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Uji Aktivitas Antibakteri Fraksi n-Heksan, Kloroform dan Air dari Ekstrak Etanolik Daun Zodia (Evodia sauveolens, Scheff.) terhadap Pseudomonas aeruginosa ATCC 27853 Ismi Rahmawati; Ratno Agung Samsumaharto; Edi Zunaidi Iryanto W
Biomedika Vol 8 No 2 (2015): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Daun zodia (Evodia sauveolens, Scheff) adalah tanaman yang secara empiris berkhasiat sebagai obat luka, sakit gigi demam dan nyeri perut. Kandungan kimia daun zodia adalah minyak atsiri, flavonoid, alkaloid, saponin dan tanin. Penelitian ini dilakukan untuk untuk mengetahui aktivitas fraksi n-heksan, kloroform, air dan ekstrak etanolik daun zodia (Evodia sauveolens, Scheff) sebagai antibakteri terhadap Pseudomonas aeruginosa ATCC 27853. Metode yang digunakan dalam penelitian ini adalah metode maserasi dengan pelarut etanol 96% dilanjutkan dengan pelarut n-heksan, kloroform dan air. Uji aktivitas antibakteri dilakukan dengan metode dilusi. Konsentrasi ekstrak etanolik dan fraksi yang digunakan 50,0%; 25%; 12,5%; 6,2%; 3,1%; 1,5%; 0,7%; 0,3%; 0,1%; 0,09%. Hasil penelitian menunjukkan bahwa ekstrak etanolik dan fraksi air memiliki konsentrasi bunuh minimum sebesar 50% terhadap bakteri Pseudomonas aeruginosa ATCC 27853. Fraksi air dari ekstrak etanolik dari daun zodia memiliki aktivitas antibakteri paling aktif dibandingkan dengan fraksi n-heksan dan fraksi kloroform. Hal ini dapat disebabkan karena pada fraksi air dari ekstrak etanolik daun zodia mengandung senyawa saponin dan tanin yang dapat berguna sebagai antibakteri.

UJI AKTIVITAS ANTIJAMUR BEBERAPA SENYAWA MONOKARBONIL ANALOG CURCUMIN HASIL SINTESIS Ismi Rahmawati; Desi Purwaningsih
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 5 No. 2 (2018): December 2018
Publisher : Balai Bioteknologi, Badan Pengkajian dan Penerapan Teknologi (BPPT)

Antifungal Activity of Some Synthesized Mono-Carbonyl Analogue CompoundsÂ of CurcuminABSTRACTFungal resistance can pose a threat to future fungal infections, therefore studies to find other compounds that have antifungal activity need to be done. The aim of this study was to examine antifungal activity of synthesized curcumin analogue compounds i.e. 2,6-Bis-(2'-furilidin)-cyclohexanone (26FuH); 2,5-Bis-(2'-furilidine)-cyclopentanone (25FuP) and 1,5-Difuril-1,4-pentadien-3-on (15FuA). The curcumin analogue compound was successfully synthesized with Aldol condensation using KOH 7.5% as the catalyst. The compound was purified and characterized by melting point, thin layer chromatography, gas chromatography with mass spectrometry, FTIR spectrophotometry, spectrophotometry 1H-NMR. The results showed pure compounds and have a structure that corresponds to the target compounds. All compound were assayed as antifungal against Candida albicans, Pityrosporum ovale, Aspergillus niger, and Trichophyton mentagrophytes. The activity of each compound represented by inhibitory diameter was analyzed by one-way ANOVA followed by post hoc Tukey (p<0.05). All three compounds showed antifungal activity against Candida albicans, Pityrosporum ovale, and Aspergillus niger. The best antifungal activity was shown by 26FuH against Pityrosporum ovale.Keywords: antifungal activity, curcumin, monocarbonyl, Pityrosporum ovale, synthesisÂ ABSTRAKResistensi jamur dapat menjadi ancaman pada kasus infeksi jamur di masa mendatang, oleh sebab itu penelitian untuk menemukan senyawa lain yang memiliki aktivitas antijamur perlu dilakukan. Penelitian ini bertujuan untuk menguji aktivitas antijamur senyawa analog curcumin hasil sintesis yaitu senyawa 2,6-Bis-(2â€™-furilidin)-sikloheksanon (26FuH); 2,5-Bis-(2â€™-furilidin)-siklopentanon (25FuP) dan 1,5-Difuril-1,4-pentadien-3-on (15FuA). Senyawa analog curcumin sudah berhasil disintesis dengan metode kondensasi Aldol menggunakan katalis KOH 7,5%. Senyawa hasil sintesis dimurnikan dan dikarakterisasi dengan menggunakan pemeriksaan organoleptis, titik lebur, kromatografi lapis tipis, kromatografi gas dengan spektrometri massa, spektrofotometri FTIR, spektrofotometri 1H-NMR. Hasil menunjukkan senyawa murni dan struktur sesuai senyawa target. Hasil sintesis diuji aktivitas antijamur terhadap Candida albicans, Pityrosporum ovale, Aspergillus niger dan Trichophyton mentagrophytes. Hasil diameter daya hambat dianalisis dengan ANOVA satu arah dilanjutkan post hoc Tukey (p<0,05). Ketiga senyawa memiliki aktivitas antijamur terhadap jamur Candida albicans, Pityrosporum ovale, dan Aspergillus niger. Aktivitas antijamur terbaik adalah senyawa 26FuH terhadap jamur Pityrosporum ovale.Kata Kunci: aktivitas antijamur, curcumin, monokarbonil, Pityrosporum ovale, sintesis

