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All Journal VALENSI The Journal of Pure and Applied Chemistry Research Alchemy Jurnal Penelitian Kimia ALCHEMY Jurnal Penelitian Kimia JPSCR : Journal of Pharmaceutical Science and Clinical Research Molekul: Jurnal Ilmiah Kimia Molekul: Jurnal Ilmiah Kimia
Muhamad Widyo Wartono
Chemistry Departement, Faculty Of Mathematics And Natural Sciences, Universitas Sebelas Maret, Surakarta
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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AMENTOFLAVONE FROM LEAVES OF NYAMPLUNG (Calophyllum inophyllum Linn.) Wartono, M. Widyo; Wulandari, Dian; Handayani, Nestri; Suryanti, Venty; Marliyana, Soerya D.
Alchemy Jurnal Penelitian Kimia Vol 8, No 1 (2012)
Publisher : Alchemy Jurnal Penelitian Kimia

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Abstract

Amentoflavone (1), a biflavonoid was isolated from leaves of Calophyllum inophyllum Linn. Isolation and purification of the compound used maceration and chromatography methods using Si-gell and sephadex LH-20. The structure was determined by UV, IR, 1H and 13C NMR spectroscopy includes HMQC/HMBC analysis and comparison with references.
A TRAPEZIFOLIXANTHONE FROM STEM BARK OF Calophyllum soulattri COLLECTED FROM CENTRAL JAVA Achadiyah, Tri Bintari; Handayani, Nestri; Wartono, M. Widyo
Alchemy Jurnal Penelitian Kimia Vol 9, No 2 (2013)
Publisher : Alchemy Jurnal Penelitian Kimia

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Abstract

A xanthone derivative namely trapezifolixanthone has been isolated and identified from EtOAc extract of stem bark ofCalophyllum soulattri. The maceration method was used to isolates the trapezifolixanthone then followed by fractionation method using vacuum liquid chromatography and purification process by flash chromatography. A 14 mg of yellowish oily solid was extracted. The compound was elucidated by 1H NMR, 13C NMR, and 2D NMR (HSQC, HMBC, COSY) supported by UV and IR spectroscopy. Base on spectral data and comparison with some references, it is  known that the compound is trapezifolixanthone.
AMENTOFLAVON DARI DAUN NYAMPLUNG (Calophyllum inophyllum Linn.) Wartono, M. Widyo; Wulandari, Dian; Handayani, Nestri; Suryanti, Venty; Marliyana, Soerya D.
Alchemy Jurnal Penelitian Kimia Vol 8, No 2 (2012)
Publisher : Alchemy Jurnal Penelitian Kimia

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Abstract

Satu senyawa biflavonoid yaitu amentoflavon (1) berhasil diisolasi dari daun tumbuhan nyamplung (Calophyllum inophyllum Linn). Ekstraksi menggunakan metode maserasi dan pemurnian dengan kromatografi kolom dengan fasa diam Si-gel dan sephadex LH-20. Elusidasi struktur menggunakan metode spektroskopi UV, IR, 1H dan 13 C NMR beserta HMQC dan HMBC. Hasil yang diperoleh dianalisis dan dibandingkan dengan data referensi.Kata kunci: Amentoflavon, biflavonoid, Calophyllum inophyllum, Daun
ISOLATION AND IDENTIFICATION OF β-SITOSTEROL AND STIGMASTEROL MIXTURE FROM ROOT BARK OF SLATRI (Calophyllum soulattri Burm. f) Saputra, Doni Eko; Handayani, Nestri; Wartono, Muhammad Widyo
Alchemy Jurnal Penelitian Kimia Vol 10, No 1 (2014)
Publisher : Alchemy Jurnal Penelitian Kimia

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Abstract

Chemical isolation and identification of root bark of Calophyllum soulattri Burm. f. have been conducted. Isolation was conducted by maceration with ethyl acetate as solvent. Ethyl acetate extract was separated and purified by vacuum liquid chromatography and flash chromatography which was guided by thin layer chromatography to obtain yellowish white solid. Isolated compounds were determined by spectroscopy methods such as UV, FTIR, 1H NMR, 13C NMR, DEPT, HSQC, HMBC and were compared to the references. Based on the analysis result it’s known that the compounds are the mixture of β-sitosterol and stigmasterol.
ISOLATION AND IDENTIFICATION OF ANANIXANTHONE FROM ETHYL ACETATE EXTRACT OF ROOT BARK OF SLATRI (Calophyllum soulattri) (CLUSIACEAE) Mulia, Dindha Ramah; Handayani, Nestri; Wartono, M. Widyo
Alchemy Jurnal Penelitian Kimia Vol 10, No 2 (2014)
Publisher : Alchemy Jurnal Penelitian Kimia

