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All Journal HERBAPHARMA : Journal of Herb Farmacological Sainstech Farma: Jurnal Ilmu Kefarmasian Edu Masda Journal Medical Sains : Jurnal Ilmiah Kefarmasian Pharmaceutical Science Journal Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kefarmasian Indonesia
Sheila Meitania Utami
STIKES WIDYA DHARMA HUSADA TANGERANG
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Aktivitas Antioksidan Sediaan Lip Balm yang Mengandung Ekstrak Etanol Buah Labu Kuning (Curcubita moschata D.) Utami, Sheila Meitania; Fadhilah, Humaira; Aprilivani, Saskia Nur
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 15 No 2 (2022): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v15i2.1087

Abstract

Antioksidan merupakan senyawa pemberi elektron (electron donor) atau reduktan. Ekstrak etanol buah labu kuning (Curcubita moschata D.) telah diakui memiliki aktivitas antioksidan dengan menggunakan metode DPPH. Pengujian aktivitas antioksidan dengan penentuan nilai IC50 diharapkan dapat menjadi informasi tentang kekuatan aktivitas antioksidan dengan memanfaatkan ekstrak buah labu kuning. Tujuan penelitian ini untuk mengetahui aktivitas antioksidan pada formulasi sediaan lip balm yang mengandung ekstrak etanol buah labu kuning. Penelitian ini menggunakan metode DPPH dan dibuat dalam sediaan lip balm yang mengandung ekstrak etanol buah labu kuning dengan variasi konsentrasi 2% (FI), 4% (FII) dan 8% (FIII). Hasil penelitian menunjukan bahwa ekstrak etanol buah labu kuning mempunyai nilai IC50 148,32 ppm, sedangkan formulasi sediaan lip balm ekstrak labu kuning pada FI mempunyai nilai IC50 242,54 ppm, dan FII diperoleh IC50 216,78 ppm yang termasuk dalam golongan aktivitas antioksidan yang sangat lemah. Sediaan FIII diperoleh IC50 172,46 ppm dan termasuk dalam golongan aktivitas antioksidan lemah. Dapat disimpulkan bahwa FIII sedian lip balm mempunyai aktivitas antioksidan yang paling baik dibandingkan FI dan FII.
FORMULASI DAN AKTIVITAS ANTIBAKTERI SEDIAAN GEL HAND SANITIZER YANG MENGANDUNG EKSTRAK TANAMAN TERHADAP BAKTERI STAPHYLOCOCCU S AUREUS DARI BERBAGAI LITERATUR Utami, Sheila Meitania; Purwaningsih, Neneng Sri; Sopian, Ahmad; Angraeni, Lutfiah
Edu Masda Journal Vol 6, No 2 (2022): Edu Masda Journal Volume 6 Nomor 2
Publisher : STIKes Kharisma Persada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52118/edumasda.v6i2.163

Abstract

Formulasi Sediaan Minuman Serbuk Fungsional Kombinasi Biji Jagung (Zea mays L. ) dan Madu Utami, Sheila Meitania; Ismaya, Nurwulan Adi; Ratnaningtyas, Tri Okta; Yunarto, Nanang
Jurnal Kefarmasian Indonesia VOLUME 12, NOMOR 2, AGUSTUS 2022
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v0i0.5536

Abstract

Corn is a food ingredient that contains carotenoids that are very potential in preventing cancer, adding endurance, as antivirals, fungi, and parasites, carotenoids are also good for vision, growth and reproduction. The highest carotenoid compound in corn is lutein which has potential as an immunomodulator. Honey is also immunomodulatory by triggering macrophages to produce cytokines involved in killing bacteria and tissue repair. The combination of corn and honey in one drink will produce a health supplement preparation that contains antioxidants and immunomodulators that are good for health. The goal of this study was to get the best formula of instant granules physically. Instant granules are made from corn kernels that have been dried with a combination of honey which is processed by dry granulation with variations of corn kernels FI & FIV (15%), FII & FV (25%), FIII & FVI (35%), and FI & FIV honey (35%), FII & FV (25%), FIII & FVI (15%). Instant granules are conducted physical test evaluations including organoleptic tests, flow time, angle of repose, compressibility index, time of granules to dissolve, particle distribution, pH, viscosity of reconstituted and RDA test. The results showed that the granule flow time, angle of repose, compressibility index, time of granules to dissolve, granules particle distribution and viscosity of reconstituted overall physical testing showed no noticeable differences, except against the most preferred taste parameters FVI. So the best formulation has obtained is FVI and shows the result of the RDA test with total energy of 350 kcal/100 grams.
FORMULASI DAN EVALUASI AKTIVITAS ANTIOKSIDAN SABUN CAIR BERBAHAN DASAR EKSTRAK DAUN KEMANGI DAN MADU Dewi, Bheta Sari; Utami, Sheila Meitania; Werawati, Ayu; Bachtiar, Wahyu; Dewantoro, Agung
PHRASE (Pharmaceutical Science) Journal Vol 4, No 2 (2024): Pharmaceutical Science Journal Vol 4 No 2
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v4i2.903

