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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Jurnal Kedokteran Syiah Kuala Herb-Medicine Journal MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan
Diah Hermayanti
University Of Muhammadiyah Malang
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The Relationship Between Neutrophil-Lymphocyte Ratio (NLR), C-Reactive Protein (CRP), Interleukin 6 (IL-6), and D-Dimer Levels on the Severity of Covid-19 Patients at RSU Muhammadiyah University of Malang Diah Hermayanti; Thahri Iskandar; Djoni Djunaedi; Silvana Gadis Ardhistix’s; Maulana Faishol Charisma M; Fajrul Falah; Muhammad Samir
Saintika Medika : Jurnal Ilmu Kesehatan dan Kedokteran Keluarga Vol. 19 No. 2 (2023): December 2023
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol19.SMUMM2.33202

Abstract

Background: COVID-19 virus infection has the potential to become severe in individuals who are susceptible or who have comorbid diseases. Natural immunity status in infected sufferers can cause an increase in the number of neutrophil cells and a decrease in the number of lymphocyte cells (increased neutrophil-lymphocyte ratio), serum inter-leukin-6 (IL-6), C-reactive protein (CRP) levels which are associated with severity. covid-19. Hypercoagulability that occurs in COVID-19 infection causes an increase in D-dimer levels, reflecting a response to prothrombotic phenomena and is associated with an increased risk of mortality in COVID-19 patients. Objective: To determine the relationship between Neutrophil-lymphocyte ratio (NLR), C-reactive protein (CRP), Interleukin-6 (IL-6), and D-dimer levels on the severity of Covid-19 patients at Muhammadiyah Malang University (UMM) Hospital Method: Using a retrospective design by taking a total sampling of medical record data for COVID-19 patients treated at UMM Hospital in 2021-2022. Results and Discussion: Spearman correlation on NLR 0.426 (p=0.000), OR=3.67, 95% CI=1.622-8.226, CRP 0.343 (p=0.000) with OR 5.143, 95%CI=1.128-23.448, D- Dimer 0.326 (p=0.000), OR 2.497, 95% CI=1.142-5.458. Meanwhile, the correlation and IL-6 estimation values could not be calculated because the sample size was insufficient. CRP levels in COVID-19 patients are the best predictor of worsening compared to other parameters. Conclusion: NLR values, CRP levels, and D-Dimer levels are related to the degree of severity in COVID-19 patients.
The Anti-Allergic And Anti-Inflammatory Effect Of Fingerroot (Boesenbergia Rotunda) Rhizome Extract In Male White Wistar Rats Induced By Ovalbumin Diah Hermayanti; Hawin Nurdiana; Alifia Salsabila Teka; Vania Nabila Putri; Yosiene Dhea Elfita
Saintika Medika : Jurnal Ilmu Kesehatan dan Kedokteran Keluarga Vol. 21 No. 1 (2025): June 2025
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol21.SMUMM1.41001

Abstract

Background: Type 1 hypersensitivity reactions are characterized by IgE elevation, cytokine release, and eosinophil recruitment leading to airway inflammation. Fingerroot rhizomes (Boesenbergia rotunda) contain flavonoids such as panduratin A with potential anti-allergic and anti-inflammatory properties.Aim: To evaluate the effect of Boesenbergia rotunda rhizome extract (BRE) on IgE, TNF-α, eosinophil counts, tissue necrosis, and alveolar cell proliferation in ovalbumin (OVA)-induced Wistar rats.Methods: Twenty-five male rats were divided into five groups: negative control, positive control, and three BRE treatment groups (350, 700, 1400 mg/kg BW). OVA was administered intraperitoneally (days 0, 7, 14) and via inhalation (days 19–22). BRE was given orally from days 15–22. IgE and TNF-α were measured by ELISA, while lung histology was assessed for eosinophils, necrosis, and alveolar proliferation.Results: BRE significantly reduced eosinophil counts, necrosis, and alveolar proliferation compared with the positive control (p < 0.05). The highest dose (1400 mg/kg) showed effects similar to the negative control. IgE and TNF-α changes were less consistent.Conclusion: BRE exhibits anti-allergic and anti-inflammatory activity in OVA-induced rats, mainly by reducing eosinophilic infiltration and lung tissue damage. It shows promise as a natural therapeutic candidate, meriting further safety and clinical studies.
Co-Authors AA Sudharmawan, AA Alifia Salsabila Teka Antia Devi Iralawati Arina Nuril Fauziyah Devi Iralawati, Antia Djoni Djunaedi Erlin Nursiloningrum erwien isparnadi erwien isparnadi Fajrul Falah Fatah Jati Pamungkas Fatah Jati Pamungkas Fathiyah S Fathiyah Safithri Fathiyah Syafitri Fauziyah, Arina Nuril Fujaya, Muhammad Yasirto Gita Sekar Prihanti Hawin Nurdiana Ifada, Rifatul Jessica Alda Latifa Octadiani Putri Maulana Faishol Charisma M Muhammad Samir Nursiloningrum, Erlin Octadiani Putri, Latifa Refa Maulana Azhar Rifatul Ifada S, Fathiyah Silvana Gadis Ardhistix’s Syafitri, Fathiyah Thahri Iskandar Thontowi Djauhari Vania Nabila Putri Wahyu Setiawan Yosiene Dhea Elfita Yoyok Subagio Yuliono Trika Nur Hasan