Strategi Pengembangan Instalasi Farmasi Rumah Sakit Muhammadiyah Siti Khodijah Gurah Kediri Kharisma Jayak Pratama; Gunawan P. Widodo; Ismi Rahmawati
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 13, No 3 (2022): Juli 2022
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf.v13i3.1988

The strategy for developing hospital pharmacy installations needs to be carried out in order to be able to adapt and control influential factors that must change, both internal and external factors. The purpose of this study was to determine the location of the Pharmacy Installation of Siti Khodijah Gurah Kediri Hospital to the internal and external environment with SWOT analysis and identify alternative strategies that were applied. This research is an exploratory descriptive study. Data were obtained from in-depth interviews, direct observation, document studies, filling out questionnaires, SWOT analysis and QSP Matrix. The results showed that the Pharmacy Installation of Siti Khodijah Gurah Kediri Hospital was in quadrant one with an aggressive growth policy strategy in an effort to implement its development strategy. The choice of strategy using the QSP matrix shows that efforts to improve the quality and quantity of human resources = 7.42; efforts to improve patient-focused pharmaceutical services = 7.39; hospital policy to apply separate inpatient depots with outpatient depots = 7,17; and attend training or seminars, efforts to improve science and technology, mastery of the internet to optimize employee capabilities = 7.08.Keywords: strategy; pharmaceutical installations; hospital; SWOT; QSPM ABSTRAK Strategi pengembangan instalasi farmasi rumah sakit perlu dilakukan agar mampu beradaptasi dan mengendalikan faktor-faktor berpengaruh yang harus berubah, baik itu faktor internal maupun faktor eksternal. Tujuan penelitian ini adalah untuk mengetahui letak Instalasi Farmasi Rumah Sakit Muhammadiyah Siti Khodijah Gurah Kediri terhadap lingkungan internal dan eksternal dengan analisis SWOT serta mengidentifikasi strategis alternatif yang diterapkan. Penelitian ini merupakan studi deskriptif eksploratif. Data diperoleh dari indepth interview, observasi langsung, studi dokumen, pengisian kuisioner, analisis SWOT dan Matrik QSP. Hasil penelitian menunjukkan bahwa Instalasi Farmasi Rumah Sakit Muhammadiyah Siti Khodijah Gurah Kediri berada pada kuadran satu dengan strategi kebijakan pertumbuhan yang agresif dalam usaha menerapkan strategi pengembangannya. Pemilihan strategi menggunakan matrik QSP menunjukkan bahwa upaya peningkaan kualitas dan kuantitas SDM = 7,42; upaya peningkatan pelayanan farmasi yang berfokus pada pasien = 7,39; kebijakan RS untuk menerapkan depo pasien rawat inap terpisah dengan depo rawat jalan = 7,17; dan mengikuti pelatihan atau seminar, usaha peningkatan IPTEK, penguasaan internet untuk mengoptimalkan kemampuan karyawan = 7,08.Kata kunci: strategi; instalasi farmasi; rumah sakit; SWOT; QSPM

PENGARUH MINYAK ATSIRI DAUN JERUK PURUT (Citrus hystrix) TERHADAP DINDING SEL BAKTERI Staphylococcus aureus Opstaria Saptarini; Ismi Rahmawati
BERITA BIOLOGI Vol 20, No 1 (2021)
Publisher : Research Center for Biology-Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/beritabiologi.v20i1.3976

