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All Journal VALENSI The Journal of Pure and Applied Chemistry Research ALCHEMY Jurnal Penelitian Kimia Molekul: Jurnal Ilmiah Kimia PRIMA: Journal of Community Empowering and Services Molekul: Jurnal Ilmiah Kimia

Muhamad Widyo Wartono

Chemistry Departement, Faculty Of Mathematics And Natural Sciences, Universitas Sebelas Maret, Surakarta

Author-ID : 489634

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Materials Science & Nanotechnology Medicine & Pharmacology

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Articles

Isolasi dan Identifikasi Senyawa Seskuiterpen dari Curcuma soloensis Val. (Temu Glenyeh) Soerya Dewi Marliyana; Muhamad Widyo Wartono; Fajar Rakhman Wibowo; Gesti Munasah
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 4, No. 2, November 2018
Publisher : Syarif Hidayatullah State Islamic University

Curcuma soloensis Val. is a family plant Zingiberaceae and is known as "temu gelnyeh". This plant has been used as a medicinal plant but has not been widely reported about its chemical components. Therefore, this study was carried out to isolation and identification of the chemical components of the C. soloensis Val. rhizome. Isolation was done by extraction, fractionation, and purification. The fractionation and purification of the compound were carried out using chromatography methods. The identification of the compound was determined by spectroscopic methods including 1D-NMR (1H NMR, 13C NMR) and 2D-NMR (HSQC, HMBC). Based on NMR spectra data analysis and compared with literature, the compound obtained yellow liquid was ar-turmerone (2-methyl-6- (4-methylphenyl) hept-2-en-4-on) which was a terpenoid sesquiterpene. Ar-turmerone is the first compound that found from Curcuma soloensis Val. rhizome.

Isolation and Elucidation Structure of 28-Hydroxy-3-Friedelanone of Nyamplung (Callophyllum inophyllum, Linn.) Leaves Triana Kusumaningsih; Muhammad Widyo Wartono; Nais Puji Wijanarti
The Journal of Pure and Applied Chemistry Research Vol 9, No 2 (2020): Edition May-August 2020
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2020.009.02.518

The isolation triterpenoid from Nyamplung (Callophyllum inophyllum, Linn.) leaves has been conducted. The isolation was employed by maceration using ethanol as solvent and liquids extraction using ethyl acetate. Ethyl acetate extract was partitioned successively using nonpolar solvent with hexane, dichloromethane, and diethyl ether, respectively. The diethyl ether extract was purified by column chromatography. The isolated compound of fraction D1 was obtained as white solids crystal with yield of 0.0035%. The isolated compound was determined based on the FTIR, 1HNMR, 13CNMR, HSQC, and HMBC spectra. The isolated compound was identified as 28-hydroxy-3-friedelanone.

KOMPOSISI KIMIA MINYAK ATSIRI BUAH SIRIH HIJAU (PIPER BETLE L), KEMUKUS (PIPER CUBEBA L) DAN CABE JAWA (PIPER RETROFRACTUM VAHL) M. Widyo Wartono; Ahmad Ainurofiq; Maya Ismaniar
Molekul Vol 9, No 1 (2014)
Publisher : Universitas Jenderal Soedirman

Tumbuhan genus Piper mempunyai kandungan minyak atsiri hampir disemua bagiannya, namun komposisi kimianya belum semua dilaporkan. Pada laporan ini kami melakukan isolasi dan identifikasi senyawa kimia minyak atsiri pada bagian buah tumbuhan Piper. Isolasi minyak atsiri buah Piper dilakukan dengan destilasi air menggunakan destilasi Stahl dan analisis komposisi kimia dengan kromatografi gas-spektroskopi masa (GC-MS). Kandungan minyak atsiri buah sirih hijau (Piper betle) 1,4% (v/b), cabe jawa (Piper retrofractum) 1% (v/b), dan buah kemukus (Piper cubeba) 1,7% (v/b). Hasil analisis GC-MS menunjukan kandungan utama minyak atsiri adalah senyawa golongan monoterpen, seskuiterpen dan fenil propanoid. Kandungan utama minyak atsiri buah sirih hijau (P. betle) adalah eugenol (12,36%), isokaryofillena (9,55%) dan β-selinena (8,09%), sedangkan komponen utama buah cabe jawa (Piper retrofractum) adalah isokaryofilen (8,88%), β-bisabolen (7,01%) dan zingiberen (6,32%), dan minyak atsiri buah kemukus (Piper cubeba) adalah spathulanol (27,05%), sativen (8,73%) dan germakren D (7,50%).

