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All Journal CIRCUIT: Jurnal Ilmiah Pendidikan Teknik Elektro Jurnal Ilmiah Didaktika : Media Ilmiah Pendidikan dan Pengajaran Jurnal Rekayasa Lingkungan Atrat: Jurnal Seni Rupa Journal of Creative Student Research Lingkar : Journal of Environmental Engineering Bayt ElHikmah: Journal of Islamic Architecture and Locality Menulis: Jurnal Penelitian Nusantara Journal of Pharmascience
Hadi Kurniawan
Universitas Islam Negeri Ar-Raniry Banda Aceh
Arts Humanities Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Education Electrical & Electronics Engineering Engineering Environmental Science Languange, Linguistic, Communication & Media Social Sciences Transportation Other

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Journal : Journal of Pharmascience

 1 
Identifikasi Gugus Fungsi Fraksi Etil Asetat dan Fraksi n-Heksan Hylocereus polyrhizus (F.A.C.Weber) Britton & Rose Sri Wahdaningsih; Fajar Nugraha; Hadi Kurniawan; Anis Marselia; Dian Novita Sari
Journal of Pharmascience Vol. 9 No. 1 (2022): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i1.11192

Abstract

Buah naga merah diketahui memiliki manfaat pada daging maupun kulit buahnya. Kulit buah naga merah yang sering dibuang sebagai limbah ternyata memiliki aktivitas antioksidan yang lebih banyak daripada daging buahnya. Penelitian ini bertujuan untuk mengidentifikasi gugus fungsi yang ada pada fraksi etil asetat dan n-heksan kulit buah naga merah. Analisis gugus fungsi dilakukan dengan menggunakan alat spektrofotometer FTIR dengan metode pelet KBr. Hasil yang diperoleh bersifat kualitatif yaitu berupa spektrum inframerah. Hasil identifikasi gugus fungsi dari fraksi etil asetat kulit buah naga merah adalah gugus fungsi O–H, C–H alkana, C=O, C–O, dan C–H aromatik. Hasil identifikasi gugus fungsi dari fraksi n-heksan kulit buah naga merah adalah gugus fungsi O-H , C-H alkana, C-H alkena, C-O, dan C=O. Senyawa yang terkandung pada fraksi etil asetat kulit buah naga merah adalah fenolik, flavonoid, terpenoid, steroid, dan alkaloid. Senyawa yang terkandung pada fraksi n-heksan kulit buah naga merah adalah flavonoid, terpenoid, dan steroid. Kata Kunci: Kulit Buah Naga Merah, Fraksinasi, Spektrum, Fourier Transform Infrared  Red dragon fruit is known have benefits in the flesh and peel of the fruit. The peel of the red dragon fruit, which is often disposed of as waste, has more antioxidant activity than its flesh. This study aimed to identify the functional groups in the ethyl acetate and n-hexane fractions of red dragon fruit peel. Functional group analysis was done by using FTIR spectrophotometer with KBr pellet method. The results obtained were qualitative in the form of an infrared spectrum. The results of the identification of functional groups from the ethyl acetate fraction of red dragon fruit peel were O–H, C–H alkanes, C=O, C–O, and C–H aromatics functional groups. The results of the identification of functional groups from the n-hexane fraction of red dragon fruit peel were O-H, C-H alkanes, C-H alkenes, C-O, and C=O functional groups. The compounds that contained in the ethyl acetate fraction of red dragon fruit peel are phenolics, flavonoids, terpenoids, steroids, and alkaloids. The compounds that contained in the n-hexane fraction of red dragon fruit peel are flavonoids, terpenoids, and steroids.
Analisis Sibutramin Hcl Dalam Jamu Pelangsing Menggunakan Metode Kromatografi Lapis Tipis dan Spektrofotometri Uv - Vis Sintya Maulidiyah; Fajar Nugraha; Hadi Kurniawan
Journal of Pharmascience Vol. 12 No. 1 (2025): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v12i1.20478

Abstract

Badan Pengawas Obat dan Makanan (BPOM) dalam PERMENKES No 07 tahun 2012 melarang penambahan Bahan Kimia Obat (BKO) di dalam jamu. Namun, sibutramin HCl sering ditemukan dalam jamu diet dan pelangsing, obat ini mampu menekan nafsu makan sehingga dapat melangsingkan badan. Penelitian ini bertujuan untuk mengidentifikasi kandungan sibutramin HCl di dalam jamu dengan metode Kromatografi Lapis Tipis (KLT) dan Spektrofotometri UV-Vis. Hasil pembacaan KLT dengan fase gerak etil : kloroform (3 : 7) dan silica gel GF254  memberikan hasil sampel C positif mengandung Sibutramin HCl dengan Rf 0,826. Validasi metode analisis yang dilakukan meliputi Linieritas, LOD dan LOQ, Akurasi serta Presisi. Linieritas menghasilkan persaman regresi y = 0,0648x + 0,0583 sehingga r = 0,9989, LOD dan LOQ hasil 0,6228 dan 1,8873 ppm, akurasi dan presisi menghasilkan %recovery dalam rentang 106,65% - 110,59% serta %RSD 1,473%, 5,196% dan 1,533%. Hasil uji kadar sampel jamu C menghasilkan rata-rata kadar (mg) sebesar 2,662 mg dan %kadar 1,331% per 200 mg. Kesimpulan penelitian ini adalah terdapat Sibutramin HCl di dalam jamu pelangsing sampel C dengan kadar 5,95 mg per kemasan. Kata Kunci: Jamu Pelangsing; Kromatografi Lapis Tipis; Sibutramin HCl; Spektrofotometri UV-Vis The Food and Drug Supervisory Agency (BPOM) in PERMENKES No. 07 of 2012 prohibits the addition of Chemical Drugs (BKO) in herbal medicine. However, Sibutramine HCl is often found in diet and slimming herbal medicine, this drug is able to suppress appetite so that it can slim the body. This study aims to identify the content of Sibutramine HCl in herbal medicine using the Thin Layer Chromatography (TLC) and UV-Vis Spectrophotometry methods. The results of TLC readings with a mobile phase of ethyl: chloroform (3: 7) and silica gel GF254 gave positive sample C results containing Sibutramine HCl with Rf 0.826. Validation of the analysis method carried out included Linearity, LOD and LOQ, Accuracy and Precision. Linearity produces a regression equation of y = 0.0648x + 0.0583 so that r = 0.9989, LOD and LOQ results of 0.6228 and 1.8873 ppm, accuracy and precision produce % recovery in the range of 106.65% - 110.59% and % RSD of 1.473%, 5.196% and 1.533%. The results of the test of the content of herbal medicine sample C produced an average content (mg) of 2.662 mg and a% content of 1.331% per 200 mg. The conclusion of this study is that there is Sibutramine HCl in the slimming herbal medicine sample C with a content of 5.95 mg per package.
Co-Authors Al-Hafidh Rahman Andrika Maili Anis Marselia Aris Munandar Darwin, Widya Dian Novita Sari Djuniwarti Djuniwarti Dori Omas Hasibuan Fajar Nugraha Ghufran Ibnu Yasa Hari Anna Lastya Herlini Puspika Sari Iqbal Zamarli Jusmardi Malahayati Malahayati Melliati Mulyadi Abdul Wahid Nurhayati Nurhayati R. Andy Erwin Wijaya Rahmatul Ummiya Rifal Alfayed Silvy Karisa Sintya Maulidiyah Sri Wahdaningsih Suci Irawanda Zia Faizurrahmany El Faridy Zul Fajjeri