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All Journal MPI (Media Pharmaceutica Indonesiana) Jurnal Farmasi Indonesia JFIOnline Jurnal Mandala Pharmacon Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Biomedika PREPOTIF : Jurnal Kesehatan Masyarakat J-ABDIPAMAS (Jurnal Pengabdian Kepada Masyarakat)
Keswara, Yane Dila
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Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Tonic Effects Test of Pegagan (Centella asiatica L.) Syrups on White Male Mice Sunarti, Sunarti; Keswara, Yane Dila; Purnamasari, Nuraini Dewi
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 8, No 2 (2016)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Centella asiatica L., or known as pegagan leaf, empirically can be used as a tonic for organs such as liver, kidneys and brain. It also can increase memory. In our society, Centella asiatica L., hasn’t been optimally processed as atonic. Commonly, it is processed by boiling or grating the leaf. Raw consumption of this leaf inflicts bad taste. The aim of this research is to find out tonic effect and determine the effective dose of herbal syrup Centella asiatica L. The effect of tonic can be determined using natatory exhaustion method, by observing stimulant effect of a certain drug to an animal.Methods : This research used male mice were divided into 5 groups of treatment. The first group: negative control without herbal syrup Centella asiatica L., substance, positive control 50 mg/kg body weight, first dose group 120 mg/kg mice’s body weight, second dose group 150 mg/kg mice’s body weight and third dose group 180 mg/kg mice’s body weight. The effect of tonic was observed through the increasing duration of the mice’s self-defense ability when it was swum.Result: This research resulted that the use of herbal syrup Centella asiatica L., gave tonic effect on dose 120 mg/kg mice’s body weight, 150 mg/kg mice’s body weight, and 180 mg/kg mice’s body weight. The most effective dose of the use of herbal syrup Centella asiatica L., is on dose 180 mg/kg mice’s body weight.
Tonic Effects Test of Pegagan (Centella asiatica L.) Syrups on White Male Mice Sunarti, Sunarti; Keswara, Yane Dila; Purnamasari, Nuraini Dewi
Jurnal Farmasi Indonesia Vol 8, No 2 (2016)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (296.933 KB) | DOI: 10.35617/jfi.v8i2.518

Abstract

Centella asiatica L., or known as pegagan leaf, empirically can be used as a tonic for organs such as liver, kidneys and brain. It also can increase memory. In our society, Centella asiatica L., hasnâ??t been optimally processed as atonic. Commonly, it is processed by boiling or grating the leaf. Raw consumption of this leaf inflicts bad taste. The aim of this research is to find out tonic effect and determine the effective dose of herbal syrup Centella asiatica L. The effect of tonic can be determined using natatory exhaustion method, by observing stimulant effect of a certain drug to an animal.Methods : This research used male mice were divided into 5 groups of treatment. The first group: negative control without herbal syrup Centella asiatica L., substance, positive control 50 mg/kg body weight, first dose group 120 mg/kg miceâ??s body weight, second dose group 150 mg/kg miceâ??s body weight and third dose group 180 mg/kg miceâ??s body weight. The effect of tonic was observed through the increasing duration of the miceâ??s self-defense ability when it was swum.Result: This research resulted that the use of herbal syrup Centella asiatica L., gave tonic effect on dose 120 mg/kg miceâ??s body weight, 150 mg/kg miceâ??s body weight, and 180 mg/kg miceâ??s body weight. The most effective dose of the use of herbal syrup Centella asiatica L., is on dose 180 mg/kg miceâ??s body weight.
Kapsul Kombinasi Ekstrak Daun Jati Belanda (Guazuma ulmifolia, L) dan Kelopak Rosella (Hibiscus sabdarifa, L) Sebagai Alternatif Penurun Trigliserida Yane Dila Keswara; Sunarti Sunarti; Dewi Ekowati
Biomedika Vol 8 No 2 (2015): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (251.36 KB) | DOI: 10.31001/biomedika.v8i2.201

