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Cinnamon Extract Effect on Osteoblast Activity in Diabetic Wistar Rats Andiwijaya, Fahrin Ramadan; Prihatanto, Fundhy Sinar Ikrar; Susanto, Hermawan
BALI MEDICAL JOURNAL Vol 5 No 2 (2016)
Publisher : BALI MEDICAL JOURNAL

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Background: Diabetes is clinically known to cause prolongation to bone fracture healing. This research aims to find the effect of cinnamon in the process of bone remodeling, and changes in the activity of osteoblast cells in diabetic bone after giving cinnamon as a supplement in diabetic rats. Method: The design employed was experimental with randomized post-test group design research. A total of 24 Wistar Rats was randomly divided into four groups, which consist of normal without treatment, normal with treatment, diabetic without treatment and diabetic with treatment. Treatment of 300 mg/kg cinnamon extract was given per orally. Upon euthanizing the samples, femur samples were taken and processed to histopathological slides. All slides were analyzed under light microscopes to find the osteoblast cells. The Kruskal-Wallis method was used to test the results; due to the population of sample was not normally distributed. Results: The osteoblast cells found were scored in mean ranks. The normal group mean rank 12.25, normal with treatment group 12.17, diabetic without treatment group 8.58, and diabetic with treatment group 17.00. Asymptotic significance was 0.195. Conclusion: This research concludes that there is no significant increase in osteoblast activity in diabetic Wistar rats after the administration of 300 mg/kg cinnamon extract.

LITERASI MATEMATIS YANG DIKAJI DARI KEMAMPUAN REPRESENTASI DALAM MATERI EKSPRESI ALJABAR SISWA SMP Susanto, Hermawan; Sugiatno, Sugiatno; Yani T, Ahmad
Jurnal Pendidikan dan Pembelajaran Khatulistiwa Vol 9, No 1 (2020): Januari 2020
Publisher : Jurnal Pendidikan dan Pembelajaran Khatulistiwa

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AbstractThis research aims to explain the mathematical literacy of junior high school students in Academic Year 2015/2016, in solving problems related to algebraic expressions in terms of iconic and symbolic representation. This research used descriptive method which applied Case Study form. The subjects of this research were 41 students of SMP Kristen Immanuel Pontianak. The results of data analysis showed that the formulate process of mathematical situations when changing the form of iconic representation, students looked better in making schemes from real situations to pictorial forms (tables). Considering from the formulate process of mathematical situations when changing the form of symbolic representation, students had difficulty in conducting manipulation by using symbols from real situations into symbolic forms. Considering from the process of using iconic representation in accomplishing mathematical literacy questions, the majority of students were able to accomplish mathematical literacy questions which were given by using table representation. Considering from the process of using symbolic representation in accomplishing mathematical literacy problems, upper level students tend to be able to accomplish the questions well. Conversely, middle level students experienced problems in calculation process.Â Â Keywords: Agebraic Expressions, Mathematical Literacy, Representations.

MANAJEMEN PEMBINAAN PRESTASI ATLET OLAHRAGA RENANG DI DELTA SWIMMING CLUB SUSANTO, HERMAWAN
Jurnal Kesehatan Olahraga Vol 4, No 4 (2016): Edisi November 2016
Publisher : Jurnal Kesehatan Olahraga

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Dalam sebuah club renang yang berprestasi tidak lepas dari manajemen pembinaan prestasi untuk mencetak dan membina para atletnya agar memperoleh juara dalam setiap perlombaan, untuk mencapai prestasi yang tinggi tidaklah mudah dibutuhkan kedisiplinan dan latihan yang keras, kualitas latihan yang diberikan juga sebagai penentu prestasi untuk atlet. Tujuan penelitian ini adalah untuk mengetahui bagaimana program pembinaan prestasi di Delta Swimming Club Kabupaten Sidoarjo. Metode penelitian ini adalah deskriptif kualitatif. Data dikumpulkan dengan cara pengamatan (Observasi), Wawancara (Interview) dan Dokumentasi. Hasil dari penelitian menejemen pembinaan prestasi atlet di delta Swimming Club Kabupaten Sidoarjo sangat baik. Dengan adanya pelatih yang berkompeten, melakukan evaluasi pada saat selesai latihan maupun perlombaan, memiliki sarana dan prasarana yang memadai dan juga sumber dana yang sudah mencakup beberapa aspek untuk proses jalannya program latihan.