Kaffir lime leaves essential oil has activity to inhibit bacterial growth. The mechanism of the inhibition is thought to be located in thebacterial cell wall. This study aimed to determine the antibacterial work location of kaffir lime leaf essential oil against Staphylococcus aureus ATCC 25923. Kaffir lime leaves were distilled by steam distillation, essential oils obtained were identified by organoleptic quality, evaporation, solubility in alcohol, refractive index and specific gravity. The results were compared under with the literature. The results of essential oils were made with various concentrations of 100, 50, 25, 12.5, 6.25, 3.13, 1.56, 0.73, 0.39, and 0.20%. The results of the concentration series were tested for antibacterial activity with the macrodilution method followed by the determination for the location of bacterial growth inhibition using the Scanning Electron Microscope (SEM). The yield of kaffir lime leaf essential oil was 0.82%. The observation of organoleptic essential oil has a light yellow color, the distinctive odor of kaffir lime, a liquid form, and distinctive lime taste. Refractive index examination resulted 1.454; specific gravity 0.8317, and soluble in 70% ethanol with a ratio of 1:1. The Minimum BactericidalConcentration (MBC) obtained from the antibacterial activity test was 6.25%. Kaffir lime leaves essential oil mechanism occurred in the cell walls and cell membranes of Staphylococcus aureus.

Pelatihan Pembuatan Balsam Stik Dari Bahan Herbal Dan Perintisan Sebagai Home Industri dwi - Ningsih; Sri Rejeki Handayani; Ismi - Rahmawati; Dewi - Ekowati; Desi - Purwaningsih
Adi Widya : Jurnal Pengabdian Masyarakat Vol 3 No 1 (2019): ADIWIDYA
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33061/awpm.v3i1.1979

Balm, a pharmaceutical product that is no stranger to the community, therefore, this product is one of the most potential commodities developed into a home industry that can improve the economy of the community. relatively simple balm formulation and easy in material, is very possible to be applied in the community. This article is a form of publication of community service that has been carried out on Tuesday, February 6, 2018,at RW XXII Bibis Luhur Kel. Nusukan Kec. Banjarsari Surakarta Central Java. This community service is entitled "training of sticks from herbal and pioneering industry as a home industry" which aims to provide understanding and skill through counseling, training, and application of herbal balsam in the form of sticks, and utilization in health by empowering natural resources optimally, produce new products, besides can be made for self-use, sticks balm is a product that is very much needed by the community, so it is possible to develop its production in the scale of home industry to improve the economy of the community.

UJI ANTIBAKTERI EKSTRAK DAN FRAKSI HERBA CEPLUKAN (Physalis angulata L.) UNTUK MENGATASI INFEKSI Staphylococcus epidermidis SELAMA PERSALINAN Renata Tri Anggreany; Ismi Rahmawati; Fransiska Leviana
DINAMIKA KESEHATAN: JURNAL KEBIDANAN DAN KEPERAWATAN Vol 11, No 1 (2020): Dinamika Kesehatan Jurnal Kebidanan dan Keperawatan
Publisher : Universitas Sari Mulia

