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All Journal Jurnal Wiyata : Penelitian Sains dan Kesehatan JPSCR : Journal of Pharmaceutical Science and Clinical Research IJMS - Indonesian Journal on Medical Science Jurnal Farmasi Indonesia Cendekia Journal of Pharmacy Jurnal Ilmiah Cendekia Eksakta Jurnal Insan Farmasi Indonesia Jurnal Farmasi dan Sains Indonesia (JFSI) JAFP (Jurnal Akademi Farmasi Prayoga) Indonesian Journal on Medical Science (IJMS) Media Farmasi Indonesia Journal of Clinical Pharmacy and Pharmaceutical Science Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Jurnal Pengabdian Ikifa
Paulina Maya Octasari
Politeknik Katolik Mangunwijaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Environmental Science Health Professions Immunology & microbiology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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POTENSI ANTIDIABETIK EKSTRAK ETANOLIK BIJI SALAK (Salacca zalacca) PADA MENCIT PUTIH JANTAN GALUR SWISS (Mus musculus) YANG DIINDUKSI ALOKSAN Rukminingsih, Fef; Maya Octasari, Paulina; Kristi Nadila, Lilis; Aulia Putri, Fayza
Jurnal Insan Farmasi Indonesia Vol 6 No 2 (2023): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v6i2.1600

Abstract

Traditional medicine is an alternative treatment for diabetes mellitus. Flavonoids are compounds that have the activity of lowering blood glucose levels. Snake fruit (Salacca zalacca) contains flavonoids. This study aims to determine the antidiabetic potential of snake fruit ethanolic extract (SFEE) on male white Swiss mice. This research is an experimental study that consisted of 2 stages, namely testing the antidiabetic power and testing the hypoglycemia side effects of SFEE. Each stage was tested on 5 treatment groups. The various doses used were 91 mg, 114 mg, and 137 mg of 20g mice. In stage 1, fasting blood sugar checks are carried out on days 0, 3 and 17. Meanwhile, in stage 2, fasting blood sugar checks are carried out on days 1, 7 and 14. The positive control in the stage 1 test was metformin, while the stage 2 test used glibenclamide. The results showed that varying doses of SFEE  91 mg, 114 mg, and 137 mg of 20g mice had antidiabetic power of 62.87%, 68.07%, and 70.98%. The greater the dose of SFEE, the greater its antidiabetic power. However, the larger the dose of SFEE and the longer it is administered, the hypoglycemic effects will occur
PENGGUNAAN ANTIHIPERTENSI PADA PASIEN STROKE NON HEMORAGIK DI INSTALASI FARMASI RAWAT JALAN RUMAH SAKIT X SEMARANG Maya OCTASARI, Paulina; Veny OKTAVIANI, Anastasia
Media Farmasi Indonesia Vol. 15 No. 2 (2020): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (448.286 KB) | DOI: 10.53359/mfi.v15i2.161

Abstract

Non-hemorrhagic stroke is a functional disorder of the brain’s neurologic deficits caused by vasocontraction due to blockage in the arterial vessel leading to the brain. There were 79% of non-hemorrhagic stroke patients are caused by hypertension. Antihypertensive therapy for the patients given as secondary therapy to prevent recurrent stroke, decreased brain edema risk, hemorrhagic risk, and prevent further vascular damage. Therefore this research aimed to evaluate antihypertensive usage in non-hemorrhagic stroke patients in the Hospital. The research is an observational descriptive with cross-sectional design and retrospective data. Data retrieval through the medical record of outpatients with ages 36-65 years were diagnosed with non-hemorrhagic stroke with or without comorbidities and National Health Insurance patients period of October - December in 2019. Data were classified based on age, gender, and antihypertensive agent, and were analyzed by calculating the percentage of patients who have decrease, stability, and increased blood pressure. 92 patients who were included in the inclusion criteria. The result showed that more male patients (68,48%), mostly age category 55-65 years (70,65%) with hypertensive (51,09%). Antihypertensive usage in non-hemorrhagic stroke is mostly used CCB group (70,65%). The percentage of patients who suffered a decrease in systolic blood pressure as much as 53 patients (57,6%), meanwhile the decrease in diastolic blood pressure as much as 63 patients (68,46%). There were 69 patients (75%) has blood pressure target therapy.
PENURUNAN SKALA NYERI PENGGUNAAN KETOROLAK INJEKSI PADA PASIEN OPERASI SESAR DI RUMAH SAKIT ROEMANI MUHAMMADIYAH SEMARANG Octasari, Paulina Maya; Inawati, Menik
Media Farmasi Indonesia Vol. 16 No. 2 (2021): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (341.799 KB) | DOI: 10.53359/mfi.v16i2.179