PERBANDINGAN LATIHAN KONTINU INTENSITAS SEDANG DAN LATIHAN INTERVAL INTENSITAS TINGGI TERHADAP KONTROL GLUKOSA DARAH Argarini, Raden; Atsari, Nadhila; Susanto, Hermawan
Majalah Kedokteran Bandung Vol 48, No 4 (2016)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Pencegahan diabetes melitus tipe 2 (DMT2) dapat dilakukan dengan memperbanyak latihan fisik. Latihan kontinu intensitas sedang (LKIS) dan latihan interval intensitas tinggi (LIIT) diketahui dapat meningkatkan kontrol glukosa pada orang dengan resistensi insulin/DMT2. Tujuan penelitian ini adalah membandingkan efek LIIT dan LKIS pada orang sehat terhadap kontrol glukosa darah, yaitu glukosa darah puasa (GDP) dan tes toleransi glukosa oral (TTGO). Laki-laki (n=27), usia (20,07±0,62), IMT (23,94±3,59) kg/m2 berpartisipasi dalam kelompok LKIS, LIIT, atau kontrol. Latihan Ergocycle dilakukan 3 sesi/minggu selama 4 minggu; LKIS dengan total durasi 46 menit/sesi (intensitas sedang 50-60% denyut jantung cadangan [HRR] selama 40 menit); LIIT dengan total durasi 24 menit/sesi (6 siklus; 2 menit intensitas tinggi 80?90% HRR + 1 menit intensitas sedang 50?60% HRR). Kontrol tidak mendapat intervensi latihan. GDP dan TTGO (120? setelah beban glukosa) diperiksa 3 hari sebelum dan setelah program latihan. Hasil penelitian menunjukkan GDP menurun pada semua kelompok, tetapi hanya LKIS yang menunjukkan penurunan signifikan (p=0,048). TTGO ditemukan tidak berubah di semua kelompok (p>0,05). LKIS memiliki potensi untuk meningkatkan kontrol glukosa darah pada subjek dewasa muda. Penelitian lanjutan dengan modifikasi dosis latihan diperlukan untuk mengetahui efek LIIT lebih lanjut. [MKB. 2016;48(4):194?9]Kata kunci: kontrol glukosa darah, latihan interval intensitas tinggi, latihan kontinu intensitas sedangComparison of Moderate Intensity Continuous Training and High Intensity Interval Training on Blood Glucose ControlAbstractType 2 diabetes mellitus (T2DM) can be prevented by intensive physical exercise/training. Moderate intensity continuous training (MICT) and high intensity interval training (HIIT) are known to improve glucose control in people with insulin resistance and T2DM. The purpose of this study was to compare the effects of MICT and HIIT in healthy people on blood glucose levels, which was measured through fasting blood glucose (FBG) and oral glucose tolerance test (OGTT). Healthy men (n=27), aged (20.07 ± 0.62), BMI (23.94 ± 3.59) kg/m2 participated in either MICT, HIIT, or Control group (n=9 each group). Ergocycle exercise were performed 3 times/week for 4 weeks; MICT with a total duration of 46 minutes/session (moderate intensity 50-60% heart rate reserve [HRR]) for 40 minutes); HIIT with a total duration of 24 minutes/session (6 cycles; 2 mins high intensity 80-90% HRR + 1 min moderate intensity 50-60% HRR). Controls did not receive any programmed training. FBG and OGTT (120? after glucose load) were checked 3 days before and after the exercise program. This study found that FBG decreased in all groups but only the MICT group showed a significant reduction (p=0.048). OGTT was found unaltered in all groups (p>0.05). MICT has the potential to improve blood glucose control in healthy young adult subjects. However, further research with exercise dose modification is required to elucidate the effects of HIIT. [MKB. 2016;48(4):194?9]Key words: Blood glucose control, high intensity interval training, moderate intensity continuous training

