Article Per Year (5 Year)
p-Index From 2020 - 2025
0.61
P-Index
This Author published in this journals
All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Medical Journal of Indonesia Biopropal Industri Jurnal Kimia Riset Jurnal Biologi Tropis ANNALES BOGORIENSES Narra J Makara Journal of Science
Marissa Angelina
Pusat Penelitian Kimia-LIPI, Kawasan PUSPIPTEK Serpong 15314, Tangerang 15314
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Public Health

Published : 12 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 12 Documents
Search

 1   2 
Characterization of Ethanol Extract from Katumpangan Air Herbs (Peperomia pellucida L. Kunth Angelina, Marissa; Amelia, Puteri; Irsyad, Muchammad; Meilawati, Lia; Hanafi, Muhammad
Biopropal Industri Vol 6, No 2 (2015)
Publisher : Balai Riset dan Standardisasi Industri Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (184.884 KB)

Abstract

Peperomia pellucida L. Kunth known as “Katumpangan Air” is a potential medicinal plants used traditionally for uric acid, rheumatic, headache, stomachache, antimicrobial. This study aims to establish  the non-specific  and specific parameters of ethanol extract from Katumpangan air (EKA). EKA was collected from three different growth places: South Tangerang (6.833%), Bogor (7.8%) and Yogyakarta (13.125%). The results show that organoleptic extract characterization from three places were same: thick, blackish green brown, bitter and have a characteristic odor. The average content of water-soluble compounds was within range 7.39-13.29%, ethanol-soluble 15.33-16.68%, flavonoid total 3.807-4.244%. The range of moisture content was 12.25-16.34%, ash total 1.21-2.78%, acid insoluble ash 0.19-1.62%, drying shrinkage 21.62-24.98%, specific gravity 1.0010-1.0034 g/mL for the non-specific parameter. Microbial contamination testing results 0.61x103-1.13x103 coloni/g, the contaminant testing mold/yeast 0.1x102-1.7x102 coloni/g, while lead metal 0.15-0.18 mg/kg, cadmium 0-0.11 mg/kg and arsenic <0.005µg/kg.
Isolation and Characterization of Compounds from the Leaves of Pterocarpus indicus Willd and Their Antioxidant Activity Hartati, Sri; Angelina, Marissa; Meilawati, Lia; Dewijanti, Indah Dwiatmi
ANNALES BOGORIENSES Vol 20, No 1 (2016): Annales Bogorienses
Publisher : Research Center for Biotechnology - Indonesian Institute of Sciences (LIPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (194.941 KB) | DOI: 10.14203/ab.v20i1.224

Abstract

The flavone glycoside was isolated from ethyl acetate fraction of ethanol extract of leaves Pterocarpus indicus Willd. The isolation was conducted by gravitation column chromatography and eluted successively with hexane, ethyl acetate and methanol by gradient, and purified by sephadex-LH20. The structure was elucidated base on spectroscopy data of NMR (1D and 2D), UV, LC-MS and FT-IR. Antioxidant was evaluated using 2,2-diphenyl-1-picrylhidrazyl (DPPH) radical scavenging. The isolation and identification led a stigmasterol as Compound 1 and a new flavonol-glycoside [(2R)-7-hydroxy-3-(3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-2-(3,4,5-trihydroxy phe nyl)chroman-4-one] or ptevon-3-D- glycoside as Compound 2. Antioxidant activity of Compound 2 showed IC50 for 18.53 mmol and blank of quercetin was 7.94 mmol and Vitamin C was 40.25 mmol. These compounds and antioxidant activities are the first time reported from this plant. 
Antiviral effect of Archidendron pauciflorum leaves extract to hepatitis C virus: An in vitro study in JFH-1 strain Hartati, Sri; Aoki, Chie; Hanafi, Muhammad; Angelina, Marissa; Soedarmono, Pratiwi; Hotta, Hak
Medical Journal of Indonesia Vol 27, No 1 (2018): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (497.399 KB) | DOI: 10.13181/mji.v27i1.2189

