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All Journal Universa Medicina Journal of Midwifery Journal Of Widya Medika Junior Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia
Samsudin, Kevin
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Pre-operative intraocular pressure as a predictor of post-operative intraocular pressure after phacoemulsification in non-glaucomatous patients Ernawati, Titiek; Hendrawan, Kevin Anggakusuma; Khudrati, Wilson Christianto; Samsudin, Kevin
Universa Medicina Vol. 41 No. 1 (2022)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2022.v41.11-17

Abstract

BackgroundCataract has been known to cause high intraocular pressure which may lead to secondary glaucoma. Some anatomical changes in cataract patients are assumed to be factors contributing to increased intraocular pressure (IOP). The changes in IOP after cataract surgery tend to help surgeons to predict clinical outcomes. Therefore, IOP control is very important in these patients. This study aimed to determine the ocular biometric parameters and pressure-to-depth (PD) ratio associated with IOP in non-glaucomatous patients who undergo cataract surgery. MethodsA prospective study using secondary clinical data collected from 81 non-glaucomatous patients. Data were collected by examining each subject pre- and post-operatively. The changes in ocular biometry parameters and IOP were measured one week before surgery and 8 weeks after the surgery. Univariate and multivariate linear regression were performed to analyze the data. ResultsThe mean anterior chamber depth (ACD) change was 0.73 ± 0.16 mm, mean PD ratio was 5.04 ± 1.16, and the mean pre-operative IOP was 16.07 ± 2.92 mmHg, decreasing by 2.35 mm Hg (14.6 %) to 13.72 ± 3.42 mm Hg at 8 weeks postoperatively. Univariate linear regression results showed a significant correlation between PD ratio and post-operative IOP (p=0.000), but no significant association was observed between PD ratio and post-operative IOP in multiple linear regression (p=0.126). However, pre-operative IOP was significantly associated with post-operative IOP (Beta=1.244; p=0.004) ConclusionsOur data demonstrated that pre-operative IOP was the most influential risk factor of IOP reduction after phacoemulsification in non-glaucomatous patients.
ANALYSIS OF INCREASED C-REACTIVE PROTEIN LEVELS IN BLOOD SERUM OF RATTUS NORVEGICUS WISTAR STRAIN DUE TO INTAKE OF POLYETHYLENE MICROPLASTICS Julian, Alvin; Suwasanti, Niluh; Sincihu, Yudhiakuari; Novita, Bernadette Dian; Samsudin, Kevin
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 6, No 2 (2024): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v6i2.5511

Abstract

Background: The widespread use of plastic and poor management of plastic waste is an environmental problem and has an impact on human health. The most commonly found microplastic contaminant is polyethylene polymer. Ingested microplastic particles will undergo an endocytosis mechanism and be absorbed into the bloodstream. This then triggers an increase in reactive oxygen species (ROS) which induces oxidative stress and results in an inflammatory response. This study tries to analyze the effect of administering microplastics on increasing blood serum C-reactive protein as a biomarker and marker of the inflammatory response due to microplastics. Method: The experimental analytical research used 42 Rattus Norvegicus Wistar Strain animals, which were divided into 5 experimental groups and 1 control group. Quantitative data measurements/collection were carried out at two times (pre-post-test control group design) and analyzed by non-parametric comparison using the Friedman Test to see the increase in C-Reactive Protein (CRP) levels in the blood serum of Rattus norvegicus Wistar Strain before and after being given intake polyethylene microplastics. Result: In all groups X0-X5, The results of the comparative test using the Friedman test showed a significant value of P = 0.000 (P < 0.05), so it can be concluded that there is a difference in pre and post experimental CRP levels. Discussion: The increase in serum CRP levels from the control group to the X5 treatment group may be due to oxidative stress mechanisms, especially in hepatocyte cells, smooth muscle cells, macrophage cells, endothelial cells, lymphocyte cells and adipocyte cells which induce the production of CRP protein, especially native C-reactive protein (nCRP) and monomeric C-reactive protein (mCRP). The difference in serum CRP levels was significant (P = 0.000), where there was an increase in serum CRP levels post treatment (post experimental) from the lowest mean of 0.05 mg/L (pre experimental) to the highest of 0.98 mg/L on average, indicating that administration of microplastic intake at the dose studied had an impact on increasing serum CRP levels in response to an inflammatory reaction. The limitation of this research is that there are no journals that examine microplastics on serum CRP levels, resulting in a lack of research that can be used as a reference or comparative theory. Conclusion: Administration of Microplastic Polyethylene at the dose studied in the treatment group caused a significant increase in Rattus Norvegicus Wistar Strain Serum CRP levels.
Anosmia Sebagai Faktor Prediktor Derajat Keparahan Ringan Pada Penderita COVID-19 Rawat Inap di Rumah Sakit Primasatya Husada Citra Surabaya Hadi, Wiyono; Ernawati, Titiek; Novita, Bernadette; Wibowo, Tjipto; Supit, Vincentius Diamantino; Setiawan, Albert; Samsudin, Kevin; Erwin, Ferdinand
Majalah Kedokteran Indonesia Vol 71 No 2 (2021): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.71.2-2021-379

