between maternal age and complications in grade I (p=0.764) and grade III (p=0.716). Obesity grades I and III had correlation with complications (p=0.035). Conclusion: No significant association was found between age and complications in grade III obesity, while there was significant correlation between obesity levels (grade I and grade III) and complications.
Hubungan Derajat Katarak Dan Durasi Diabetes Melitus Tipe 2 Di Instalasi Rawat Jalan Mata Rsud Dr. Soetomo Surabaya Novia Novia; Indri Wahyuni; Rio Wironegoro
Jurnal Ners Vol. 7 No. 1 (2023): APRIL 2023
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v7i1.13122

Abstract

Diabetes melitus tipe 2 adalah penyakit akibat penurunan produksi insulin, penurunan kerja insulin atau akibat kedua kondisi di atas yang terjadi secara bersamaan. Ciri khas diabetes melitus tipe 2 adalah hiperglikemia yang lambat laun akan menjadi masalah serius untuk berbagai sistem organ salah satunya mata (WHO,2021). Katarak merupakan salah satu bentuk komplikasi diabetes pada mata yang dapat terjadi dalam beberapa derajat sesuai kekeruhannya yaitu derajat 1, derajat 2, derajat 3, derajat 4, dan derajat 5 (Buratto, Brint, and Sacchi, 2014). Penelitian ini bertujuan untuk mengetahui hubungan antara derajat katarak dan durasi diabetes melitus tipe 2. Penelitian ini merupakan penelitian observasional analitik dengan desain cross sectional menggunakan data sekunder berupa rekam medis pasien di instalasi rawat jalan mata di RSUD Dr. Soetomo Surabaya periode Januari 2019 - Desember 2021. Sampel berjumlah 29 sampel sesuai dengan kriteria inklusi dan eksklusi yang diambil dengan teknik total sampling. Analisis data dilakukan dengan aplikasi pengolahan data SPSS dengan uji kolerasi Rank Spearman. Pada penelitian ini diketahui sebanyak 17 mata dari responden yang memiliki durasi diabetes melitus tipe 2 ?5 tahun mengalami katarak derajat 5 (29,3%) dan diantara 15 mata responden yang memiliki diabetes melitus tipe 2 <5 tahun, 6 diantaranya responden (10,3%) mengalami katarak derajat 1 dengan p value=0,385 dan koefisien korelasi=0,116. Terdapat korelasi yang sangat lemah antara derajat keparahan katarak dengan durasi diabetes melitus tipe 2.
Weight Gain in Type 2 Diabetes Mellitus Patients Receiving Sulfonylurea Medications at a Tertiary Hospital in Surabaya, Indonesia Respati, Ghagat Dresta Putra; Prajitno, Jongky Hendro; Setiawati, Rosy; Wironegoro, Rio
Current Internal Medicine Research and Practice Surabaya Journal Vol. 6 No. 1 (2025): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v6i1.52126

Abstract

Introduction: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by persistent hyperglycemia. The prevalence of diabetes in Indonesia is 1.5%, although East Java recorded a 2.1% rate in 2013. T2DM medications, such as sulfonylureas, may lead to hypoglycemia and weight gain. This study aimed to investigate the weight gain effects of sulfonylureas in T2DM patients at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Methods: This retrospective cross-sectional study used retrograde anamnesis on 41 T2DM patients receiving sulfonylurea medications for the preceding six months. The data were collected from medical records and interviews with the T2DM patients who received treatment at the Internal Medicine Clinic of Dr. Soetomo General Academic Hospital from January to June 2022. Results: Most patients were 46–65 years old (73.2%), female (51.2%), and had been diabetic for over 15 years (48.8%). The predominant medications administered to the patients were glimepiride (41.4%) and a combination of glibenclamide 5 mg, metformin 500 mg, and acarbose 100 mg (19.5%). Almost all patients took their medications in the morning before meals (92.6%). The average weight gain was 4.6 kg, with the glibenclamide and metformin combination resulting in a 17% incidence. Conclusion: T2DM patients who use sulfonylureas generally gain weight and exhibit specific traits, including being middle-aged, female, and diabetic for multiple years. The most commonly used sulfonylureas are glimepiride for monotherapy and glibenclamide for combination therapy with metformin and acarbose. Future research is required to understand weight gain in T2DM patients treated with sulfonylureas more comprehensively.   Highlights: 1. This study investigated weight changes in type 2 diabetes mellitus (T2DM) patients receiving sulfonylureas, with a special focus on the emergence of weight gain as a new problem in T2DM management. 2. The importance of this study pertains to its findings regarding weight gain in T2DM patients treated with sulfonylureas, offering additional data that aids in preventing adverse effects of the medications.
High blood glucose level increase cardiovascular disease risk in type 2 diabetes mellitus Marchelia, Laili Zahrina; Purwati, Purwati; Wironegoro, Rio
Folia Medica Indonesiana Vol. 52, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Type 2 diabetes mellitus (DM) is the 10th leading cause of death in the world and had a risk 4.06 times greater to have cardiovascular disease (CVD). Fasting plasma glucose and 2-hours postprandial glucose level as diagnostic tests to evaluate DM and also as a predictive factors to CVD. This research uses descriptive analytic research with cross sectional design. The subject of this study is Type 2 DM patients came to Dr Soetomo hospital from January-October 2014. Data was recorded from medical records of patients and was analyzed with Chi Square test with p<0.05. As result, there is 102 Type 2 DM patients with 36 patients have CVD manifestation and 66 patients without complication. There is a significant association between fasting plasma glucose (FPG), 2-hours postprandial glucose (2hPPG) level, and CVD manifestation (p=0.00). So FPG and 2hPPG have a significant association with CVD manifestation. There are other factors that influencing the formation of CVD, hence, further research is needed.
Effects of edamame (glycine max) extracton post-prandial serum triglyceride in wistar rats Kamal, Imran H; Dewanti, Linda; Wironegoro, Rio
Folia Medica Indonesiana Vol. 52, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