Poor Glycemic Control is Correlated with Reduced Cognitive Function in Type 2 Diabetes Mellitus Patients Archangela Olivia Eugenia; Achmad Firdaus Sani; Hermawan Susanto; Jongky Hendro Prajitno
Biomolecular and Health Science Journal Vol. 5 No. 1 (2022): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v5i1.31880

Introduction: The prevalence of type 2 Diabetes Mellitus (T2DM) in Indonesia is increasing and is known to cause several complications related to the patient’s glycemic control. A chronic hyperglycemic state will lead to microvascular injury of the brain resulting in cognitive impairment as one of the complications of T2DM. Therefore, our present study observed the correlation between glycemic control and cognitive impairment in patients with T2DM.Methods: This was an observational study with a cross-sectional design of T2DM patients in endocrine outpatient clinics of Dr. Soetomo General Academic Hospital from October 2020 to March 2021. The subjects were recruited consecutively then categorized into groups with controlled (HbA1c < 7%) and uncontrolled (HbA1c ≥ 7%) blood glucose. The cognitive function was evaluated using the AD8 informant-based questionnaire.Results: A total of 43 adult T2DM patients aged < 65 years were recruited. The incidence of cognitive impairment was not significantly different (p=0.127) between controlled and uncontrolled blood glucose groups. However, HbA1c levels were positively and significantly correlated with AD8 scores (p=0.031, R=0.330). Moreover, the duration of T2DM was found to significantly affect cognitive abnormalities in these patients. (p=0.021).Conclusion: Poor glycemic control in T2DM patients increased the risk of developing reduced cognitive function.

EFEKTIFITAS KOMBINASI PUPUK ANORGANIK DAN PUPUK HAYATI TERHADAP PERTUMBUHAN DAN HASIL TANAMAN JUNGGULAN (Crassocephalum crepidioides) hermawan susanto
AGRONISMA Vol 8, No 1 (2020)
Publisher : AGRONISMA

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This study aims to determine the effectiveness of a combination of inorganic fertilizers and the interval of biological fertilizer on the growth of superior crops (crassocephalum crepidiodes). This research was conducted in Pendem Village, Junrejo District, Batu City and integrated laboratory of Islamic University of Malang with the height of the area ± 641 meters above sea level, average temperature of 20º C. Rainfall 30 mm. This research was conducted in December 2018 until March 2019. This research uses factorial randomized block design (RBD) consisting of 2 factors. Factor 1 is the composition of inorganic fertilizer (P) consisting of 4 levels, namely P0 (without the provision of inorganic fertilizer), P1 (100 kg urea Ha-1), P2 (100 kg urea Ha-1 + 25 kg TSP Ha-1), P3 (100kg urea Ha-1 + 25 kg TSP Ha-1 + 25 kg KCl Ha-1). Factor 2 is the interval of biological fertilizer (K) consisting of 4 levels, namely, K0 (without the administration of Ultra-gen fertilizer), K1 (Provision of Ultra-gene fertilizer once every 5 days), K2 (Provision of Ultra-gene fertilizer once every 7 days) and K3 (Provision of Ultra gene fertilizer every 9 days) from 2 factors obtained 16 combinations, each treatment contained 3 samples and repeated 3 times so that there were 144 samples.The results of this study indicate that there is an interaction between inorganic fertilizers and biological fertilizer intervals. In general, inorganic fertilizer treatment yields tend to yield better results on the growth and yield of predominantly dominated plants in the P3 treatment (100kg urea Ha-1 + 25 kg TSP Ha-1 + 25 kg KCl Ha-1). Biological fertilizer treatment can provide interaction with plant height, leaf area.

