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All Journal International Journal of Public Health Science (IJPHS) Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Pharmascience Jurnal Ilmu Kefarmasian Indonesia JCPS (Journal of Current Pharmaceutical Sciences) Jurnal Kefarmasian AKFARINDO Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kesehatan Bakti Tunas Husada Medical Sains : Jurnal Ilmiah Kefarmasian
Adnan, Adnan
Faculty Of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Special Region Of Yogyakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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Evaluasi terapi erytropoetin pada pasien hemodialisa di rumah sakit PKU Muhammadiyah Yogyakarta Adnan, Adnan; Dania, Haafizah; Supadmi, Woro
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (258.863 KB) | DOI: 10.12928/pharmaciana.v8i2.7725

Abstract

Most of the patients with end-stage renal disease who undergoing hemodialysis received erythropoietin (EPO) therapy for the anemia treatment. Deficiency anemia erythropoietin is a common complication of chronic kidney disease (CKD). EPO therapy is expected to improve the anemia and can improve the quality of life of patients.This study was conducted in an analytic observational with Cross Secsional design. The purpose of this study was to know there was a difference of red blood cell profile involve hemoglobin (Hb), Mean Corpusculair Volume (MCV), Mean Corpusculair Haemoglobin (MCH), Mean Corpusculair Haemoglobin Concentration (MCHC) and quality of life of CKD patients who received EPO and non EPO therapy in PKU Muhammadiyah Yogyakarta Hospital. Inclusion criteria in this study were PGK ICD N18.9 patients who were undergoing hemodialysis therapy at RS PKU Muhammadiyah Yogyakarta, outpatient, can read and understand the questionnaire, and accept to be a respondent.The results of this study showed no significant difference (p>0,05) in red blood cell (Hb, MCV, MCH, MCHC) between EPO and non EPO therapy groups. The associated of EPO with the quality of life of patients in all of KDQOL domains was p> 0.05.The conclusions of this study showed that there was no significant difference between EPO and Non EPO therapy and there was no correlation between EPO and non EPO therapy with quality of life of hemodialysis patients.
Nicotine level associated with decreasing Treg number in smoker healthy volunteers Akrom Akrom; Tri Julia Purnamasari; Zaky Nurfaiz; Adnan Adnan; Endang Darmawan; Muhammad Muhlis
International Journal of Public Health Science (IJPHS) Vol 10, No 1: March 2021
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v10i1.20570

Abstract

The intensity of cigarette exposure is associated with the severity of the inflammatory reaction. Treg cell plays a role in suppressing the inflammatory response. There has been no clear evidence on the relationship between smoker behavior with the nicotine level and Treg number. We will investigate the relationship between smoking behavior with the nicotine level and Treg number. We conducted a cross-sectional study of 106 healthy volunteers in Yogyakarta. We interviewed the subjects and took their blood samples for hemogram, Treg number, nicotine level, and blood chemistry examination. The inclusion criteria were fit, male or female, aged 18 years or older, and willing to volunteer proven by completing and signing the informed consent. We collected the data on smoking habits through interviews guided by a questionnaire. We examined hemogram and blood chemistry using a spectrophotometer, while the levels of nicotine were measured using The enzyme-linked immunosorbent assay (ELISA). We described the characteristics of the subjects by univariate analysis. The bivariate analysis was to determine the relationship between cigarette smoking length with nicotine level and Treg number. The results show a connection between the range of tobacco and cigarette number with nicotine levels in the blood with a value of r=0.63 in the Pearson correlation test p<0.00. It can be concluded that there is a relationship between behavior smoking with nicotine levels and Treg counts.
Reliability and Validaty of St George Respiratory Questionnaire (SGRQ) into Indonesian Version Adnan Adnan; Dyah Aryani Perwitasari; Ully Adhie Mulyani
International Journal of Public Health Science (IJPHS) Vol 3, No 3: September 2014
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (180.187 KB) | DOI: 10.11591/ijphs.v3i3.4691