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Abstract

A xanthone, named ananixanthone (1) has been isolated and identified from the ethyl acetate extract of the root barks of Calophyllum soulattri. Structure of the compound was determined based on spectroscopic data, including UV, IR, NMR 1D, NMR 2D and by comparison with references.
IDENTIFICATION AND ANTIBACTERIAL ACTIVITY TEST OF THE MIMBA LEAF (Azadirachta Indica A. Juss) Handayani, Nestri; Wartono, M. Widyo; Murti, Riskha Kurnia
Alchemy Jurnal Penelitian Kimia Vol 8, No 1 (2012)
Publisher : Alchemy Jurnal Penelitian Kimia

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Abstract

The purpose of this research was to evaluate antibacterial activity of Neem (Azadirachta indica A. Juss) leaves fraction against some pathogenic bacterial and to identificate the most active fraction. Leaves powder of Neem was macerated with ethanol and factionated by vacuum liquid chromatography using hexane, ethyl acetate and ethanol as eluent, respectively. The antibacterial activity of the fraction was evaluated by diffusion method, then the most active fraction of antibacterial was evaluated by zone of inhibition. The most active fraction of antibacterial was evaluated for Minimum Inhibitory Concentration (MIC) and equivalent value, compared with amoxicillin and chloramphenicol, then identified using phytochemical screening and Gass Chromatography-Mass Spectroscopy (GC-MS).The fraction of Neem leaves fractionated by vacuum liquid chromatography had antibacterial activity againstStaphylococcus epidermidis, Bacillus cereus, and Shigella flexneri. The ethyl acetate fraction showed the most active fraction of antibacterial against all bacterial tested. Ethyl acetate fraction had MIC 0.075% againstStaphylococcus epidermidis 0.05% against Bacillus cereus and Shigella flexneri. The antibacterial activity of ethyl acetat fraction compared to amoxicillin was 0.01% for S. epidermidis, 0.02% for B. cereus, and 0.02% for S. flexneri. Then compared to chloramphenicol was 0.04% for S. epidermidis, 0.02% for B. cereus, and 0.06% for S. flexneri. The result of GC-MS showed that the ethyl acetate fraction contained palmitic acid, ethyl linoleolate, stearic acid, trans-phytol, DOP (di octyl phthalate), and suggested 1 class of compound fatty acid and 5 classes of compound triterpenoids.
Isolasi dan Identifikasi Senyawa Seskuiterpen dari Curcuma soloensis Val. (Temu Glenyeh) Soerya Dewi Marliyana; Muhamad Widyo Wartono; Fajar Rakhman Wibowo; Gesti Munasah
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 4, No. 2, November 2018
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (729.169 KB) | DOI: 10.15408/jkv.v4i2.7443

Abstract

Curcuma soloensis Val. is a family plant Zingiberaceae and is known as "temu gelnyeh". This plant has been used as a medicinal plant but has not been widely reported about its chemical components. Therefore, this study was carried out to isolation and identification of the chemical components of the C. soloensis Val. rhizome. Isolation was done by extraction, fractionation, and purification. The fractionation and purification of the compound were carried out using chromatography methods. The identification of the compound was determined by spectroscopic methods including 1D-NMR (1H NMR, 13C NMR) and 2D-NMR (HSQC, HMBC). Based on NMR spectra data analysis and compared with literature, the compound obtained yellow liquid was ar-turmerone (2-methyl-6- (4-methylphenyl) hept-2-en-4-on) which was a terpenoid sesquiterpene. Ar-turmerone is the first compound that found from Curcuma soloensis Val. rhizome.  
Isolation and Elucidation Structure of 28-Hydroxy-3-Friedelanone of Nyamplung (Callophyllum inophyllum, Linn.) Leaves Triana Kusumaningsih; Muhammad Widyo Wartono; Nais Puji Wijanarti
The Journal of Pure and Applied Chemistry Research Vol 9, No 2 (2020): Edition May-August 2020
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2020.009.02.518

