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All Journal The Journal of Experimental Life Sciences (JELS) AL KAUNIYAH El-Hayah : Jurnal Biologi El-QUDWAH Prosiding Seminar Biologi Jurnal Biodjati Scripta Biologica Berkala Penelitian Hayati
Evika Sandi Savitri
UNIVERSITAS ISLAM NEGERI MAULANA MALIK IBRAHIM MALANG
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Education Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience

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Uji Antifungi Ramuan Tradisonal Madura “Subur Kandungan” Savitri, Evika Sandi
Al-Kauniyah: Jurnal Biologi Vol 8, No 1 (2015): Al-Kauniyah Jurnal Biologi
Publisher : Department of Biology, Faculty of Science and Technology, Syarif Hidayatullah State Islami

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (318.149 KB) | DOI: 10.15408/kauniyah.v8i1.2698

Abstract

Jamu herb Madura "Kandungan Subur" for women's reproductive health widely consumed to overcome the problem of reproduction. Some species are used traditional ingredients "Lush content" is Curcuma longa, Curcuma zedoria, Centella asiatica, Foeniculi dulcis; there has been no scientific studies and standardization adequate to ensure the safety and usefulness. To answer these problems, need to be screened early stage potential medicinal plants used in herbal Madura is an analysis of potential medicinal plants such as antifungal and phytochemical content contained. The extraction of active compounds with maceration, test active phytochemical compounds with the test reagents. Antifungal test includes a minimum inhibitory concentration and minimum killing concentration. Compounds contained in the herb "Fertile Content" are flavonoids and alkaloids.  Ethanol extract of 70% and 100% can inhibit the growth of fungi at a concentration of 1%.
Protein Expression of Soybean (Glycine Max L. Merr) Varieties In Drought Stress Savitri, Evika Sandi; Arumingtyas, Estri Laras
El-Hayah : Jurnal Biologi Vol 6, No 2 (2017): EL-HAYAH (VOL 6, NO 2,March 2017)
Publisher : Department of Biology Science and Technology Faculty UIN Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/elha.v6i2.4822

Abstract

Drought is one of the most severe limitations on the productivity of soybean. There are many genes and proteins involved in drought stress tolerance.  Identification of proteins which could be used as the base for the development of molecular study is very important to understand drought tolerance thoroughly. The objective of the research was to investigate protein expression of soybean to drought stress. Changes in protein expression were analyzed using SDS PAGE and two dimensional gel electrophoresis. Image analysis of 2D protein was performed by using the PDQuest 8.0 software program (Bio-Rad). Tolerant variety, Dering-1, was subjected to drought stress using limitation of watering, while Detam-1, a sensitive variety, was used as comparator.  The result showed that protein concentration have decreased in drought condition from 3,22 mg/ml to 0,77 mg/ml. The new protein band with the 24,95 kDa have been found in drought condition. This protein is osmotin like protein with the accession number NP915414 which may play a role in the mechanism of drought resistance. The identification of the protein based on sequence amino acid literature review
PENGUJIAN IN VITRO BEBERAPA VARIETAS KEDELAI (Glycine max L. Merr) TOLERAN KEKERINGAN MENGGUNAKAN Polyethylene Glikol (PEG) 6000 PADA MEDIA PADAT DAN CAIR Savitri, Evika Sandi
El-Hayah : Jurnal Biologi Vol 1, No 2 (2010): EL-HAYAH (VOL 1, NO 2, Maret 2010)
Publisher : Department of Biology Science and Technology Faculty UIN Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/elha.v1i2.1687

