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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) GHIDZA: Jurnal Gizi dan Kesehatan Journal Health & Science : Gorontalo Journal Health and Science Community Jurnal Maternitas Kebidanan Jurnal Aisyah : Jurnal Ilmu Kesehatan PROFESSIONAL HEALTH JOURNAL PRIMER (Prima Medical Journal)
Maya Sari Mutia
Universitas Prima Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Veterinary

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SUATU STUDI LITERATUR: AKTIVITAS ANTIDIABETIC DARI KULIT JERUK (Citrus sp.) Maya Sari Mutia; Chrismis Novalinda Ginting; OK Yulizal
Jurnal Maternitas Kebidanan Vol. 6 No. 2 (2021): Jurnal Maternitas Kebidanan
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jumkep.v6i2.2054

Abstract

Diabetes mellitus is a chronic metabolic disease, which is not able to secrete insulin in sufficient quantities or the body is unable to use insulin effectively so there is an excess glucose level and immediately suffer from some complications against the organs. Diabetes mellitus can be cured by herb utility which are thought to have compounds that has an antidiabetic effect. Therefore, this literature study discusses the antidiabetic activity of orange peel (Citrus sp.). The literature search was carried out on the Google Scholar search engine which used some keyword included antidiabetic, extract, orange peel, Citrus. In this literature study, there are inclusion and exclusion criteria for selecting journals as literature sources. The results of 12 literatures review that orange peel had antidiabetic activity by decrease blood glucose levels in some animal trials that had received an effective dose of orange peel extract in each of the reviewed studies. Hence, it can be concluded that various type of Citrus peels has antidiabetic effect.
DESCRIPTION OF THE LEVEL OF COMMUNITY KNOWLEDGE OF GENERIC DRUG AND BRANDED DRUG AT A PHARMACY MEDAN CITY DISTRICT Nini Tiatira Tobing; Maya Sari Mutia
Journal Health & Science : Gorontalo Journal Health and Science Community Vol 6, No 2 (2022): JULI: JOURNAL HEALTH AND SCIENCE : GORONTALO JOURNAL HEALTH AND SCIENCE COMMUNIT
Publisher : Gorontalo State University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/gojhes.v5i3.13917

Abstract

Abstrak Obat generik bermerek adalah obat yang telah diberi nama dagangnya oleh perusahaan dan umumnya kualitasnya sama dengan obat generik berlogo tetapi dengan harga yang relatif lebih tinggi. Kebaruan penelitian ini adalah meneliti tentang tingkat pengetahuan masyarakat terhadap obat generic dan obat merek dagang di apotik. Tujuan untuk mengetahui gambaran tingkat pengetahuan masyarakat terhadap obat generik dan obat merek dagang di apotek Kecamatan Medan Kota. Penelitian ini merupakan penelitian deskriptif dengan pendekatan cross sectional. Pengambilan data dilakukan dengan teknik accidental sampling pada 192 responden. Analisa data univariat. Hasil yang diperoleh dari 192 masyarakat di apotek Kecamatan Medan Kota, umur terbanyak adalah 18-29 tahun yaitu 69 orang (35,9%), jenis kelamin terbanyak adalah perempuan yaitu 102 orang (53,1%), pendidikan terbanyak adalah perguruan tinggi yaitu 130 orang (67,7%), dan pekerjaan terbanyak adalah wiraswasta yaitu 48 orang (25,0%), serta dari 192 masyarakat di apotek Kecamatan Medan Kota, tingkat pengetahuan masyarakat kategori baik sebanyak 33 reponden (17,2%), tingkat pengetahuan kategori cukup sebanyak 134 responden (69,8%), dan tingkat pengetahuan kategori kurang baik sebanyak 25 responden (13%). Kesimpulan, bahwa umur terbanyak adalah 18-29 tahun, jenis kelamin terbanyak adalah perempuan, pendidikan terbanyak adalah perguruan tinggi, dan pekerjaan terbanyak adalah wiraswasta, serta tingkat pengetahuan masyarakat terhadap obat generik dan obat merek dagang di apotek Kecamatan Medan Kota masih dalam kategori cukup. Kata Kunci : Obat Generik; Obat Merek Dagang; Tingkat Pengetahuan Masyrakat. AbstractBranded generic drugs are drugs that have been given a trade name by the company and generally have the same quality as generic drugs with the logo but at a relatively higher price. The novelty of this research is the description of the level of public knowledge of generic drugs and trademarked drugs in pharmacies. The purpose of this study is to describe the level of public knowledge of generic drugs and trademarked drugs in pharmacies in Medan Kota District. This research is a descriptive study with a cross sectional approach. Data collection was done by accidental sampling technique on 192 respondents. Univariate data analysis. The results obtained from 192 people in pharmacies in Medan Kota District, the most age were 18-29 years, namely 69 people (35.9%), the most gender were women, namely 102 people (53.1%), the most education was college, namely 130 people (67.7%), and the most occupations are self-employed, namely 48 people (25.0%), and from 192 people in the Medan City district pharmacy, the level of community knowledge is in the good category as many as 33 respondents (17.2%), the level of knowledge in the good category is 33 respondents (17.2%). sufficient knowledge category as many as 134 respondents (69.8%), and the level of knowledge is not good category as many as 25 respondents (13%). The conclusion is that the most age is 18-29 years, the most gender is female, the most education is college, and the most occupation is self-employed, and the level of public knowledge of generic drugs and trademarked drugs in pharmacies in Medan Kota District is still in the sufficient category.
Formulation and Physical Characteristics of Effervescent Granules from Sunkist Peels Ethanol Extract Maya Sari Mutia; Stephanie Raibalaki; Siti Rahma; Anita Zahra; Ali Napiah Nasution; Widya Yanti Sihotang
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 2: June 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v8i3.2087

