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All Journal Jurnal Kesehatan Jurnal Katalisator Journal of Pharmaceutical Science and Herbal Technology Proceeding International Conference Of Innovation Science, Technology, Education, Children And Health Proceeding International Conference Of Innovation Science, Technology, Education, Children And Health
Nurjannah Bachri
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Agriculture, Biological Sciences & Forestry Chemistry Computer Science & IT Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Formulation And Testing The Effectiveness Of Gel Extract Of Red Ginger (Zingiber officinale Var. Rubrum) As Antiinflamatory In White Male Rats (Rattus norvegicus). Nurjannah Bachri; Nielma Auliah; Sri Wahyuningsih; Husna Dewi
Proceeding International Conference Of Innovation Science, Technology, Education, Children And Health Vol. 3 No. 1 (2023): Proceeding of The International Conference of Inovation, Science, Technology, E
Publisher : Program Studi DIII Rekam Medis dan Informasi Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/icistech.v3i1.61

Abstract

Red Ginger is a type of rhizome that is widely used as an ingredient in traditional medicine in Indonesia. The efficacy of red ginger has been widely studied as an effective anti-inflammatory. One of the main components of red ginger is the gingerol class of compounds. This study aims to determine the anti-inflammatory effect that is applied to the red ginger extract gel (Zingiber officinale var. Ruburum) gel preparation with the HPMC gel-forming ingredient. The gel preparation was then tested for stability up to day 7 and evaluated for its anti-inflammatory power against white rats (Rattus norvegicus). The method used was the artificial inflammation ordering method, where the test was carried out by injection of carrageenan as a mediator for inflammation of the thighs of white rats, then topically giving Red Ginger extract gel with a concentration of 1%, 3% and 5%, HPMC as a negative control and diclofenac sodium as a Positive control. Measurements were carried out every 8 hours every day after being induced by carrageenan to use a caliper. The results showed that the reduction in inflammation to reduce the diameter of 1% after induction was 1.76 cm and decreased to 1.22 cm, the concentration of 3% after induction was 1.68 cm and decreased to 1.33 cm, the concentration of 5% after induction was 1 , 79 cm and decreased to 1.35 cm. Data were statistically analyzed using ANOVA showing that the negative HPMC controls did not show any anti-inflammatory effects. It can show that 1%, 3% and 5% Red Ginger ethanol extract gel has anti-inflammatory effects and the greatest effect is that the 5% concentration has an anti-inflammatory effect.
Co-Authors Ainun Jariah Benedikta Winne Angela Farid, Nurfiddin Husna Dewi Imrawati Mahfuzun Bone Muhammad Asri SR Nielma Auliah Nurhikma Awaluddin Rahmah Mustarin Saldi Hapiwaty Sri Wahyuningsih Winarni Zahira Amody