Abstract

Tuberculosis (TB) is one of the disease as the highest contributor to the disease burden in Indonesia. Tuberculosis can affect the patients’ quality of life, such as psychological, physical, and social functioning. St. George's Respiratory Questionnaire (SGRQ) is a special instrument which was widely used to measure the patients’ quality of life with respiratory disease. The objective of this study was to validate the Indonesian version of the SGRQ as instrument to collect data. A descriptive cross section design with 61 subjects was conducted at the Pulmonary Clinics and Primary Health Centers in the region of Yogyakarta within 3 months. The validation process included the known group validity, convergent and discriminant validity and factor analysis. There were 14 items question numbers which did not meet the criteria for convergent validity and 9 items which did not meet the criteria for discriminant validity. Known group validity analysis on gender showed that of the three domains of SGRQ, the activity domain gave statistically significant result. The factor analysis showed the result of Kaiser Meyer Olkin analysis (KMO) was less than 0.5. With a few modifications, the Indonesian version of SGRQ is valid and reliable for measuring quality of life in tuberculosis patients.
Cost-effectiveness analysis of cefazolin and clindamycin in postpartum patients at PKU Muhammadiyah Hospital Yogyakarta Anggita Esa Putri Fitrichia; Susan Fitria Candradewi; Dewi Inggit Karnasi; Adnan Adnan
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 6 No. 2 (2021)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v6i2.17289

Abstract

Postpartum infections can occur after normal or cesarean delivery. Proper administration of antibiotics can reduce the risk of postpartum infection The occurrence of postpartum infections can increase the cost of childbirth. The purpose of this study is to find out the cost-effectiveness of antibiotic therapy at PKU Muhammadiyah Hospital Yogyakarta.  This study was retrospective observational and was conducted during October to December 2020. The inclusion criteria in this study were postpartum patients who received cefazolin and clindamycin therapy and were over 20 years old, while the exclusion criteria in this study were patients who died, had incomplete data, and had complications of the disease. The effectiveness of antibiotic therapy was measured from the clinical outside of body temperature and length of hospitalization. Cost-effectiveness were assessed from ACER (Average Cost-effectiveness Ratio) and ICER (Incremental Cost-effectiveness Ratio). The results showed that the effectiveness of antibiotics based on the clinical outcome temperature and length of  cefazolin of 81.3% and 2.7 days while in clindamycin by 18.8% and 1.8 days. The ACER (Average cost effectiveness ratio) based on the clinical output of body temperature in both groups was IDR 64,348 (cefazolin) and IDR 98,319 (clindamycin). ACER values based on long of stay (LOS) clinical discharge in both groups amounted to IDR 19,375 (cefazolin) and IDR 10,268 (clindamycin). The value of ICER (Incremental Cost- effectiveness Ratio) cefazolin against clindamycin based on the clinical output of temperature and length of hospitalization (LOS) respectively is IDR 54,129 and IDR 37,590 for each effectiveness achieved. The conclusion of this study is that the use of cefeazoline is more therapeutically effective than clindamycin with greater therapeutic costs.
VALIDASI KUESIONER POLA HIDUP PADA PASIEN HIPERTENSI DI PUSKESMAS DI YOGYAKARTA Adnan Adnan; N.S Mansur
Jurnal Insan Farmasi Indonesia Vol 1 No 2 (2018)
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hipertensi adalah peningkatan tekanan darah sistolik dan diastolik melebihi batas normal. Kualitas hidup dari pasien hipertensi dipengaruhi oleh banyak faktor, salah satunya adalah pola hidup pasien, yaitu aktifitas fisik, pola makan, konsumsi alkohol, dan kebiasaan merokok. Tujuan penelitian ini adalah melakukan uji validasi dan reliabilitas terhadap kuesioner pola hidup sebagai instrument pengumpul data untuk mengukur pola hidup pasien hipertensi.Jenis penelitian ini adalah observasional diskriptif dengan pendekatan cross sectional. Sampel penelitian adalah 30 pasien hipertensi di salah satu Puskesmas di. Pengambilan sampel menggunakan metode non-probability sampling. Instrument peneltian adalah kuesioner pola hidup untuk mengukur pola hidup pasiaen hipertensi. Analisa terhadap validitas penelitian menggunakan metode pearson korelasi.Hasil peneltian untuk validitas diperoleh nilai koefisien pearson korelasi lebih besar dari 0,30, dan untuk uji reliabilitas diperoleh nilai Cronbach α adalah 0,715.Dari hasil peneltian dapat disimpulkan bahwa kuesioner pola hidup valid (koefisien pearson korelasi > 0,30) dan reliabael (cronbach α > 0,70), artinya bahwa kuesioner pola hidup valid dan reliabel sebagai instrument pengumpul data untuk mengukur pola hidup pasien hipertensi. 
ANALISIS EFEKTIVITAS PENGGUNAAN ANTIBIOTIKA PADA PASIEN SIROSIS HEPATIS DENGAN KOMPLIKASI SPONTANEOUS BACTERIAL PERITONITIS DI SALAH SATU RUMAH SAKIT DI YOGYAKARTA Adnan Adnan; Lolita Lolita
Jurnal Insan Farmasi Indonesia Vol 3 No 1 (2020): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v3i1.489