Abstract

Citrus fruit has a sweet taste and attractive shape, which is also enriched various health benefits. Some studies have been performed to investigate the pharmacology effects from the Sunkist peel extract. However, none of this study was look for the development of pharmaceutical products. Hence this study was performed to investigate the pharmaceutical formulation as an effervescent granule from Sunkist peel extract. This study was an experimental study to investigate the optimum formulation that was made by wet granulation methods. There were three formulation of Sunkist peel extract effervescent granule that were combination of organic acids (citric acid and tartaric acid), sodium bicarbonate as base compound, and some sweetener including aspartame, lactose, and mannitol. After that, the formulation was evaluated the physical properties including organoleptic, flow rate, dissolution time, foam height, pH, and angle of repose. The result of this study showed that these three formulations of Sunkist Peel extract effervescent granule showed significant different in almost all of physical properties including: flow rate (P-Value = 0.027), dissolution time (P-Value less than 0.05), foam height (P-Value = 0.004), and angle of repose (P-Value: 0.043), except the degree of acidity or pH (P-Value = 0.128). Third formulation (F3) reveals the best physical properties as a Sunkist peel extract effervescent granule. Overall, it can be concluded that the third and second formulation fulfils a well physical properties of effervescent granule for Sunkist peel extract.
Uji Ekstrak Etanol Pakkat Terhadap Gambaran Histopatologi Pankreas Tikus Wistar Jantan Yang Diinduksi Aloksan Roland Daniel Theodore Amudi Matondang; Aleksander Marganda Sidebang; Yolanda Eliza Putri Lubis; Maya Sari Mutia; Stevenie -
PRIMER (Prima Medical Journal) Vol. 8 No. 1 (2023): Edisi April
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/pmj.v8i1.3239

Abstract

Objective: This take a look at ambitions to study the effectiveness of pakkat extract on the histopathological functions of the pancreas of male Wistar rats (Rattus novergicus) prompted with the aid of alloxan. methods: The layout used was an experimental layout with a pre-take a look at and publish-check randomized manipulate layout, the pattern used became 25 hyperglycemic rats divided into 5 groups: terrible manage (given NaCMC), high quality control (metformin), remedy 1 ( pakkat extract 125 mg/weight), remedy 2 (packkat extract 250 mg/ weight), treatment 3 (packkat extract 500 mg/weight) for 14 days. outcomes: The outcomes showed that pakkat extract (Calamus caesius blume) with tracking doses of one hundred twenty five mg/weight and 250 mg/weight for 14 days continuously ought to lessen the advent of alloxan-caused damage to the pancreas of male Wistar rats, which became characterized with the aid of reduced cellular look. infection, decreased interstitial bleeding, and reduced vascular congestion. conclusion: Pakkat extract (Calamus caesius blume) in positive doses can repair the harm to the structure of histopathological picture in male Wistar rats prompted via alloxan with the finest dose of 250 mg/weight.
Determination of Patient Satisfaction with Dental and Oral Care Services for Clinical Students at Dental and Oral Hospital Prima Medan Silvi Tiara Dewi; Chrismis Novalinda Ginting; Maya Sari Mutia
Jurnal Penelitian Pendidikan IPA Vol 9 No SpecialIssue (2023): UNRAM journals and research based on science education, science applic
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9iSpecialIssue.6459

