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All Journal The Indonesian Biomedical Journal Journal of Social Research JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Pengabdian Kepada Masyarakat KABANTI MEDULA Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo
Tomy Nurtamin
Departemen Fisiologi, Fakultas Kedokteran, Universitas Halu Oleo, Kendari, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Immunomodulatory Effect of Momordica charantia L. Fruit Ethanol Extract on Phagocytic Activity and Capacity of Mice Peritoneal Macrophages Parawansah Parawansah; Tomy Nurtamin; Sufiah Asri Mulyawati; Nuralifah Nuralifah; Wa Ode Arlina Misnaeni
The Indonesian Biomedical Journal Vol 10, No 2 (2018)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v10i2.390

Abstract

BACKGROUND: The purpose of this research is to understand the secondary metabolites of Momordica charantia L. extract, as well as to disclose the potential of M. charantia extract in the phagocytic activity and capacity of peritoneummacrophages.METHODS: Examination of immunomodulatory effect was done by giving M. charantia ethanol extract on 5 treatment groups, given intra-peritoneally to mice daily. Echinacea extract as positive control and double distilled water as negative control were also given. On the 8th day, mice were infected with Staphylococcus epidermidis. After 30 minutes, peritoneum fluid was obtained to observe the activity and capacity of macrophage cells.RESULTS: The results showed significant phagocytic activity (p<0.05) at a concentration of 1,200 ppm compare to the other groups. Meanwhile the macrophage cell capacity was found statistically insignificant (p>0.05). The highest phagocytic activity was the group treated with 1,200 ppm (62%), significantly higher than other groups.CONCLUSION: The secondary metabolite content of M. charantia is alkaloids, flavonoids, tannins, saponins, and triterpenoids. The 1,200 ppm M. charantia ethanol extract is potential in inducing phagocytic activity and capacity. These results indicate that the M. charantia can be suggested as a natural immunomodulator.KEYWORDS: pare fruit, Momordica charantia L., phagocytosis, macrophage, immunomodulator
Antibacterial Activity of Eel (Anguilla spp.) Mucus against Salmonella typhi Tomy Nurtamin; Resty Yulianita Nurman; Indria Hafizah
The Indonesian Biomedical Journal Vol 8, No 3 (2016)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v8i3.231

Abstract

BACKGROUND: Typhoid fever has become one global health problem. Typhoid fever is caused by a Gram-negative bacterium, Salmonella typhi. Eel (Anguilla spp.) is a fish which lives in the sea or in freshwater. Several previous studies have found that Anguilla spp. mucus has the ability as antibacterial against Gram-positive and negative. Although the antibacterial activity of Anguilla spp. against various pathogens had been reported, very little is known about its activity against Salmonella typhi. The aim of this study was to investigate antibacterial activity of Anguilla spp. mucus against Salmonella typhi bacteria.METHODS: Present study was an experimental in vitro test. Antibacterial activity assays were carried out by the disc diffusion method. Antibacterial activity was determined by the clear zone formed around the paper disc and minimum inhibitory concentration was determined by observing the lowest concentration which could inhibit the growth of Salmonella typhi.RESULTS: Result of the present study showed that the Anguilla spp. mucus has inhibitory effects against Salmonella typhi. Minimum inhibitory concentration from the Anguilla spp. mucus was 12.5%.CONCLUSION: Anguilla spp. mucus has antibacterial activity against the Salmonella typhi bacteria.KEYWORDS: eel fish mucus, Anguilla spp., antibacterial activity, Salmonella typhi
In Vitro Anti-Inflammatory Activities of Ethanolic Extract Elephantopus Scaber Leaves Tomy Nurtamin; I Putu Sudayasa; Tien Tien
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 9, No 1, (2018)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol9.Iss1.art9