Abstract

Pain management after cesarean section must be done properly to prevent the emergence of chronic pain in patients. Ketorolac is the first choice as an analgesic to treat that pain. The appropriate dosage and time of analgesic treatment have impact to pain scale decreasing and another analgesic adding. The purpose of this study was to determine the magnitude of the reduction in the pain scale of using ketorolac injection in cesarean section patients at Roemani Muhammadiyah Semarang Hospital. This research is a descriptive observational study. The research design is cross-sectional study by using retrospective data. The data were taken through the medical records of patients with cesarean section at Roemani Muhammadiyah Hospital Semarang for the period July - December 2019. The sample of this study was elective caesarean section patients who received ketorolac injection therapy in that period. The age range of patients taken was 18- 45 years. The reduction in pain scale was measured by the Numeric Rating Scale (NRS) method. The results showed that the sample data obtained and those who met the inclusion criteria were 88 patients. Before the administration of ketorolac injection, the number of patients with moderate pain was in the greatest number, namely 53.41% and after the administration of ketorolac injection, the number of patients with mild pain was the greatest, namely 63.64%. Patients who experienced a decrease in the pain scale of 39.78%, the stability of the pain scale of 47.72%, and an increase in the pain scale of 12.50%. The average reduction in the pain scale of cesarean patients who received ketorolac injection at the Roemani Muhammadiyah Semarang Hospital was 1.09. Keywords: Cesarean section, Pain, Pain scale, Ketorolac, Roemani Muhammadiyah Hospital Semarang.
Pola Peresepan Obat Psikotropika Di Apotek Karangrejo Kota Semarang Paulina Maya Octasari; Devita Wityaninda
Journal Clinical Pharmacy and Pharmaceutical Science Vol. 2 No. 2 (2023): Oktober : Journal of Clinical Pharmacy and Pharmaceutical Science
Publisher : Prodi D3 Farmasi Politeknik Katolik Mangunwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61740/jcp2s.v2i2.39

Abstract

Psychotropics can lead to dependence if misused or used without control and supervision. Psychotropic drugs can only be given using a prescription in healt facilities such as pharmacies, clinics or hospitals. One way to control and supervise psychotropic drugs is to plan. This study aims to determine the pattern of prescribing psychotropic drugs at the Karangrejo’s Pharmacy, Semarang City. This research is a type of descriptive observational research. The design of this research is a Cross-Sectional Study. The data collected is retrospective, in the period October - December 2022. The data source is a psychotropic drug prescription sheet at the Karangrejo Pharmacy, Semarang City. The data collected included date of prescription, prescription number, age, gender, origin of prescription, psychotropic drug used and dosage. The data were analyzed qualitatively, grouping data based on patient and prescription characteristics. Patient characteristics include the patient's age and gender while prescription characteristics include the origin of the prescription, and the psychotropic drugs used include the name of the drug, drug class, amount of drug therapy and drug combinations. Quantitative analysis is by calculating the percentage of data that has been processed. From this study, the data obtained were 106 patients who received psychotropic drugs at the Karangrejo Pharmacy, Semarang City. From the results of this study, it was obtained that the most age group was 56-65 years (34.91%) with the most gender, namely women (65.09%), the origin of the prescription that prescribed the most psychotropics was prescription from external doctors (50.94%) with the highest speciality of prescribing doctors, namely specialist doctors (82.07%), the most widely used type of psychotropic drug, namely Chlordiazepoxide (50.73%), the highest number of drug therapies, namely single drug therapy (76.42%), the highest drug combinations namely Chlordiazepoxide 5mg and diazepam 2mg (56%), and the most common class of therapy was antispasmodics (50.72%).
PERCEPTION OF JAMU USAGE AT ROWOBELANG VILLAGE, BATANG DISTRICT Asri, Kurnia Ika Setya; Octasari, Paulina Maya
Jurnal Wiyata Penelitian Sains dan Kesehatan Vol 11, No 1 (2024)
Publisher : LP2M IIK (Lembaga Penelitian dan Pengabdian Masyarakat Institut Ilmu Kesehatan) Bhakti Wiy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/wiyata.v11i1.788