ISOLASI, IDENTIFIKASI KOMPONEN DAN UJI AKTIVITAS ANTIBAKTERI MINYAK ATSIRI RIMPANG LEMPUYANG WANGI (Zingiber aromaticum Val.) Nestri Handayani; Widyo Wartono; Nirub Wijaya
Molekul Vol 7, No 2 (2012)
Publisher : Universitas Jenderal Soedirman

Isolasi, identifikasi dan uji aktivitas antibakteri minyak atsiri rimpang lempuyang wangi (Zingiber aromaticum Val.) telah dilakukan. Minyak atsiri diisolasi dengan metode destilasi Stahl dan dianalisis dengan GC-MS. Kadar minyak atsiri yang dihasilkan 0,6% (v/b). Identifikasi komponen dilakukan dengan membandingkan spektrum massa masing-masing senyawa dengan spektrum massa senyawa standar dari literatur Wiley 7. LIB. Hasil analisis menunjukkan 27 senyawa teridentifikasi yaitu α – pinen (0.36%), Z – β ocimen (2.70%), Champhen (10.91%), Sabinen (0.07%), β – pinen (0.18%), β – myrcen (0.29%),(Z)-α-osimen (0.51)%, allo-osimen (0.08)%, p – cimen (0.50%), 1,8 cineol (2.75%), β – trans ocimen (0.05%), γ – terpinen (0.14%), α – terpinolen (27.19%), champor (2.71%), Isobornyl alcohol (1.51%), Terpinen 4-ol (1.11%), 3-cycloheksan 1 metanol (0.25%), Isobornyl acetat (0.29%), Trans caryophilen (0.47%), α-humulen (7.53%), α-kurkumen (0.13)%, farnesol (0.11%), (-)-kariofilen oksida (2.07%), patchulana (0.25%), Zerumbon (31.05%).Uji aktivitas antibakteri minyak atsiri rimpang lempuyang wangi (Zingiber aromaticum Val.) telah dilakukan terhadap Pseudomonas aeruginosa dan Salmonella typhi dengan metode difusi agar menggunakan metode difusi dengan membuat sumuran. Hasil uji antibakteri menunjukkan bahwa minyak atsiri rimpang lempuyang wangi (Zingiber aromaticum Val) memiliki aktivitas antibakteri terhadap semua bakteri uji dengan Konsentrasi Hambat Minimum (KHM) 0,25% untuk Pseudomonas aeruginosa, dan 0,075% untuk Salmonella typhi. Dibandingkan dengan amoksisilin, potensi antibakteri minyak atsiri rimpang lempuyang wangi (Zingiber aromaticum Val) pada kedua bakteri uji adalah 0,001% dari potensi amoksisilin.

