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All Journal Jurnal Berkala Epidemiologi Universa Medicina IJRETINA - International Journal of Retina Ophthalmologica Indonesiana Jurnal Widya Medika
Hendrawan, Kevin Anggakusuma
Ophthalmology Department, Faculty Of Medicine, Widya Mandala Catholic University Surabaya
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Pre-operative intraocular pressure as a predictor of post-operative intraocular pressure after phacoemulsification in non-glaucomatous patients Ernawati, Titiek; Hendrawan, Kevin Anggakusuma; Khudrati, Wilson Christianto; Samsudin, Kevin
Universa Medicina Vol. 41 No. 1 (2022)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2022.v41.11-17

Abstract

BackgroundCataract has been known to cause high intraocular pressure which may lead to secondary glaucoma. Some anatomical changes in cataract patients are assumed to be factors contributing to increased intraocular pressure (IOP). The changes in IOP after cataract surgery tend to help surgeons to predict clinical outcomes. Therefore, IOP control is very important in these patients. This study aimed to determine the ocular biometric parameters and pressure-to-depth (PD) ratio associated with IOP in non-glaucomatous patients who undergo cataract surgery. MethodsA prospective study using secondary clinical data collected from 81 non-glaucomatous patients. Data were collected by examining each subject pre- and post-operatively. The changes in ocular biometry parameters and IOP were measured one week before surgery and 8 weeks after the surgery. Univariate and multivariate linear regression were performed to analyze the data. ResultsThe mean anterior chamber depth (ACD) change was 0.73 ± 0.16 mm, mean PD ratio was 5.04 ± 1.16, and the mean pre-operative IOP was 16.07 ± 2.92 mmHg, decreasing by 2.35 mm Hg (14.6 %) to 13.72 ± 3.42 mm Hg at 8 weeks postoperatively. Univariate linear regression results showed a significant correlation between PD ratio and post-operative IOP (p=0.000), but no significant association was observed between PD ratio and post-operative IOP in multiple linear regression (p=0.126). However, pre-operative IOP was significantly associated with post-operative IOP (Beta=1.244; p=0.004) ConclusionsOur data demonstrated that pre-operative IOP was the most influential risk factor of IOP reduction after phacoemulsification in non-glaucomatous patients.
COVID-19 PATIENTS’ CHARACTERISTIC IN COVID-19 REFERRAL HOSPITAL, SURABAYA, INDONESIA Titiek Ernawati; Nunung Nugroho; Bernadette Dian Novita; Paul L Tahalele; Niluh Suwasanti; Epriyanto T Darmadi; Kevin Anggakusuma Hendrawan; Albert Setiawan; Audrey Fedora Irawan; Alyssa Claudia Valerie Gunawan; Claudia Tjipto; Kevin Samsudin; Ferdinand Erwin; Gerardo Axel Ruslie; Nevan Go; Melvin F Gonga
Jurnal Berkala Epidemiologi Vol. 10 No. 1 (2022): Jurnal Berkala Epidemiologi (Periodic Epidemiology Journal)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbe.V10I12022.48-57

Abstract

Background: Coronavirus 2019 (COVID-19) is a global pandemic with various clinical manifestations and is affected by multifactor. Epidemiological data of COVID-19 in Indonesia, especially in Surabaya have not been well established yet. Purpose: This study aims to provide the COVID-19 patients profile in Surabaya City, Indonesia. Method: The study data were retrospectively collected from electrical medical records in Primasatya Husada Citra (PHC) Hospital of Surabaya, one of the referral hospitals for COVID-19 in Surabaya. Descriptive and Spearman correlation statistics were done for data analysis. Results: Between 1 July – 31 August 2020, 456 subjects were diagnosed positive for COVID-19 by real-time polymerase chain reaction and enrolled in the study. Study subjects were dominated by the group age of 21-30 (26.75%), male (60.30%), living in East Surabaya (16.22%), and mild to moderate disease severity (47.59%) according to the patient’s clinical manifestation, respiration rate, and peripheral oxygen saturation. Subjects with symptoms were majorly having cough (37.93%), fever (29.38%), malaise (28.07%), and dyspnoea (25.00%). Positive correlation was found between disease severity and group of age (r=0.35; p=0.01), gender (r = 0.13; p=0.01), comorbidities (diabetes mellitus, hypertension, and cardiovascular disease), and X-ray findings (r=0.14; p=0.02). A negative correlation was found between disease severity and the region of domicile (r=-0.15; p=0.01). Conclusion: This epidemiological data of COVID-19 patients in Surabaya city, Indonesia, may help in diagnosing COVID-19 patients and improving health management strategies during a pandemic. Patients need to be aware of COVID-19 and understand disease transmission, especially with symptoms and risk factors.
COMBINED IMMEDIATE PARS PLANA VITRECTOMY AND PHACOEMULSIFICATION AS AN EFFECTIVE TREATMENT ON MACULA-OFF RHEGMATOGENOUS RETINAL DETACHMENT Hendrawan, Kevin Anggakusuma; Andayani, Ari; Siska, Siska; Umbu Lapu, Ervan Suryanti; Yudistira, Yudistira
International Journal of Retina Vol 8 No 1 (2025): International Journal of Retina (IJRetina) - INAVRS
Publisher : Indonesian Vitreoretinal Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35479/ijretina.2025.vol008.iss001.295

