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All Journal International Journal of Public Health Science (IJPHS) Jurnal Ilmiah Farmasi Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Klinik Indonesia Jurnal Dinamika Pengabdian (JDP) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Kefarmasian AKFARINDO Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Borneo Journal of Pharmacy
. Lolita
Universitas Ahmad Dahlan
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Social Sciences

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ISOLASI DAN AKTIVITAS LARVACIDA MINYAK ATSIRI AKAR (Curcuma mangga, Val.) TERHADAP LARVA Aedes Aegypti DAN PROFIL GC-MS NYA Lolita, .
PHARMACIANA Vol 2, No 2: November 2012
Publisher : PHARMACIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (82.03 KB)

Abstract

Curcuma mangga.,Val has been recognized as a traditional drug since a long time ago. The active ingrediences of this plant especially the volatile oil contains monoterpenes and sesquiterpenes. This research was aimed to study about the larvacide’s activity of the volatile oil Curcuma mangga., Val rhizome and also to analyze its chemical compounds using the GC-MS. The volatile oil was isolated from Curcuma mangga, Val with steam and water distillation. The test method for larvicide was done by dissolving the substances into water and added by Tween 20 10%v/v to the the volatile oil. The concentration of the volatile oil of Curcuma mangga,Val rhizome were 100 ppm, 150 ppm, 200 ppm, 250 ppm, 300 ppm, and 350 ppm. The concentration of positive control “abate” were 0,01 ppm; 0,025 ppm; 0,05 ppm; 0,1 ppm; 0,5 ppm while as the negative control was Tween 20 solution. The perception time of larvae’s mortality was 24 hours. The chemical compound of Curcuma mangga., Val can be analysed by the GC-MS. Data of larvae’s mortality were used to estimate the values of LC50 with the probit analyzis method. This study showed that the volatile oil of Curcuma mangga, Val. have clear-brass colour, bitter taste, typically aromatic like mango, rendement equal to (1,23 ± 0,029)% v/b and refractive index 1,4881. The value of LC50 for the volatile oil of Curcuma mangga, Val. rhizome is (216,17 ±12,51) ppm while abate equal to (0,072 ± 0,024) ppm. This finding indicates that abate were more potent to larvae of Aedes aegypti. The GC-MS showes 30 peaks chromatogram and six peaks which indicates the possibility of alpha-pinene, camphene, beta-pinene, beta-myrcene, eukalyptole, ar-turmerone presence.
Effectiveness of web based educational on improving knowledge of acne vulgaris self medication among senior high school students Lolita, Lolita; Meita Putri, Ni Putu Isabela
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (340.3 KB) | DOI: 10.12928/pharmaciana.v7i2.7240

Abstract

The presence of technology can provide real alternatives to build knowledge in delivering health education materials. The aim of this study was to investigate if web-based education methods may rising a student’s knowledge about self medication of acne. This research using an experimental pretest-posttest control group design while the sampling technique using convenience nonprobability sampling. Inclusion criteria for participants were senior high school students aged 13-19 years, active social media users, and willing to fill out the research questionnaire. Participants were allocated to the exclusion criteria as students who perform routine skin care in the acne treatment. Control group consisted of 62 respondents who were given face to face education and treatment group consisted of 62 respondents who were given website-based education. Data analysis were performed with a student t-test to assess the effect of educational intervention on student’s knowledge. The independent t-test showed there was a significant increase of knowledge between the control and the treatment groups   (p = 0,000) with 95% confidence level. This study demonstrate that web-based educational intervention had a significant increase on the student’s knowledge about acne vulgaris self medication.
Knowledge, precautionary actions, and perceived risk of COVID-19 among Indonesian people Ratih Oktri Nanda; Lolita Lolita; Wiwik Indayati; Ivong Rusdiyanti; Azis Ikhsanudin; Silvia Mareti
International Journal of Public Health Science (IJPHS) Vol 10, No 1: March 2021
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v10i1.20589

