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All Journal Natural Sciences Engineering and Technology Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Scientica: Jurnal Ilmiah Sains dan Teknologi
Desy Nawangsari
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PROFIL DISOLUSI TABLET LEPAS LAMBAT KALIUM DIKLOFENAK MENGGUNAKAN PATI PREGELATINASI TALAS PRATAMA (Colocasia esculenta (L). Schott var. Pratama) Desy Nawangsari; Rani Prabandari; Ammanu Kurniadi
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 1 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i1.1493

Abstract

Starch is one of the commonly used excipients in tablet preparations. Natural starch has limitations in the form of poor flow rate and compressibility, so it is not suitable for use in the manufacture of tablets by direct compression. One source of plants that produce starch and has not been widely developed is (Colocasia esculenta (L). Schott var. Pratama). The purpose of this study was to modify (Colocasia esculenta (L). Schott var. Pratama) starch by gelatinization used in diclofenac potassium slow-release tablets. This research is a type of laboratory experimental research that begins with the isolation of starch from taro tubers, modification of starch by pregelatinization, manufacture of diclofenac potassium slow release tablet press mass, evaluation of physical properties and finished tablet dissolution tests. The results of the printing mass test showed that the use of (Colocasia esculenta (L). Schott var. Pratama) pregelatinated starch matrix had good flowability. The results of the tablet test showed that the average tablet weight was 209 ± 3.40 mg, the diameter and thickness were 7.69 ± 0.02 and 2.82 ± 0.01 mm respectively, the hardness was 7.00 ± 0.35 kg, the friability was 0. 73 ± 0.27 % and disintegration time 65.33 ± 2.52 minutes and the dissolution results showed that within 8 hours the potassium diclofenac sustained release tablet dissolved 60.20%. Based on the physical properties and dissolution tests performed, it can be concluded that the use of pregelatinated modified starch as a matrix in diclofenac potassium slow-release tablets fulfills the specified test parameters.
Evaluation of the Moisturizing Efficacy and Stability of an Essence Sheet Mask Formulated with Red Dragon Fruit (Hylocereus polyrhizus) Peel Extract Al Mu’izzah, Nurul; Desy Nawangsari; Adita Silvia Fitriana
Natural Sciences Engineering and Technology Journal Vol. 4 No. 2 (2024): Natural Sciences Engineering and Technology Journal
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/nasetjournal.v4i2.55

Abstract

The pursuit of effective and natural skincare solutions has led to the exploration of plant-based ingredients. Red dragon fruit (Hylocereus polyrhizus) peel, rich in flavonoids and antioxidants, presents a promising avenue for developing moisturizing skincare products. This study aimed to evaluate the moisturizing efficacy and stability of an essence sheet mask formulated with red dragon fruit peel extract. Red dragon fruit peel extract was obtained using ethanol extraction. Essence sheet masks were formulated with varying concentrations of the extract (0%, 3%, 5%, and 7%). The physical properties (organoleptic characteristics, pH, viscosity, and homogeneity), stability (cycling test), skin irritation potential (patch test), and moisturizing efficacy (corneometer measurements) of the sheet masks were assessed. The hedonic attributes of the masks were also evaluated through a consumer perception study. The formulated essence sheet masks exhibited desirable physical properties and were stable under accelerated storage conditions. No skin irritation was observed in the patch test. The sheet masks containing red dragon fruit peel extract demonstrated a significant increase in skin hydration compared to the control group. The consumer perception study indicated high acceptance of the masks, particularly those with higher extract concentrations. The findings suggest that red dragon fruit peel extract can be effectively incorporated into essence sheet masks to enhance skin hydration. The developed sheet masks were well-tolerated and exhibited good stability, making them promising candidates for natural moisturizing skincare products.
FORMULASI GEL EKSTRAK DAUN KAMBOJA PUTIH (Plumeria acuminata W.T.Ait) TERHADAP PENGHAMBATAN Staphylococcus aureus DENGAN PERBANDINGAN KARBOPOL 940 DAN HPMC Anisa Rakhma Diantri; Desy Nawangsari; Galih Samodra
Scientica: Jurnal Ilmiah Sains dan Teknologi Vol. 2 No. 4 (2024): Scientica: Jurnal Ilmiah Sains dan Teknologi
Publisher : Komunitas Menulis dan Meneliti (Kolibi)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Daun kamboja putih (Plumeria acuminata W.T.Ait) merupakan salah satu tanaman yang memiliki kandungan flavonoid, tanin, dan saponin yang berpotensi sebagai antibakteri. Metode penelitian ini bersifat eksperimental yang terdiri dari pembuatan simplisia dan pembuatan ekstrak dengan menggunakan metode maserasi dengan pelarut etanol 96%. Penelitian ini bertujuan mengetahui aktivitas antibakteri dengan perbandingan yang tepat antara basis gel karbopol 940 dan HPMC terhadap stabilitas sifat fisik gel ekstrak daun kamboja putih (Plumeria acuminata W.T.Ait). Gel dibuat tiga formulasi dengan perbandingan karbopol dan HPMC yaitu FI (1:2), FII (1:1) dan FIII (2:1). Hasil uji sediaan gel memberikan pengaruh signifikan terhadap karakteristik fisik dilihat dari parameter pH (4,8- 5,0), viskositas (16.103-16.135 cPs), daya lekat (4,3-6,4 detik) dan daya sebar (5,2-6,0 cm) yang ditandai dengan nilai p value<0,05 namun tidak memberikan pengaruh pada homogenitas. Pengujian stabilitas pada semua parameter uji sifat fisik dengan paired sample t test yang dilakukan selama 6 siklus didapatkan hasil yaitu FIII merupakan sediaan gel yang paling stabil dengan nilai Sig.(2-tailed)>0,05 kecuali pada uji daya sebar. Berdasarkan uji aktivitas antibakteri FIII memiliki aktivitas antibakteri terbaik yaitu 5,82mm. Maka dapat disimpulkan bahwa gel ekstrak daun kamboja putih stabil dalam penyimpanan.
Co-Authors Adita Silvia Fitriana Al Mu’izzah, Nurul Ammanu Kurniadi Anisa Rakhma Diantri Asa Dwi Oktavia Galih Samodra Rani Prabandari