Edamame (Glycine max) is a preparation of immature soybeans in the pod, which is high in calcium and dietary fiber, two elements described in previous studies that could alter the level of post-prandial serum triglyceride.The purpose of this research is to analyze the effect of edamame (Glycine max) extract on post-prandial serum triglyceride in rats after intragastric administration of palm oil.The materials used in this study are palm oil, edamame extract, and ether. The design of this study is experimental post-test study design, which is a design to measure the serum triglyceride level after meal with and without Glycine max. Triglyceride is measured on each subject two times on total, first one after consumption of meal without Glycine max and the second one after consumption of meal with Glycine max. There is a washout period of 1 week between two times the samples were taken. Both results are then compared in every subject.The level of 2-hour post-prandial serum triglyceride in rats after palm oil without intragastric edamame (Glycine max) extract administration and with intragastric edamame (Glycine max) extract administration showed no significant difference. In conclusion, edamame (Glycine max) extract had no effect on 2-hour post-prandial serum triglyceride after palm oil administration via intragastric tube.
Comparison of Clinical Characteristics of Pulmonary Tuberculosis Patients with and without Diabetes Mellitus at Dr. Soetomo Hospital Idwar, Fadiah Dini Putri; Wahyunitisari, Manik Retno; Wironegoro, Rio; Rosyid, Alfian Nur
Indonesian Journal of Tropical and Infectious Disease Vol. 13 No. 3 (2025)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v13i3.78117

Abstract

Tuberculosis (TB) is a transmissible infectious condition attributable to Mycobacterium tuberculosis. Common symptoms of tuberculosis include a persistent cough lasting more than two weeks, fever, fatigue, malaise, and unintended weight loss. These symptoms may become more severe in individuals with co-infected Diabetes Mellitus (DM) due to impaired immunity. In 2021, approximately 400,000 people were reported to have TB-DM. Active TB can disrupt glucose tolerance, contributing to TB-DM2. Studies indicate this combination affects disease progression and treatment outcomes from both patients. This study employed an observational design with descriptive and analytical approaches. The study utilized medical record data from individuals diagnosed with TB who were managed at Dr. Soetomo General Academic Hospital in 2023.  There were 245 total patients, comprising 151 TB without DM and 94 TB with DM cases. The analysis demonstrated a statistically significant difference in mean age between the two groups (p = 0.000). In both groups, the majority were male (69.5%; 63.8%). Cough was more frequent in TB with DM patients (p = 0.038). The most common systemic symptom in both groups was weight loss (70.9%; 63.8%). AFB and GeneXpert MTB/RIF assays results showed no significant differences in between. However, significant differences were found in leukocyte, ALT, AST, and BUN levels (p = 0.001; 0.004; 0.019; 0.007). Radiological examinations showed no significant differences. TB patients with and without DM differ significantly in age, symptoms, and several laboratory parameters, suggesting that comorbidity may influence TB characteristics and clinical presentation.
Co-Authors Hermanto Tri Joewono Idwar, Fadiah Dini Putri Indri Wahyuni Jongky Hendro Prajitno Kamal, Imran H Linda Dewanti Marchelia, Laili Zahrina Naura Ega Kahayani Novia Novia Purwati Purwati Respati, Ghagat Dresta Putra Rosyid, Alfian Nur Setiawati, Rosy Wahyunitisari, Manik Retno