Abstract

Introduction: Macula-off rhegmatogenous retinal detachment (RRD) is a complicated condition which can caused poor visual prognosis if not treated properly. Recent studies have been proposed an early surgical treatment on this condition to get better anatomical and functional outcomes. Case Report: A 55-year-old male patient presented with history of blurred vision in left eye of 18 hours duration. Patient had history of seeing flashing light and black dots prior to the symptoms. On evaluation there was a macula-off RRD with immature senile cataract. Immediate phacoemulsification followed by pars plana vitrectomy was done. Good visual recovery with best corrected visual acuity 0.00 logMAR was obtained 3 months after the initial surgery. Discussion: In patient with macula-off RRD, delaying the surgical treatment could possibly worsen the visual prognosis. Accurate diagnosis with timely surgical intervention give a good visual outcome by allowing faster rearrangement of macula anatomy. Conclusion: Early surgical intervention is required to provide better visual outcome on macula-off RRD. In the presents of cataract, combined phacoemulsification with PPV as the main intervention may be considered an appropriate approach. The development of ERM is one of the difficulties that RRD patients face, and it needs to be carefully evaluated to avoid the need for additional surgery.
Evaluation Of Surgical Induced Astigmatism In 2.75 Mm Temporal Clear Corneal Incision After Phacoemulsification Titiek Ernawati; Kevin Anggakusuma Hendrawan; Okky Imanuel Samantha; Kevin Samsudin
JURNAL WIDYA MEDIKA Vol. 6 No. 2 (2020): October
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v6i2.2784

Abstract

Background : Cataract is still one of the eye health problem. Blindness due to cataract can be prevented with cataract surgery so the vision can be corrected. Cataract surgery have huge development and now phacoemulsification is used widely. Surgically induced astigmatism is one of many tools to evaluate the success of cataract surgery. Surgically induced astigmatism will affect visual acuity. There are many factors contributing the incident of surgically induced astigmatism such as size of incision, location of incision, and pre surgery astigmatism. Objective : to analyze surgically induced astigmatism after cataract surgery with 2.75 mm temporal clear corneal incision phacoemulsification technique. Material and Methods : Cross-sectional studies has been conducted on 92 subject. Astigmatism were evaluated in every subject before and after cataract surgery. Surgically induced astigmatism were evaluated by evaluating keratometry before and after cataract surgery. Comparative statistics were used to evaluate comparison between variable. Result : The mean pre-operative astigmatism were 0.88 D, and mean of post-operative astigmatism were 0.81 D. Decreased in post-operative astigmatism found in 41 subject (44.6%), increased in 31 subject (33.7%), and 20 subject (21.7%) had no changes in astigmatism. There was no statistically significant difference between pre and post-operative astigmatism (p = 0.214). Conclusion : There was no significant surgically induced astigmatism in patients undergo phacoemulsification with 2.75 mm temporal clear corneal incision.
Diabetic retinopathy: pathogenesis, pathophysiology, and treatment Yudistira, Yudistira; Hendrawan, Kevin Anggakusuma; Andayani, Ari; Suryathi, Ni Made Ari
Universa Medicina Vol. 44 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.270-284