Abstract

Novel coronavirus was first identified in China in December 2019, causing several cases of the new type of pneumonia. The exported cases were found in other countries, including countries in the Southeast Asia region. At the same time, no cases were confirmed in Indonesia. We aimed to assess COVID-19 related knowledge, precautionary actions, and perceived risk among general Indonesian population when there were no confirmed cases in Indonesia. This study was a descriptive cross-sectional study involving 382 participants aged 17 years and above residing in Indonesia. The data was collected through the online questionnaire from February 19th to February 29th 2020. The average score of COVID-19 related knowledge was 88.0%, whereas 83.8% of the participants had a high level of knowledge. The average score of taking precautionary actions was 77.4% and 65.7% had a high level of performance. In terms of the perceived risk of COVID-19, only 11.3% of the participants perceived themselves likely to acquire COVID-19 when compared with other diseases or accidents. The perceived risk of COVID-19 was significantly associated with precautionary action (p<0.05). Perceived risk of COVID-19 was at a low level when there were no confirmed cases. Effective strategies of risk communication are needed to improve precautionary actions to prevent COVID-19.
Knowledge and quality of life among Indonesian students during the COVID-19 pandemic Prasojo Pribadi; Lolita Lolita; Rayi Citra Ayu Pangestuti; Heni Lutfiyati; Silvia Mareti; Azis Ikhsanudin
International Journal of Public Health Science (IJPHS) Vol 10, No 2: June 2021
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v10i2.20819

Abstract

The increasing of online coronavirus disease-2019 (COVID-19) information-sharing in digital media can contribute to the emergence of misinformation in public. Much insufficient knowledge will confuse public understanding and affect their quality of life. The study purposed to assess the knowledge and its influence on Indonesian students' quality of life during the COVID-19 crisis. A cross-sectional study was conducted between October and December 2020 by distributing online questionnaires. The data analysis was run through the Spearman correlation method by using SPSS version 21.0. A total of 200 respondents aged over 17 years were recruited using a snowball sampling technique. Most study respondents had insufficient knowledge about COVID-19, 23% of them had moderate knowledge, and only 17.5% had high knowledge. They obtained primary sources of COVID-19 information from social media platforms. The results showed that health science students have a better understanding than social science students (ρ<0.001). The level of knowledge has a significant associated with psychological domain (ρ=0.020), environmental domain (ρ=0.046), and overall quality of life (ρ=0.047). Thus, the media control center is vital to encounter valid information in providing better knowledge and quality of life during a pandemic.
Larvicidal activity of granulated pharmaceutical products using Indonesian holy basil leaf extract Azis Ikhsanudin; Lolita Lolita; Zayyana Septya Ramadani
International Journal of Public Health Science (IJPHS) Vol 10, No 4: December 2021
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v10i4.21004

Abstract

Ocimum sanctum Linn, known as holy basil, is a larvicide, which is relatively safe compared to synthetic insecticides. This study investigates the larvicidal activity of a granule formulation of Indonesian holy basil leaf extract against third larval instar of Aedes aegypti. The extract of holy basil leaves was obtained by a maceration process with 96% ethanol. The granule was formulated with various concentrations of holy basil leaf extract, including F1 (2000 ppm), F2 (4000 ppm), and F3 (6000 ppm). The extract contained terpenoid, alkaloid, saponin, flavonoid, and polyphenol compounds. The extract granules had a moisture content of 3.01%, flowability of 1.51 seconds, and dispersion time of 1.09 seconds. The mortality rates of mosquitos treated with the different formulation groups were significantly different from positive control with values of 25.33% (F1), 50.67% (F2), and 90.67% (F3). In conclusion, the granulated formulation of holy basil leaf extract has a larvicidal LC50 of 4405.803 ppm and LC90 of 6080.714 ppm. Therefore, a granulated pharmaceutical product derived from holy basil leaf extract could be developed as a potent larvicide to control dengue fever.
Anti-inflammatory activity of Indonesian nutmeg seeds (Myristica fragrans Houtt): A topical gel formulation Azis Ikhsanudin; Lolita Lolita; Daniar Dyanas Rais
International Journal of Public Health Science (IJPHS) Vol 10, No 3: September 2021
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v10i3.20921

Abstract

Herbal medicines have been shown as anti-inflammatory with potentially lesser side effects. The active compound of nutmeg seed is proven to accelerate the healing process of inflammation. This study aimed to evaluate the gel formulation of Indonesian nutmeg (Myristica fragrans Houtt) seed extract for anti-inflammatory activity. A true experimental post test only with control group design was used in this study. The gel was formulated with various concentrations of nutmeg seed extract, namely formulations F1 (0%), F2 (2%), F3 (4%), F4 (8 %), and F5 (12%). Analysis of variance (ANOVA) followed by the least significant difference (LSD) methods were performed with SPSS version 22. The results showed that all formulas had an opaque physical appearance, brownish-yellow color, soft texture, and aromatic odor. The increase of extract concentration in gel formula will affect the adhesion and spreadability. F5 showed the highest anti-inflammatory activity compared to other groups. This formula was generally identified as having a good physical appearance, homogeneity, and stability with a pH value of 6.16±0.24, adhesiveness of 51.12±0.15 sec, and a spreadability of 19.54±0.12 cm2. Therefore, Indonesian nutmeg has the potential to be well-acceptable as a candidate for topical anti-inflammatory agents in global health benefits.
COVID-19 risk perception among Indonesians in early stage of the outbreak Ratih Oktri Nanda; Lolita Lolita; Wiwik Indayati; Ivong Rusdiyanti; Nurjannah Nurjannah; Azis Ikhsanudin; Silvia Mareti
International Journal of Public Health Science (IJPHS) Vol 10, No 2: June 2021
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v10i2.20678

