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Journal : Kinetik: Game Technology, Information System, Computer Network, Computing, Electronics, and Control

QSAR Study on Aromatic Disulfide Compounds as SARS-CoV Mpro Inhibitor Using Genetic Algorithm-Support Vector Machine Rizki Amanullah Hakim; Annisa Aditsania; Isman Kurniawan
Kinetik: Game Technology, Information System, Computer Network, Computing, Electronics, and Control Vol. 7, No. 2, May 2022
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/kinetik.v7i2.1428

Abstract

COVID-19 is a type of pneumonia caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). This virus causes severe acute respiratory syndrome and 2 million active cases of COVID-19 have been found worldwide. A new strain of the SARS-CoV-2 virus emerged that proved to be more virulent than its predecessor. Regarding the design of a new inhibitor for this strain, SARS-CoV Main Protease (Mpro) was used as the target inhibitor. In the in silico development, the Quantitative Structure-Activity Relationship (QSAR) method is commonly used to predict the biological activity of unknown compounds to improve the process of drug design of a disease, including COVID-19. In this study, we aim to develop a QSAR model to predict the activity of aromatic disulfide compounds as SARS-CoV Mpro inhibitors using Genetic Algorithm (GA) – Support Vector Machine (SVM). GA was used for feature selection, while SVM was used for model prediction. The used dataset is set of features of aromatic disulfide compounds, along with information on the toxicity activity. We found that the best SVM model was obtained through the implementation of the polynomial kernel with the value of R2­­train and R2test­ scores are 0.952 and 0.676, respectively.
Content-based Filtering Movie Recommender System Using Semantic Approach with Recurrent Neural Network Classification and SGD Salsabil, Adinda Arwa; Setiawan, Erwin Budi; Kurniawan, Isman
Kinetik: Game Technology, Information System, Computer Network, Computing, Electronics, and Control Vol. 9, No. 2, May 2024
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/kinetik.v9i2.1940

Abstract

The application of recommendation systems has been applied in various types of platforms, especially applications for watching movies such as Netflix and Disney+. The recommendation system is purposed to make it easier for users, especially in choosing a movie because currently the number of movie productions is increasing every day. This research proposed a CBF movie recommendation system by comparing the performance of several semantic methods to be able to get the best rating prediction results. In order to improve the performance quality to get the best rating prediction results, this research  utilized semantic feature methods by comparing the performance of the evaluation results produced by the TF-IDF method and word embedding applications, such as BERT, GPT-2, RoBERTa, and implemented RNN model to classify the results of rating prediction. The data were used to generate the recommendation system by involving 854 data movie and 39 accounts with a total of 34,056 movie reviews on Twitter. This research has succeeded in getting a method that produced rating predictions, namely RoBERTa. In the classification process with the RNN model and SGD optimization, the measurement results with confusion matrix by classifying the RoBERTA rating prediction obtained an evaluation value of 0.6514 loss, 95.59% accuracy, and 0.6514 precision.