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All Journal Medula JURNAL ILMIAH KESEHATAN SANDI HUSADA JURNAL PENELITIAN PERAWAT PROFESIONAL Indonesian Journal of Global Health research Jurnal Sehat Indonesia (JUSINDO) Jurnal Ilmiah Kesehatan Sandi Husada JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Nurul Islamy
universitas lampung
Dentistry Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Hubungan Usia dan Gambaran Histopatologi Hiperplasia Endometrium di RSUD DR H Abdul Moeloek Provinsi Lampung periode 2021-2024 Salsa Nurfajri Yuska; Nur Ayu Virginia Irawati; Nurul Islamy; Indri Windarti
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 12 No 3 (2026): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol. 12.3 (2026)
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v12i3.1019

Abstract

Pendahuluan: Hiperplasia endometrium merupakan kondisi proliferatif yang berpotensi menjadi lesi prakanker. Ketidakseimbangan hormonal, terutama dominasi estrogen tanpa antagonisme progesteron, diyakini menjadi faktor penting dalam perkembangan gangguan ini. Penelitian ini dilakukan untuk menganalisis hubungan antara usia dan gambaran histopatologi hiperplasia endometrium di RSUD Dr. H. Abdul Moeloek Provinsi Lampung. Metode: Penelitian analitik observasional dengan desain cross-sectional ini menggunakan data rekam medis pasien hiperplasia endometrium periode 2021–2024 di RSUD Dr. H. Abdul Moeloek. Total sampling digunakan untuk mengumpulkan seluruh pasien yang dilakukan kuretase dengan hasil histopatologi hiperplasia endometrium. Analisis hubungan antarvariabel dilakukan menggunakan uji Fisher exact. Hasil: Dari 31 sampel yang memenuhi kriteria, sebagian besar pasien berusia ?45 tahun dan terbanyak memiliki gambaran hiperplasia non-atipik. Analisis statistik menunjukkan hubungan bermakna antara usia dan tipe histopatologi, dengan kecenderungan peningkatan hiperplasia atipik pada kelompok usia lebih tua. Pembahasan: Usia berperan sebagai faktor penting terhadap gambaran histopatologi hiperplasia endometrium. Perubahan hormonal pada fase perimenopause dan pascamenopause mendukung peningkatan risiko lesi atipik seiring bertambahnya usia. Simpulan: Terdapat hubungan signifikan antara usia dan gambaran histopatologi hiperplasia endometrium dengan kelompok usia yang lebih tua menunjukkan proporsi hiperplasia atipik yang lebih tinggi.
Neutrophil-to-Lymphocyte Ratio as a Predictor of Renal Function Decline Based on Serum Urea, Creatinine, and Estimated Glomerular Filtration Rate in Non-Hemodialysis Chronic Kidney Disease Patients Ade Yonata; Nurul Islamy; Khairun Nisa Berawi
Jurnal Sehat Indonesia (JUSINDO) Vol. 8 No. 2 (2026): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/-.v8i2.543

Abstract

Chronic kidney disease (CKD) is a progressive condition affecting 9–13% of the global population, with diabetes and hypertension being the predominant risk factors. Chronic low-grade inflammation contributes to CKD progression, and the neutrophil-to-lymphocyte ratio (NLR) provides a simple and routinely available inflammatory index. This study examined whether NLR was associated with serum urea, serum creatinine, and estimated glomerular filtration rate (eGFR) in non-hemodialysis CKD patients. A cross-sectional analytical study was conducted at Dr. H. Abdul Moeloek Regional Hospital, Bandar Lampung, from March to May 2026. Using consecutive sampling, 264 patients with CKD stages G2–G4 were enrolled. Spearman’s correlation analysis was applied with a significance threshold of p < 0.05. The mean NLR was 2.52 ± 1.32. NLR demonstrated a positive correlation with serum creatinine (rs = +0.151; p = 0.014) and a negative correlation with eGFR (rs = −0.155; p = 0.012), whereas no significant correlation was observed with serum urea (rs = +0.066; p = 0.284). The consistent direction of NLR associations with creatinine and eGFR supports its potential as a cost-effective supplementary marker for monitoring renal function decline in resource-limited settings.
Co-Authors ade yonata Anggita Dwi Paramitha Citra Yuliyanda Pardilawati Ellyta Septyarani fahmi ikhtiar Ghaaliya dyah adheline I Made Merta Jaya Indri Windarti Khairun Nisa Km Allan Wahyu Permana Marzuqi Sayuti Muhammad Arifin Ilham Muhammad Hasbi Sahbani Nur Ayu Virginia Irawati nur sazaro tudhur Odi Wijaya Ramadhan Triyandi Ratna Dewi Puspita Sari Reva Dwi Yanty Riska Dwi Febriyanti Salsa Nurfajri Yuska Sherly Melvinia Malia Siti Nurkomala Sari Syahrul Hamidi Nasution Vidi Ibrahim Pratomo Affandi