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Agriculture, Biological Sciences & Forestry Humanities Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Library & Information Science Medicine & Pharmacology Public Health Social Sciences

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Journal : Journal of Global Pharma Technology

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Liver Regenerative and Hepatoprotective Effects OF Moringa Oleifera Extract in the Liver Fibrosis Animal Model Supriono Supriono
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: This study was conducted to know the liver regenerative and hepatoprotective effects of Moringa oleifera (MO) in the animal models of liver fibrosis. Methods: The study was a randomized post-test only controlled group design. Male Rattus novergicus of liver fibrosis caused by induction of CCl4 was treated with extract of (MO). Histological of the liver tissue with hematoxylin and eosin (H&E) staining were investigated by a light microscope. We calculate the number of hepatocytes expressing MDA and cytokeratin-7 (CK-7) in liver tissue using the immunohistochemical analysis. Results: Induction of CCL4 for 14 weeks results in liver fibrosis (METAVIR score F-3) and improves by the administration of MO. The number of hepatocytes expressing MDA in liver fibrosis models sevenfold higher than normal models and significantly lower after treated with MO. ALT and AST in the treated models significantly lower than in the liver fibrosis models. On the other hand, the number of hepatocytes expressing CK-7 in both normal and liver fibrosis models was lower. The CK-7 significantly higher after the administration of MO. Many ductular reactions develop in the treated animal models. Conclusions: in our knowledge, this is the first study reported a liver regenerative effect of MO in the liver fibrosis, beyond its hepatoprotective effect. The mechanism of liver regenerative probably through a hepatic progenitor cell proliferation. Keywords: Moringa oleifera, liver fibrosis, liver regenerative, CK7, MDA.
Co-Authors Ade Elbani Adhinta Salsabiila Agnes Christy Anggrainy Ajеng Diviе Еkananda Akbar Ilham Andika Restu Putra P. Andika Yoga Baskara Andreas Andreas Angelina Diah Kusumasari Annisa Nur Faida Ardy Dwi Juniantoko Aulia Devi Maharani Azmi Yuliana Bagus Nur Herawan Bambang Petrus Simamora Bhirawa Manggala Bogi Pratomo Christina Rimbun S L Sitanggang Clarissa Yovianingtyas Darlis Edfan Dean Mutiara Dendy Derganata Gustria Desy Melania Dwi Anita Dinda Mei Diana Dwi Fitriani Eka Intan Kumala Putri Elok Lestyani Purboningrum Elza Zuhry Enni Savitri Fahmy Zulkifli Fandi Achmad Fitriana Fajrin Ramadhany Fitrios Ruhul Harijono Achmad I Made Budi Suksmadana I Nyoman Wahyu Satiawan I Nyoman Wahyu Setiawan Ida Bagus Fery Citarsa Ika Septiana Puspita Sari Imеyla Еknis Lеstari Inаs Аrfiеny Hаlimаtus Nаdiyаh Khansa Sanchia Salsabila Komang Pandu Triwiyana Lionides Andrean Putra Yoni Luqfia Refina Mazidatus Sakinah Miftahur Rohmah Oktavia Mochammad Al Musadieq Mohamad Rizaldy Muchtar Tsabit Mukhamad Subandi Mukhammad Kholid Mawardi Muntakoh Ahmad Mustaring Mustaring Mu’adz Shidqi Noraimah Noraimah Novrika Yanti Nurmalaika Ayuni Kesuma Pangestuti, Edriana Puput Solekhah Putra Yuananda Yogi R.Adri Satriawan Surya Raden Mohamad Herdian Bhakti Rahmah Alfiani Raka Argiansyah Arya Narindra Rasul M Rasuli M. Rasuli Rasuli Ratmiaji Ratmiaji Restu Agusti Revi Salas Ristantri Reza Dimas Syahputra Rilian Pratama Rinaldy Achmad Roberth Fathoni Rita Anugrah Rizka Rakhmawati Rosmiza Bidin Rеgina Hеidy Pangеstu Sahrani S Almaida Septhea Dwi Pratiwi Solly Aryza Sudarmiatin Supriyatna Supriyatna Surya Adri Satriawan Raja Syahra Ariesta Fitria Sari Syifa Mustika Tarsono Ulya Hasna Wilujeng Warindi D Wiyadindi Novian Zahra Yesi Mutia Basri Yohana Rise Yulius Duma Zakiyah Zakiyah Zirman Zirman