Latar Belakang: Herba ceplukan (Physalis angulata L.) merupakan salah satu dari tanaman obat yang mengadung beberapa senyawa aktif yang diduga bersifat antibakteri. Kehamilan dengan ancaman persalinan preterm dikarenakan pertumbuhan kuman Staphylococcus epidermidis.Tujuan: dari penelitian ini adalah mengetahui aktivitas antibakteri ekstrak etanol, fraksi n-heksan, etil asetat, dan air herba ceplukan terhadap bakteri Staphylococcus epidermidis.Metode: Penelitian eksperimental dengan melakukan penyarian herba ceplukan dengan metode maserasi menggunakan pelarut etanol 70%, kemudian difraksinasi dengan pelarut n-heksan, etil asetat, dan air. Hasil ekstrak dan fraksinasi diuji aktivitas antibakteri menggunakan metode difusi dengan konsentrasi 20%; 10% dan 5%. HasilÂ fraksi teraktif dilanjutkan uji makrodilusi. Identifikasi kandungan kimia herba ceplukan dikerjakan dengan menggunakan uji tabung dan Kromatorafi Lapis Tipis (KLT).Hasil: Penelitian menghasilkan rendemen ekstrak, fraksi n-heksan, fraksi etil asetat dan fraksi air berturutan sebesar 21,88; 10,90; 3,96 dan 52,00%. Hasil uji aktivitas antibakteriÂ menunjukkan fraksi n-heksan, etil asetat danÂ air memiliki aktivitas antibakteri terhadap Staphylococcus epidermidis. Fraksi etil asetat merupakan fraksi teraktif dibandingkan fraksi yang lain dengan diameter daya hambat terbesar pada konsentrasi 20% sebesar 23,33 mm. Fraksi etil asetat mengandung senyawa flavonoid, alkaloid, saponin, dan terpenoid yangÂ bertanggung jawab terhadap aktivitas antibakteri. Hasil penelitian dengan metode dilusi menunjukkan bahwa Konsentrasi Bunuh Minimum fraksi etil asetat adalah 5%.Â Kata kunci: herba ceplukan (Physalis angulata L.), fraksinasi, Staphylococcus epidermidis, antibakteriÂ AbstractBackground: Cutleaf groundcherry herb (Physalis angulata L.) is one of the medicinal plants that contains several active compounds that are suspected to be antibacterial. Pregnancy with preterm labor risk caused by the growth of Staphylococcus epidermidis.Aim: This study was conducted to Â determine the antibacterial activity of ethanol extract, fraction of n-hexane, ethyl acetate, and cutleaf groundcherry herb water against Staphylococcus epidermidis.Method: The extraction of cutleaf groundcherry herb was carried out by maceration method using 70% ethanol, then fractionated with n-hexane, ethyl acetate, and water. The extract and fractionation results were tested for antibacterial activity using a diffusion method with a concentration of 20%; 10% and 5%. Identification of the chemical content of the herbal cep need is done by using tube test and Thin Layer Chromataphy (TLC).Result: The study produced extract yield, n-hexane fraction, ethyl acetate fraction and water fraction of 21.88; 10,90; 3.96 and 52.00%, respectively. Antibacterial activity test results showed that the n-hexane, ethyl acetate and water fractions had antibacterial activity against Staphylococcus epidermidis. Ethyl acetate fraction was the most active fraction compared to other fractions with the largest inhibitory diameter of 23.33 mm at a concentration of 20%. The ethyl acetate fraction contained flavonoids, alkaloids, saponins, and terpenoids which are responsible for antibacterial activity. The results of the study using the dilution method showed that the Minimum Killing Concentration of ethyl acetate fraction was 5%.Â Key Words: Cutleaf groundcherry herb (Physalis angulata L.), fractionation, Staphylococcus epidermidis, antibacterial.

UJI AKTIVITAS SITOTOKSIK HERBA KELAKAI (Stenochlaena palustris (Burm.F.) Bedd.) TERHADAP SEL KANKER HATI HEPG2 Masyitah Novia Yanti; Ismi Rahmawati; Wiwin Herdwiani
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 8 No. 2 (2021): December 2021
Publisher : Balai Bioteknologi, Badan Pengkajian dan Penerapan Teknologi (BPPT)