Abstract

The aim of this research is to determine the determinants of patient satisfaction with dental and oral care services for clinical students at Dental and Oral Hospital Prima Medan. This type of research is quantitative research with a cross-sectional design. The sample in this study was 200 patients. Data analysis in this study used univariate, bivariate and multivariate analysis. The results of the study showed that there was a correlation between patient satisfaction with dental and oral care services among clinical students at Dental and Oral Hospital Prima Medan based on time, procedure, attitude, level of knowledge, p < 0.05 (0.000 < 0.05) with a very high correlation level strong. There is a correlation between patient satisfaction with dental and oral care services among clinical students at Dental and Oral Hospital Prima Medan based on communication and spatial comfort, p < 0.05 (0.000 < 0.05) with a strong correlation level. The influence of service time, procedures, attitudes, level of knowledge, communication and spatial comfort on dental and oral care patient satisfaction among clinical students at Dental and Oral Hospital Prima Medan was 83.7%. The variable that most influences patient satisfaction with dental and oral care services for clinical students at Dental and Oral Hospital Prima Medan is the procedure variable
Peran Selenium dan Vitamin C sebagai Antioksidan dalam Mengatasi Sepsis Akibat Infeksi Bakteri Escherichia Coli : Systematic Literature Review Olivia Des Vinca Albahana Napitupulu; Gusbakti Rusip; Maya Sari Mutia
Ghidza: Jurnal Gizi dan Kesehatan Vol. 9 No. 1 (2025): June
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/ghidza.v9i1.2034

Abstract

Sepsis merupakan respons sistemik yang berbahaya akibat infeksi bakteri, termasuk Escherichia coli, yang dapat menyebabkan kegagalan organ dan kematian. Stres oksidatif dan inflamasi merupakan dua faktor kunci dalam patogenesis sepsis. Penelitian ini bertujuan untuk mengevaluasi peran selenium dan vitamin C sebagai antioksidan dalam menangani sepsis akibat infeksi E. coli. Studi ini merupakan tinjauan literatur sistematis terhadap 10 artikel yang dipublikasikan antara tahun 2015–2024, dengan pendekatan eksperimen hewan, eksperimental klinis, dan kajian literatur. Data dianalisis berdasarkan tahun, metode penelitian, serta efek biologis yang dilaporkan. Selenium berkontribusi dalam meningkatkan aktivitas enzim glutathione peroxidase, menurunkan stres oksidatif, serta melindungi ginjal dari kerusakan. Vitamin C meningkatkan mikrosirkulasi, memperbaiki fungsi imun, dan berperan sebagai antioksidan protektif selama sepsis. Selenium dan vitamin C menunjukkan potensi besar sebagai terapi adjuvan dalam mengatasi sepsis akibat infeksi E. coli. Hasil kajian ini dapat menjadi dasar untuk pengembangan strategi terapi suportif berbasis antioksidan dalam praktik klinis.
Potential Role of Diffusion Tensor Imaging in the Assessment of Renal Microstructural Changes in Diabetic Kidney Disease: A Systematic Review Ikhwanul Hakim Nasution; Maya Sari Mutia; Gusbakti Rusip
PROFESSIONAL HEALTH JOURNAL Vol. 8 No. 2 (2027)
Publisher : Pusat Penelitian dan Pengabdian Masyarakat (PPPM) STIKES Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54832/phj.v8i2.1575