Synthesis and Characterization of Anethole-lauryl Methacrylate Copolymer via Cationic Polymerization Handayani, Desi Suci; Tahara, Alfia Uke; Firdaus, Maulidan; Suryanti, Venty; Kusumaningsih, Triana; Marliyana, Soerya Dewi; Wibowo, Fajar Rakhman; Wartono, Muhammad Widyo
Molekul Vol 18 No 3 (2023)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2023.18.3.7078

The synthesis of anethole-lauryl methacrylate (LMA) copolymer had been carried out by cationic polymerization using BF3O(C2H5)2 as the initiator without the use of solvent at room temperature (28-30 °C) over atmospheric N2 conditions. Polymerization was conducted by varying LMA concentration i.e. 2%, 4%, and 6%, (w/w) with respect to the anethole weight. Structural determination of co-poly(anethole-LMA) was done using FTIR and 1H-NMR spectrophotometer. The relative molecular weight (Mv) of co-poly (anethole-LMA) was measured by an Ostwald Viscometer at room temperature. Morphological characterization and surface area analysis of co-poly(anethole-LMA) was performed using SEM and SAA, respectively. The successful synthesis of co-poly(anethole-LMA) was proven by the disappearance of vinyl group absorption at 1696, 1638, 965, and 938 cm-1 of the FTIR spectra, as well as the loss of vinyl group proton signals at 6.4-5.5 ppm in the 1H-NMR spectra. Increasing the weight of the LMA affected the characteristics of co-poly(anethole-LMA). The relative molecular weight of co-poly(anethole-LMA) was found to rise by increasing the weight of LMA. The Mv of co-poly(anethole-LMA) 2%, 4%, and 6% were 32378.62, 50611.05, and 65133.79 g/mol, respectively. The morphology of co-poly(anethole-LMA) showed that the surface distance between particles was getting tighter and the highest surface area in co-poly(Anethole-LMA) 6% was 233.80 m2/g.

Labdane Aldehyde Diterpenoids from Curcuma mangga Rhizome Wartono, Muhammad Widyo; Aini, Qurotul; Suryanti, Venty; Firdaus, Maulidan; Rakhman Wibowo, Fajar; Dewi Marliyana, Soerya; Kusumaningsih, Triana; Suci Handayani, Desi
The Journal of Pure and Applied Chemistry Research Vol. 12 No. 3 (2023): September-December 2023
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2023.012.03.694

Curcuma mangga val. (Zingiberaceae) is one of the plants that used as traditional medicine by Indonesian. Several studies have been reported on the content of compounds of C. mangga, but it is not yet known which compounds have medicinal properties. In this study, two labdane diterpenes were isolated from the extract of rhizome of C. mangga. Determination of the structure conducted by NMR (1H, 13C, HSQC and HMBC) that obtained two compounds, calcaratarin A (1) and labda-8(17),12-diene-15,16-dial (2). Both compounds have an aldehyde functional group. However, both compounds did not show antibacterial activity on Escherichia coli.

Isolation and Identification of Ananixanthone from Ethyl Acetate Extract of Root Bark Of Slatri (Calophyllum Soulattri) (Clusiaceae)) Mulia, Dindha Ramah; Wulandari, Nestri; Wartono, Muhammad Widyo
ALCHEMY Jurnal Penelitian Kimia Vol 10, No 2 (2014): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.10.2.56.130-136

A xanthone, named ananixanthone (1) has been isolated and identified from the ethyl acetate extract of the root barks of Calophyllum soulattri. Structure of the compound was determined based on spectroscopic data, including UV, IR, NMR 1D, NMR 2D and by comparison with references.

Isolation and Identification of β-Sitosterol and Stigmasterol Mixture from Root Bark of Slatri (Calophyllum soulattri Burm. f) Doni Eko Saputra; Nestri Handayani; Muhammad Widyo Wartono
ALCHEMY Jurnal Penelitian Kimia Vol 10, No 1 (2014): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.10.1.14.87-93

Chemical isolation and identificationof root bark of CalophyllumsoulattriBurm. f. have been conducted. Isolation was conducted by maceration with ethyl acetate as solvent. Ethyl acetate extract was separated and purified by vacuum liquid chromatography and flash chromatography which was guided by thin layer chromatography to obtain yellowish white solid. Isolated compounds were determined by spectroscopy methods such as UV, FTIR, 1H NMR, 13C NMR, DEPT, HSQC, HMBC and were compared to the references. Based on the analysis result it’s known that the compounds are the mixture of?-sitosterol and stigmasterol.