Abstract

Background: Hepatitis C virus (HCV) is a leading cause of chronic liver diseases. Drug resistance to the regimen is also increasing. Hence, there is a need for new anti-HCV agents that are less toxic and more efficacious. The aim of this study is to evaluate the  possibility of A. pauciflorum extracts can be a antiviral drug.Methods: Huh-7it cells were infected with the HCV genotype 2a strain JFH-I in the presence of methanol extracts of Archidenron pauciflorum. The methanol extract further partition used n-hexane, ethyl acetate, n-butanol, and water showed in which butanol extracts exerted the strongest IC50 (6.3 g/ml). Further, the butanol fraction was fractionated and yielded into 13 fractions.Results: The methanol extract of the leaves of A. pauciflorum exhibited concentration dependent inhibition against the JFH1 strain of HCV genotype 2a with an IC50 is 72.5 μg/ml. The butanol fraction exhibited the highest anti-HCV activity with an IC50 is 6.3 μg/ml. The butanol fraction was fractionated which yielded 13 fractions. Fractions 5 and 13 exhibited high anti-HCV activities with IC50 is 5.0 μg/ml and 8.5 μg/ml and a time-of-addition study demonstrated that fraction 5 inhibited viral infection at the post-entry step, whereas fraction 13 primarily inhibited the viral entry step.Conclusion: The extract A. pauciflorum can be used as a herbal-based antiviral drug.
Antiviral Effect of Pterocarpus indicus Willd Leaves Extract Against Replication of Dengue Virus (DENV) In Vitro Dewi, Beti Ernawati; Angelina, Marissa; meilawati, lia; Hartati, Sri; Dewijanti, Indah Dwiatmi; Santi, Mei Ria; Desti, Hidayati; Sudiro, Mirawati
Journal of Tropical Life Science Vol 8, No 1 (2018)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (886.48 KB) | DOI: 10.11594/jtls.08.01.10

Abstract

Dengue hemorrhagic fever (DHF) is major public health problem in tropical and subtropical areas of the world with lack of approved vaccines and effective antiviral therapies. With no current treatment for illness attributed to dengue virus (DENV) infection other than supportive care, therapeutic strategies that use natural extract was developed. Indonesia have many plants that potential for antiviral drµgs such as Pterocarpus indicus Willd (P. indicus). The objective of this study was to determine the effect of P. indicus to inhibit DENV replication. We used a well-differentiated hepatocytes-derived cellular carcinoma cell line (Huh-7 it-1 cells) to determine and select antiviral activity. The toxicity effects were determined by MTT assay. Then, the suppression of DENV replication was determined by Focus assay. Dengue infected cells with DMSO were used as control. We found that crude extract (Pi), hexane (Pi.1) and ethyl acetate (Pi.2) extract showed strong inhibition with high selectivity index (SI) of 1,392; 285.36 and 168.56 respectively.  Sub fraction of Pi.1 and Pi.2 still showed strong inhibition with high SI.  Further sub-sub fraction of Pi.2 such as Pi.2.12 and Pi.2.12.1 still showed inhibition of DENV replication but there was reduction of SI value. The mechanism experiment of Pi.2.12, we found that Pi 2.12 more profound to inhibit in the post infection stage that entry or pre-infection. We conclude that the sub-fraction of Pi.2.12 has potential antiviral activity against DV infection in vitro. Further studies are still needed to investigate the pure compound of Pi.2.12 that inhibit and have advantages in the future as alternative for treatment of DENV infection.
Toxicity and Lethality Evaluations of Koordersiodendron pinnatum Leaves Methanolic Extract in DDY Mice Banjarnahor, Sofna Dewita Sari; Dewijanti, Indah Dwiatmi; Angelina, Marissa; Fajriah, Sofa
Journal of Tropical Life Science Vol 6, No 3 (2016)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.06.03.10

