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All Journal Reaktor Alchemy : Journal of Chemistry BERITA BIOLOGI Jurnal Kimia Riset FaST : Jurnal Sains dan Teknologi Pharmaceutical Sciences and Research (PSR) Makara Journal of Science
Antonius Herry Cahyana
Departemen Kimia, FMIPA, Universitas Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Energy Environmental Science Materials Science & Nanotechnology

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SKRINING DAN ISOLASI METABOLIT AKTIF ANTIBAKTERI KULTUR JAMUR ENDOFIT DARI TUMBUHAN Albertisia papuana Becc. [Screening and Isolation of Antibacterial Active Metabolite from the Culture of Endophytic Fungi from Albertisia papuana Becc.] Fathoni, Ahmad; Ilyas, Muhammad; Cahyana, Antonius Herry; Agusta, Andria
BERITA BIOLOGI Vol 12, No 3 (2013)
Publisher : Research Center for Biology-Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (8087.938 KB) | DOI: 10.14203/beritabiologi.v12i3.639

Abstract

Totally 15 isolates of endophytic fungi were obtained from leaves and young stems of a medicinal plant Albertisia papuana Becc.(Menispermaceae). The antibacterial screening of the ethyl acetate extract derived from the fungi cultures in potato dextrose broth (PDB)were performed on a non eluted Thin Layer Chromatography Bioautography assay (TLC bioautography assay). From the screening test, itwas found that the ethyl acetate extract of the fungus Xylaria sp. DAP-KRI-5 culture showed strong antibacterial activity against Staphylococcus aureus. The isolation of active metabolite based on the bioautography guided assay from ethyl acetate extract of the Xylaria sp. DAP-KRI-5, led us to identify phloroglucinol as a main antibacterial compound. The chemical structure of phloroglucinol was deduced from it spectral data, including UV-Vis, 1H and 13C-NMR, GC-MS and published data elsewhere.
Kopling Oksidatif Eugenol Menggunakan Ekstrak Enzim Peroksidase dari Akar Tanaman Sawi Hijau serta Uji Bioaktivitasnya Ardiansah, Bayu; Cahyana, Antonius Herry; Suwarso, Wahyudi Priyono; Maryana, Rianti; Merly, Siti
ALCHEMY Vol 5, No 3 (2017): ALCHEMY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (630.772 KB) | DOI: 10.18860/al.v5i3.3776

Abstract

Peroxidase has been successfully extracted and partially purified from Brassica juncea L. Czern root with protein content and specific activity of 0.747 mg/mL and 0.244 U/mg, respectively. Then, it was applied as biocatalyst for green oxidative coupling reaction of eugenol to produce an orange crystal, dimeric form of eugenol (84% yield). Structure elucidation was done by using FTIR, UV-Vis and GC-MS instruments. The optical activity of dimeric eugenol was found to have Ra-configuration. Furthermore, biological activity of the product as antioxidant has been evaluated resulting in IC50 values of 32.14 and 42.43 ppm for dimeric and monomeric eugenol, respectively.
Enzim Papain: Aspek Green Chemistry pada Reaksi Knoevenagel Haryanto, Laurentius; Cahyana, Antonius Herry
Pharmaceutical Sciences and Research Vol. 2, No. 2
Publisher : UI Scholars Hub

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Abstract

Green chemistry aspect is the chemical approach that has been studied in the past two decade. One of the principles is the development of green synthesis process that is friendly for the environment. This research showed that papain can be used as catalyst for Knoevenagel reaction with 3 kinds of substituted-benzaldehyde and malononitrile as substrates in aqueous medium. The best reaction condition with 80% yield was reached by utilizing of 25 mg papain/mmol substrate. Reaction was conducted at ambient temperature and pressure for 30 min. Products were as yellowish to yellow needle crystals and successfully characterized by melting point, UV-Vis, IR, mass spectra, and 13C & 1H-NMR, named as 2-(4-hydroxybenzylidene)-malononitrile); 2-(3-hydroxybenzylidene)-malononitrile); and 2-(4-hydroxy-3-methoxybenzylidene)-malononitrile).
Study of Antioxidant Activity of the Derivatives of Quinoline-4-carboxylic Acids by the Modification of Isatin via Pfitzinger Reaction Fikriya, Sakti Hidayati; Cahyana, Antonius Herry
Makara Journal of Science Vol. 27, No. 2
Publisher : UI Scholars Hub