Abstract

The isolation triterpenoid from Nyamplung (Callophyllum inophyllum, Linn.) leaves has been conducted. The isolation was employed by maceration using ethanol as solvent and liquids extraction using ethyl acetate. Ethyl acetate extract was partitioned successively using nonpolar solvent with hexane, dichloromethane, and diethyl ether, respectively. The diethyl ether extract was purified by column chromatography. The isolated compound of fraction D1 was obtained as white solids crystal with yield of 0.0035%. The isolated compound was determined based on the FTIR, 1HNMR, 13CNMR, HSQC, and HMBC spectra. The isolated compound was identified as 28-hydroxy-3-friedelanone.
KOMPOSISI KIMIA MINYAK ATSIRI BUAH SIRIH HIJAU (PIPER BETLE L), KEMUKUS (PIPER CUBEBA L) DAN CABE JAWA (PIPER RETROFRACTUM VAHL) M. Widyo Wartono; Ahmad Ainurofiq; Maya Ismaniar
Molekul Vol 9, No 1 (2014)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (228.325 KB) | DOI: 10.20884/1.jm.2014.9.1.143

Abstract

Tumbuhan genus Piper mempunyai kandungan minyak atsiri hampir disemua bagiannya, namun komposisi kimianya belum semua dilaporkan. Pada laporan ini kami melakukan isolasi dan identifikasi senyawa kimia minyak atsiri pada bagian buah tumbuhan Piper. Isolasi minyak atsiri buah Piper dilakukan dengan destilasi air menggunakan destilasi Stahl dan analisis komposisi kimia dengan kromatografi gas-spektroskopi masa (GC-MS). Kandungan minyak atsiri buah sirih hijau (Piper betle) 1,4% (v/b), cabe jawa (Piper retrofractum) 1% (v/b), dan buah kemukus (Piper cubeba) 1,7% (v/b). Hasil analisis GC-MS menunjukan kandungan utama minyak atsiri adalah senyawa golongan monoterpen, seskuiterpen dan fenil propanoid. Kandungan utama minyak atsiri buah sirih hijau (P. betle) adalah eugenol (12,36%), isokaryofillena (9,55%) dan β-selinena (8,09%), sedangkan komponen utama buah cabe jawa (Piper retrofractum) adalah isokaryofilen (8,88%), β-bisabolen (7,01%) dan zingiberen (6,32%), dan minyak atsiri buah kemukus (Piper cubeba) adalah spathulanol (27,05%), sativen (8,73%) dan germakren D (7,50%).
Isolation and Identification of Ananixanthone from Ethyl Acetate Extract of Root Bark Of Slatri (Calophyllum Soulattri) (Clusiaceae)) Dindha Ramah Mulia; Nestri Wulandari; Muhammad Widyo Wartono
ALCHEMY Jurnal Penelitian Kimia Vol 10, No 2 (2014): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.10.2.56.130-136

Abstract

A  xanthone,  named  ananixanthone  (1)  has  been  isolated  and  identified  from  the  ethyl acetate  extract of the root barks of  Calophyllum soulattri. Structure of the compound was determined based on spectroscopic data, including UV, IR, NMR 1D, NMR 2D and by comparison with references.
Co-Authors Ahmad Ainurofiq Desi Suci Handayani Dewi Marliyana, Soerya Dian Wulandari Dindha Ramah Mulia Dindha Ramah Mulia, Dindha Ramah Doni Eko Saputra Doni Eko Saputra, Doni Eko Fajar Rakhman Wibowo Gesti Munasah Ida Dahlia Maulidan Firdaus Maya Ismaniar Nais Puji Wijanarti Nestri Handayani Nestri Handayani, Nestri Nestri Wulandari Qurotul Aini Rakhman Wibowo, Fajar Riskha Kurnia Murti, Riskha Kurnia Soerya Dewi Marliyana Soerya Dewi Marliyana Soerya Dewi Marliyana Tahara, Alfia Uke Tri Bintari Achadiyah, Tri Bintari Triana Kusumaningsih Triana Kusumaningsih Venty Suryanti