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All Journal Jurnal Kedokteran Raflesia JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Nur Ayu Virginia Irawati
Universitas Lampung
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Hubungan Usia dan Gambaran Histopatologi Hiperplasia Endometrium di RSUD DR H Abdul Moeloek Provinsi Lampung periode 2021-2024 Salsa Nurfajri Yuska; Nur Ayu Virginia Irawati; Nurul Islamy; Indri Windarti
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 12 No 3 (2026): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol. 12.3 (2026)
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v12i3.1019

Abstract

Pendahuluan: Hiperplasia endometrium merupakan kondisi proliferatif yang berpotensi menjadi lesi prakanker. Ketidakseimbangan hormonal, terutama dominasi estrogen tanpa antagonisme progesteron, diyakini menjadi faktor penting dalam perkembangan gangguan ini. Penelitian ini dilakukan untuk menganalisis hubungan antara usia dan gambaran histopatologi hiperplasia endometrium di RSUD Dr. H. Abdul Moeloek Provinsi Lampung. Metode: Penelitian analitik observasional dengan desain cross-sectional ini menggunakan data rekam medis pasien hiperplasia endometrium periode 2021–2024 di RSUD Dr. H. Abdul Moeloek. Total sampling digunakan untuk mengumpulkan seluruh pasien yang dilakukan kuretase dengan hasil histopatologi hiperplasia endometrium. Analisis hubungan antarvariabel dilakukan menggunakan uji Fisher exact. Hasil: Dari 31 sampel yang memenuhi kriteria, sebagian besar pasien berusia ?45 tahun dan terbanyak memiliki gambaran hiperplasia non-atipik. Analisis statistik menunjukkan hubungan bermakna antara usia dan tipe histopatologi, dengan kecenderungan peningkatan hiperplasia atipik pada kelompok usia lebih tua. Pembahasan: Usia berperan sebagai faktor penting terhadap gambaran histopatologi hiperplasia endometrium. Perubahan hormonal pada fase perimenopause dan pascamenopause mendukung peningkatan risiko lesi atipik seiring bertambahnya usia. Simpulan: Terdapat hubungan signifikan antara usia dan gambaran histopatologi hiperplasia endometrium dengan kelompok usia yang lebih tua menunjukkan proporsi hiperplasia atipik yang lebih tinggi.
Polycystic Ovary Syndrome: Pathophysiology, Risk Factors, and Clinical Management – A Literature Review Luluk Hermawati; I Made Arya Subadiyasa; Nur Bebi Ulfah Irawati; Hilizza Awalina Zulfa; Nur Ayu Virginia Irawati; Rossa Amelia
JURNAL KEDOKTERAN RAFLESIA Vol 12 No 1 (2026): Juni
Publisher : UNIVERSITAS BENGKULU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/juke.v12i1.48386

Abstract

Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder commonly observed in women of reproductive age and is associated with reproductive, metabolic, and psychological disturbances. This article aims to comprehensively review the pathophysiology, risk factors, and clinical management of PCOS based on current scientific evidence. The method employed was a narrative literature review, conducted through a systematic search of scientific articles in PubMed, Scopus, Google Scholar, and ScienceDirect databases. The keywords used included polycystic ovary syndrome, PCOS pathophysiology, insulin resistance, anti-Müllerian hormone, and clinical management. Publications in English and Indonesian from 2015 to 2025 were included. The selected articles comprised original research studies, systematic reviews, and relevant literature reviews. The findings indicate that the pathophysiology of PCOS is multifactorial, involving hormonal alterations, insulin resistance, hyperandrogenism, and dysfunction of the hypothalamic–pituitary–ovarian axis, which leads to chronic anovulation. The main risk factors for PCOS include obesity, insulin resistance, sedentary lifestyle, unbalanced nutritional status, as well as metabolic and genetic predispositions, all of which contribute to the heterogeneous clinical manifestations of the syndrome. The management of PCOS is individualized and multidisciplinary, with lifestyle modification as the first-line therapy, supported by dietary interventions, physical activity, and pharmacological treatment according to clinical indications. This review highlights the importance of an integrated approach in the management of PCOS to improve clinical outcomes and prevent long-term complications.
Co-Authors Hilizza Awalina Zulfa I Made Arya Subadiyasa Indri Windarti Luluk Hermawati Nur Bebi Ulfah Irawati Nurul Islamy Rossa Amelia Salsa Nurfajri Yuska