Abstract

The study of toxic features of Koordersiodendron pinnatum is vital for further studies of its pharmacological activities. Acute toxicity test was done on methanolic extracts of K. pinnatum in DDY mice. Animals were grouped into five: Group 1 was given 1 mL solution of 2.5% Tween 80 in a single oral dose; the remaining groups were orally given a single dose of 2, 4, 8 and 16 g/kg of K. pinnatum, respectively. Toxic effects of the extract were evaluated on the basis of behavioral observations in the form of locomotor activity; curiosity; defecation; urination and also animal mortality. Observations were carried out for 14 days. No significant changes on body weight, and behavioural activities were recorded. Mortality was recorded up to 2% of the male group, and no mortality within the female group. The extract is practically non toxic for both male and female (LD50>15 g/kg).
Acute Toxicity Studies of Brucea javanica Merril Leaves Extract on Mice Angelina, Marissa; Dewijanti, Indah D; S, Banjarnahor S D; megawati, Megawati; Yuliani, Tri
Journal of Tropical Life Science Vol 2, No 2 (2012)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Isolation and Characterization Compounds From Hexane and Ethyl Acetate Fractions of Peperomia pellucida L. Hartati, Sri; Angelina, Marissa; Dewiyanti, Indah; Meilawati, Lia
Journal of Tropical Life Science Vol 5, No 3 (2015)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.05.03.02

Abstract

      Peperomia pellucida was used traditionally in Indonesia for health treatment: wounds, boils, pimples, abscesses, abdominal pain, colic, gout, kidney, rheumatic pain, fatigue headache, furuncles, conjunctivitis and anti dermatogenic and also for dengue treatment. The isolation compounds from hexane and ethyl acetate fractions of Peperomia pellucida L. are  conducted by maceration of the dry herbs sample with methanol and partition with hexane, ethyl acetate, butanol and water.The hexane and ethyl acetate fractions were fractionated by gravitation column chromatography and eluted successively with hexane, ethyl acetate and methanol by the gradient. The structure was elucidated base on spectroscopy data of NMR proton and carbon for one and two dimension, LC-MS and FT-IR. The isolation founded three compounds are stigmasterol, analogue of pheophytin and b-sitosterol-D-glucopyranoside.
Toxicological Evaluation of Tetrameles nudiflora Methanolic Extract Banjarnahor, Sofna Dewita Sari; Dewijanti, Indah D; Angelina, Marissa; Megawati, Megawati; Fajriah, Sofa
Journal of Tropical Life Science Vol 5, No 1 (2015)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Exploration of Mekongga national park resulted in novel finding of anticancer property from Tetrameles nudiflora. The investigation of toxic features of T. nudiflora is vital for further studies of its pharmacological activities. Acute toxicity test was done on methanolic extracts of T. nudiflora in DDY mice. Animals were divided into 5 groups: Group 1 was given 1 ml solution of 2.5% Tween 80 in a single oral dose; Group 2, 3, 4 and 5 were orally administrated a single dose of 1, 2, 4 and 8 g/kg body weight T. nudiflora, respectively. Toxic effects of the extract were evaluated on the basis of behavioral observations in the form of locomotor activity; curiosity; defecation; urination and also animal mortality. Observations were carried out for 14 days. No significant changes on body weight, and behavioural activities were recorded. Mortality was recorded up to 22% of the male group, and 11% within the female group. The T.nudiflora extracts tested for toxicity against brine shrimp had 50% lethal concentration (LC50) values of 46.67 μg/ml. It can be concluded that methanol extracts of T. nudiflora are potential to be explored as anticancer (LC50=46.67 μg/ml). The extract is slightly toxic in male mice with Lethal Dose 50 (LD50) 12.6 g/kg body weight, and practically non toxic for female (LD50>15 g/kg body weight).Key words : Tetrameles nudiflora, brine shrimp lethality test, acute oral toxicity, LD 50.
PENENTUAN LD50 DAUN CINCO (Cyclea barbata Miers.) PADA MENCIT Angelina, Marissa; Hartati, Sri; Dewijanti, Indah D; Banjarnahor, Sofna D.S.; Meilawati, Lia
Makara Journal of Science Vol. 12, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