Abstract

Indonesia confirmed its first coronavirus disease 19 (COVID-19) case on 2nd March 2020, when other countries have already reported several numbers in the previous month. This study aimed to explore the risk perception of Indonesians in the early stage of the COVID-19 outbreak. This cross-sectional study was conducted among 495 participants using a web-based questionnaire. Primary data were collected from 3rd to 27th March 2020 including the perceived severity, vulnerability, threat, self, and response efficacy of the participants. The results showed that the perceived threat of the outbreak in its early stage is the second highest compared to other diseases. The perceived severity among the participants was high. However, they had a low vulnerability. Those in the middle region showed a higher level of self and response efficacy. Meanwhile, people who work as private sector employee (β=0.146, p=0.004), live in the western region (β=-0.184, p=0.000), with a higher knowledge score (β=0.096, p=0.032) had a higher perceived threat. These results found those who had high knowledge, was also had higher perceived risk. The most important of these studies have determined various factors related to risk perception, thus it could be good preliminary evidence for public health authorities to arrange an effective way for epidemic control.
COVID-19 risk perceptions among healthcare workers during early “new behavior norms” phase Lolita Lolita; Azis Ikhsanudin
International Journal of Public Health Science (IJPHS) Vol 11, No 1: March 2022
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v11i1.21252

Abstract

The coronavirus disease 2019 (COVID-19) pandemic poses a serious health threat among Indonesian healthcare workers. As front-line workers, they were facing higher risk due to the prolonged exposure of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study aimed to explore various factors affecting perceived risk among healthcare professionals. A cross-sectional study was conducted among health practitioners who met the inclusion criteria of being over the age of 17 years and resided in Indonesia. This study was conducted during the early "new normal behavior" period from April to July 2020. The sampling technique was convenience sampling which involved collecting data through the online questionnaire. The data were analyzed through the Spearman correlation method using SPSS version 22.0. A total of 248 respondents were included in the final analysis. Overall, age (p=0.017) and health status (p=0.001) significantly affected the COVID-19 risk perception among healthcare workers. Therefore, comprehensive COVID-19 risk communication should be established to optimize health behavior and crisis control management among healthcare workers.
ANALISIS EFEKTIVITAS PENGGUNAAN ANTIBIOTIKA PADA PASIEN SIROSIS HEPATIS DENGAN KOMPLIKASI SPONTANEOUS BACTERIAL PERITONITIS DI SALAH SATU RUMAH SAKIT DI YOGYAKARTA Adnan Adnan; Lolita Lolita
Jurnal Insan Farmasi Indonesia Vol 3 No 1 (2020): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v3i1.489

Abstract

Cirrhosis is a diffusion process characterized by fibrosis and changes from normal hepatic structures to structurally abnormal nodules. In general, complications that often occur in hospitalized patients are Spontaneous Bacterial Peritonitis (SBP). Many antibiotic therapies can be used for SBP, for example aminoglycosides, third-generation cephalosporins, penicillins, quinolones and sulfa groups. The purpose of this study was to determine whether there are differences in the effectiveness of antibioics used in SBP therapy. This type of research is observational analytic with cross sectional approach. Retrospective data collection in patients with cirrhosis of the liver with SBP complications in PKU Muhammadiyah Yogyakarta Hospital in 2018. Samples are all patients with cirrhosis of the liver with SBP complications who meet the inclusion and exclusion criteria. The sampling method is purposive sampling. The data taken is demographic characteristic data and clinical characteristics. Analysis of the data used in this study is multivariate analysis and different tests. There were 30 samples that met the criteria with a composition of 18 men (60%) and 12 women (40%). There were 8 people who received ceftriaxone antibiotics and 22 people got cefotaxime therapy.
Evaluasi kerasionalan dan kuantitas penggunaan antihipertensi pada pasien gagal jantung di instalasi rawat inap rumah sakit PKU Muhammadiyah Gamping Yogyakarta Lolita Lolita; Asih Istiani
Jurnal Ilmiah Farmasi Vol. 15 No. 1 (2019): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol15.iss1.art5

