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All Journal METAMORFOSA Journal of Biological Sciences Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan Natural Sciences Engineering and Technology Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Scientica: Jurnal Ilmiah Sains dan Teknologi
Desy Nawangsari
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Antibacterial Activity And Stability Test Of Bidara Leaf Extract Toothpaste (Ziziphus mauritiana Lam) Against The Growth Of Streptococcus Mutans desy nawangsari; Asa Dwi Oktavia; Galih Samodra
Metamorfosa: Journal of Biological Sciences Vol 10 No 2 (2023)
Publisher : Prodi Magister Ilmu Biologi, Fakultas MIPA, Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/metamorfosa.2023.v10.i02.p15

Abstract

Ekstrak daun bidara dengan konsentrasi 20% terbukti dapat menghambat pertumbuhan bakteri Streptococcus mutans dengan nilai hambat 12,00 mm. Kandungan senyawa dalam daun bidara meliputi alkaloid, flavonoid, tannin dan saponin. Tujuan penelitian ini yaitu mengetahui sifat fisik, stabilitas dan aktivitas antibakteri sediaan pasta gigi dengan perbedaan konsentrasi ekstrak daun bidara yaitu FI(15%), FII(20%) dan FIII(25%). Metode ekstraksi yang digunakan yaitu remaserasi dengan pelarut etanol 70%, sedangkan metode penghambatan aktivitas antibakteri menggunakan difusi sumuran. Hasil evaluasi sifat fisik parameter pH FI(7,4±0,1); FII(7,1±0,1) dan FIII(7,0±0,1), parameter viskositas FI(5.581,5±61,25); FII(5.801,9±9,60) dan FIII(6.000,7±8,01). Dari hasil uji Oneway anova perbedaan konsentrasi ekstrak berpengaruh signifikan terhadap parameter pH dan viskositas (p-value<0,05). Sedangkan nilai pembentukan busa adalah FI(7,4±0,1); FII(7,3±0,3) dan FIII(7±0,1), dari hasil uji Oneway anova perbedaan konsentrasi ekstrak tidak berpengaruh signifikan pada parameter pembentukan busa (p-value>0,05). Hasil stabilitas uji T-test perbedaan konsentrasi ekstrak pasta gigi stabil pada parameter pH, dan FI pada parameter pembentukan busa karena nilai sig.(2-tailed<0,05). Sedangkan perbedaan konsentrasi ekstrak pasta gigi tidak stabil pada parameter viskositas serta FII, FIII pada parameter pembentukan busa karena nilai sig.(2-tailed<0,05). Pengujian antibakteri sediaan pasta gigi ekstrak daun bidara semua formula dapat menghambat pertumbuhan bakteri Streptococcus mutans dengan zona hambat FI 4,39±0,45cm, FII 5,44±0,49cm dan FIII 8,38±0,28cm. Dari hasil tersebut dapat disimpulkan bahwa FIII merupakan formula yang paling baik dengan nilai zona hambat paling besar.
PROFIL DISOLUSI TABLET LEPAS LAMBAT KALIUM DIKLOFENAK MENGGUNAKAN PATI PREGELATINASI TALAS PRATAMA (Colocasia esculenta (L). Schott var. Pratama) Desy Nawangsari; Rani Prabandari; Ammanu Kurniadi
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 1 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i1.1493

Abstract

Starch is one of the commonly used excipients in tablet preparations. Natural starch has limitations in the form of poor flow rate and compressibility, so it is not suitable for use in the manufacture of tablets by direct compression. One source of plants that produce starch and has not been widely developed is (Colocasia esculenta (L). Schott var. Pratama). The purpose of this study was to modify (Colocasia esculenta (L). Schott var. Pratama) starch by gelatinization used in diclofenac potassium slow-release tablets. This research is a type of laboratory experimental research that begins with the isolation of starch from taro tubers, modification of starch by pregelatinization, manufacture of diclofenac potassium slow release tablet press mass, evaluation of physical properties and finished tablet dissolution tests. The results of the printing mass test showed that the use of (Colocasia esculenta (L). Schott var. Pratama) pregelatinated starch matrix had good flowability. The results of the tablet test showed that the average tablet weight was 209 ± 3.40 mg, the diameter and thickness were 7.69 ± 0.02 and 2.82 ± 0.01 mm respectively, the hardness was 7.00 ± 0.35 kg, the friability was 0. 73 ± 0.27 % and disintegration time 65.33 ± 2.52 minutes and the dissolution results showed that within 8 hours the potassium diclofenac sustained release tablet dissolved 60.20%. Based on the physical properties and dissolution tests performed, it can be concluded that the use of pregelatinated modified starch as a matrix in diclofenac potassium slow-release tablets fulfills the specified test parameters.
Evaluation of the Moisturizing Efficacy and Stability of an Essence Sheet Mask Formulated with Red Dragon Fruit (Hylocereus polyrhizus) Peel Extract Al Mu’izzah, Nurul; Desy Nawangsari; Adita Silvia Fitriana
Natural Sciences Engineering and Technology Journal Vol. 4 No. 2 (2024): Natural Sciences Engineering and Technology Journal
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/nasetjournal.v4i2.55