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Abstract

In this study, a quinoline-4-carboxylic acid derivative was synthesized through Pfitzinger reaction. In this reaction, isatin is modified via its reaction with ketone and refluxed for 24 h to obtain quinoline-4-carboxylic acid. The presence of a carboxylic group was identified by Fourier Transform Infrared (FTIR) spectroscopy and ultraviolet–visible (UV-Vis) spectrophotometry. The results showed that the absorption peaks of C=O and O–H stretching’s were detected in the range of 1724–1708 and 3436–3242 cm−1, respectively. In the UV-vis spectrum, a shift in the absorption peak was observed toward a larger wavelength, which is referred as a bathochromic shift. The formation of quinoline-4-carboxylic acid derivative was also characterized using the mass spectrometry method. The modification of isatin aims to increase antioxidant activity to obtain quinoline-4-carboxylic acid, which has a better inhibition percentage than isatin. Antioxidant tests were conducted using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The antioxidant activity is measured based on the ability of quinoline-4-carboxylic acid derivative to donate hydrogen radicals, which revealed that the product had a relatively better inhibitory effect than isatin. At a concentration of 5 mg/L, isatin did not show antioxidant activity with the DPPH method. By contrast, the inhibition percentages of 2-methylquinoline-4-carboxylic acid and 2-(4-methylphenyl)quinoline-4-carboxylic acid were approximately 30.25% and 40.43%, respectively. Furthermore, the presence of an aromatic ring makes the antioxidant activity.
Synthesis of Copper (II) Oxide Nanoparticles using Vitis vinifera L. Leaf Ex-tract and its Application as a Catalyst in Doebner Reaction Kurniawan, Felie Virgayani; Cahyana, Antonius Herry; Yunarti, Rika Tri
Makara Journal of Science Vol. 27, No. 3
Publisher : UI Scholars Hub

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Abstract

Plant extracts can be used to synthesize nanoparticle because it is efficient, economical, and friendly to the environment. Copper oxide nanoparticles (CuO NPs) were synthesized using an aqueous fraction of Vitis vinifera L leaf extract and Cu(NO3)2 solution as a precursor. This fraction contains secondary metabolites as a reduction agent and stabilizing agents to formed CuO NPs. CuO NPs can be used as a catalyst in a chemical reaction, one of which is the Doebner reaction, which is a simple and efficient reaction of aniline, aromatic aldehydes, and pyruvic acid under reflux conditions to produce derivatives quinoline-4-carboxylic acid. CuO NPs were effectively used in the Doebner reaction and yielded a product is 79.84%. The CuO NPs characterized by Fourier Transform Infra-Red (FTIR), and X-ray Diffraction (XRD) which showed CuO NPs were formed with a size of 24.39 nm. The product synthesized was characterized by TLC (Thin Layer Chromatography), FTIR, UV-Vis Spectrophotometry, and Liquid Chromatography Mass Spectrometry (LC-MS) and confirmed 2-phenylquinoline-4-carboxylic acid was formed.
PHYTOCHEMICAL PROFILES, ANTIOXIDANT, AND ANTICANCER ACTIVITIES FROM LEAVES AND SEEDS EXTRACT OF Myristica fragrans Saputri, Ariyanti; Fajriah, Sofa; Cahyana, Antonius Herry; Putria, Devi Kasih; Saputra, Ziyan; Angelina, Marissa
Jurnal Kimia Riset Vol. 9 No. 2 (2024): December
Publisher : Universitas Airlangga, Campus C Mulyorejo, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkr.v9i2.65245

Abstract

Nutmeg (Myristica fragrans) is a plant that grows naturally in Indonesia and widely used in the food and industrial sectors. Nutmeg seeds have been widely studied because they have a variety of compounds with good activities, but research on the leaves still needs to be completed. Therefore, this research compared nutmeg leaves and seed extracts' secondary metabolite content and bioactivity. This study aims to determine the phytochemical contents of nutmeg leaves and seed extracts by phytochemical screening and GC-MS analysis, as well as its potential as an antioxidant and anticancer. The antioxidant activity test uses the DPPH (1,1-diphenyl-2-picrylhydrazyl) method measured at a wavelength of 517 nm. Meanwhile, the anticancer activity test uses MCF-7 cells with the MTT assay method. Nine compounds (lipid, phenylpropanoid, lignan, terpenoid, and quinone groups) were identified by GC-MS analysis in the leaf extracts. Meanwhile, seed extract has 23 compounds from the lipid, fatty acid, phenylpropanoid, lignan, and terpenoid groups. The antioxidant activity of nutmeg leaves and seed extracts was carried out using the DPPH method, while the cytotoxic activity against MCF-7 cells used the MTT method. Nutmeg leaves have more potent antioxidant activity than nutmeg seeds, with IC50 values of 17.80 µg/mL and 53.01 µg/mL, respectively. The cytotoxic activity test on MCF-7 cells also showed that the inhibition value of nutmeg extract (26%) was higher than that of nutmeg seeds (22.73%). This research shows that nutmeg leaf extract has the potential to carry out further research regarding the bioactivity of its compounds.
Synthesis of Isatin-based Chalcone Derivatives and Their Activity as Antioxidants Saputri, Yosephine Liliana Intan Danar; Cahyana, Antonius Herry; Yunarti, Rika Tri
Reaktor Volume 23 No.2 August 2023
Publisher : Department of Chemical Engineering, Faculty of Engineering, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/reaktor.23.2.62-70