Abstract

Cirrhosis is a diffusion process characterized by fibrosis and changes from normal hepatic structures to structurally abnormal nodules. In general, complications that often occur in hospitalized patients are Spontaneous Bacterial Peritonitis (SBP). Many antibiotic therapies can be used for SBP, for example aminoglycosides, third-generation cephalosporins, penicillins, quinolones and sulfa groups. The purpose of this study was to determine whether there are differences in the effectiveness of antibioics used in SBP therapy. This type of research is observational analytic with cross sectional approach. Retrospective data collection in patients with cirrhosis of the liver with SBP complications in PKU Muhammadiyah Yogyakarta Hospital in 2018. Samples are all patients with cirrhosis of the liver with SBP complications who meet the inclusion and exclusion criteria. The sampling method is purposive sampling. The data taken is demographic characteristic data and clinical characteristics. Analysis of the data used in this study is multivariate analysis and different tests. There were 30 samples that met the criteria with a composition of 18 men (60%) and 12 women (40%). There were 8 people who received ceftriaxone antibiotics and 22 people got cefotaxime therapy.
EFEKTIVITAS CEFOTAXIME DAN CEFIXIME PADA DIARE AKUT KARENA INFEKSI DI BANGSAL ANAK RAWAT INAP DI SALAH SATU RUMAH SAKIT DI YOGAYAKARTA PERIODE JANUARI – DESEMBER 2018 Adnan Adnan; Nurkhalisa Ekaputri
Jurnal Insan Farmasi Indonesia Vol 4 No 1 (2021): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v4i1.694