EFEKTIFITAS KOMBINASI PUPUK ANORGANIK DAN PUPUK HAYATI TERHADAP PERTUMBUHAN DAN HASIL TANAMAN JUNGGULAN (Crassocephalum crepidioides) hermawan susanto; Mahayu Woro Lestari; Novi Arfarita
AGRONISMA Vol. 8 No. 1 (2020)
Publisher : AGRONISMA

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This study aims to determine the effectiveness of a combination of inorganic fertilizers and the interval of biological fertilizer on the growth of superior crops (crassocephalum crepidiodes). This research was conducted in Pendem Village, Junrejo District, Batu City and integrated laboratory of Islamic University of Malang with the height of the area Â± 641 meters above sea level, average temperature of 20Âº C. Rainfall 30 mm. This research was conducted in December 2018 until March 2019. This research uses factorial randomized block design (RBD) consisting of 2 factors. Factor 1 is the composition of inorganic fertilizer (P) consisting of 4 levels, namely P0 (without the provision of inorganic fertilizer), P1 (100 kg urea Ha-1), P2 (100 kg urea Ha-1 + 25 kg TSP Ha-1), P3 (100kg urea Ha-1 + 25 kg TSP Ha-1 + 25 kg KCl Ha-1). Factor 2 is the interval of biological fertilizer (K) consisting of 4 levels, namely, K0 (without the administration of Ultra-gen fertilizer), K1 (Provision of Ultra-gene fertilizer once every 5 days), K2 (Provision of Ultra-gene fertilizer once every 7 days) and K3 (Provision of Ultra gene fertilizer every 9 days) from 2 factors obtained 16 combinations, each treatment contained 3 samples and repeated 3 times so that there were 144 samples.The results of this study indicate that there is an interaction between inorganic fertilizers and biological fertilizer intervals. In general, inorganic fertilizer treatment yields tend to yield better results on the growth and yield of predominantly dominated plants in the P3 treatment (100kg urea Ha-1 + 25 kg TSP Ha-1 + 25 kg KCl Ha-1). Biological fertilizer treatment can provide interaction with plant height, leaf area.

PENGARUH SAAT PEMANGKASAN TUNAS LATERAL DAN DOSIS PUPUK NPK TERHADAP PERTUMBUHAN DAN HASIL TANAMAN CABAI KERITING (Capsicum annum L.) Hermawan Susanto; Djoko Heru Pamungkas; Zamroni Zamroni
JURNAL ILMIAH AGROUST Vol 3 No 1 (2019): Maret
Publisher : Universitas Sarjanawiyata Tamansiswa

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This study aims to determine the effect of NPK fertilizer dosage and when Â trimming lateral shoots to growth and yield of curly chili plants. This research was conducted in Kukap, Poncosari, Srandakan, Bantul, Yogyakarta with a height of 20 masl, regusol soil type, pH between 5.3 - 6.8 and average temperature 260 C - 380 C , and is held from September to December 2018. This study was conducted using a 2 x 2 + 1 control factorial experiment compiled in a Complete Randomized Block Design (RAKL). The treatment consists of two factors, the first factor is the treatment of pruning. The second factor is the dose of NPK fertilizer. Each treatment was repeated three times. The results of the analysis showed that there were interactions between the two factors in the outcome variable, where the control treatment of pruning at 7 days and 14 days and the fertilizer dose of 1.25 tons/ha gave the highest fruit weight yield. Giving fertilizer doses and pruning times showed no significant effect on plant growth and quality

