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All Journal Journal of Islamic Pharmacy Adi Widya : Jurnal Pengabdian Masyarakat Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Biomedika Indonesian Journal on Medical Science (IJMS)
Sri Rejeki Handayani
Fakultas Farmasi - Universitas Setia Budi
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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The Effect Cytotoxic and Apoptotic Propagation Chloroform Fraction of Ocimum sanctum L. Towards Hela Cells Line Culture Ghani Nurfiana Fadma Sari; Sri Rejeki Handayani
Biomedika Vol 13 No 1 (2020): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/biomedika.v13i1.774

Abstract

Materials used in the research are Ocimum sanctum L, a herbaceous shrub used in traditional medicine displaying as immunomodulator, anti-stress, hepatoprotective, kemopreventif, and anti-inflammatory. A research to identify its ethanol extract of Ocimum sanctum has been conducted, showing that it possesses cytotoxic activities to HeLa cells with IC50 value of 209µg/ml. The aim of this research is to find out activities cytotoxic and apoptotic propagation chloroform fraction of Ocimum sanctum towards HeLa cells line. The extraction was done using maceration using ethanol 96% solvent and fractionation was done using chloroform. Effects of chloroform fraction on HeLa cells were tested using MTT at various dosages (500, 250, 125, 62.5, and 31.25) µg/ml. Cisplatin (Kalbe) was applied as positive control. The effect apoptotic propagation chloroform fraction of Ocimum sanctum on HeLa cells was observed by DNA painting method using orange ethridium bromide-acridine. The test results showed that the chloroform fraction of Ocimum sanctum extract on HeLa cells had an IC50 value of 155.67 µg / ml ± 46.99 and Cisplatin had an IC50 value of 16.81 µg / ml ± 20.37. Double staining test shows the existence of cells undergoing apoptosis. Based on these results, the chloroform fraction Ocimum sanctum has been shown to be cytotoxic and has the possibility of stimulating apoptosis of cervical cancer cells (HeLa). This can be used as a basis for the development of these plants as anticancer agents with specific action targets.
Uji Aktivitas Analgetik Ekstrak Etanol Daun Inggu (Ruta angustifolia [l.] Pers) Pada Tikus Putih Jantan Yane Dila Keswara; Sri Rejeki Handayani
Journal Syifa Sciences and Clinical Research Vol 1, No 2 (2019): Volume 1 Edisi 2 2019
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (563.874 KB) | DOI: 10.37311/jsscr.v1i2.2662

Abstract

Pain is an uncomfortable feeling caused by strong or destructive stimulation, if unchecked can affect daily routine. This study aims to determine the analgesic effect and dosage of the leaf extract ethanol, as well as to determine the effectiveness of the leaf extract ethanol as a narcotic analgesic by the Tail Flick method or as a non-narcotic analgesic by the Paw Pressure Test Randall Selitto method. Extraction was done by maceration of leaf powder with a solvent 96% ethanol. 25 male Wistar white rats were divided into 5 groups, positive group mefenamic acid 9 mg /200 g BW for the Paw Pressure Test Randall Selitto Method and tramadol 0.9 mg /200 g BW for the Tail Flick Method, negative control CMC Na 0,5%, ethanol extract leaves inggu leaves a dose of 10 mg /200 g BW, 20 mg /200 g BW and 40 mg /200 g BW. The data obtained were analyzed by ANOVA test, then LSD test was used to determine differences between groups. The results showed extract dosage of 10 mg /200 g BW, 20 mg /200 g BW, 40 mg /200 g BW had analgesic effect. Extract dosage of 20 mg /200 g BW and 40 mg /200 g BW in the Randall selitto Paw Pressure Test method is equivalent to mefenamic acid, extract dose 10 mg /200 g BW, 20 mg /200 g BW, and 40 mg /200 g BW the Tail Flick method is equivalent to Tramadol. Ethanol leaf extract is more effective as a narcotic analgesic by the Tail Flick method.
Pelatihan Pembuatan Balsam Stik Dari Bahan Herbal Dan Perintisan Sebagai Home Industri dwi - Ningsih; Sri Rejeki Handayani; Ismi - Rahmawati; Dewi - Ekowati; Desi - Purwaningsih
Adi Widya : Jurnal Pengabdian Masyarakat Vol 3 No 1 (2019): ADIWIDYA
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33061/awpm.v3i1.1979