Abstract

Diare akut karena infeksi adalah buang air besar yang frekuensinya lebih sering dari bisanya (3 kali atau lebih per hari) dengan konsistensi tinja cair. Di Indonesia, angka kejadian diare akut masih tinggi setiap tahunnya dan masih menjadi permasalahan yang perlu diperhatikan secara serius. Cefotaxime dan cefixime adalah golongan antibiotika golongan sefalosporin yang bisa digunakan untuk kasus diare akut spesifik karena infeksi bakteri. Penelitian ini bertujuan untuk mengetahui perbandingan efektivitas penggunaan cefotaxime dibandingkan dengan cefixime di bangsal anak rawat inap di RSUD Panembahan Senopati Bantul periode januari–desember 2018. Jenis penelitian adalah observasional analitik dengan pengambilan data menggunakan metode retrospektif. Parameter efektifitas yang digunakan adalah lama waktu rawat inap. Hasil penelitian menunjukkan bahwa pasien diare akut karena infeksi anak paling banyak terjadi pada 57 pasien anak laki-laki (65,5%) dan 30 pasien anak perempuan (34,5%), dengan kelompok usia <1tahun (1,1%); 1-5 tahun (69,0%) dan 6-11 tahun (29,9), pasien anak yang belum sekolah 66 anak (75,9%) dan yang sedang menempuh SD 21 anak (24,1%), dan penggunaan antibiotika yang paling banyak digunakan yaitu cefotaxime 59,8%, cefixime yaitu 40,2%.Kesimpulan dari penelitian ini tidak terdapat perbedaan bermakna pada lama rawat inap kedua antibiotik tersebut (p value >0,05).
UJI AKSEPTABILITAS PEMBERIAN IMUNAX@ PADA RELAWAN SEHAT ACCEPTIBILITY TEST OF IMUNAX@ IN HEALTHY RESPONDEN Adnan; Akrom
Jurnal Kefarmasian Akfarindo Vol 2 No 2 (2017)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.v0i0.23

Abstract

Latar belakang: Minyak biji jinten hitam (MBJH)/imunax@ yang mengandung timokuinon bersifat antioksidatif dan antiinflamasi. Imunax@ potensial untuk dikembangkan sebagai agen imunomodulator antioksidan untuk terapi ajuvan atau profilaktif kelompok berisiko tinggi mengalami penyakit degenerative. Namun data akseptabilitas dan tolerabilitas penggunaan imunax@ pada manusia belum diketahui. Penelitian ini bertujuan untuk mendapatkan masukan tentang pendapat dan tanggapan relawan terhadap penggunaan imunax@ dosis 2,5; 5 dan 7,5 mL/hari selama 4 minggu meliputi rasa, bau, akibat atau dampak ketidak nyamanan yang ditimbulkan. Metode: Penelitian eksperimental klinik desain prospektif dengan kelompok kontrol selama 4 minggu. Sebanyak 48 relawan sehat, 11 pria dan 37 wanita, dibagi dalam 3 kelompok yaitu kelompok dosis 2,5; 5; dan 7,5 mL/hari peroral masing-masing 16 relawan. Kriteria inklusi meliputi laki-laki dan wanita sehat, berusia 18 – 60 tahun dan bersedia mengisi inform consent. Data yang diambil meliputi parameter klinis dan pendapat relawan terkait rasa, bau, dan kondisi ketidak nyamanan yang dirasakan selama mengkonsumsi imunax@. Data dianalisis dengan uji one way anova. Hasil: Hasil penelitian didapatkan skor total di atas 3 yang berarti paling tidak memberikan lebih dari cukup puas hingga lebih dari puas konsumen dalam mengkonsumsi sediaan ini. Ada 6 pertanyaan yaitu pertanyaan 1,2,5,6, 8 dan 9, memiliki rata-rata skor total lebih dari 4 (lebih dari puas) sedangkan ada 4 pertanyaan (3,4,7 dan 10) memiliki rata-rata skor total lebih dari 3 (lebih dari cukup puas). Kesimpulan: Kesimpulan bahwa sediaan soft capsul MBJH (imunax@) dapat diterima oleh konsumen.
Evaluation of erythropoietin therapy in hemodialysis patients at PKU Muhammadiyah Hospital Yogyakarta Adnan Adnan; Haafizah Dania; Woro Supadmi
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (45.535 KB) | DOI: 10.12928/pharmaciana.v8i2.7725