Abstract

Salah satu penyebab penyakit arterosklerosis adalah tingginya konsentrasi kolesterol dalam darah. Pemakaian jangka panjang obat -obat sintetik menimbulkan banyak efek samping. Penelitian ini bertujuan untuk mengkaji efek penurunan trigliserid dari kapsul bahwa kombinasi rosella dan jati belanda pada hewan uji yang dibuat hipertrigliserid. Penelitian ini menggunakan metode meserasi dari daun jati belanda dan bunga rosella kemudian dibuat granul dalam 6 formula. Sediaan diuji aktivitasnya yang terbagi atas 6 kelompok yaitu kelompok kontrol hiperlipidemia, kontrol normal, kelompok sediaan tunggal ekstrak daun jati belanda, kelompok sediaan tunggal kelompok pembanding simvastatin, ekstrak bunga rosella dan kelompok kombinasi daun jati belanda dan ektrak rosella (100%:50%).Hewan hipertrigliserid diberi perlakuan sekali tiap hari sampai didapat kadar kolesterol terkendali. Hasil penelitian menunjukkan bahwa ekstrak daun jati belanda, ekstrak daun rosella dan sediaan kombinasi dalam perbandingan 100%:50% (ekstrak daun jati belanda 500 mg dan ekstrak rosella 250 mg) dapat dibuat dengan baik. Hasil uji aktivitas antihiperkolesterolmia menunjukkan bahwa sediaan kapsul kombinasi ekstrak daun jati belanda dan ekstrak bunga rosella mempunyai aktivitas meurunkan kadar trigliserida.
PENGARUH EKSTRAK ETANOL KULIT BUAH MANGGIS DAN DAUN PEPAYA TERHADAP KADAR BILIRUBIN PADA TIKUS PUTIH YANG DIINDUKSI ISONIAZID DAN RIFAMPISIN Meta Kartika Untari; Yane Dila Keswara; Nur Aini Dewi Purnamasari
Jurnal Farmasi Indonesia Vol 12 No 2 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (130.771 KB) | DOI: 10.31001/jfi.v12i2.88

Abstract

Tuberculosis (TB) is a disease with a very high prevalence in Indonesia. Clinical trials of drugs isoniazid and rifampicin have known most active in combating tuberculosis in the lungs. Side effects caused by administration of OAD (anti-tuberculosis drugs) one of them is a liver function disorders characterized by elevated levels of serum bilirubin. This study aimed to determine the activity of a decrease in serum bilirubin levels in rats induced after administration of isoniazid and rifampin combination of ethanol extract of mangosteen peel and papaya leaf. Serum bilirubin measurement method using a spectrophotometer, the bilirubin level is expressed in mg / dl. Data were analyzed using Kruskal-Wallis method shows that there was a significant difference between the treatment groups (p <0.05), while between the time measurements showed no significant difference. A combination of ethanol extract of papaya dose of 120 mg / 200 g BW rat, and the ethanol extract of mangosteen peel dose of 160 mg / 200 g rat BW the most effective of all treatment groups in lowering levels of bilirubin in isoniazid and rifampicin induced rat.
Uji Aktivitas Analgetik Ekstrak Etanol Daun Inggu (Ruta angustifolia [l.] Pers) Pada Tikus Putih Jantan Yane Dila Keswara; Sri Rejeki Handayani
Journal Syifa Sciences and Clinical Research Vol 1, No 2 (2019): Volume 1 Edisi 2 2019
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (563.874 KB) | DOI: 10.37311/jsscr.v1i2.2662