Abstract

Basil leaves  (Ocimum sanctum L.) and honey contain flavonoids and polyphenol compounds such as methyl eugenol, which are known to have antioxidant activity. Liquid soap is a form of pharmaceutical product that is often used to cleanse the body and provide additional protection to the skin. Objective: The aim of this study was to obtain the best physical formulation of a liquid soap combination of basil leaf extract and honey and its antioxidant activity. Method: Liquid soap preparations were made by adding basil leaf extract with various concentrations of 2g (FI), 4g (FII) and 8g (FIII) and honey, namely 5g (FI), 5g (FII) and 5g (FIII). Evaluation of liquid soap preparations included organoleptic, pH, and homogenity, as well as antioxidant activity test using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method with a wavelength of 516 nm. Results: The results showed that Formula III (FIII) had the best results, namely organoleptic milk chocolate color, pH preparation (9.71-9.89), homogeneous preparation, stable preparation in storage for 12 days and showed the best IC50 value of 118.39 ppm. Conclusion: In conclusion, the combination of basil leaf extract and honey can be formulated as a liquid soap preparation with a concentration of 8g basil leaf extract and 5g honey in formula III (FIII) showing the effectiveness as the best formulation.
Nutraceutical Drink as Immune Booster Made from Red Ginger Combined with Lime and Honey to Prevent Viral Infection Hasanah, Nur; Utami, Sheila Meitania; Ismaya, Nurwulan Adi; Imansari, Aulia Nadya Rizki
Jurnal Kefarmasian Indonesia VOLUME 15, NUMBER 1, FEBRUARY 2025
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Nutraceutical drinks are increasingly being chosen by the public as alternative medicine or as supportive therapy for disease prevention, offering minimal side effects with long-term use. This trend has gained momentum, mainly due to the rising incidence of COVID-19 and the emergence of highly transmissible variants. The combination of red ginger, lime juice, and honey will produce a healthy drink preparation containing antioxidants with vitamin C levels as an immune booster. This study aims to formulate a nutraceutical drink made from red ginger ((Zingiber officinale var. rubrum) combined with lime (Citrus aurantifolia) and honey also determine the antioxidant activity and the highest vitamin C levels. Physical stability tests include organoleptic, homogeneity, pH, specific gravity, viscosity, and accelerated stability tests using freeze-thaw cycling method. The antioxidant activity test using DPPH (1,1-diphenyl-2-picrylhydrazyl) method and analysis of vitamin C levels using the UV-Vis spectrophotometry method. The formulation was made with variations of lime juice FI (1%), FII (2%), and FIII (4%). The results of physical stability of the three formulations are not much different but based on organoleptic, FI has the best taste which is not too spicy and we are sure that most people will like it. Meanwhile, the highest antioxidant activity was possessed by FIII with an IC50 value of 11.21 ppm, which is classified as very strong and has the highest vitamin C content of 9103.88 µg/mL.
Formulation and Antioxidant Activity of Syrup Preparation Containing Saga Leaf Extract (Abrus precatorius L.) Dewi, Bheta Sari; Utami, Sheila Meitania; Sayyidah, Sayyidah; Alamsyah, Salwa Season; Rahmadani, Novita Tri
Jurnal Kefarmasian Indonesia VOLUME 15, NUMBER 1, FEBRUARY 2025
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Saga leaf (Abrus precatorius L.) have tannins, saponins, alkaloids, and flavonoids that have functions as antioxidants. The plant belongs to the Fabaceae family and is widespread in the tropics and subtropics. Syrup is one form of pharmaceutical preparation used in providing drugs in liquid form so that it is easily drunk by patients, especially children. The purpose of this study was to obtain the best syrup preparation formulation physically and its antioxidant activity. Saga leaf are extracted in ethanol and then syrup preparations by adding saga leaf extract with concentration variations of 0.5% (FI), 1% (FII), and 2% (FIII). Evaluation of syrup preparations includes organoleptic, pH, homogeneity, and antioxidant activity test using DPPH (1,1-diphenyl-2-picrylhydrazyl) measured by UV-Vis spectrophotometer at wavelength 516 nm. The results showed that Formula III had the best results, namely clear dark brown organoleptic, slightly viscous shape, distinctive smell and slightly bitter taste, pH 6.15, homogeneous, and the preparation was stable in storage for 12 days and showed the best IC50 value of 116.94 g/mL compared to FI (132.65 g/mL) and FII (118.03 g/mL). The antioxidant activity of saga leaf extract is categorized as moderate. In conclusion, saga leaf can be formulated as a syrup preparation with an extract concentration of 2% in formula III showing effectiveness as the best IC50 value of 116.94 g/mL and the best formulation.
Co-Authors Agung Dewantoro Ahmad Sopian, Ahmad Alamsyah, Salwa Season Angraeni, Lutfiah Aprilivani, Saskia Nur Ayu Werawati Bachtiar, Wahyu Bheta Sari Dewi Diah Permata Sari Diah Permata Sari Erwin Herdiawan Gina Aulia Holidah Holidah Humaira Fadhilah Ignesia Rara Denanti Imansari, Aulia Nadya Rizki Liswati Friana Sipayung Mita Nur Malasari Nanang Yunarto Nanang Yunarto Neneng Sri Purwaningsih Nur Hasanah Nur Hasanah Nurwulan Adi Ismaya Oktavendriyastuti Tabrani Rahmadani, Novita Tri Sayyidah, Sayyidah Tifani Monika Tri Okta Ratnaningtyas Widia Apriandini