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All Journal Indonesian Journal of Cancer Chemoprevention Majalah Obat Tradisional Jurnal Kefarmasian Indonesia
Sofa Farida
Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Public Health

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SynergisticCombinationofCiplukan(Physalis angulata) HerbsEthanolicExtractandDoxorubicinonT47DBreast CancerCells Armandari, Inna; Palupi, Kartika Dyah; Farida, Sofa; Hermawan, Adam; Susidarti, Ratna Asmah; Meiyanto, Edy
Indonesian Journal of Cancer Chemoprevention Vol 1, No 1 (2010)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4.399 KB)

Abstract

Doxorubicinisoneofchemotherapeuticagentwidelyusedinbreastcancertreatment,but in high dose doxorubicin gives negative side effect, including vomit, nausea, immune suppression, and cardiac toxicity. This toxicity hopefully could be reduced by combination chemotherapy using natural herbs such as ciplukan herb. This research was conducted to explorecytotoxicactivityofsingleciplukanherbsethanolicextractanditscombinationwith doxorubicinonT47Dbreastcancercells.Cytotoxicactivityofciplukanherbsethanolicextract only and its combination with doxorubicinwere tested on T47D cells using MTT assay toobtainIC50valueandcombinationindex(CI),respectively.Singleextractshowedcytotoxic activityonT47DcellswithIC50valueofwas160*g/ml.Thus,combinationtreatmentfrom ciplukanherbsethanolicextractanddoxorubicinshowedsynergisticeffect(CI<1,0).Thiseffect wasreachedatconcentrationofciplukanherbsethanolicextract-doxorubicin80μg/ml-2nM, 80 μg/ml-4 nM, and 80 μg/ml-8 nM. This research indicated that ciplukan herbs ethanolic extractispotentialtobeappliedasco-chemotherapeuticagentinbreastcancertherapy.
Antiproliferative Activity of Ethanolic Extract of Ciplukan Herbs (Physalis angulata L.) on 7,12-Dimethylbenz[a]nthracene-Induced Rat Mammary Carcinogenesis Putri, Laras Widawaty; Ikhtiarsyah, Yurista Gilang; Meiyanto, Edy; Monikawati, Ameilinda; Farida, Sofa
Indonesian Journal of Cancer Chemoprevention Vol 2, No 2 (2011)
Publisher : Indonesian Research Gateway

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Physalis angulata  L.  is  an  annual  herb  widely  used  as  popular  medicine  for  the treatment of cancer. Physalis angulata L. ethanolic extract (PEE) has been demonstrated to have strong cytotoxic activity against breast cancer, inhibited cancer cell’s proliferation and induced  cell  cycle  arrest.  The  aim  of  our  study  is  to  investigate  the  effect  of  PEE  as  a cancer  chemopreventive  agent  on  7,12-dimethylbenz[a]nthracene  (DMBA)-induced  rats mammary. The antiproliferative activity was characterized by monitoring the histopatology representation  and  expression  of  cell  proliferation  on  DMBA-induced  mammary  rats  that were  treated  with  PEE  against  control  groups.  The  histopatology  representation  were analyzed  by  Haematoksilin  Eosin  (HE)  staining  method,  while  proliferative  activity  was detected by AgNOR method. The HE staining results showed significant differences in cells morphology  of  treatment  groups  compared  to  the  control  groups.  Thus  results  suggest that  PEE  was  able  to  repair  morphology  of  cells  undergoing  carcinogenesis.  AgNOR method  showed  decreasing  occurrence  of  black  dots  between  treatment  and  control groups. Thus, we conclude that PEE has an antiproliferative activity on DMBA-induced rat mammary.  Therefore,  the  ethanolic  extract  of  Physalis  angulata  herbs  is  a  potential chemopreventive agent on cancer. Further study on its molecular mechanism needs to be explored. Keywords:  Physalis  angulata,  breast  cancer, 7,12-dimethylbenz[a]nthracene, carcinogenesis, antiproliferative
Calophyllum inophyllum: A Comprehensive Analysis of its Ethnobotanical, Phytochemical, and Pharmacological Properties Farida, Sofa; Jenie, Riris Istighfari; Fakhrudin, Nanang
Majalah Obat Tradisional Vol 29, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.87488

Abstract

Nyamplung (Calophyllum inophyllum L.) is reported to have ethnomedicinal benefits in traditional medicine systems. Leaves, fruit, seeds, flowers, stems, roots and essential oils are the parts that are often used. Previous scientific studies revealed that this plant part is a valuable resource of secondary metabolites and exhibits a wide range of biological activities. The purpose of this review is to deliver thorough and detailed insights into the traditional uses, chemical ingredients, biology, and pharmacological studies as scientific evidence about the useful efficacy of C. inophyllum in the development of modern medicine. Traditional use shows C. inophyllum is widely used to treat skin diseases, wounds, boils, vaginal discharge, bleeding, gonorrhea, chronic bronchitis, sore eyes, heatstroke, and headaches. C. inophyllum is rich in phenols, polyphenols, flavonoids, xanthones, coumarins, and terpenoids. Several research results show that C. inophyllum possesses a multitude of pharmacological properties including anti-cancer, anti-inflammatory, antimicrobial, antioxidant, antiplatelet, antiviral, and antidiabetic activities.
Uji Aktivitas Antibakteri Ekstrak Etanol Tanaman Obat Suku Musi di Kabupaten Musi Banyuasin, Sumatera Selatan Muharni, Muharni; Fitrya, Fitrya; Farida, Sofa
Jurnal Kefarmasian Indonesia VOLUME 7, NOMOR 2, AGUSTUS 2017
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v7i2.3493

Abstract

Musi tribe community used medicinal plants generally based on cultural heritage. Unproper use of medicinal plants unproperly cause the drug does not work effectively. Ten medicinal plants were selected for antibacterial activity tested using disc diffusion method against two testb bacteria i.e Escherichia coli (E. coli) and Staphylococcus aureus(S. aureus) at concentrations of 125, 250, 500, and 1000 μg/mL. Minimum inhibitory concentration (MIC) were determined for the active extract which still gives antibacterial activity using well method. The result showed only three test extracts, i.e Coleus scutellarioides, Blumea balsamifera and Lantana camara gave inhibition zone diameter of 11-20 mm against E. coli. Meanwhile, four extracts i.e Coleus scutellarioides, Blumea balsamifera, Dillenia alata and Dimocarpus melayensis gave inhibition zone diameter of 11-20 mm against S. aureus. Determination of MIC values for Coleus scutellarioides and Blumea balsamifera extracts gave the same MIC value of 125 μg/mL for both test bacteria. Meanwhile, Lantana camara gave MIC value of 250 ug/mL for E. coli. Dillenia alata and Dimocarpus melayensis also provide MIC value of 125 ug/mL againts E. Coli. It was found that there were five active extracts among ten extracts tested. Two extracts which active against both test bacteria were Coleus scutellarioides and Blumea balsamifera. One extract, Lantana camara only active against E. coli and the two others Dillenia alata and Dimocarpus melayensis were active against S. auerus.
Co-Authors Adam Hermawan Ameilinda Monikawati Edy Meiyanto Fitrya Fitrya Inna Armandari Kartika Dyah Palupi Laras Widawaty Putri Muharni Muharni Nanang Fakhrudin, Nanang Ratna Asmah Susidarti Riris Istighfari Jenie Yurista Gilang Ikhtiarsyah