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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Jurnal Ilmu Kesehatan JURNAL KEPERAWATAN
Widjiati Widjiati
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Health Professions Medicine & Pharmacology Nursing Public Health

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Mozart Music Increases The Number Of Glial Cells Compared To Indonesia Pop And Religious Music Pipit Sri Estuning Rahayu; Hermanto Hermanto; Widjiati Widjiati
Saintika Medika Vol. 15 No. 2 (2019): December 2019
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol15.SMUMM2.10265

Abstract

Music stimulation is an important component for prenatal fetal development. Both pop and religious music are easy to listen and widely accepted in Indonesia. This study was to analyze the effect of Mozart, pop, and religious music exposure during pregnancy to the number of glial cells in the brain of Rattus norvegicus offspring. The samples were divided into three groups based on the exposure for each group, namely Mozart, pop, and religious music, duration of 60 minutes with 65dB intensity, initiated on the 10th day of pregnancy for 9 days in the soundproof chamber. Three brains of the offsprings were dissected and prepared for Hematoxylin-Eosin staining counted on 5 fields of view and 400 magnification strength.Different glial cells number of Rattus norvegicus brain between groups were observed. Mozart music (28,29) showed a highest mean and pop music (18,67)  showed the lowest mean. Significant difference of the number of brain glial cells between Mozart music compared to pop and religious music groups were observed, with p value <0,005.The number of brain glial cells of Rattus norvegicus offsprings in the Mozart group were significantly higher than those in pop and religious groups.
- Musik Mozart Memiliki Ekspresi Brain Deriverd Neurotrophic Factor Tertinggi Pada Serebrum dan Serebellum Rattus norvegicus Dibandingkan Dengan Gamelan Jawa, Sunda Dan Bali Selama Kehamilan Virki Widoyanti; Hermanto Tri J; Widjiati Widjiati
coba Vol 8 No 2 (2020): Mei 2020
Publisher : Akademi Keperawatan Dharma Husada Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (251.414 KB) | DOI: 10.32831/jik.v8i2.243

Abstract

Introduction: Music can affect the parasympathetic nervous system or the automatic nervous system, both directly and indirectly. The exposure of Mozart's music, Javanese, Sundanese and Balinese gamelan influences neurotropic factors in the brain. Methods: This study was an experimental laboratory with a random post-test design only in the design of the control group used by Rattus norvegicus as a model. Results: There were significant differences in brain deriverd neurotrophic factor expressions in Rattus norvegicus children between groups with p = 0.018 (mean 1.60 ± 0.42 for the control group, 4.00 ± 1.85 for the mozart music group, 3.00 ± 0.96 for Javanese gamelan groups, 2.48 ± 0.68 Sundanese Gamelan groups, and 2.16 ± 1.27 in Balinese Gamelan groups) also in the cerebellum with p = 0.022 (average 1, 44 ± 0 , 29 for the control group, 3.92 ± 1.81 for the Mozart event, 3.04 ± 0.94 Javanese gamelan groups, 2.92 ± 0, 41 Sundanese gamelan groups, and 2.57 ± 1,053 Balinese gamelan groups). Discussion: There are differences in the expression of brain derived neurotrophic factors in the cerebrum and Rattus norvegicus cerebellum between those exposed to Mozart music, Javanese, Sundanese, Balinese gamelan and control.. Key words : Mozart, Javanese Gamelan, Sundanese Gamelan, Balinese Gamelan, Brain Deriverd Neurotrophic Factor
Pengaruh frekuensi paparan stresor cahaya saat kebuntingan terhadap jumlah dendrit dan ekspreis mTorc1 otak mencit (Mus musculus) baru lahir Dwi Puji Wijayanti; Hermanto Tri Joewono; Widjiati Widjiati
Jurnal Keperawatan Vol 17 No 1 (2019): Jurnal Keperawatan Volume 17 No 1
Publisher : STIKES Insan Cendekia Medika Jombang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35874/jkp.v17i1.471

Abstract

Latar Belakang : Pada stres prenatal akan memicu peningkatan kadar CRH dan kortisol maternal. ini akan meningkatkan jumlah CRH dan kortisol pada janin dan menurunkan ekspresi 11β-HSD2 di plasenta. Meningkatnya kadar CRH akan meningkatkan aktifitas glukokortikoid yang akan menurunkan Growth Factors,juga akan mempengaruhi ekspresimTORC1 sebagai mekanisme pertahanan sel. GH, dan IGF-1 sedangkan menurunnya ekspresi 11β-HSD2 pada akhirnya akan menyebabkan perkembangan organ yang tak seimbang. Tujuan.Untuk mengetahui pengaruh frekuensi paparan stresor cahaya selama kebuntingan terhadap jumlah dendrit dan ekspresi mTORC1 anak mencit (Mus musculus). Metode : Penelitian ini merupakan penelitian eksperimen dengan post test only group design. Jumlah dendrit diukur dengan Golgy Cox hasil rerata jumlah dendrit dalam 5x lapangan pandang. Ekspresi mTORC1diukur dengan indeks skala Remelle . Analisis data menggunakan uji Post Hoc dengan tingkat kemaknaan 95% (0,05). Hasil : Hasil penelitian menunjukkan adanya perbedaan rerata jumlahdendrit yang signifikan antara kelompok kontrol (22.30) dan kelompok perlakuan 2 (7.55 ) lebih rendah. Hal yang serupa juga didapatkan padaekspresimTORC1. Terdapat perbedaan yang berarti padaekspresimTORC1. kelompok kontrol (1.14) dan kelompok perlakuan 2 (4.28) lebih tinggi. Selain itu, didapatkan juga hubungan (p < 0,05) antara jumlah sel dendrit danekspresimTORC1 otak anak mencit baru lahir dengan menggunakan korelasiPearson. Hasil uji korelasi Pearson didapatkan nilai signifikansi 0,068 dengan p < 0,05 dan nilai korelasi 0,338 dengan arah korelasi negative Kesimpulan : Jumlah dendrit pada kelompok perlakuan1 dan 2 lebih rendah dibandingkan kelompok kontrol, sedangkan ekspresi mTORC1 pada kelompok perlakuan1 dan 2 lebih tinggi dibandingkan kelompok kontrol.
Co-Authors Dwi Puji Wijayanti Fedik Abdul Rantam Hermanto Hermanto Hermanto Tri J Hermanto Tri Joewono Ika WAHYUNI Pipit Sri Estuning Rahayu Pudji Srianto Sri Pantja Madyawati Suherni Susilowati Virki Widoyanti Viski Fitri Hendrawan