Abstract

Background: The use of traditional medicine as herbs increased relatively neither in developing countries nor developed countries. Efficacy of herbs trusted hereditary. People use herbs as treatment therapy and maintain the health of the body. Some herbs mix medicinal chemical materials illegally. Abuse of it can affect public perception about used herbs in Rowobelang Village, Batang District. Method: This research is a descriptive observational study using a questionnaire instrument containing respondents' sociodemographic data and ten statements to measure public perception about using herbs. The public perception profile was measured in three aspects, there were efficacy aspect, accessibility aspect and safety aspect. Data was taken by using purposive sampling. Results: This research uses 320 respondents as the sample who belong to the inclusion criteria. Characteristics of respondents who filled out the questionnaire are 36-45 years old (35%), high school educated (43,8%), female (63,4%), and have a job (66,5%). The highest aspect that had a high percentage was the efficacy aspect, and the lowest was the safety aspect (28,46%).Conclusion: The result indicates the public perception of herbs used in Rowobelang Village is in the good perception category (72,5%).
Tekanan Darah Pasien Hipertensi Dengan Diabetes Melitus Tipe II Di Puskesmas Ngemplak Simongan Kota Semarang Rukminingsih, Fef; Octasari, Paulina Maya; Dewi, Restu Anita Sukma
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p41-46

Abstract

Hypertension is often asymptomatic and if left untreated can cause complications. Hypertension is an increase in systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg. The blood pressure target for hypertensive patients with type II diabetes melitus (HT-DMTII) is <130/80 mmHg. The risk of complications increases if blood pressure does not reach the therapeutic target. Ngemplak Simongan Health Center, Semarang City has quite a lot of HT-DMTII patients, who undergo routine check-ups every month. This study aims to determine the achievement of blood pressure targets for HT-DMTII patients at Ngemplak Simongan Health Center, Semarang City. This study is an observational descriptive study using purposive sampling technique. The data used is retrospective data obtained from medical record data of HT-DMTII patients for the period August - October 2023. The inclusion criteria used were patients aged ≥36 years, receiving the same treatment for 2 consecutive months and having blood pressure data for 2 consecutive months. The data taken included medical record number, age, gender, blood pressure data for 2 consecutive months in the period August - October 2023, antihypertensives given and duration of use. From 62 patients, it was known that the majority were female patients 72.58%, aged >60 years as many as 58.06% and those who used antihypertensives for more than 5 years as many as 61.29%. A total of 59 people (95.16%) received single antihypertensive therapy. The most widely used antihypertensive was amlodipin (90.32%). There were 20 patients (32.26%) whose blood pressure reached the target.
Kejadian Nyaris Cidera (KNC) Pada Pelayanan Resep Pasien Poli Penyakit Dalam di Instalasi Farmasi Rawat Jalan RS Roemani Muhammadiyah Semarang Octasari, Paulina Maya; Yulia, Rika; Rukminingsih, Fef
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p1-6