Abstract

Background: Inflammation is a protective physiological response to tissue injury that can be caused by harmful stimuli. If the inflammatory process is prolonged and cannot restore to homeostatic conditions, this may lead to pathological effects that can damage cells and cause various diseases. Elephantopus scaber is a plant that can easily be found in Indonesia. Elephantopus scaber is a type of plant that is often used as a traditional medicines. Several studies have shown that the compound bioactive content contained in plants has enormous potential as alternative medicine.Objective: This present study was to investigate the anti-inflammatory activity of ethanolic extract of Elephantopus scabe leaves.Methods: The Elephantopus scaber leaves were extracted using ethanol solvent into different concentration (50 mg/mL, 100 mg/mL, and 120 mg/mL). Diclofenac sodium was used as the standard. Anti-inflammatory assays were performed by the human red blood cell (HRBC) membrane stabilization method and heat-induced hemolysis method. Phytochemical screening that used in the present study was a conventional method.Results: Phytochemical screening showed the presence of flavonoids, tannins, and saponins. In the present study, ethanolic extract of Elephantopus scaber leaves has anti inflammatory activity by protecting the stability of red blood cell membrane. The highest protection capability possessed by the ethanolic extract of Elephantopus scaber leaves in both human red blood cell (HRBC) membrane stabilization method and heatinduced hemolysis method was at a concentration of 100 mg/mL.Conclusion: The ethanolic extract of Elephantophus scaber has antiinflammatory activities by in vitro assays.
The Effect of Physical Stress on the Quality of Mouse Sperm (Mus Musculus L.) Adult Males Grace Hanna Christian; Juminten Saimin; Tomy Nurtamin
Journal of Social Research Vol. 2 No. 7 (2023): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v2i7.1135

Abstract

Physical stress is one cause that can affect sperm quality. Vibration exposure as a form of physical stress that can stimulate the hormonal system so that it can disturb the process of spermatogenesis which consequently can decrease quality of sperm. This was a true experimental research with post test only control group design was done in the Integrated Laboratory of the Faculty of Medicine Halu Oleo University. Samples was 28 mice (Mus musculus L.) adult male, it were divided into 4 groups: control group (K), the treatment group 7 minutes 30 second (P1), 15 minutes (P2) and 30 minutes (P3) with the vibrations of 50 Hz for 21 days. Sperm quality include motility, viability, concentration and morphology. Data were analyzed descriptively test and Fisher's test. The results of this study indicated the significant differences (p<0,05) to quality of spermatozoa of adult mice.The conclusion of this study was vibration exposure at 50 Hz in the duration of 7 minutes 30 seconds, 15 minutes and 30 minutes for 21 days can decreased quality of sperm. It was suggested for further research can examined the levels of testosterone and histology on Leydig cells and Sertoli cells of the testis.
Peningkatan Deteksi Dini Kondisi Kesehatan Masyarakat Pesisir melalui Kegiatan Skrining Kesehatan di Wilayah Kerja Puskesmas Liya, Kabupaten Wakatobi La Ode Alifariki; Heriviyatno J. Siagian; I Putu Sudayasa; Wa Ode Salma; Tomy Nurtamin
Jurnal Pengabdian Kepada Masyarakat Kabanti Vol. 2 No. 1 (2026): Jurnal Kajian Akademik Multidisiplin Kesehatan: KABANTI
Publisher : Progres Ilmiah Kesehatan

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Abstract

Masyarakat pesisir merupakan kelompok rentan terhadap berbagai masalah kesehatan akibat keterbatasan akses layanan kesehatan, kondisi lingkungan, serta faktor sosial ekonomi. Rendahnya deteksi dini penyakit menyebabkan banyak masalah kesehatan ditemukan pada tahap lanjut dan berdampak pada penurunan kualitas hidup masyarakat. Kegiatan pengabdian ini bertujuan untuk meningkatkan deteksi dini kondisi kesehatan masyarakat pesisir melalui kegiatan screening kesehatan di wilayah kerja Puskesmas Liya, Kabupaten Wakatobi. Metode pelaksanaan meliputi tahap persiapan, pelaksanaan, evaluasi, dan monitoring dengan pendekatan berbasis komunitas. Kegiatan dilaksanakan pada bulan September 2025 dengan melibatkan 124 orang masyarakat pesisir sebagai peserta. Screening kesehatan dilakukan melalui pemeriksaan kesehatan dasar dan edukasi kesehatan secara langsung. Hasil kegiatan menunjukkan tingginya partisipasi masyarakat serta ditemukannya berbagai faktor risiko kesehatan, terutama terkait tekanan darah, status gizi, dan keluhan kesehatan kronis yang sebelumnya belum teridentifikasi. Selain itu, terjadi peningkatan pemahaman masyarakat mengenai pentingnya pemeriksaan kesehatan rutin dan perilaku hidup sehat. Kesimpulan dari kegiatan ini adalah bahwa screening kesehatan berbasis komunitas efektif dalam meningkatkan akses layanan kesehatan preventif dan kesadaran kesehatan masyarakat pesisir.
Relationship Between Risk Factors Affecting the Occurrence of Diabetic Ulcer Classification in Patients with Type 2 Diabetes Mellitus in Kendari City Hospital Andi Nur Meilia Jufriyani; Tomy Nurtamin; Adry Leonardy Tendean
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 12 No. 2 (2025): Juli
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