Abstract

Introduction: Anosmia is one of the clinical characteristics of COVID-19 patients. Anosmia was reported as the first symptom before other symptoms were discovered. Prior studies have shown anosmia implications as a favorable prognostic factor in COVID-19 patients. The research aim is to describe the characteristics of COVID-19 patients with anosmia and its correlation with disease severity.Methods: This study was a descriptive, cross-sectional, retrospective study with a total sample of 149 patients confirmed COVID-19. This research was conducted on hospitalized patients from March 1 to July 31, 2020, at the Primasatya Husada Citra Hospital Surabaya. Our study classified patients into two groups, with and without anosmia. The patient’s clinical characteristics were described in a table and odds ratio was calculated to determine the risk factors incidence of severe degree in COVID-19 patients.Results: The mean age of patients with anosmia was 32 years old, the patient’s gender was dominated with the female (63.2%). Patients with anosmia had lower severity, the odds ratio of having severe degree is 0.479. Patients with anosmia also had other symptoms such as cough, rhinorrhea, sore throat, tightness, headache, and muscle aches (p less than 0.05).Conclusion: COVID-19 patients with anosmia had lower severity than patients without anosmia.
Tackling Pediatric Obesity: Overcoming Challenges and Implementing Effective Management Practices Angelina, Zenia; Tahalele, Paul L; Samsudin, Kevin; Ludia, Grace Margaretha; Gumelar, Agustinus Bimo
Journal of Midwifery Vol. 9 No. 2 (2024): Published on Desember 2024
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jom.9.2.67-79.2024

Abstract

Obesity is described as an excess of adipose tissue accumulating in a body. Obesity can occur at any age, including pediatrics. In addition to the related health problems, obesity in children can increase the risk of developing chronic diseases. This literature review was carried out using search engines PubMed, Elsevier and Google Scholar, limiting the last 5 years to articles from 2019 to 2024. The main intervention to overcome pediatric obesity is dietary intervention, but a combination with other interventions such as physical activity, behavioral adjustments, and parental support may be more effective. With early intervention, pediatric obesity can be managed well
Co-Authors Agustinus Bimo Gumelar Angelina, Zenia Ernawati, Titiek Erwin, Ferdinand Hadi, Wiyono Hendrawan, Kevin Anggakusuma Julian, Alvin Khudrati, Wilson Christianto Ludia, Grace Margaretha Novita, Bernadette Novita, Bernadette Dian Paul L Tahalele Setiawan, Albert Sincihu, Yudhiakuari Supit, Vincentius Diamantino Suwasanti, Niluh Wibowo, Tjipto