Abstract

The pursuit of effective and natural skincare solutions has led to the exploration of plant-based ingredients. Red dragon fruit (Hylocereus polyrhizus) peel, rich in flavonoids and antioxidants, presents a promising avenue for developing moisturizing skincare products. This study aimed to evaluate the moisturizing efficacy and stability of an essence sheet mask formulated with red dragon fruit peel extract. Red dragon fruit peel extract was obtained using ethanol extraction. Essence sheet masks were formulated with varying concentrations of the extract (0%, 3%, 5%, and 7%). The physical properties (organoleptic characteristics, pH, viscosity, and homogeneity), stability (cycling test), skin irritation potential (patch test), and moisturizing efficacy (corneometer measurements) of the sheet masks were assessed. The hedonic attributes of the masks were also evaluated through a consumer perception study. The formulated essence sheet masks exhibited desirable physical properties and were stable under accelerated storage conditions. No skin irritation was observed in the patch test. The sheet masks containing red dragon fruit peel extract demonstrated a significant increase in skin hydration compared to the control group. The consumer perception study indicated high acceptance of the masks, particularly those with higher extract concentrations. The findings suggest that red dragon fruit peel extract can be effectively incorporated into essence sheet masks to enhance skin hydration. The developed sheet masks were well-tolerated and exhibited good stability, making them promising candidates for natural moisturizing skincare products.
FORMULASI GEL EKSTRAK DAUN KAMBOJA PUTIH (Plumeria acuminata W.T.Ait) TERHADAP PENGHAMBATAN Staphylococcus aureus DENGAN PERBANDINGAN KARBOPOL 940 DAN HPMC Anisa Rakhma Diantri; Desy Nawangsari; Galih Samodra
Scientica: Jurnal Ilmiah Sains dan Teknologi Vol. 2 No. 4 (2024): Scientica: Jurnal Ilmiah Sains dan Teknologi
Publisher : Komunitas Menulis dan Meneliti (Kolibi)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Daun kamboja putih (Plumeria acuminata W.T.Ait) merupakan salah satu tanaman yang memiliki kandungan flavonoid, tanin, dan saponin yang berpotensi sebagai antibakteri. Metode penelitian ini bersifat eksperimental yang terdiri dari pembuatan simplisia dan pembuatan ekstrak dengan menggunakan metode maserasi dengan pelarut etanol 96%. Penelitian ini bertujuan mengetahui aktivitas antibakteri dengan perbandingan yang tepat antara basis gel karbopol 940 dan HPMC terhadap stabilitas sifat fisik gel ekstrak daun kamboja putih (Plumeria acuminata W.T.Ait). Gel dibuat tiga formulasi dengan perbandingan karbopol dan HPMC yaitu FI (1:2), FII (1:1) dan FIII (2:1). Hasil uji sediaan gel memberikan pengaruh signifikan terhadap karakteristik fisik dilihat dari parameter pH (4,8- 5,0), viskositas (16.103-16.135 cPs), daya lekat (4,3-6,4 detik) dan daya sebar (5,2-6,0 cm) yang ditandai dengan nilai p value<0,05 namun tidak memberikan pengaruh pada homogenitas. Pengujian stabilitas pada semua parameter uji sifat fisik dengan paired sample t test yang dilakukan selama 6 siklus didapatkan hasil yaitu FIII merupakan sediaan gel yang paling stabil dengan nilai Sig.(2-tailed)>0,05 kecuali pada uji daya sebar. Berdasarkan uji aktivitas antibakteri FIII memiliki aktivitas antibakteri terbaik yaitu 5,82mm. Maka dapat disimpulkan bahwa gel ekstrak daun kamboja putih stabil dalam penyimpanan.
Characterization of Pregelatinized, Pentanol and Acetylated Modified Primary Starch Desy Nawangsari; Rani Prabandari; Dina Febrina
Viva Medika Vol 17 No 1 (2024)
Publisher : Universitas Harapan Bangsa Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35960/vm.v17i1.1354

Abstract

Tablets are pharmaceutical preparations consisting of active ingredients and excipients. One of the commonly used excipients is starch. (Colocasia esculenta (L). Schott var, Pratama) is a plant that contains a high source of starch. The use of natural starch in tablets has limitations in the form of less fast flow and poor compressibility. The purpose of this study was to modify natural starch by pregelatinization, pentanol and acetylation. This research was conducted using laboratory experimental methods, starting with sorting the starch tubers of (Colocasia esculenta (L). Schott var, Pratama), starch isolation, modification and characterization of the resulting starch. The characterization results showed that the flow rate of natural starch, pregelatinized, pentanol and acetylated sequentially was 1.9 ± 0.19; 2.15 ± 0.37; 1.35 ± 0.15; and 1.95 ± 0.14 g/s with an angle of repose of 20.49 ± 1.99; 17.12 ± 1.99; 22.92 ± 1.18 and 20.06 ± 1.97°, while the compressibility value is 20.23 ± 5.31; 15.47 ± 3.03; 21, 09 ± 2.8 and 19.09 ± 2.05%.
Co-Authors Adita Silvia Fitriana Al Mu’izzah, Nurul Ammanu Kurniadi Anisa Rakhma Diantri Asa Dwi Oktavia Dina Febrina Galih Samodra Rani Prabandari