Hubungan Fungsi Tiroid Dengan Pertumbuhan Pada Anak Sindrom Down Di Poli Endokrin Anak Rsud Dr. Soetomo Surabaya Hafidhatul Aisy; Nur Rochmah; Hermawan Susanto; Azwin Mengindra Putera Lubis
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Anak-anak dengan Sindrom Down (SD) memiliki peningkatan risiko mengalami disfungsi tiroid. Hormon tiroid berperan penting dalam proses pertumbuhan sehingga gangguan fungsi tiroid dapat mempengaruhi pertumbuhannya. Penelitian ini bertujuan untuk mengetahui hubungan antara fungsi tiroid dengan pertumbuhan pada anak SD. Metode: Penelitian ini merupakan penelitian analitik observasional dengan metode cross-sectional menggunakan sumber data rekam medis pasien. Variabel bebas dalam penelitian ini adalah fungsi tiroid dan variabel terikatnya adalah pertumbuhan. Tinggi/ panjang badan merupakan parameter pertumbuhan yang dinilai menggunakan kurva standar untuk anak-anak dengan SD. Hasil dari penelitian ini adalah subjek penelitian terdiri dari 27 pasien SD (17 laki-laki, 20 perempuan) yang berusia 1 sampai 47 bulan dengan rerata usia 10.00Â±10.87 bulan. Distribusi fungsi tiroid terdiri dari 15 hipotiroid sentral (55.6%), 8 hipotiroid subklinis (29.6%), 3 hipotiroid primer (11.1%), dan 1 eutiroid (3.7%). Mayoritas subjek memiliki tinggi badan normal (22/27, rerata z-score -0,03Â±2,37). Nilai signifikansi korelasi antara fungsi tiroid (kadar TSH dan FT4) dan pertumbuhan (perubahan z-score) berturut-turut p=0,287 dan p=0,143 yang berarti p>0,05 sehingga tidak ada korelasi yang signifikan. Sehingga dapaty diterik kesimpulan bahwa tidak terdapat hubungan antara fungsi tiroid dengan pertumbuhan anak dengan SD. Namun disarankan untuk melakukan skrining fungsi tiroid, mendiagnosis, memonitor, dan memberikan terapi dini pada anak SD untuk mencegah perburukan kondisi perkembangan, pertumbuhan, dan metabolisme.

Hubungan Fungsi Tiroid Dengan Pertumbuhan Pada Anak Sindrom Down Di Poli Endokrin Anak Rsud Dr. Soetomo Surabaya Hafidhatul Aisy; Nur Rochmah; Hermawan Susanto; Azwin Mengindra Putera Lubis
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Anak-anak dengan Sindrom Down (SD) memiliki peningkatan risiko mengalami disfungsi tiroid. Hormon tiroid berperan penting dalam proses pertumbuhan sehingga gangguan fungsi tiroid dapat mempengaruhi pertumbuhannya. Penelitian ini bertujuan untuk mengetahui hubungan antara fungsi tiroid dengan pertumbuhan pada anak SD. Metode: Penelitian ini merupakan penelitian analitik observasional dengan metode cross-sectional menggunakan sumber data rekam medis pasien. Variabel bebas dalam penelitian ini adalah fungsi tiroid dan variabel terikatnya adalah pertumbuhan. Tinggi/ panjang badan merupakan parameter pertumbuhan yang dinilai menggunakan kurva standar untuk anak-anak dengan SD. Hasil dari penelitian ini adalah subjek penelitian terdiri dari 27 pasien SD (17 laki-laki, 20 perempuan) yang berusia 1 sampai 47 bulan dengan rerata usia 10.00Â±10.87 bulan. Distribusi fungsi tiroid terdiri dari 15 hipotiroid sentral (55.6%), 8 hipotiroid subklinis (29.6%), 3 hipotiroid primer (11.1%), dan 1 eutiroid (3.7%). Mayoritas subjek memiliki tinggi badan normal (22/27, rerata z-score -0,03Â±2,37). Nilai signifikansi korelasi antara fungsi tiroid (kadar TSH dan FT4) dan pertumbuhan (perubahan z-score) berturut-turut p=0,287 dan p=0,143 yang berarti p>0,05 sehingga tidak ada korelasi yang signifikan. Sehingga dapaty diterik kesimpulan bahwa tidak terdapat hubungan antara fungsi tiroid dengan pertumbuhan anak dengan SD. Namun disarankan untuk melakukan skrining fungsi tiroid, mendiagnosis, memonitor, dan memberikan terapi dini pada anak SD untuk mencegah perburukan kondisi perkembangan, pertumbuhan, dan metabolisme.

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