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Evaluasi Sifat Fisik Tablet Floating Ekstrak Etanol Daun Kelor (Moringa oleifera L.) Dengan Kombinasi Xanthan Gum Dan HPMC Sebagai Polimer Yunita, Fadella Nur; Nawangsari, Desy; Febrina, Dina
Seminar Nasional Penelitian dan Pengabdian Kepada Masyarakat 2025 Prosiding Seminar Nasional Penelitian dan Pengabdian Kepada Masyarakat (SNPPKM 2025)
Publisher : Universitas Harapan Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35960/snppkm.v4i1.1401

Abstract

Moringa leaves (Moringa oleifera L.) have gastroprotective activity, making them suitable for use in floating tablets to prolong the residence time of drugs in the stomach. Floating tablets typically use xanthan gum and hydroxypropyl methylcellulose (HPMC) polymers as drug release matrices. This study aims to evaluate the physical properties of floating tablets made from ethanol extract of moringa leaves with a combination of xanthan gum and HPMC, as well as to determine the appropriate polymer concentration. Experimental studies were conducted with three formulas: F1 (15% xanthan gum; 5% HPMC), F2 (10% xanthan gum; 10% HPMC), and F3 (5% xanthan gum; 15% HPMC), using the wet granulation method. The physical properties of the granules were evaluated by testing the flow rate, Carr index, and Hausner ratio, then molded into 750 mg tablets and evaluated for physical properties (n = 3), including organoleptic properties, weight uniformity, size, hardness, friability, and floating test in 0.1 N HCl medium (pH 1.2; 37 ± 0.5 °C). The results showed that all formulations did not meet the weight uniformity and friability test (> 1%). Size uniformity and hardness (4–8 kg) met the requirements. The floating test showed that no formula was able to float for up to 30 minutes (floating lag time > 30 minutes; floating time = 0 minutes). It was concluded that the combination of xanthan gum and HPMC in the range of 5–15% did not produce moringa leaf extract floating tablets that met the physical parameters and floating test.
OPTIMASI FORMULA DAN EVALUASI MASSA CETAK TABLET HISAP BERBAHAN YOGURT DENGAN METODE SIMPLEX LATTICE DESIGN Pujianti, Ayu; Nawangsari, Desy; Febrina, Dina
Jurnal Buana Farma Vol 5 No 4 (2025): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i4.1558

Abstract

Yocanserah® yogurt contains peanuts, ginger, and lemongrass, which have potential anti-diabetic properties. Yocanserah has a limited shelf life and sour taste, so it needs to be developed into a more acceptable lozenge formulation with a longer shelf life. The purpose of this study is to optimize the formulation of yogurt-based lozenge tablets using the simplex lattice design method. The materials or factors used in the optimization were Avicel PH 102, isomalt, and SSG, with the response being flow rate and compressibility. The data were analyzed using Design Expert software with the simplex lattice design method. The yogurt-based lozenge tablet mass was made using the wet granulation method with gelatin solution as a binder. The results showed that the tablet mass with variations in Avicel PH 102, isomalt, and SSG made using the wet granulation method produced flow rate and compressibility in accordance with the specifications. The use of variations in these three ingredients had a significant effect on the flow rate and compressibility of the tablet mass with a p-value < 0.05. The optimal formula for yogurt-based lozenge molding mass was obtained with a proportion of 49% Avicel PH 102, 1% isomalt, and 5% SSG, which produced a flow rate of 5.58 g/s and compressibility of 6.69% with a resulting desirability value of 0.311.
Pengaruh Suhu Penyimpanan Ekstrak Etanol Daun Pandan Wangi (Pandanus amaryllifolius Roxb) Terhadap Aktivitas Antioksidan Handayani, Wike Deni Setyo; Febrina, Dina; Nawangsari, Desy
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.862

Abstract

Pandanus amaryllifolius Roxb atau daun pandan wangi diketahui memiliki aktivitas antioksidan dengan kategori yang sangat kuat. Faktor lingkungan seperti kondisi pH, oksigen, cahaya dan suhu pada penyimpanan ekstrak dapat mempengaruhi aktivitas antioksidan. Salah satu faktor penting dalam ketidakstabilan senyawa antioksidan pada ekstrak yaitu adanya perbedaan dalam suhu penyimpanan. Penelitian ini bertujuan untuk mengetahui pengaruh suhu penyimpanan ekstrak etanol daun pandan wangi terhadap aktivitas antioksidan. Metode yang digunakan dalam penelitian ini adalah metode DPPH. Ekstrak etanol dari daun pandan wangi disimpan dalam tiga kondisi suhu yang berbeda yaitu pada suhu 27±2 ? (suhu ruang), suhu 5±2 oC (suhu dingin), dan suhu -10±2 ? (suhu beku) selama 14 hari (2 minggu). Selanjutnya, ekstrak etanol daun pandan wangi diuji aktivitas antioksidannya pada hari ke-0 dan ke-14. Hasil aktivitas antioksidan pada hari ke-0 sebesar 37,47 ppm dan hari ke-14 disuhu ruang sebesar 54,03 ppm, suhu dingin sebesar 42,52 ppm, dan suhu beku sebesar 59,55 ppm. Hasil analisis ANOVA dan uji lanjutan post hoc Tukey menunjukkan adanya perbedaan nilai IC50 pada seluruh suhu penyimpanan. Hal ini menunjukkan bahwa suhu penyimpanan berpengaruh nyata (p<0,05) terhadap nilai IC50.
Flavonoid Identification and Antioxidant Activity of Graded Extracts from Kesambi (Schleichera oleosa) Leaves Hanifah, Vika; Febrina, Dina; Rahmawati, Nur
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.971

Abstract

Flavonoids are secondary metabolites widely distributed in plants and are recognized for their antioxidant potential, which plays a vital role in neutralizing free radicals and protecting against oxidative stress. Schleichera oleosa (kesambi) leaves are known to contain bioactive compounds, yet comprehensive studies on their flavonoid composition and antioxidant activity remain limited. This study aimed to identify flavonoid groups present in graded extracts of kesambi leaves and to evaluate their antioxidant activity. Graded maceration was performed sequentially with solvents of increasing polarity (n-hexane, ethyl acetate, and methanol). Flavonoids were identified through colorimetric reactions using specific reagents, while antioxidant activity was determined using the DPPH radical scavenging assay, with IC?? values calculated by linear regression. The results showed that n-hexane extract contained flavanones, ethyl acetate extract contained flavones, isoflavones, and flavonols, while methanol extract contained chalcones and aurones. Antioxidant testing revealed that methanol extract exhibited the strongest activity (IC?? = 9.65 ± 0.81 ppm), categorized as very strong, whereas ethyl acetate (IC?? = 102.46 ± 6.82 ppm) and n-hexane (IC?? = 141.67 ± 15.74 ppm) showed moderate activity. These findings confirm that solvent polarity greatly influences both flavonoid composition and antioxidant potency, with methanol extract emerging as the most promising natural antioxidant source. The study provides scientific support for the traditional use of kesambi leaves and highlights their potential for pharmaceutical and nutraceutical applications.
Co-Authors Adita Silvia Fitriana Agustiar agustiar Amelia, Siti Anhar, Khairul Aurellia, Rizky Natasya Dzikra, Aulia Mar'atu Ellya Roza Etmi Hardi Firdaus, Anisa Kautsar Handayani, Wike Deni Setyo Hanifah, Vika Karo, Tiy Kusmarrabi Martiana, Wilsa Nawangsari, Desy Nur Rahmawati Pujianti, Ayu Sunarti Suri, Natasha Triska Syahri, Hanifa Yunita, Fadella Nur