Liver cancer is a disease with a high number of cases. Kelakai herb (Stenochlaena palustris (Burm.f.) Bedd.) has cytotoxic activity against MCF-7, MDA-MB-231, DU-145 and HeLa cells. The aim of this study was to determine the cytotoxic activity of the herbal fraction of kelakai against HepG2 liver cancer cells. Kelakai herb was macerated using ethanol 96% followed by fractionation using n-hexane, ethyl acetate, and water as solvent. Cytotoxic test of the kelakai extracts and fractions were undertaken using the 3-[4,5-dimetilthiazol-2yl] 2,5-difeniltetrazolium bromide (MTT) assay method. Immunocytochemical reactions were applied to determine the expression of p53 and caspase-3 proteins in the apoptotic pathway of HepG2 cells. The results showed that the extract, n-hexane, and ethyl acetate fraction of kelakai herbs had cytotoxic activity against HepG2 cells, while the water fraction had no cytotoxic activity. Ethyl acetate fraction as the most active fraction of kelakai herbs could increase the expression of caspase-3 and p53 proteins in HepG2 cells. The ethyl acetate fraction had flavonoids, alkaloids, and tannins which are potent as a cytotoxic against HepG2 cells. Kanker hati merupakan salah satu penyakit dengan jumlah kasus yang cukup tinggi. Herba kelakai (Stenochlaena palustris (Burm.f.) Bedd.) memiliki aktivitas sitotoksik terhadap sel MCF-7, MDA-MB-231, DU-145, dan HeLa. Penelitian ini bertujuan untuk mengetahui aktivitas sitotoksik dari fraksi herba kelakai terhadap sel kanker hati HepG2. Herba kelakai dimaserasi dengan etanol 96%, dilanjutkan fraksinasi menggunakan pelarut n-heksan, etil asetat, dan air. Uji sitotoksik ekstrak dan fraksi herba kelakai dilakukan menggunakan metode 3-[4,5-dimetilthiazol-2yl] 2,5-difeniltetrazolium bromide (MTT assay). Reaksi imunositokimia digunakan untuk mengetahui ekspresi protein p53 dan caspase-3 pada jalur apoptosis sel HepG2. Hasil penelitian menunjukkan bahwa ekstrak, fraksi n-heksan, dan etil asetat herba kelakai memiliki aktivitas sitotoksik terhadap sel HepG2, sedangkan fraksi air tidak memiliki aktivitas sitotoksik. Fraksi etil asetat sebagai fraksi teraktif dari herba kelakai dapat meningkatkan ekspresi protein caspase-3 dan p53 pada sel HepG2. Fraksi etil asetat memiliki golongan senyawa flavonoid, alkaloid, dan tanin yang memiliki kemampuan sitotoksik terhadap sel HepG2.

Identifikasi potensi drug related problems diabetes melitus tipe 2 dengan penyakit komorbid pasien rawat jalan Moh Rasyid Kuna; Gunawan Pamudji Widodo; Ismi Rahmawati
MEDIA ILMU KESEHATAN Vol 12 No 1 (2023): Media Ilmu Kesehatan
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/mik.v12i1.849

Latar Belakang: Penatalaksanaan pengobatan pasien diabetes melitus tipe 2 dengan penyakit komorbid sangat kompleks dalam pemberian obat yaitu kemungkinan terjadinya ketidaksesuaian pengobatan dalam mencapai terapi. Tujuan: Penelitian ini bertujuan untuk mengidentifikasi potensi terjadinya DRPs pasien DM tipe 2 yang disertai dengan penyakit komorbid pada pasien rawat jalan di RSUD Toto Kabila Metode: Penelitian menggunakan metode penelitian non-eksperimental dengan pengambilan data retrospektif, data yang diambil berupa catatan rekam medik pasien DM tipe 2 dengan penyakit komorbid. Pengolahan data dilakukan dengan rancangan deskriptif, mengklasifikasikan karakteristik setiap pasien kemudian dilanjutkan dengan mengidentifikasi potensi kejadian dari setiap DRPs Hasil: Hasil penelitian menunjukan jenis kelamin pasien laki-laki sebanyak 48 pasien (35,82%) perempuan sebanyak 86 pasien (64,18%), dominan terjadi direntang usia 51-60 tahun 63 pasien (47,01%). Berat badan yang lebih sering mengalami DM tipe 2 yaitu 51-60 kg 74 pasien (55,22%) status pendidikan terbanyak SD 57 pasien (42,54%) pekerjaan terbanyak adalah IRT 69 pasien (51,49%) komplikasi yang paling sering terjadi yaitu hipertensi 94 pasien (32,53%) terapi antidiabetes yang paling banyak digunakan metformin 85 pasien (42,29%). Kesimpulan : terdapat Kejadian DRPs terdapat 90 pasien dan 44 lainnya tidak mengalami, interaksi obat sebanyak 111 pasien (53,62%), obat tidak efektif terjadi pada 45 pasien (51,15%), indikasi tanpa obat 23 pasien(10,60%), obat tanpa indikasi 15 pasien (6,91%) pemberian obat dengan dosis terlalu rendah 9 pasien (4,15%) dan dosis terlalu tinggi 14 pasien (6,45%).