Abstract

Kondisi stres kekeringan secara in vitro dapat disimulasi dengan menurunkan potensial air media, yaitu dengan penambahan PEG (polietilena glikol). Penapisan secara in vitro dilakukan dengan memanfaatkan komponen penyeleksi yang dapat mensimulasikan cekaman lingkungan. Pada penapisan in vitro, penambahan komponen seleksi harus dipilih, sehingga pada konsentrasi yang tepat dapat mengelompokkan verietas kedelai yang peka, moderat dan toleran. Salah satu respon tanaman terhadap cekaman kekeringan yaitu terjadi perkecambahan yang abnormal. Tujuan penelitian ini ialah untuk mengetahui respon perkecambahan varietas kedelai yang ditanam pada media in vitro dengan penambahan PEG 6000 dan untuk mengetahui konsentrasi PEG yang mampu menyeleksi varietas kedelai peka dan toleran kekeringan pada media padat dan media cair.Penelitian ini terdiri dari 2 tahap yang pertama pengujian pada media padat, menggunakan  Rancangan Acak Lengkap (RAL) 2 faktor.  Faktor pertama adalah konsentrasi PEG 6000 yang terdiri dari 4 taraf perlakuan (0 gr/l; 20 gr/l; 40 gr/l dan 60 r/l), dan faktor kedua adalah varietas kedelai (Wilis, Tanggamus, Grobogan, Argomulyo, Kaba dan Panderman). Penelitian ini menggunakan 24 kombinasi perlakuan dengan 3 ulangan.  Penelitian kedua pengujian pada media cair, menggunakan  Rancangan Acak Lengkap (RAL) 2 faktor.  Faktor pertama adalah varietas kedelai yang terdiri dari 3 taraf yaitu: Wilis, Tanggamus dan Grobogan. Faktor kedua adalah konsentrasi PEG 6000 yang terdiri dari 4 taraf perlakuan yaitu: 0%, 5%, 10% dan 15%, yang masing-masing setara dengan potensial air 0; -0,13; -0,19; -0,41 MPa. Pada penelitian media padat, berdasarkan hasil indeks sensivitas kekeringan, varietas Grobogan, Argomulyo dan Kaba menunjukkan respon peka kekeringan, sedangkan varietas Wilis dan Argomulyo menunjukkan respon toleran kekeringan dan varietas Tanggamus menunjukkan respon medium toleran. Konsentrasi PEG 60 gr/l  mampu mensimulasi kekeringan pada media padat.  Pada media cair, berdasarkan indeks sensivitas menunjukkan varietas Tanggamus dan Wilis bersifat medium toleran dan Grobogan peka terhadap kekeringan.  Konsentrasi PEG 5% pada media MS cair in vitro mampu mensimulasikan cekaman kekeringan.Kata kunci :  Pengujian in vitro, varietas kedelai, media padat, media cair
PEMANFAATAN BIJI KELOR (Moringa oleifera Lamk.) SEBAGAI BIOFLOKULAN LOGAM BERAT Hg, Pb DAN Cr PADA LIMBAH CAIR INDUSTRI KERAMIK DINOYO MALANG Evika Sandi Savitri, Eny Yulianti
El-QUDWAH El-Qudwah (10-2006)
Publisher : lp2m-uin malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (213.313 KB)

Abstract

The research is conducted on the effectiveness of Moringa oleifera as “bioflokulan” of Hg, Pb, and Cr to liquid waste of ceramics industry in Dinoyo Malang. It includes the analysis of chemical and physical nature of the liquid waste and also the effect of adding Moringa oleifera to the liquid sample of Hg, Pb, and Cr. The research on physical nature shows that liquid waste of ceramics industry in Dinoyo Malang is turbid, odorless and it has white colour, 25.3 C temperature, 258 S conductivity and TDS 185 ppm. While the research on the chemical nature shows that it has pH 7.8, Hg and Pb are unidentified, and Cr 0.0402ppm. Both analyses indicate that they are below the limit line. The analysis also shows that there is significant concentration decrease after adding Moringa oleifera to the sample of Hg, Pb, and Cr, and this happen because Moringa oleifera contains 4-alfa-4-rhamnosiloxy-benzil-isothiosianat that can coagulate ions in metal.Kata kunci :  Moringa oleifera, bioflokulan, limbah cair industri keramik
Growth and Flavonoid Content of Gynura procumbens (Lour) Merr. in Different Soil Water Content Evika Sandi Savitri; Farrikhatun Khusnia
Jurnal Biodjati Vol 4, No 2 (2019): November
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v4i2.4446

