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All Journal VALENSI Jurnal Penelitian Saintek SAINS DAN MATEMATIKA JURNAL KIMIA SAINS DAN APLIKASI Jurnal Akademika Biologi Chem Info Prosiding Seminar Nasional Sains Dan Teknologi Fakultas Teknik JKPK (Jurnal Kimia dan Pendidikan Kimia) Greensphere: Journal of Environmental Chemistry
Enny Fachriyah
Departemen Kimia, Fakultas Sains Dan Matematika, Universitas Diponegoro, Jl. Prof. Soedarto, Tembalang, Kota Semarang, Jawa Tengah, 50275
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Engineering Mathematics

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Journal : Chem Info

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Sintesis Etil Sinamat dari Sinamaldehid pada Minyak Kayu Manis (Cinnamomum cassia) dan Uji Aktivitas sebagai Antidiabetes Amalia, Dian; , S.Si., M.Si., Ngadiwiyana; Fachriyah, M.Si, Dra. Enny
Chem Info Journal Vol 1, No 2 (2013)
Publisher : Chem Info Journal

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Abstract

Cinnamon oil is obtained by distillation from the bark of cinnamon. The main component in cinnamon oil is cynnamaldehyde (42-75%). Cynnamaldehyde is a compounds which has aldehyde group that can be modified into the ester group that can be used as an antidiabetic. The synthesis cinnamic esters was oxidation and esterification. This research aims to isolate cynnamaldehyde of cinnamon oil, synthesized cinnamic acid and activities test as antidiabetic. Ethyl cinnamic is obtained from the synthesis of a clear yellow liquid and fragrant with a yield 98.86%. The results of FTIR showed the formation of cinnamic ethyl ester in the presence of CO groups, where as the results obtained by GC-MS abudance of 99.01% ethyl cinnamate. From the antidiabetic test results, ethyl cinnamate coumpounds IC50 values of 215.509 ppm.
SINTESIS ISOPROPIL SINAMAT DARI SINAMALDEHID PADA MINYAK KAYU MANIS (Cinnamomum cassia) DAN UJI AKTIVITAS SEBAGAI ANTIDIABETES Anwar, Finalia Femmy; , S.Si., M.Si., Ngadiwiyana; Fachriyah, M.Si, Dra. Enny
Chem Info Journal Vol 1, No 2 (2013)
Publisher : Chem Info Journal

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Has done research on use of synthesis isopropyl cinnamate of cinnamaldehyde in cinnamon oil (Cinnamomum cassia) and test activities as the antidiabetic. The purpose of this study was to isolate cinnamaldehyde of cinnamon oil, synthesis cinnamic acid, cinnamic isopropyl synthesis and test the antidiabetic activity. The method used in this study by using the method of oxidation and esterification through cinnamoil chloride. Analysis of compounds synthesis was using infra red spectrophotometry, gas chromatography-mass pectroscopy. Activity test of anti-diabetic compounds isopropyl cinnamic was with the measurement of inhibition α-glucosidase activity. Cinnamaldehyde which is isolated from cinnamon oil was yellow orange oil and cinnamaldehyde’s yield   1    was up to 76.41% and its purity was 99.87%. Cinnamaldehyde analysis using of infra red spectrophotometer showed carbonyl vibration at 1676 cm-1, C-H aldehyde at 2813.9 cm-1. From mass spectra, it can be known that cinnamaldehyde had M+ 132. Cinnamic acid which is oxidation was a white solid with yield was up to 41,89%. Cinnamic acid analysis using of infra red spectrophotometer showed O-H ad 3433.29 cm-1. Esterification of cinnamic acid chloride sinamoil through using 2-propanol produces brownish yellow liquid with a yield of as much as 84.62% and its purity was 98.43%. Isopropyl cinnamic analysis using of infra red spectrophotometer showed C-O ester at 1165.00 cm-1 and C-O isopropyl at 1111.10 cm-1. From mass spectra, it can be known that isopropyl cinnamic had M+ 190. At concentrations of 74.219 ppm isopropyl cinnamate synthesis results showed activity as antidiabetic of the enzyme that can inhibit α-glucosidase by 96.94% with IC50 value of 45.42 ppm.
Co-Authors Andriyani Budi Listyo Arina Tri Lunggani Arsalan, Sausan Syakib Asy'ari, Mukhammad Dewi Kusrini Dian Amalia Dwi Hudiyanti Dwi Listiorini Femmy Nurul Akbar Gian Restu Prinanda Hanum, Rahma Farida Huda, Muhammad Badrul Ismiyarto Ismitarto Khodijah Baharun Kurnia, Any Laksmitasari, Nuraini Dwi MG Isworo Rukmi Mumtazati, Qonita Ngadiwiyana M.Si. S.Si. Nies Suci Mulyani Nor Basid Adiwibawa Prasetya Pandelaki, Elmi Christi Julia Pratama Jujur Wibawa Purbowatiningrum Ria Sarjono Rahman, Muhammad Kevin Ramadhan, Eko Febrianto Rosyadah, Jihan Sumardjo, Damin Wati, Mei Riska