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All Journal VALENSI Molekul: Jurnal Ilmiah Kimia Proceeding of The International Conference on Health Sciences and Nursing
Soerya Dewi Marliyana
Universitas Sebelas Maret
Chemical Engineering, Chemistry & Bioengineering Chemistry

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Isolasi dan Identifikasi Senyawa Seskuiterpen dari Curcuma soloensis Val. (Temu Glenyeh) Soerya Dewi Marliyana; Muhamad Widyo Wartono; Fajar Rakhman Wibowo; Gesti Munasah
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 4, No. 2, November 2018
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (729.169 KB) | DOI: 10.15408/jkv.v4i2.7443

Abstract

Curcuma soloensis Val. is a family plant Zingiberaceae and is known as "temu gelnyeh". This plant has been used as a medicinal plant but has not been widely reported about its chemical components. Therefore, this study was carried out to isolation and identification of the chemical components of the C. soloensis Val. rhizome. Isolation was done by extraction, fractionation, and purification. The fractionation and purification of the compound were carried out using chromatography methods. The identification of the compound was determined by spectroscopic methods including 1D-NMR (1H NMR, 13C NMR) and 2D-NMR (HSQC, HMBC). Based on NMR spectra data analysis and compared with literature, the compound obtained yellow liquid was ar-turmerone (2-methyl-6- (4-methylphenyl) hept-2-en-4-on) which was a terpenoid sesquiterpene. Ar-turmerone is the first compound that found from Curcuma soloensis Val. rhizome.  
Time-Kill Assay of 4-Hydroxypanduratin A Isolated from Kaempferia Pandurata Against Foodborne Pathogens Soerya Dewi Marliyana; Didin Mujahidin; Yana M Syah; Yaya Rukayadi
Molekul Vol 12, No 2 (2017)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (402.658 KB) | DOI: 10.20884/1.jm.2017.12.2.363

Abstract

Time–kill assay was performed for 4-hydroxypanduratin A that was isolated from Kaempferia pandurata rizhome against four important foodborne pathogens, namely Bacillus cereus ATCC 21772, Bacillu subtilis ATCC 6633, Staphylococcus aureus ATCC 29737,  and  Proteus mirabilis ATCC 21100. The methods have been investigated in term of Minimum Inhibitory Concentration (MIC) and killing time curve using methods of Clinical and Laboratory Standards Institute (CLSI) guidelines. The results showed that 4-hydroxypanduratin A rapid acting in killing bacteria as follow: B. cereus : 1×MIC for 4 h, P. mirabilis: 4×MIC for 0.5 h, meanwhile  B. subtilis and S. aureus were 1×MIC for 2 h. In conclusion, 4-hydroxypanduratin A showed strong antimicrobial activity against four important foodborne pathogens.
Phytochemical Screening for Phenol and Optimizing the SNEDDS (Self-Nanoemulsifying Drug Delivery System) Formula Using the Simplex Lattice Design Method on Curcuma caesia Roxb Rhizome Extract Sholichah Rohmani; Okid Parama Astirin; Soerya Dewi Marliyana; Nestri Handayani
Proceeding of the International Conference on Health Sciences and Nursing Vol. 1 No. 2 (2024): December : Proceeding of the International Conference on Health Sciences and Nu
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/ichsn.v1i2.33

Abstract

This research aims to screen the phytochemistry of phenol and optimize the formulation of Curcuma caesia Roxb. rhizome extract, which is difficult to dissolve in water, in the form of Self-Nanoemulsifying Drug Delivery System (SNEDDS) using the simplex lattice design method. The phenol content was identified using thin-layer chromatography,and the compound levels were determined spectrophotometrically. An initial screening was conducted to determine the oil phase, surfactant, and co-surfactant to use. The characterization of SNEDDS in the optimal formula includes transmittance, particle size, and polydispersity-index (PI). Olive oil, Tween 80,and polyethyleneglycol (PEG)-400 are the oil phase, surfactant, and co-surfactant selected due to the highest ability to dissolve Curcuma caesia Roxb.rhizome extract. The results of phytochemical screening of the polyphenol compound group using thin-layer chromatography produced spots with an Rf value of 0.76 and a phenol content of 61.823 mgGAE/g. The optimization results showed that the optimal formula was obtained at a composition of 1:8:1 for olive oil, Tween 80, and PEG-400. The SNEDDS of C.caesia Roxb.rhizome extract produced a nanoemulsion with a loading dose of 250 mg/5 g SNEDDS, a transmittance of 98.6%, a particle size of 14.1 nm, and a polydispersity index (PI) of 0.363.
Co-Authors Didin Mujahidin Fajar Rakhman Wibowo Gesti Munasah Muhamad Widyo Wartono Nestri Handayani Okid Parama Astirin Sholichah Rohmani Yana M Syah YAYA RUKAYADI