Abstract

Diabetic retinopathy (DR) is the most common microvascular complication of diabetes mellitus (DM) and one of the leading causes of vision impairment worldwide. Prolonged hyperglycemia initiates a cascade of molecular events including chronic inflammation, oxidative stress, advanced glycation end products, and the activation of plasma kallikrein and protein kinase C signaling pathways, which leads to endothelial damage and pericyte loss. The resulting endothelial barrier dysfunction promotes serum leakage and retinal edema, while advanced disease stages are characterized by ischemia-driven retinal neovascularization mediated by elevated intraocular vascular endothelial growth factor (VEGF) levels. Current therapeutic strategies for diabetic retinopathy include laser therapy, intravitreal administration of anti-VEGF agents or corticosteroids, and vitreoretinal surgery. Despite their efficacy, a number of patients experience suboptimal responses. Consequently, novel therapeutic approaches are under investigation, including alternative anti-angiogenic agents, gene therapies, and visual cycle modulators currently undergoing clinical trials. A comprehensive understanding of the pathogenesis and pathophysiology of diabetic retinopathy is essential to improve existing treatment modalities and address current limitations in patient outcomes. In this review, we systematically searched and analyzed articles published in English from 2014 to 2024 using PubMed, ScienceDirect, SpringerLink, and Google Scholar. Relevant search terms included “diabetic retinopathy,” “pathophysiology,” “pathogenesis,” “treatment,” and “diabetic macular edema.” This review presents recent insights into the pathogenesis of diabetic retinopathy, including oxidative stress, inflammation, and neurodegeneration, followed by an overview of its pathophysiology such as microvascular dysfunction and neovascularization. Finally, current and emerging treatment modalities, encompassing both pharmacological and surgical approaches, are discussed. This structured approach provides essential background to understand the complexity of diabetic retinopathy and recent advances in its management.
UTILIZATION OF ANGIOTENSIN-CONVERTING ENZYME INHIBITORS AND ANGIOTENSIN RECEPTOR BLOCKERS FOR GLAUCOMA Gunawan, Alyssa Claudia Valerie; Ernawati, Titiek; Hendrawan, Kevin Anggakusuma; Khudrati, Wilson Christianto
JURNAL WIDYA MEDIKA Vol. 10 No. 1 (2024): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v10i1.5439

Abstract

Glaucoma is a crucial ocular health issue that warrants meticulous attention according to its status as the leading cause of irreversible visual impairment on a global scale. The incidence of this illness has been on a steady rise, notably within the Asian region. Blood pressure impacts both intraocular pressure (IOP) and ocular perfusion pressure (OPP), which is the pressure responsible for facilitating blood flow to the eyeball. Hypertension is considered a contributing factor in the development of glaucoma. The Renin-Angiotensin-Aldosterone System (RAAS) plays a crucial role in the pathophysiology of hypertension and also contributes to the pathogenesis of glaucoma. The presence of Renin-angiotensin-aldosterone system (RAAS) inhibitors medications, such as angiotensin-converting enzyme inhibitors (ACE-I) and angiotensin receptor blockers (ARB) have demonstrated efficacy in reducing intraocular pressure (IOP) and reducing ganglion cell apoptosis. Consequently, these pharmacological agents present a viable therapeutic approach to patients afflicted with hypertension and glaucoma.
Strabismus Surgery for Traumatic Ocular Misalignment: Twelve Cases in Five Years: Poster Presentation - Case Series - Ophthalmologist SURASMIATI, NI MADE AYU; RATNASARI, NI LUH MADE NOVI; HENDRAWAN, KEVIN ANGGAKUSUMA; SUTYAWAN, I WAYAN EKA
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/pdg34475

Abstract

Introduction : Trauma can cause an ocular misalignment due to damage of extraocular muscles, nerves and orbital tissue around the eye. Direct trauma causing extraocular muscle rupture needs immediate surgery, meanwhile indirect trauma resulting in traumatic sixth nerve palsy or other reversible ocular misalignment without orbital floor fracture can be observed for six months. This study describe the characteristic of patients undergo single-step strabismus surgery for traumatic ocular misalignment, mechanism of injury, eye alignment, amount of ocular deviation before and after strabismus surgery. Case Illustration : This was a case series based on medical record of patients underwent strabismus surgery secondary to head or eye injury from 2017 until 2022. Discussion : Twelve individuals with post-traumatic strabismus correction participated in this study. All subjects were male age ranging from 18-51 years. Direct trauma was observed in 6 (50%) patients causing medial rectus muscle rupture in 4 patients and inferior rectus muscle rupture in 2 patients. Indirect trauma was observed in 6 (50%) patients caused by sixth nerve palsy on 4 patients The misalignment was exotropia, esotropia, and hypertropia with amount of 5, 4, and 3 respectively. The deviation was between 30-90 prism dioptre (PD) and 7 (58%) patients had deviation less than 65 PD. Strabismus surgery performed was muscle transposition with or without recession of the antagonist muscle. Conclusion : Single step surgery for traumatic ocular misalignment can provide good result in cases of deviation less than 65 PD
Co-Authors Albert Setiawan Alyssa Claudia Valerie Gunawan Ari Andayani Audrey Fedora Irawan Bernadette Dian Novita Claudia Tjipto Epriyanto T Darmadi Ernawati, Titiek Ferdinand Erwin Gerardo Axel Ruslie Gunawan, Alyssa Claudia Valerie Kevin Samsudin Kevin Samsudin Khudrati, Wilson Christianto Melvin F Gonga Nevan Go Ni Made Ari Suryathi Ni Made Ayu Surasmiati Niluh Suwasanti Nunung Nugroho Okky Imanuel Samantha Paul L Tahalele Ratnasari, Ni Luh Made Novi Samsudin, Kevin Siska Siska Sutyawan, I Wayan Eka Titiek Ernawati Titiek Ernawati Umbu Lapu, Ervan Suryanti Yudistira Yudistira