Abstract

The paradigm changing in health care form “quality” to “quality and safety” aims to improve the quality of life of patient. One of the efforts is to minimize the occurrence of incidents. The largest number of the patient safety incidence is Nearly Injury Incidence, which is 18.53%. The increased risk of NPC can be caused by their presence of polypharmacy. Polypharmacy is often experienced in patients at the Internal Medicine Polyclinic at Roemani Muhammadiyah Semarang Hospital. Therefore, it is necessary to conduct research to determine the number of KNCs in the prescription service of poly internal medicine patients in the Outpatient Pharmacy Installation of Roemani Muhammadiyah Hospital Semarang. The study was a descriptive observational study with prospective data from prescription services for patients with internal medicine at the Outpatient Pharmacy Installation of Roemani Muhammadiyah Hospital Semarang in March 2020. Evaluations were carried out at each stage of prescription service. Stages consist of prescribing, taking drugs, and preparing medicines etiquette, checking. Data were analyzed and grouped according to the type of KNC at each stage of prescription service for patients with internal medicine, the number and percentage of KNC on each prescription sheet. The results showed that there were 25 KNCs on 375 sheets of prescribed poly patients in internal medicine at Roemani Muhammadiyah Hospital Semarang. The percentage of KNC is the drug entry stage of 9 KNC (2.4%), the taking stage of 15 KNC (4%), the preparation stage of 1 KNC (0.27%).
Toksisitas Subkronis Ekstrak Biji Salak (Salacca Zalacca) Terhadap Fungsi Hati Mencit Putih Octasari, Paulina Maya; Rukminingsih, Fef; Vita, Cristin Yulia
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p119-125

Abstract

Salak seeds (Salacca zalacca) contain several secondary metabolites like as 0.059% flavonoids, 0.082% tannins and 0.063% alkaloids. Salak is a potential plant as a medicinal ingredient, so it is necessary to conduct a drug safety study. Subchronic toxicity test needs to be done in traditional drug therapy because it is given continuously. This study objective was to examine the subchronic toxicity of salak seed extract on liver function in male Swiss strain mice. This type of research is an experimental study with a completely randomized design with a one-way pattern with one treatment factor. There are four treatment groups with a total of 7 mice replications. Variations in the dose of salak seed extract administration were 91 mg/20 gBW of mice, 114 mg/20 gBW of mice, and 137 mg/20 gBW of mice. The toxicity test were SGPT and SGOT values on days 0 and 14. The data tested with one-way ANOVA followed by a t-test. The Salak Seed Extract (EBS) is a viscous extract with a dark brown colour, a distinctive smell of salak, and a chelate taste. The amount of the extraction result was 12.26%. Positive EBS contains flavonoids with a reddish-orange colour. The treatment of Salak Seed Extract ( 91 mg/20 g BW and 137 mg/20 g BW) was not increased significantly the SGPT and SGOT levels for 14 days (p-value 0.896 and 0.072). Although the second dose (114 mg/20 g BW) was increased the SGPT and SGOT levels (p-value 0.002), this enhancement was less than twice
KEPUASAN PASIEN POLI IBU TERHADAP PELAYANAN KEFARMASIAN DI INSTALASI FARMASI RAWAT JALAN RUMAH SAKIT HERMINA PANDANARAN SEMARANG Octasari, Paulina Maya; Fatimah, Siti Nur
CENDEKIA EKSAKTA Vol. 6 No. 1 (2021)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/ce.v6i1.4403