Abstract

Gynura procumbens contains tannins, saponins, steroids, triterpenoids, essential oils and flavonoids which have bioactivity as a medicine for various diseases. One effort to obtain the quality of medicinal plants uses management of soil water content. The opti-mum of soil water content will support optimal growth of a plant. Whereas in conditions of low soil water content resulted in the induc-tion of the production of secondary metabolites as a self-defense sys-tem. This study aimed to determine the effect of soil moisture content on the growth and total content of plant flavonoids G. procumbens. This study was carried out experimentally using a one-factor com-plete randomized design (CRD) consisting of 4 treatments with five replications. The treatment used is the difference in soil water content of 40%, 60%, 80% and 100% field capacity. The data obtained in the form of quantitative data will be analyzed by One Way ANOVA Test. Measurement of the content of total flavonoid compounds was car-ried out using UV-Vis spectrophotometer analysis. The results of the study indicate the influence of soil moisture level on the growth and total content of G. procumbens. Parameter growth of fresh weight, dry weight, and root G. procumbens showed an increase in 40% soil water content. The flavonoid content showed the highest total flavo-noid content 18.884 mg/g in the 40% field capacity soil water content 
Induksi Mutasi Dengan Mutagen EMS (Ethyl Methane Sulfonate) Pada Fase Perkecambahan dan Pertumbuhan Varietas Kedelai (Glycine max) Toleran Kekeringan EVIKA SANDI SAVITRI; AINIYATUL FIKRIYAH
Prosiding Seminar Biologi Vol 2 No 1 (2016): Prosiding Seminar Nasional From Basic Science to Comprehensive Education
Publisher : Jurusan Biologi, Fakultas Sains dan Teknologi, Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/psb.v2i1.3533

Abstract

Upaya peningkatan produksi kedelai nasional salah satunya dapat ditempuh melalui peningkatan dan perluasan areal tanam. Di Indonesia lahan kering merupakan  area yang sangat luas dan berpotensi dalam upaya peningkatan produksi pertanian. Penelitian ini bertujuan untuk mengetahui pengaruh konsentrasi dan lama perendaman dalam EMS terhadap mutasi yang terjadi pada beberapa varietas kedelai dan untuk menguji daya berkecambah dan pertumbuan mutant kedelai hasil mutasi  dalam EMS. Rancangan penelitian yang digunakan adalah Rancangan Acak Kelompok (RAK) Faktorial dengan menggunakan 2 faktor, 9 kombinasi perlakuan dan 3 kali ulangan, sebagai berikut: Faktor pertama adalah konsentrasi EMS yang terdiri dari 3 taraf, yaitu:K1 = 0,03%, K2 = 0,05%, K3 = 0,07%. Faktor kedua adalah lama perendaman dalam EMS yang terdiri dari 3 taraf, yaitu: L1 = 4 jam, L2 = 6 jam, L3 = 8 jam. Hasil penelitian pada perkecambahan varietas Dering dipengaruhi oleh mutagen EMS perlakuan pada konsentrasi 0,05% dengan lama perendaman selama 4 jam menunjukkan persentase kecambah normal (%), rata-rata panjang hipokotil (cm), rata-rata panjang akar (cm) dan berat kecambah (g) yang lebih tinggi dari perlakuan yang lain. Pada pertumbuhan pada varietas Dering 1 menunjukkan jumlah cabang yang tinggi pada perlakuan konsentrasi 0,07% selama 4 jam.
PEMANFAATAN EKSTRAK JINTAN HITAM UNTUK MENURUNKAN KADAR ENZIM LP-PLA2 SEBAGAI KANDIDAT PENGOBATAN ATEROSKLEROSIS Retno Susilowati; Evika Sandi Savitri; Kholifah Holil
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 18 No 1 (2012): December 2012
Publisher : The East Java Biological Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (220.795 KB) | DOI: 10.23869/154

Abstract

Ox-LDL deposits in the sub-endothelial easily occur in individuals who have hyperlipidemia accompanied with oxidative stress. The enzyme Lp-PLA2 is an enzyme marker of three proaterogenik conditions, those are hyperlipidemia, oxidative stress and inflammation. Black cumin seeds (Nigella sativa L.) have antioxidants ingredient that can inhibit lipid peroxidation, and expected to inhibit atherosclerosis through decreased levels of the enzyme Lp-PLA2 and F2-Isp. This study used posttest only control group design using experimental animals Rattus norvegicus Wistar males. The study analysied the number of foam cells, lipid profi le, Lp-PLA2 andF2-Isp plasma levels in hyperlipidemia rats were given extracts of black cumin seeds with 3 different doses (0; 3.6 and 7.2 mg / kg). The results showed that the extract of black cumin seeds can decrease serum levels of Lp-PLA2, tend to reduce the formation of foam cells,but not signifi cant to decreasing levels of F2-Isp. Black cumin seeds extract can decrease cholesterol, TG, LDL and increase HDL in the blood serum. The extract of black cumin seeds is anti atherogenic by reducing the enzyme Lp-PLA2 and improve lipid profi les.
Phytochemistry Screening and Antioxidant Activities of Extract Pomegranate, Grape, Fig, and Olive in the Various Solvent Evika Sandi Savitri; Kholifah Holil; Ruri Siti Resmisari
Jurnal Biodjati Vol 7, No 1 (2022): May
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v7i1.13424