Abstract

Most of the patients with end-stage renal disease who undergo hemodialysis receive erythropoietin (EPO) therapy for anemia treatment. Anemia with EPO deficiency is a common complication of chronic kidney disease (CKD). EPO therapy is expected to improve anemia and quality of life of patients. This analytic observational study was conducted in a cross-sectional design. It aimed to identify the difference in red blood cell profiles, namely hemoglobin (Hb), Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), and Mean Corpuscular Hemoglobin Concentration (MCHC), and quality of life of CKD patients on EPO and non-EPO therapy at PKU Muhammadiyah Hospital in Yogyakarta. The inclusion criteria were PGK ICD N18.9 outpatients who received hemodialysis therapy at this hospital and were literate, able to understand the questionnaire, and willing to be a respondent. The results showed that there was no significant difference (p>0,05) between the red blood cells (Hb, MCV, MCH, MCHC) of the EPO and non-EPO therapy groups. The correlation between the EPO and the quality of life of patients in all of the KDQOL domains was p> 0.05. Aside from the insignificant difference between the EPO and non-EPO therapy groups, the research concluded that there was no correlation between either the EPO or the non-EPO therapy with the quality of life of hemodialysis patients.
HUBUNGAN PERSEPSI TERHADAP OUTCOME KLINIS PADA PASIEN DIABETES MELLITUS-HIPERTENSI DI RUMAH SAKIT PKU MUHAMMADIYAH BANTUL Adnan Adnan; Desy Munawaroh
Media Farmasi: Jurnal Ilmu Farmasi Vol 17, No 2: September 2020
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (374.189 KB) | DOI: 10.12928/mf.v17i2.19139

Abstract

Diabetes melitus (DM) tipe 2 terdapat lebih dari 75% penderita kategori dewasa memiliki komplikasi dengan hipertensi, hal tersebut harus diwaspadai karena dapat meningkatkan resiko kematian 7,2 kali lipat. Persepsi terhadap penyakit yang diderita adalah salah satu faktor dari keberhasilan terapi yang dapat membuat kadar gula dan tekanan darah tetap terkontrol sehingga resiko kematian dapat dicegah. Penelitian ini bertujuan untuk mengetahui hubungan persepsi dengan outcome klinis pasien DM-hipertensi. Metode penelitian ini observasional analitik dengan desain penelitian cross-sectional. Sampel dalam penelitian ini merupakan pasien diabetes melitus dengan hipertensi yang memenuhi kriteria inklusi yang meliputi pasien dewasa laki-laki dan perempuan, mendapat terapi lebih dari atau sama dengan satu obat antidiabetik oral dan antihipertensi, serta bersedia mengikuti penelitian dengan menandatangani informed consent. Pengambilan data persepsi menggunakan kuesioner B-IPQ, dan data rekam medis untuk mendapatkan data kadar gula darah sewaktu dan tekanan darah sebagai data keberhasilan terapi. Hasil penelitian dari 73 pasien terdapat 38 orang (52,1%) memiliki persepsi yang positif dan 35 orang (47,9%) memiliki persepsi yang negatif. Ada 31 orang (42,5%) outcome klinisnya terkontrol dan ada 42 orang (57,5%) tidak terkontrol. Hasil uji chi-square menunjukkan tidak ada hubungan persepsi dengan outcome klinis dengan nilai P value 0,948. Kesimpulan dari penelitian ini adalah tidak terdapat hubungan antara persepsi dengan outcome klinis pasien DM-hipertensi di Rumah Sakit PKU Muhammadiyah Bantul.
Co-Authors . Lolita Akrom, Akrom Anggita Esa Putri Fitrichia Anzili Winda Nur Azizah Debby Anggita Desy Munawaroh Dewi Inggit Karnasi Dyah Aryani Perwitasari Dyah Purmi Ta Arum Endang Darmawan Haafizah Dania Herlanisa Yuliana Maliza, Rita Muhammad Muhlis N.S Mansur Nanik Sulistyani Nurkhalisa Ekaputri Saputri, Ginanjar Zukhruf Susan Fitria Candradewi Tri Julia Purnamasari Ulfah Nurul Qoyimah Ully Adhie Mulyani Vivi Alna Nur Afriani Woro Supadmi Zaky Nurfaiz