Abstract

Background: One of the main causes of end-stage renal disease in the globe is diabetic kidney disease (DKD). Estimated glomerular filtration rate (eGFR) and albuminuria are examples of conventional biomarkers that frequently miss early microstructural alterations prior to a major functional loss. Using metrics like fractional anisotropy (FA) and apparent diffusion coefficient (ADC), diffusion tensor imaging (DTI) provides a non-invasive method of measuring renal tissue integrity. Objective: The objective of this systematic review is to identify patterns of DTI parameter alterations, assess their link with clinical indicators, and compile information about the relevance of DTI in detecting renal microstructural changes in DKD. Methods: A systematic literature search was conducted in PubMed, Scopus, Google Scholar, ScienceDrect for original research articles reporting renal DTI parameters in DKD patients published between 2017 and 2025. The review followed PRISMA guidelines. Data were extracted using a standardized form and synthesized narratively. Methodological quality was assessed using QUADAS-2 for diagnostic accuracy studies, Newcastle-Ottawa Scale for cohort studies, and JBI Critical Appraisal Checklist for clinical trials. Results: The inclusion criteria were met by ten original studies. Quality assessment revealed four studies with low risk of bias and six with moderate risk, primarily due to lack of histopathological correlation. FA levels were repeatedly found to be considerably lower in DKD patients compared to healthy participants in observational studies. The most consistent differences between DKD and controls were found in medullary FA. FA had an inverse relationship with albuminuria and serum creatinine, and a correlation with eGFR (r values ranging from 0.38 to 0.69). ADC results were more inconsistent, with some studies finding no discernible differences and others reporting lower ADC in diabetics. A significant rise in FA after intervention (from 242.57±63.97 to 305.61±152.32, p=0.042) was reported in one clinical trial assessing autologous dendritic cell treatment, indicating DTI's potential for tracking therapeutic response. Conclusion: As a non-invasive biomarker for identifying renal microstructural alterations in DKD, DTI, in particular medullary FA, shows potential. FA's diagnostic value is supported by its association with renal function measures and its persistent decrease in DKD patients. To determine DTI's place in clinical practice, more studies using standardized procedures and long-term designs are required.
Ekstrak Granul Nanopartikel Kulit Jeruk Sunkist (Citrus Sinensis (L.) Osbeck) Dan Ekstrak Kulit Jeruk Nipis (Citrus Aurantifolia) Terhadap Gambaran Perlemakan Hati Pada Tikus (Rattus Norvegicus) Model Diabetes) Maya Sari Mutia; Putri Nabila; Ulpah Zahara Hamsi; Yolanda Eliza Putri Lubis
Jurnal Maternitas Kebidanan Vol. 9 No. 2 (2024): Jurnal Maternitas Kebidanan
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jumkep.v9i2.5623

Abstract

Sunkist oranges (Citrus sinensis (L.) Osbeck have a high content of anthocyanins (95% of which are cyanidin-3-glucoside and cyanidine-3-6"-malonyl-glucoside), flavanone (hesperidin and narirutin), as well as hydroxynamic acid (caffeic acid, cumaric acid, cinnamic acid, and ferulic acid), carotenoids, sugars, minerals, and fiber, considered a good food source of bioactive substances with beneficial effects on health. This study aims to examine the potential for liver improvement in mice with a diabetes model after the administration of nanoparticle granules combining sunkist orange peel and lime peel. The design of this experimental research is Post Test Only Control Group Design. Twenty-five male rats of the wistar strain were used which were divided into 5 groups at random, namely the negative control group (aloxan), the positive control group (aquadest), Treatment 1 (aloxan + nanoparticle granules 50mg/kgBB), Treatment 2 (aloxan + nanoparticle granules 100mg/kgBB) Treatment 3 (aloxan + nanoparticle granules 200mg/kgBB). The liver organ was prepared for observation with 10x ocular magnification and 40x objective lens magnification. Liver improvement had an effect on the decrease of SGPT, SGOT, and Histopathological picture of the liver in diabetic model mice after the administration of nanoparticle granules combined with sunkist orange peel and lime peel at concentrations of 50 mg/KgBB, 100 mg/KgBB and 200 mg/KgBB showed significant differences. The best liver improvement is by administering nanoparticle granules a combination of sunkist orange peel and lime peel at a concentration of 200 mg/KgBB. Keyword: Diabetes Mellitus, Sunkist orange and lime peel extracts, fatty live.  
Co-Authors Aleksander Marganda Sidebang Anita Zahra Chrismis Novalinda Ginting Gusbakti Rusip Ikhwanul Hakim Nasution Nasution, Ali Napiah Nini Tiatira Tobing Olivia Des Vinca Albahana Napitupulu Putri Nabila Roland Daniel Theodore Amudi Matondang Silvi Tiara Dewi Siti Rahma Stephanie Raibalaki Stevenie - Ulpah Zahara Hamsi Widya Yanti Sihotang Yolanda Eliza Putri Lubis Yulizal, Ok