Abstract

The active compounds of grape, pomegranate, olive, and fig have anthocyanins that potential as antioxidant are flavonoids. Flavonoids have potential as antioxidant  to prevent and therapy various oxidative stress and related diseases. This study aimed to examine the antioxidant activity of a combination of pomegranate, grape, fig, and olive extracts using the DPPH (diphenyl-2-picrylhydrazyl) method.  The maceration method used was maceration of dry Simplicia with methanol 95% solvent, fresh maceration with 95% methanol and dry Simplicia with 95% ethanol solvent. The results of the phytochemistry test showed several compounds found in the extract combination pomegranate, grapes, fig, and olives such as polyphenol, flavonoid, tannin, steroid/triterpenoid. The result of the antioxidant test showed the fresh maceration 95% methanol showed higher results with the IC50 of 25.22 with a potent antioxidant activity category.
ANALYSIS OF GENETIC VARIATION MUTANT SOYBEAN (Glycine max. L.MERR) GAMMA RAYS AND EMS (ETHYL METHANE SULFONATE) INDUCTION THROUGH ISSR MOLECULAR MARKERS Evika Sandi Savitri
Scripta Biologica Vol 5, No 3 (2018)
Publisher : Fakultas Biologi | Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.sb.2018.5.3.874

Abstract

Mutation induction in soybeans was carried out to develop high genetic diversity as a basis for plant breeding to get superior varieties.  Mutation induction can be done using physically mutagen gamma rays and chemically using EMS mutagens.  This study aims to determine the effectiveness of chemical mutagen (EMS) and physical mutagen (gamma rays) in the induction of genetic diversity in soybeans. Mutation detection can be done with molecular markers to characterize plant genetic diversity. In this study, ISSR molecular markers were used consisting of 4 primers. The method of mutation induction used EMS and gamma rays treatment. The results of the primary PCR amplification of ISSR2, ISSR3 and UBC888 showed 100% polymorphism. The treatment of mutation induction using EMS chemical agents showed a higher degree of polymorphism compared to gamma rays treatment
The Genetic and Morphoagronomy Character Diversity of Black Soybean Plant (Glycine soja (L.)): Responses to Mutation Induction by Gamma Rays Irradiation and Ethyl Methane Sulfonate Shaddiqah Munawaroh Fauziah; Evika Sandi Savitri; Estri Laras Arumingtyas
The Journal of Experimental Life Science Vol. 10 No. 3 (2020)
Publisher : Postgraduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jels.2020.010.03.02

Abstract

Indonesia has a high dependence on imports of black soybeans. National black soybean needs continue to increase. Therefore, some efforts are needed to increase soybean production. Genetic resources of Black Soybeans with high diversity is also needed to develop superior varieties. One of the ways to increase soybean production is by mutation induction. Therefore, genetic resources of Black Soybeans with high diversity is needed to develop superior varieties. Mutagenesis using gamma rays and EMS can be used to increase genetic diversity. Doses used in this research were 1000 Gy gamma rays, 1% EMS, and combinations. This research was using a completely randomized design with morphoargonomy and molecular parameters. Morphoagronomy parameters observed were plant height, leaf area, seed weight, number of leaves, number of pods, and number of branches. ISSR markers with four primers (UBC 888, ISSR3, UBC876, and UBC889) were used to determine genetic variation of Black Soybeans. Based on the analysis of variance (ANOVA), it was shown that all parameters were able to give an effect on the morphoagronomy of black soybean plants. Gamma rays 1000 Gy were more effective in improving morphoagronomy of the plant in terms of plant height, seed weight, number of leaves, number of pods, leaf area, and number of branches. UBC 888 was the most effective primer to identify the genetic diversity of black soybeans that have been given mutation treatments.   Keywords: Black soybean, EMS, gamma rays, genetic variation, morphoagronomy.
Co-Authors AINIYATUL FIKRIYAH Eko Budi Minarno Estri Laras Arumingtyas Estri Laras Arumingtyas Farrikhatun Khusnia Kholifah Holil Khusnia, Farrikhatun Rahmi Annisa Retno Susilowati Ruri Siti Resmisari Shaddiqah Munawaroh Fauziah Shinta