Abstract

Balm, a pharmaceutical product that is no stranger to the community, therefore, this product is one of the most potential commodities developed into a home industry that can improve the economy of the community. relatively simple balm formulation and easy in material, is very possible to be applied in the community. This article is a form of publication of community service that has been carried out on Tuesday, February 6, 2018,at RW XXII Bibis Luhur Kel. Nusukan Kec. Banjarsari Surakarta Central Java. This community service is entitled "training of sticks from herbal and pioneering industry as a home industry" which aims to provide understanding and skill through counseling, training, and application of herbal balsam in the form of sticks, and utilization in health by empowering natural resources optimally, produce new products, besides can be made for self-use, sticks balm is a product that is very much needed by the community, so it is possible to develop its production in the scale of home industry to improve the economy of the community.
Uji Aktivitas Antidiabetes Infusa Daun Kemuning (Murraya Paniculata L Jack.) Pada Mencit Putih Jantan Yang Diinduksi Glukosa Sri Rejeki Handayani; Pramesti Tiwi Mahanani - Universitas Setia Budi
Indonesian Journal on Medical Science Vol 6 No 1 (2019): IJMS 2019
Publisher : Unit Penelitian dan Pengabdian Masyarakat Politeknik Kesehatan Bhakti Mulial

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (500.008 KB)

Abstract

Abstract: Orange Jessamine or Kemuning (Murraya Paniculata L. Jack) is known to be useful treat various diseases, one of which is diabetes mellitus. This study aimed to determine the antidiabetic activity of kemuning infusion on glucose-induced male white mice and find out the most effective dose.Kemuning dry leaves were extracted using a water solvent by the infusion method. The antidiabetic test was carried out using the glucose tolerance method. Test animals were divided into 5 groups, each group consisting of 5 mice. Group I (diabetes control) CMC 0.5%, group II (drug control) glibenclamide, group III (2,5% of infusion of kemuning leaves), group IV (5% infusion of kemuning leaves), and V (10% of infusion leaves). Measurement of glucose levels was carried out 4 times every 30 minutes. The obtained data were then analyzed by ANOVA with a confidence level of 95% followed by a Post Hoc test. The results showed that infusion of yellow leaves had antidiabetic activity in male white mice given a glucose load. The effective dose of infusion of yellow leaves which gives an antidiabetic effect is a concentration of 5%.Key words: kemuning leaves, infusion, antidiabetic. Abstrak: Tanaman kemuning (Murraya Paniculata L. Jack) merupakan salah satu tanaman yang dapat digunakan sebagai obat untuk mengatasi berbagai macam penyakit, salah satunya diabetes melitus. Penelitian ini bertujuan untuk mengetahui aktivitas antidiabetes infus daun kemuning terhadap mencit putih jantan yang diinduksi glukosa serta mengetahui dosis yang paling efektif.Kemuning diekstrasi menggunakan pelarut air dengan metode infus. Metode uji antidiabetes menggunakan metode toleransi glukosa. Hewan uji dibagi 5 kelompok, tiap kelompok terdiri dari 5 ekor mencit. Kelompok I (kontrol diabetes) CMC 0,5%, kelompok II (kontrol obat) glibenklamid, kelompok III (infus daun kemuning konsentrasi dosis 2,5%), kelompok IV (infus daun kemuning konsentrasi dosis 5%), dan V (infus daun kemuning konsentrasi dosis 10%). Pengukuran kadar glukosa dilakukan pada menit ke-30, ke-60, ke-90, ke-120. Data yang diperoleh dianalisis dengan statistik ANOVA dengan taraf kepercayaan 95% dilanjutkan dengan uji Post Hoc test. Hasil penelitian menunjukkan bahwa infus daun kemuning mempunyai aktivitas antidiabetes pada mencit putih jantan yang diberi beban glukosa. Dosis efektif infus daun kemuning yang memberi efek antidiabetes yaitu konsentrasi dosis 5%.Kata kunci: Daun kemuning, infus, antidiabetes.
Analisis Tingkat Kepuasan Pasien Terhadap Pelayanan Kefarmasian Di Instalasi Farmasi Rawat Jalan Puskesmas Nawangan Pacitan Dwi Setiawan; Dwi Ningsih; Sri Rejeki Handayani
Journal of Islamic Pharmacy Vol 7, No 2 (2022): J. Islamic. Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v7i2.17439