Peningkatan Rendemen Minyak Atsiri Melalui Maserasi Awal dengan Metode Ultrasonikasi di Rumah Atsiri Indonesia Firdaus, Maulidan; Suryanti, Venty; Kusumaningsih, Triana; Handayani, Desi Suci; Marliyana, Soerya Dewi; Wibowo, Fajar Rakhman; Wartono, Muhammad Widyo; Karimah, Qosrul; Darmawan, Dhea Afrisa
PRIMA: Journal of Community Empowering and Services Vol 9, No 1 (2025): June
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/prima.v9i1.86385

Enhancing Essential Oils Yield through Initial Maceration using Ultrasonication Method at Rumah Atsiri Indonesia. Metode ekstraksi minyak atsiri yang paling umum digunakan adalah destilasi uap. Pada umumnya, metode destilasi uap banyak digunakan oleh industri kecil termasuk di Rumah Atsiri Indonesia (RAI), karena memiliki beberapa keuntungan, diantaranya pengoperasian yang mudah serta peralatan yang sederhana. Akan tetapi, metode ini juga memiliki beberapa kelemahan, seperti membutuhkan waktu yang cukup lama dan hasil produksi yang kurang optimal. Untuk mengatasi kelemahan tersebut, solusi yang dapat dilakukan adalah melakukan proses destilasi minyak atsiri yang didahului maserasi dengan bantuan ultrasonik. Bekerja sama dengan RAI, Tim Riset Group Natural Products and Synthetic Organic Chemistry Prodi Kimia FMIPA UNS telah melaksanakan Program Pengabdian kepada Masyarakat (PkM). PkM bertujuan memberikan penyuluhan sekaligus praktik mengenai cara destilasi minyak atsiri dengan memulai proses maserasi dan menerapkan teknik ultrasonikasi di RAI. Pendekatan ini bertujuan untuk meningkatkan efisiensi dan hasil proses destilasi dengan menggunakan gelombang ultrasonik untuk membantu memecah bahan tanaman sebelum destilasi. Hal ini memudahkan untuk mengekstrak lebih banyak minyak dan meningkatkan kualitas minyak atsiri secara keseluruhan. Kegiatan dimulai dengan diskusi tentang teori dan aplikasi maserasi awal dengan metode ultrasonikasi. Sesi selanjutnya adalah praktik maserasi awal dengan metode ultrasonikasi sebelum dilakukan destilasi. Luaran dari pelatihan ini adalah adanya peningkatan performa metode destilasi minyak atsiri. Hasil perlakuan ekstraksi awal dengan teknik ultrasonikasi bisa meningkatkan rendemen minyak sereh wangi dari 0,86% menjadi 1,86% atau meningkat 2,2 kali lebih banyak dibandingkan tanpa maserasi awal.

Co-Authors Ahmad Ainurofiq Darmawan, Dhea Afrisa Desi Suci Handayani Dewi Marliyana, Soerya Dian Wulandari Dindha Ramah Mulia, Dindha Ramah Doni Eko Saputra Doni Eko Saputra, Doni Eko Fajar Rakhman Wibowo Gesti Munasah Ida Dahlia Karimah, Qosrul Maulidan Firdaus Maya Ismaniar Nais Puji Wijanarti Nestri Handayani Nestri Handayani Nestri Handayani, Nestri Nirub Wijaya Qurotul Aini Rakhman Wibowo, Fajar Riskha Kurnia Murti, Riskha Kurnia Soerya Dewi Marliyana Soerya Dewi Marliyana Soerya Dewi Marliyana Tahara, Alfia Uke Tri Bintari Achadiyah, Tri Bintari Triana Kusumaningsih Triana Kusumaningsih Venty Suryanti Wulandari, Nestri

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