Abstract

Pain is an uncomfortable feeling caused by strong or destructive stimulation, if unchecked can affect daily routine. This study aims to determine the analgesic effect and dosage of the leaf extract ethanol, as well as to determine the effectiveness of the leaf extract ethanol as a narcotic analgesic by the Tail Flick method or as a non-narcotic analgesic by the Paw Pressure Test Randall Selitto method. Extraction was done by maceration of leaf powder with a solvent 96% ethanol. 25 male Wistar white rats were divided into 5 groups, positive group mefenamic acid 9 mg /200 g BW for the Paw Pressure Test Randall Selitto Method and tramadol 0.9 mg /200 g BW for the Tail Flick Method, negative control CMC Na 0,5%, ethanol extract leaves inggu leaves a dose of 10 mg /200 g BW, 20 mg /200 g BW and 40 mg /200 g BW. The data obtained were analyzed by ANOVA test, then LSD test was used to determine differences between groups. The results showed extract dosage of 10 mg /200 g BW, 20 mg /200 g BW, 40 mg /200 g BW had analgesic effect. Extract dosage of 20 mg /200 g BW and 40 mg /200 g BW in the Randall selitto Paw Pressure Test method is equivalent to mefenamic acid, extract dose 10 mg /200 g BW, 20 mg /200 g BW, and 40 mg /200 g BW the Tail Flick method is equivalent to Tramadol. Ethanol leaf extract is more effective as a narcotic analgesic by the Tail Flick method.
TRAINING OF SCIENTIFIC PAPERS WRITING FOR HIGH SCHOOL TEACHER TO IMPROVE THE QUALITY OF THE TEACHER Rina Herowati; Gunawan Pamuji Widodo; Supriyadi Supriyadi; Sunarti Sunarti; Yane Dila Keswara; Nuraini Dewi Purnamasari
J-ABDIPAMAS (Jurnal Pengabdian Kepada Masyarakat) Vol 2, No 1 (2018): April
Publisher : IKIP PGRI Bojonegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (611.43 KB) | DOI: 10.30734/j-abdipamas.v2i1.176

Abstract

ABSTRACTThe professional development of the teachers through the writing of scientific papers needs to be improved. The obstacle faced by teachers so they did not write scientific paper mainly are caused by limitation of time and not understanding the rules of writing a scientific paper. This devotional activity aims to improve  teachers' motivation to write scientific papers and improve the ability for the teachers to write scientific papers to produce as many articles as published in scientific journals. The method used is situational analysis by interviewing the principal and distributing questionnaires. Furthermore, the preparation of materials, lectures and discussions, as well as accompaniment of scientific writing until the participants successfully publish their articles in scientific journalsKeywords: quality improvement, scientific papers, teachers ABSTRAKPengembangan profesionalitas guru melalui penulisan karya ilmiah perlu ditingkatkan. Kendala yang dihadapi guru sehingga tidak menulis karya ilmiah terutama adalah belum ada waktu dan belum paham aturan penulisan karya ilmiah. Kegiatan pengabdian ini bertujuan untuk meningkatkan motivasi guru menulis karya ilmiah dan  meningkatkan kemampuan guru menulis karya ilmiah hingga dihasilkan sebanyak mungkin artikel yang dipublikasikan di jurnal ilmiah. Metode yang dilakukan adalah analisis situasi dengan wawancara dengan kepala sekolah dan penyebaran kuesioner.  Selanjutnya dilakukan penyusunan materi, ceramah dan diskusi, serta pendampingan penulisan karya ilmiah hingga peserta berhasil menerbitkan artikelnya di jurnal ilmiah.KataKunci: guru, karya ilmiah, peningkatan kualitas
Pengujian Toksisitas Akut Minyak Atsiri Biji Pala pada Mencit Jantan (Mus musculus) Ghani Abhi Majid; Yane Dila Keswara; Hery Muhamad Ansory
Jurnal Farmasi Indonesia Vol 20 No 2 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i2.2263

Abstract

Nutmeg seed essential oil works as an antibacterial, antioxidant, antifungal and anti-inflammatory. It is not yet known the safety of using nutmeg seed essential oil as a medicine so it is necessary to carry out safety tests, namely acute toxicity tests. The purpose of this study was to determine the safety of nutmeg seed essential oil and determine the LD50 value, influence on body weight, behavioral changes and macropathology of mouse organs. Isolation of nutmeg seed essential oil using the steam distillation method. Nutmeg seed essential oil was analyzed using GS-MS. Acute toxicity test in this study used fixed dose method. The test animals used 30 male white mice were divided into 6 test groups, namely the placebo control group and the treatment group given nutmeg essential oil doses of 5, 50, 300, 2000 and 5000 mg / KgBB. The observation parameters of test animals include toxic symptoms, body weight, and organ macropathology. The analysis method used is one way ANOVA followed by Tukey's Post-Hoc test. The results showed that after giving nutmeg seed essential oil there were no significant toxic effects but could affect the body weight of mice. Macropathological observation of mouse organs in all groups looked normal and no damage to mouse organs resulted from the administration of test preparations. Thus, the LD50 essential oil of nutmeg seeds is pseudo ≥ 5000 mg/KgBB, including the classification of practically non-toxic.
Hubungan Pelayanan Farmasi dengan Kepatuhan Pengobatan Pasien Penyakit Paru Obstruktif Kronik (PPOK) Fitriarahmah, Giyan; Peranginangin, Jason Merari; Keswara, Yane Dila
MPI (Media Pharmaceutica Indonesiana) Vol. 5 No. 2 (2023): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v5i2.5808