Abstract

Kualitas pelayanan terhadap pasien di rumah sakit berdampak pada kepuasan pasien. Pada bulan Januari – September 2019, jumlah pasien di poli ibu Rumah Sakit Hermina Pandanaran Semarang mencapai 30% dari 123.536 total pasien. Kepuasan pasien dapat diukur melalui lima dimensi kepuasan yaitu, wujud nyata, perhatian, jaminan kepastian, kehandalan, dan ketanggapan. Tujuan dari penelitian ini adalah untuk mengetahui kepuasan pasien poli ibu di Instalasi Farmasi Rumah Sakit Pandanaran Semarang. Penelitian ini merupakan penelitian deskriptif observasional dengan desain cross sectional. Data diambil secara prospektif melalui pengisian kuesioner tentang pelayanan farmasi kepada pasien. Usia responden berkisar 17 – 65 tahun. Data dianalisis berdasarkan karakteristik responden dan persentase kepuasan pasien di setiap dimensi.Hasil menunjukkan bahwa usia pasien paling banyak adalah 26 – 35 tahun (57%) dengan tingkat pendidikan terakhir pendidikan tinggi (63.3%). Kepuasan pasien menunjukkan hasil berurutan sebagai berikut: dimensi wujud nyata 94%, perhatian 90,7%, jaminan kepastian 99,5%, kehandalan 100%, dan ketanggapan 99%. Hasil penelitian menunjukkan bahwa kepuasan pasien telah melampaui standar yang ditentukan di RS Hermina Pandanaran Semarang, yaitu > 90%. Meskipun demikian terdapat satu pertanyaan dalam dimensi perhatian yang menghasilkan kepuasan sebesar 81.3%. Kata kunci: Kepuasan pasien, poli ibu, rumah sakit
EVALUASI KADAR GLUKOSA DARAH PASIEN DIABETES MELITUS TIPE 2 DENGAN HIPERTENSI DI RUANG CEMPAKA RUMAH SAKIT PANTI WILASA CITARUM SEMARANG Wisma Supriatining Krestiana; Paulina Maya Octasari
Journal Clinical Pharmacy and Pharmaceutical Science Vol. 1 No. 1 (2022): April: Journal of Clinical Pharmacy and Pharmaceutical Science
Publisher : Prodi D3 Farmasi Politeknik Katolik Mangunwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61740/jcp2s.v1i1.5

Abstract

Diabetes mellitus is a degenerative disease that increases every year in the world. The most common case of DM is a case of type 2 DM (90%). Type 2 DM with hypertension is one of the ten biggest diseases in Panti Wilasa Citarum Hospital Semarang. The purpose of this study was to evaluate and calculate the value of decreasing blood glucose levels. The type of research conducted was descriptive observational using a prospective method. The study was conducted in Cempaka Room at Panti Wilasa Citarum Hospital Semarang in the period March-April 2019. The research subjects were patients aged 18-60 years with National Health Insurance who met the inclusion-exclusion criteria who were willing to be respondents in this study. Data is processed and analyzed qualitatively and quantitatively. The results showed that the target blood glucose level of type 2 DM patients with hypertension at Panti Wilasa Citarum Hospital Semarang was achieved. Patients experienced a decrease in GD2JPP and GDP levels in single antidiabetic therapy of 73.68%, two combinations of antidiabetic 95%, three combinations of antidiabetic 100%.
Co-Authors Angela Desiani Ampur Aqilatul Maziah Asri, Kurnia Ika Setya Aulia Putri, Fayza Cristin Yulia Vita Daisy Ariani Daniar Kusuma Wardani Devita Wityaninda Dewi, Restu Anita Sukma Elisabeth Lionida Sari Febyana Dewi Shinta Fef Rukminingsih Fef Rukminingsih Fef Rukminingsih Fransiska Ayuningtyas Inawati, Menik Kristi Nadila, Lilis Nova Silvianingsih Oktavia Dwi Danira Pujiastuti, Anasthasia Rika Yulia Rika Yulia Septiana Laksmi Ramayani Setyorini - Politeknik Katolik Mangunwijaya, Siska Silvi, Niken Hidayatus Sisca Devi Siska Setyorini - Politeknik Katolik Mangunwijaya Siti Nur Fatimah Veny OKTAVIANI, Anastasia Vita, Cristin Yulia Wisma Supriatining Krestiana