LD50 of Cinco (Cyclea barbata Miers.) Leaf on Mice. The acute toxicity of ethanol extract of Cyclea barbata Miers. (Cb) leaves has been carried out on mice. The extract was administered by oral route in 4 different doses, i.e. 300 mg/kg BW, 1500 mg/kg BW, 3000 mg/kg BW, 30000 mg/kg BW. The toxic effect of the extract were evaluated by observation of behaviour, spinal reflexes, central nervous system, urination, and defecation, and also number of dead animal. The observation period lasted for 14 days. The results showed that up to 30000 mg/kg BW, the test material did not cause any significant toxic effects. The LD50 of the cyclea barbata Miers. leaves on mice was found to be more than 30000 mg/kg BW
PHYTOCHEMICAL PROFILES, ANTIOXIDANT, AND ANTICANCER ACTIVITIES FROM LEAVES AND SEEDS EXTRACT OF Myristica fragrans Saputri, Ariyanti; Fajriah, Sofa; Cahyana, Antonius Herry; Putria, Devi Kasih; Saputra, Ziyan; Angelina, Marissa
Jurnal Kimia Riset Vol. 9 No. 2 (2024): December
Publisher : Universitas Airlangga, Campus C Mulyorejo, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkr.v9i2.65245

Abstract

Nutmeg (Myristica fragrans) is a plant that grows naturally in Indonesia and widely used in the food and industrial sectors. Nutmeg seeds have been widely studied because they have a variety of compounds with good activities, but research on the leaves still needs to be completed. Therefore, this research compared nutmeg leaves and seed extracts' secondary metabolite content and bioactivity. This study aims to determine the phytochemical contents of nutmeg leaves and seed extracts by phytochemical screening and GC-MS analysis, as well as its potential as an antioxidant and anticancer. The antioxidant activity test uses the DPPH (1,1-diphenyl-2-picrylhydrazyl) method measured at a wavelength of 517 nm. Meanwhile, the anticancer activity test uses MCF-7 cells with the MTT assay method. Nine compounds (lipid, phenylpropanoid, lignan, terpenoid, and quinone groups) were identified by GC-MS analysis in the leaf extracts. Meanwhile, seed extract has 23 compounds from the lipid, fatty acid, phenylpropanoid, lignan, and terpenoid groups. The antioxidant activity of nutmeg leaves and seed extracts was carried out using the DPPH method, while the cytotoxic activity against MCF-7 cells used the MTT method. Nutmeg leaves have more potent antioxidant activity than nutmeg seeds, with IC50 values of 17.80 µg/mL and 53.01 µg/mL, respectively. The cytotoxic activity test on MCF-7 cells also showed that the inhibition value of nutmeg extract (26%) was higher than that of nutmeg seeds (22.73%). This research shows that nutmeg leaf extract has the potential to carry out further research regarding the bioactivity of its compounds.
Co-Authors . Megawati A.A. Ketut Agung Cahyawan W Agustiyanti, Dian F. Anak Agung Istri Sri Wiadnyani Antonius Herry Cahyana Aoki, Chie Beti Ernawati Dewi Desti, Hidayati Dewijanti, Indah Dwiatmi Dewijanti, Indah Dwiatmi Dwi Hilda Putri HAK HOTTA Indah D Dewijanti, Indah D Indah Dewiyanti, Indah Irdawati Irdawati Kamarisima, Kamarisima Lia Meilawati Megawati - Meitha, Karlia Mirawati Sudiro Muchammad Irsyad, Muchammad Ningrum, Ratih A. Nugroho, Herjuno A. Priharto, Neil Putria, Devi Kasih RAHMANI, SILMI S, Banjarnahor S D Santi, Mei Ria Saputra, Ziyan Saputri, Ariyanti Septiani, Popi Soedarmono, Pratiwi Sofa Fajriah Sofna D.S. Banjarnahor Sofna Dewita Sari Banjarnahor, Sofna Dewita Sari Sri Hartati Tan, Marselina I. Tri Yuliani, Tri Wisnuwardhani, Popi H. Zakri, Dwika Febriana