Abstract

IntisariLatar belakang: Terapi anti hipertensi pada pasien gagal jantung digunakan untuk menguraagi progresifitas, mengurangi resiko infark miokard serta kematian mendadak akibat gagal jantung. Penggunaan obat dikatakan rasional jika pasien diberikan obat sesuai dari segi indikasi, pemilihan, dosis, aturan dan lama penggunaan, yang memenuhi kebutuhan individu pasien. Evaluasi penggunaan obat bertujuan mengidentifikasi dan meminimalisasi masalah terkait obat serta menjamin pengobatan yang sesuai dengan kebutuhan pasien dalam periode waktu yang adekuat dengan harga yang terjangkau.Tujuan: Mengevaluasi rasionalitas dan kuantitas penggunaan antihipertensi pada pasien gagal jantung rawat inap di RS PKU Muhammadiyah Gamping YogyakartaMetode: Observational deskriptif dengan pengambilan data melalui rekam medis secara retrospektif pada Januari-Desember tahun 2016. Rasionalitas diperoleh dengan menghitung persentase jumlah kasus rasional dibagi dengan jumlah total kasus. Sedangkan perhitungan kuantitas penggunaan obat antihipertensi dengan menggunakan metode ATC/DDD.Hasil: Terdapat 106 kasus yang terinklusi dengan 50% pasien berjenis kelamin pria dan 50% pasien berjenis kelamin perempuan. Persentase tertinggi rentang usia responden berkisar 65-74 tahun. Rata-rata total jumlah hari rawat pasien di RS PKU Muhammadiyah Gamping Yogyakarta tahun 2016 adalah 6 hari.Kesimpulan: Penelitian menunjukkan bahwa ditemukan 100% tepat obat, 94% tepat pasien, 38% tepat dosis serta 36% dikatakan rasional. Jenis antihipertensi yang banyak digunakan di Instalasi Rawat Inap RS PKU Muhammadiyah Gamping Yogyakarta tahun 2016 yaitu furosemid 76,6 DDD/100 patient-days. Hal ini berarti 76,6% dari pasien gagal jantung rawat inap memperoleh 1 DDD obat furosemide setiap hariKata kunci : Antihipertensi, gagal jantung, rawat inap, rasionalitas, ATC/DDDEvaluation of rationality and quantity of anti-hypertension use in heart failure patients in inpatient department of PKU Muhammadiyah Gamping Yogyakarta HospitalAbstractBackground: Anti hypertensive therapy in patients with heart failure aims to reduce disease proggession, risk of myocardial infaction and sudden death from heart failure. Rational drug use defines that “patient receive appropriate medication in terms of adequate indications, drug selection, route of administration, therapy duration that met their own individual requirements. Drug use evaluation aims to identify drug related problems and ensure the best therapy in accordance with patient needs within an adequate timeframe at an affordable price.Objective: To assess quantity and rationality of antihypertensive drug use in patients with heart failure at PKU Muhammadiyah Hospital, Gamping YogyakartaMethod: Observational descriptive with retrospective data retrieval from January to December 2016.Rationality was obtained by calculating the percentage of rational cases divided by total number of cases. While calculating the antihypertensive utilization by using ATC/DDD methodResults: From the result of 106 inclusion cases, there were 50% of male and 50% of female patients. The highest percentage of respondent age range was 65-74 years old. The average number of length of stay of heart failure patients in 2016 was 6 days.Conclusion: The research showed that there were 100% right medicine, 94% right patient, 38% right dose and 36% cases said to be rational. The most widely antihypertensive use of heart failure inpatients at PKU Muhammadiyah Hospital, Gamping Yogyakarta in 2016 was furosemide 76,6 DDD/100 bed days. It suggest that 76.6% of the heart failure inpatient might receive a DDD of furosemide every dayKeywords: Antihypertensive, heart failure, hospitalized, rationality, ATC / DDD  
Co-Authors Adnan, Adnan Andriana Sari Andriana Sari Asih Istiani Aulea Rahmawati Aulia Rahmah Azis Ikhsanudin Daniar Dyanas Rais Dewi Kurniati Eka Angriani Hasan Fairuz Yaumil Afra Fauzia Fauzia Heni Lutfiyati Ikrimah Ikrimah Ivong Rusdiyanti Mas Ulfah Lestari Meita Putri, Ni Putu Isabela Ni Putu Isabela Meita Putri Nurjannah Nurjannah Prasojo Pribadi Ratih Oktri Nanda Rayi Citra Ayu Pangestuti Rossie Wiedya Nusantara Shinta Wulandari Silvia Mareti Tri M. Andayani Wiwik Indayati YVI, Urai Suci Zayyana Septya Ramadani