Abstract

The body needs antioxidants to combat free radicals and guard against their damaging effects on healthy cells that might result in degenerative disorders. Several degenerative diseases include hypertension, heart disease, diabetes, stroke, and cancer. The human body can deal with free radical attacks caused by radiation, stress, cigarette smoke, and environmental pollution, so it requires additional external antioxidants to protect against free radical attacks. Chalcone is a compound that has an α,β-unsaturated carbonyl system, which makes chalcone compounds have biological activity. Chalcone compounds may be used in pharmacology as antioxidants, antifungals, antibacterial agents, anticancer agents, and for other biological activities. This study aims to synthesize a chalcone derivative, namely 3-(2-oxo-2-phenylethylidene)indolin-2-one and 5-chloro-3-(2-oxo-2-phenylethylidene)indolin-2-one containing a chloro substituent, as well as test the potential of these compounds as antioxidants. The reflux method of claisen-schmidt condensation of isatin and acetophenone was used to create chalcone derivatives. Spectroscopy was used to characterize the produced chemicals (UV-VIS, IR, and LCMS) and their antioxidant activity using the DPPH method. This study showed that the antioxidant activity of 3-(2-oxo-2-phenylethylidene)indolin-2-one and 5-chloro-3-(2-oxo-2-phenylethylidene)indolin-2-one compounds is very weak at low concentrations.
AKTIVITAS ANTIOKSIDAN NANOPARTIKEL SENG OKSIDA PADA DAUN DAN BUAH PIRDOT (Saurauia vulcani Korth.) [ANTIOXIDANT ACTIVITY OF ZINC OXIDE NANOPARTICLES ON THE LEAVES AND FRUIT OF PIRDOT] (Saurauia vulcani Korth.) Lumantobing, Lukas Hotma Parulian; Handayani, Ratna; Cahyana, Antonius Herry
FaST - Jurnal Sains dan Teknologi (Journal of Science and Technology) Vol. 8 No. 2 (2024): NOVEMBER
Publisher : Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/jstfast.v8i2.8998

Abstract

One of the potential local sources of Indonesia for nanoparticle synthesis is pyrdot (Saurauia vulcani Korth.). This study aims to synthesize zinc oxide nanoparticles with pyrdot leaf and fruit extracts by maceration. Total phenolic testing using the Folin-Ciocalteau method, antioxidant activity using the DPPH method. Antioxidant activity with IC50 of 0.891 ± 0.045 (leaf ZnONPs), 2.181 ± 0.167 (leaf extract), 2.945 ± 0.009 (fruit ZnONPs), and 4.017 ± 0.277 (fruit extract) respectively. ZnoNPs were subjected to morphological testing using SEM and TEM methods as well as particle size testing with the general results that the nanoparticles obtained met the requirements as a nanoparticle in terms of particle size, with leaf ZnONPs generally having a smaller particle size than fruit, although morphologically they are generally irregular in shape.Bahasa Indonesia Abstract:Salah satu sumber lokal Indonesia yang potensial untuk sintesis nanopartikel adalah pirdot (Saurauia vulcani Korth.). Penelitian ini bertujuan untuk mensintesis nanopartikel seng oksida dengan ekstrak daun dan buah pirdot dengan maserasi. Pengujian total fenolik menggunakan metode Folin-Ciocalteau, aktivitas antioksidan menggunakan metode DPPH. Aktivitas antioksidan dengan IC50 masing-masing sebesar 0,891 ± 0,045 (ZnONPs daun), 2,181 ± 0,167 (ekstrak daun), 2,945 ± 0,009 (ZnONPs buah), dan 4,017 ± 0,277 (ekstrak buah). ZnoNPs dilakuan pengujian morforlogi dengan metode SEM dan TEM serta pengujian ukuran partikel dengan hasil secara umum bahwa nanopartikel yang didapat memenuhi syarat sebagai sebuah nanopartikel dalam hal ukuran partikel, dengan ZnONPs daun secara umum memiliki ukuran partikel lebih kecil dari buah, meskipun secara morfologi pada umumnya berbentuk tidak beraturan.
Co-Authors Ahmad Fathoni Aliya Nur Hasanah ANDRIA AGUSTA Ardiansah, Bayu Fikriya, Sakti Hidayati Kurniawan, Felie Virgayani Laurentius Haryanto Laurentius Haryanto, Laurentius Lumantobing, Lukas Hotma Parulian Marissa Angelina Maryana, Rianti Merly, Siti Muhammad Ilyas Putria, Devi Kasih Ratna Handayani Saputra, Ziyan Saputri, Ariyanti Saputri, Yosephine Liliana Intan Danar Sofa Fajriah Yunarti, Rika Tri