Abstract

Puskesmas Nawangan Pacitan merupakan salah satu puskemas yang terletak di daerah terpencil dan hanya memiliki satu tenaga kefarmasian. Minimnya tenaga kefarmasian di puskesmas dapat mempengaruhi kualitas pelayanan kefarmasian. Kualitas pelayanan yang diberikan dapat berdampak pada tingkat kepuasan pasien. Tujuan dari penelitian ini adalah untuk mengetahui tingkat kepuasan pasien rawat jalan terhadap pelayanan kefarmasian di Puskesmas Nawangan, Pacitan berdasarkan dimensi service quality (servqual). Penelitian yang dilakukan merupakan penelitian deskriptif cross sectional. Pengambilan sampel dilakukan dengan metode purposive sampling berdasarkan kriteria inklusi dan eksklusi. Sumber data penelitian diambil berdasarkan kuesioner yang dibagikan pada pasien rawat jalan yang menebus obat di Puskesmas Nawangan yang berisi lima indikator yaitu kehandalan (reliability), ketanggapan (responsiveness), jaminan (assurance), empati (emphaty), dan kenyataan (tangible). Penentuan sampel dalam penelitian ini dengan metode purposive sampling berdasarkan kriteria inklusi dan eksklusi pengumpulan data berupa data kuantiatif dari kuisioner servqual. Hasil dari pengukuran tingkat kepuasan pasien terhadap pelayanan kefarmasian Puskesmas Nawangan menggunakan model servqual menunjukkan hasil bahwa dimensi tangible berada pada kategori puas (61,44%), dimensi reliability berada pada kategori puas (60,97%), dimensi responsiveness berada pada kategori puas (66,50%), dimensi assurance berada pada kategori puas (61,97%), dan dimensi emphaty berada pada kategori puas (70,97%). Dimensi reliability (kehandalan) memiliki gap (kesenjangan) yang tertinggi jika dibandingkan dengan dimensi lainnya yaitu -6,00. 
Analisis Tingkat Kepuasan Pasien Terhadap Pelayanan Kefarmasian di Instalasi Farmasi Rawat Jalan Puskesmas Pracimantoro I Wonogiri Unggul Joko Mahendro; Dwi Ningsih; Sri Rejeki Handayani
Journal of Islamic Pharmacy Vol 7, No 2 (2022): J. Islamic. Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v7i2.17455

Abstract

Puskesmas merupakan fasilitas kesehatan yang memiliki tugas utama dalam memberikan pelayanan kesehatan preventif dan promotif. Pelayanan yang berkualitas akan berpengaruh pada peningkatan kesehatan dan kesejahteraan masyarakat. Kualitas pelayanan yang diberikan akan berdampak pada tingkat kepuasan pasien yang biasa disebut service quality (servqual). Penelitian ini bertujuan untuk melihat tingkat kepuasan pelayanan kefarmasian dan mengetahui hasil analisis gap tingkat kepuasan pasien rawat jalan di Instalasi Farmasi Puskesmas Pracimantoro I Wonogiri berdasarkan dimensi servqual. Penelitian ini adalah penelitian deskriptif observasional prospektif. Sampel diambil dengan metode purposive sampling dengan kriteria inklusi dan eksklusi. Sumber data penelitian berdasarkan kuesioner yang dibagikan pada pasien yang menebus obat di Instalasi Farmasi Rawat Jalan Puskesmas Pracimantoro I Wonogiri yang berisi lima indikator service quality. Hasil penelitian tingkat kepuasan pasien terhadap pelayanan kefarmasian menggunakan model service quality dapat disimpulkan bahwa tingkat kepuasan pasien terhadap pelayanan kefarmasian menggunakan model service quality menunjukkan hasil bahwa dimensi tangible sangat puas (86,62%), dimensi reliability sangat puas (88,53%), dimensi responsiveness sangat puas (91,85%), dimensi assurance sangat puas (89,61%), dan dimensi empathy sangat puas (92,23%). Dari nilai gap (kesenjangan) menunjukkan bahwa pelayanan yang diberikan oleh Puskesmas sudah melebihi ekspektasi masyarakat. 
Co-Authors Desi Purwaningsih Dewi Ekowati Dwi Ningsih Dwi Setiawan Ghani Nurfiana Fadma Sari Keswara, Yane Dila Pramesti Tiwi Mahanani - Universitas Setia Budi Rahmawati, Ismi Unggul Joko Mahendro