Abstract

Pelayanan farmasi dibutuhkan untuk mendorong pengobatan yang optimal guna mengurangi resiko kejadian Penyakit Paru Obetruktif Kronik (PPOK). Pelayanan farmasi yang berkualitas mampu meningkatkan kepatuhan pengobatan melalui kepuasan pasien setelah mendapatkan pelayanan yang baik, sehingga mempengaruhi minat pasien dalam menjalankan dan melanjutkan pengobatan. Tujuan dari penelitian ini adalah untuk mengetahui dan menganalisis hubungan pelayanan farmasi dengan kepatuhan pengobatan pasien PPOK di RSUD dr. Soeratno Gemolong. Penelitian ini merupakan penelitian kuantitatif dengan desain penelitian analitik cross sectional. Teknik sampling menggunakan consecutive sampling agar sesuai kriteria inklusi dalam kurun waktu tertentu. Pengambilan data dilakukan menggunakan kuesioner dan data rekam medik pasien PPOK rawat inap di RSUD dr. Soeratno Gemolong. Jumlah sampel sebanyak 48 orang pasien PPOK rawat inap. Data dianalisis menggunakan analisis univariat, bivariat, dan multivariat. Hasil penelitian menunjukkan kualitas pelayanan farmasi rawat inap RSUD dr. Soeratno Gemolong tergolong baik. Pelayanan farmasi dimensi bukti langsung/fisik (tangible), dimensi ketanggapan (responsiveness), dimensi jaminan kepastian (assurance), dan dimensi kepedulian (emphaty) berhubungan signifikan dengan kepatuhan pengobatan. Kesimpulan, pelayanan farmasi memiliki hubungan dengan kepatuhan pengobatan pasien PPOK di RSUD dr. Soeratno Gemolong dengan korelasi rendah dan arah hubungan yang positif. Pharmaceutical services are needed to encourage optimal treatment to reduce the risk of COPD. Quality pharmacy services are able to improve treatment adherence through patient satisfaction after getting good service, thus affecting patient interest in carrying out and continuing treatment. The purpose of this study were determining and analyzing the relationship between pharmaceutical services and treatment compliance of COPD patients at RSUD dr. Soeratno Gemolong. This research is a quantitative research with a cross-sectional analytical research design. The sampling technique uses consecutive sampling to fit the inclusion criteria within a certain period of time. Data collection was carried out using questionnaires and medical record data of inpatient COPD patients at RSUD dr. Soeratno Gemolong. The number of samples were 48 inpatient COPD patients. The data was analyzed using univariate, bivariate, and multivariate analyses. The results showed that the quality of inpatient pharmacy services at RSUD dr. Soeratno Gemolong was good. Pharmaceutical services dimensions of direct/physical evidence (tangible), dimensions of responsiveness (responsiveness), dimensions of assurance (assurance), and dimensions of concern (emphaty) were significantly related to treatment adherence. In conclusion, pharmaceutical services have a relationship with treatment compliance of COPD patients at RSUD dr. Soeratno Gemolong with low correlation and positive relationship direction.
EVALUASI KESESUAIAN PENYIMPANAN OBAT HIGH ALERT DI SELURUH AREA RUMAH SAKIT X KOTA SURAKARTA Hapsari, Fitriana Nur; Keswara, Yane Dila; Widyaningrum, Riana
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 1 (2025): APRIL 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i1.40919