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Abstract

Background. Diabetes mellitus is a metabolic disease caused by the body being unable to produce insulin hormone or peripheral insulin resistance. This chronic hyperglycemia condition can cause complications of diabetes mellitus, one of which is diabetic ulcers. Diabetic ulcer is a chronic complication of diabetes mellitus caused by several factors that can affect it. Some of these factors are age, comorbidities, length of suffering and drug compliance which play a role in causing diabetic ulcers. This study aims to determine the relationship between several factors that cause the classification of diabetic ulcers in patients with type 2 diabetes mellitus at Kendari City Hospital. Methods. This study was conducted with observational analytic method with cross sectional approach conducted at Kendari City Hospital with 62 respondents. Data were collected and analyzed using Fischer's exact test with a significant value of p≤ 0.05. Results. This study shows that there is a significant relationship between the age variable and the classification of diabetic ulcers with a p-value of 0.04, a significant relationship between comorbidities and the classification of diabetic ulcers with a p-value of 0.00, there is no significant relationship between the duration of DM and the classification of diabetic ulcers with a p-value of 0.15, and there is a significant relationship in drug compliance and the classification of diabetic ulcers with a p-value of 0.00. Conclusion. There is a significant relationship between three risk factors such as age, comorbidities, and medication compliance with the occurrence of diabetic ulcer classification. And there is no significant relationship between the duration of DM and the occurrence of diabetic ulcer classification in type 2 diabetes mellitus patients at Kendari City Hospital. This underlines the importance of avoiding factors that can cause complications of diabetes mellitus in the form of diabetic ulcers.
Optimalisasi Peran Pengawas Minum Obat (PMO) dalam Meningkatkan Kepatuhan Terapi pada Penderita Hipertensi La Ode Alifariki; Heriviyatno J. Siagian; I Putu Sudayasa; Tomy Nurtamin; Dewi Nopiska Lilis
Jurnal Pengabdian Kepada Masyarakat Kabanti Vol. 2 No. 2 (2026): Jurnal Kajian Akademik Multidisiplin Kesehatan: KABANTI
Publisher : Progres Ilmiah Kesehatan

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Abstract

Kepatuhan minum obat merupakan faktor penting dalam pengelolaan hipertensi. Keterlibatan keluarga sebagai Pengawas Minum Obat (PMO) diyakini dapat meningkatkan kepatuhan pasien, khususnya di daerah dengan keterbatasan akses layanan kesehatan seperti Kabupaten Wakatobi. Kegiatan pengabdian ini bertujuan untuk mengoptimalkan peran anggota keluarga sebagai PMO dalam meningkatkan kepatuhan terapi pada penderita hipertensi. Kegiatan dilaksanakan di wilayah kerja Puskesmas Liya pada bulan Oktober 2025, melibatkan 40 penderita hipertensi beserta anggota keluarganya. Intervensi meliputi edukasi kesehatan, pelatihan PMO, simulasi praktik, dan pendampingan. Evaluasi dilakukan melalui pre-test dan post-test pengetahuan serta pemantauan kepatuhan minum obat menggunakan lembar kontrol harian. Monitoring berkala dilakukan untuk memastikan keberlanjutan intervensi. Peningkatan kepatuhan minum obat terlihat signifikan, dari 55% sebelum intervensi menjadi 85% setelah intervensi. Anggota keluarga mampu menjalankan peran PMO secara efektif, termasuk mengingatkan jadwal minum obat, memberikan dukungan emosional, dan memantau kepatuhan pasien. Optimalisasi peran keluarga sebagai PMO terbukti efektif meningkatkan kepatuhan terapi pada penderita hipertensi. Pendekatan ini dapat dijadikan model intervensi berkelanjutan di masyarakat, khususnya di wilayah dengan keterbatasan akses kesehatan.
Co-Authors Adry Leonardy Tendean Andi Nur Meilia Jufriyani Dewi Nopiska Lilis Grace Hanna Christian Heriviyatno J. Siagian I Putu Sudayasa I Putu Sudayasa Indria Hafizah Juminten Saimin La Ode Alifariki Mulyawati, Sufiah Asri Nuralifah Nuralifah, Nuralifah Parawansah, P Resty Yulianita Nurman Tien Tien Wa Ode Arlina Misnaeni Wa Ode Salma