Peningkatan Kepuasan Pasien Terhadap Kualitas Pelayanan Instalasi Farmasi Rawat Jalan Menggunakan Pendekatan Lean Hospital Kartini Nur Wulandari; Gunawan Pamudji Widodo; Ismi Rahmawati
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 14, No 1 (2023): Januari 2023
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf14147

Lean is a continuous effort to eliminate waste and increase the value added of both goods and services in order to provide value to customers. The purpose of this study was to identify critical wastes that affect patient satisfaction at the Pharmacy Installation at Abdul Wahab Sjahranie Hospital, Samarinda. This qualitative research method was a case study. The stages of the research were observing the flow of the service process in the form of value stream mapping, distributing questionnaires about value waste and patients, conducting interviews using the 5-why method to find out the root causes and critical waste that occurs. The results showed that the lead time for concoction recipes was 100.4 minutes and the VAR for recipes was 67%, while the lead time for non-concocted recipes was 45.2 minutes and the VAR for non-concocted recipes was 48%. This shows that drug prescription service activities at the Outpatient Pharmacy Installation at Abdul Wahab Sjahranie Hospital Samarinda were included in the lean category. Critical waste was waste motion (53.3%). It could be concluded that critical waste is motion and waiting waste which is caused by several cases of drug shortages that often occur. What can be suggested is to improve drug planning or procurement in order to minimize drug vacancies.Keywords: pharmaceutical installation; lean hospital; critical waste; service improvement ABSTRAK Lean adalah suatu upaya terus menerus untuk mengeliminasi pemborosan (waste) dan meningkatkan value added produk baik barang maupun jasa agar memberikan nilai kepada pelanggan. Tujuan penelitian ini adalah mengidentifikasi waste kritis yang berpengaruh terhadap kepuasan pasien di Instalasi Farmasi RSUD Abdul Wahab Sjahranie Samarinda. Metode penelitian kualitatif ini adalah studi kasus. Tahapan penelitian yaitu observasi alur proses pelayanan dalam bentuk value stream mapping, penyebaran kuisioner tentang value waste dan pasien, melakukan wawancara dengan metode 5-why untuk mengetahui akar penyebab dan waste kritis yang terjadi. Hasil penelitian menunjukkan bahwa lead time resep racikan adalah 100,4 menit dan VAR resep adalah 67%, sedangkan lead time resep non racikan adalah 45,2 menit dan VAR resep non racikan adalah 48%. Ini menunjukkan bahwa aktivitas pelayanan resep obat di Instalasi Farmasi Rawat Jalan RSUD Abdul Wahab Sjahranie Samarinda termasuk dalam kategori lean. Waste kritis adalah waste motion (53,3%). Disimpulkan bahwa waste kritis adalah waste motion dan waiting yang disebabkan oleh adanya beberapa kasus kekosongan obat yang sering terjadi. Hal yang dapat disarankan adalah memperbaiki perencanaan atau pengadaan obat agar dapat meminimalisir terjadinya kekosongan obat.Kata kunci: instalasi farmasi; lean hospital; waste kritis; perbaikan pelayanan

Potensi Antibakteri Sediaan Sabun Cair Ekstrak Kulit Nanas (Ananas comosus L. Merr.) Terhadap Bakteri Staphylococcus aureus ATCC 25923 Ismi Rahmawati; Riesky Maulida; Siti Aisyah
Jurnal Farmasi & Sains Indonesia Vol 4 No 2 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol4no2p1-11

Pineapple peels extract (Ananas comosus (L.) Merr.) has antibacterial activity against Staphylococcus aureus bacteria which causes skin infections. One of the infection prevention is by using antibacterial hand soap. This study aims to determine the physical quality, stability and antibacterial activity of the pineapple peels extract soap against S. aureus ATCC 25923. Pineapple peels extract obtained from maceration with 70% ethanol solvent was formulated into liquid hand washing soap. Soap formulations were made with the respective concentrations of 3%, 6%, and 9%. Each formula was tested for physical quality with parameters: organoleptic, homogeneity, pH, specific gravity, viscosity, and foaming capacity. Stability test using the freeze thaw method with organoleptic , pH, and viscosity. The formulation results were tested for antibacterial activity against S. aureus ATCC 25923 by the well diffusion method. Panelists testing was done with several respondents. Data analysis of physical quality, stability and activity was tested by SPSS statistics with a confidence level of 95%. Pineapple peel extract contains flavonoids, alkaloids, tannins, saponins and phenols. All three soap formulas have physical quality in accordance with SNI 2588: 2017. The three formulas are stable until the fifth cycle (one cycle of 48 hours). The three liquid soap formulas had antibacterial activity against S. aureus ATCC 25923. The formula with a concentration of 9% was not significantly different from the positive control and had the highest inhibitory diameter of 21.78 ± 0.84mm. The formula with a concentration of 9% were most preferred by the panelists.

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