Abstract

Obat high alert  adalah obat yang memiliki resiko tinggi membahayakan keselamatan pasien jika tidak disimpan dan digunakan secara tepat. Menurut Permenkes No.72 Tahun 2016 tentang standar pelayanan kefarmasian di rumah sakit, high alert medicine adalah obat yang harus diwaspadai karena sering menyebabkan terjadi kesalahan serius (sentinel event) dan obat yang berisiko tinggi menyebabkan Reaksi Obat Yang Tidak Diinginkan (ROTD). Kelompok obat High Alert diantaranya adalah kategori Risiko Tinggi, LASA (Look Alike Sound Alike), dan Elektrolit Konsentrat. Tujuan dalam penelitian ini adalah untuk mengetahui dan mengevaluasi penyimpanan obat high alert di seluruh area Rumah Sakit X Kota Surakarta di unit farmasi yang meliputi depo rawat jalan, depo rawat inap, depo IGD, depo IBS dan gudang farmasi dan di luar unit farmasi yang meliputi penyimpanan di Emergency Kit, Trolley Emergency, dan Floorstock di ruang perawatan berdasarkan Permenkes No.72 Tahun 2016 dan SPO Rumah Sakit. Teknik pengambilan sampel menggunakan teknik sampling jenuh di seluruh area Rumah Sakit X Kota Surakarta. Metode dalam penelitian ini adalah penelitian kualitatif dengan pendekatan deskriptif observasional. Data dikumpulkan dengan cara melakukan observasi secara langsung  dengan mengggunakan lembar observasi checklist evaluasi kesesuaian penyimpanan obat high alert dan diolah menadi bentuk presentase. Penelitian dilaksanakan pada bulan Oktober dan November 2024. Hasil penelitian menunjukkan presentase kesesuaian penyimpanan obat high alert  berdasarkan Permenkes No. 72 Tahun 2016 sebesar 87,82% kategori sangat baik dan berdasarkan SPO menunjukkan presentase sebesar 84,69%  kategori sangat baik di Rumah Sakit X Kota Surakarta.
EVALUASI PENGELOLAAN OBAT NARKOTIKA, PSIKOTROPIKA DAN PREKURSOR DI RUMAH SAKIT X KOTA SURAKARTA BERDASARKAN PERATURAN PERUNDANGAN YANG BERLAKU Putri, Uthia Narida; Keswara, Yane Dila; Widyaningrum, Riana
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 1 (2025): APRIL 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i1.42320

Abstract

Golongan obat narkotika, psikotropika, dan prekursor dikenal memiliki potensi tinggi untuk disalahgunakan, yang dapat menyebabkan ketergantungan fisik dan psikologis. Oleh karena itu, pengelolaannya diatur secara ketat melalui regulasi yang diterapkan oleh pemerintah. Penelitian ini bertujuan untuk mengevaluasi pengelolaan obat tersebut di Rumah Sakit X Kota Surakarta berdasarkan regulasi yang berlaku guna mencegah penyalahgunaan dan meningkatkan mutu pelayanan kesehatan. Metode yang digunakan adalah kombinasi (mixed methods), dengan pendekatan kualitatif dan kuantitatif. Data primer diperoleh melalui observasi dan wawancara dengan petugas farmasi, sementara data sekunder dikumpulkan dari pedoman pengelolaan farmasi, SOP rumah sakit, dan dokumen supervisi farmasi. Evaluasi dilakukan berdasarkan Permenkes No. 72 Tahun 2016 tentang Standar Pelayanan Kefarmasian di Rumah Sakit dan Permenkes No. 5 Tahun 2023 tentang Narkotika, Psikotropika, dan Prekursor Farmasi. Hasil penelitian menunjukkan tingkat kesesuaian 100% terhadap standar yang berlaku menunjukkan sistem pengelolaan yang aman dan terkendali, mampu mencegah penyalahgunaan, kehilangan, dan dampak negatif lainnya, serta mencerminkan komitmen rumah sakit dalam menjaga kualitas pelayanan kesehatan dan memenuhi tanggung jawab hukum.
Co-Authors A.A. Ketut Agung Cahyawan W Damayanti, Distia Dewi Ekowati Fitriarahmah, Giyan Ghani Abhi Majid Gunawan Pamuji Widodo Hafidah, Hafidah Hapsari, Fitriana Nur Ika Purwidyaningrum Jason Merari Peranginangin Meta Kartika Untari Muhamad Ansory, Hery Purnamasari, Nur Aini Dewi Purwoko, Agus Putri, Uthia Narida Sri Rejeki Handayani Sunarti Sunarti Sunarti Sunarti Sunarti Supriyadi Widyaningrum, Riana