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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Jurnal Kedokteran Syiah Kuala Herb-Medicine Journal MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan
Diah Hermayanti
University Of Muhammadiyah Malang
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The Relationship Between Neutrophil-Lymphocyte Ratio (NLR), C-Reactive Protein (CRP), Interleukin 6 (IL-6), and D-Dimer Levels on the Severity of Covid-19 Patients at RSU Muhammadiyah University of Malang Hermayanti, Diah; Thahri Iskandar; Djoni Djunaedi; Silvana Gadis Ardhistix’s; Maulana Faishol Charisma M; Fajrul Falah; Muhammad Samir
Saintika Medika Vol. 19 No. 2 (2023): December 2023
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol19.SMUMM2.33202

Abstract

Background: COVID-19 virus infection has the potential to become severe in individuals who are susceptible or who have comorbid diseases. Natural immunity status in infected sufferers can cause an increase in the number of neutrophil cells and a decrease in the number of lymphocyte cells (increased neutrophil-lymphocyte ratio), serum inter-leukin-6 (IL-6), C-reactive protein (CRP) levels which are associated with severity. covid-19. Hypercoagulability that occurs in COVID-19 infection causes an increase in D-dimer levels, reflecting a response to prothrombotic phenomena and is associated with an increased risk of mortality in COVID-19 patients. Objective: To determine the relationship between Neutrophil-lymphocyte ratio (NLR), C-reactive protein (CRP), Interleukin-6 (IL-6), and D-dimer levels on the severity of Covid-19 patients at Muhammadiyah Malang University (UMM) Hospital Method: Using a retrospective design by taking a total sampling of medical record data for COVID-19 patients treated at UMM Hospital in 2021-2022. Results and Discussion: Spearman correlation on NLR 0.426 (p=0.000), OR=3.67, 95% CI=1.622-8.226, CRP 0.343 (p=0.000) with OR 5.143, 95%CI=1.128-23.448, D- Dimer 0.326 (p=0.000), OR 2.497, 95% CI=1.142-5.458. Meanwhile, the correlation and IL-6 estimation values could not be calculated because the sample size was insufficient. CRP levels in COVID-19 patients are the best predictor of worsening compared to other parameters. Conclusion: NLR values, CRP levels, and D-Dimer levels are related to the degree of severity in COVID-19 patients.
Differences in Complete Blood Results and Nutritional Status of Patients with Cleft Lip and Palate at the CLP Center in University of Muhammadiyah Malang from 2020 to 2022 Asparini, Ruby Riana; Feby Alfina Damayanti; Kusuma Andriana; Diah Hermayanti
Saintika Medika : Jurnal Ilmu Kesehatan dan Kedokteran Keluarga Vol. 21 No. 2 (2025): December 2025
Publisher : Universitas Muhammadiyah Malang

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Abstract

Background: Patients with Cleft Lip (CL) and Cleft Lip and Palate (CLP) have difficulties with eating and breastfeeding, which makes them more susceptible to malnutrition (measured using the z-score parameter) and infections. CLP is caused by inappropriate levator palatini muscles and velopharyngeal insufficiency, which can lead to infection, inflammation, and allergies that can affect the immune system. The immune system responds to these components with leukocytes, particularly neutrophils, eosinophils, and lymphocytes. Objective: To determine the difference in complete blood results and nutritional status between cleft lip and cleft palate at the CLP Centre Faculty of Medicine, University of Muhammadiyah Malang in 2020-2022. Methods: The research was conducted at the CLP Centre FK UMM using observational methods with a total sample size. Results: The study found that males had a higher prevalence of CL and CLP. The most common z-score for patients with CL and CLP was below average for those under 24 months old, and above average for those over 35 months old. Extremely low z-scores were more common in CLP patients aged between 24 and 35 months. Patients with CL and CLP were less likely to have anemia, and there was no correlation between the z-score and anemia. Patients below 2 years old with CL and CLP had normal white blood cell counts, while those over 2 years old had higher levels of white blood cells, mainly neutrophils and lymphocytes. Eosinophilia, a condition with high levels of eosinophils, occurred only in patients with CL. Only lymphocytes showed statistically significant hematological values, with a p-value of 0.021 (p<0.05). Conclusion: It has been found that patients with CL and CLP have a statistically significant difference in their lymphocyte cells. Most cases of nutritional status issues occur in children younger than 24 months with a normal z-score. In contrast, children aged 24-35 months with an inadequate z-score are more likely to have nutritional issues in cases of CLP.
Co-Authors AA Sudharmawan, AA Antia Devi Iralawati Arina Nuril Fauziyah Devi Iralawati, Antia Djoni Djunaedi Erlin Nursiloningrum erwien isparnadi erwien isparnadi Fajrul Falah Fatah Jati Pamungkas Fatah Jati Pamungkas Fathiyah S Fathiyah Safithri Fathiyah Syafitri Fauziyah, Arina Nuril Feby Alfina Damayanti Fujaya, Muhammad Yasirto Gita Sekar Prihanti Hawin Nurdiana Ifada, Rifatul Jessica Alda Kusuma Andriana Latifa Octadiani Putri Maulana Faishol Charisma M Muhammad Samir Nursiloningrum, Erlin Octadiani Putri, Latifa Refa Maulana Azhar Rifatul Ifada Ruby Riana Asparini S, Fathiyah Silvana Gadis Ardhistix’s Syafitri, Fathiyah Thahri Iskandar Thontowi Djauhari Wahyu Setiawan Yoyok Subagio Yuliono Trika Nur Hasan