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UJI EFEKTIVITAS GEL EKSTRAK ETANOL DAUN BINAHONG (Anredera cordifolia) SEBAGAI PENYEMBUHAN LUKA INSISI PADA TIKUS WISTAR JANTAN Nurhikma Awaluddin; Nurfiddin Farid; Nurjannah Bachri
Jurnal Kesehatan Vol 13 No 2 (2020): JURNAL KESEHATAN
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v13i2.16435

Abstract

The effectiveness test of Binahong Leaf (Anredera cordifolia) ethanol extract gel as an incision wound healing in male Wistar rats by Nurhikma Awaluddin and Nurfiddin Farid. Injuries are structural or physiological integument disorders that require a normal or abnormal tissue repair response. An incisor wound is a wound caused by a tool that has a sharp tip and hits the skin layer. The purpose of this study was to determine the effectiveness of binahong leaf ethanol extract gel on incision wound diameter and wound healing time in male Wistar rats. The method used is experimental laboratory. The incision wound was observed for 14 days. Observations consisted of changes in wound length and duration of healing. The incision wound is characterized by tearing of the epidermal tissue 2 cm long. Binahong leaf extract gel preparation test was given to the incision wound of male Wistar rats by observing the formation of maturation, the time of wound closure. For administration of extracts with a concentration of 2% for tenth days at a concentration of 10%, the wound closure occurred on the ninth day and at a concentration of 15% occurred on the eighth day. Observation of wound healing is characterized by the occurrence of complete closure of the wound on the skin, which begins with inflammation which is then followed by a process of proliferation and maturation or remodeling. The treatment of positive control using bioplastone preparation experienced faster wound closure compared to the other four formulas. The results of the ANOVA statistical analysis using SPSS, the relationship between formula and speed of closed wounds are 100%, where Fcount> Ftable at the 5% and 1% confidence levels, this means that there is a difference in wound healing time of 100% which is very different / very significant from the use of each. each formula. Binahong leaf ethanol extract gel formula is effective in healing cuts in male Wistar rats with healing time less than 14 days.ABSTRAKUji efektivitas gel ekstrak etanol Daun Binahong (Anredera cordifolia)  sebagai penyembuhan luka insisi pada tikus wistar jantan oleh Nurhikma Awaluddin dan Nurfiddin Farid.  Luka adalah gangguan pada structural atau fisiologi integument yang membutuhkan respons perbaikan jaringan yang normal atau tidak normal. Luka insisi merupakan luka yang disebabkan oleh alat yang berujung tajam dan mengenai lapisan kulit. Tujuan penelitian ini adalah  Untuk melihat efektivitas gel ekstrak etanol daun binahong pada  diameter luka insisi dan lama penyembuhan luka pada hewan uji tikus wistar jantan. Metode yang digunakan adalah eksperimental laboratorium. Pengamatan luka insisi dilakukan selama 14 hari. Pengamatan terdiri dari perubahan panjang luka dan lama penyembuhan. Luka insisi ditandai dengan merobek jaringan epidermis sepanjang 2 cm. Uji sediaan gel ekstrak daun binahong diberikan pada luka insisi tikus wistar jantan dengan  melihat pembentukan maturasi, waktu penutupan luka. untuk pemberian ekstrak dengan konsentrasi 2% selama sepuluh hari, pada pemberian formula dengan konsentrasi  10%  terjadi penutupan luka pada hari kesembilan dan pada konsentrasi 15% terjadi pada hari kedelapan. Pengamatan penyembuhan luka ditandai dengan terjadinya penutupan luka secara menyeluruh pada bagian kulit yang berawal adanya inflamasi  kemudian disusul dengan proses proliferasi dan maturasi atau remodeling. Perlakuan pada kontrol positif yang menggunakan sediaan bioplasenton, mengalami penutupan luka yang cepat dibandingkan dengan keempat formula yang lain. Hasil  analisis statistik Anova secara SPSS hubungan antara formula dan kecepatan luka tertutup 100%, di mana Fhitung > Ftabel pada taraf  kepercayaan 5% dan 1%, ini berarti terdapat perbedaan waktu penyembuhan luka 100% yang sangat berbeda nyata/sangat signifikan dari penggunaan masing-masing formula. Formula gel ekstrak etanol daun Binahong   memiliki efektivitas dalam menyembuhkan luka sayat pada tikus wistar jantan dengan lama penyembuhan kurang dari 14 hari. 
UJI AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL TUNAS REBUNG (Bambusa SP) PADA KAKI TIKUS WISTAR JANTAN YANG DIINDUKSI KARAGENAN Muhammad Asri SR; Winarni; Nielma Auliah; Nurjannah Bachri
Journal of Pharmaceutical Science and Herbal Technology Vol. 8 No. 2 (2023): Journal of Pharmaceutical Science and Herbal Technology
Publisher : STIKES Nani Hasanuddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35892/jpsht.v1i1.1455

Abstract

Penelitian ini bertujuan untuk mengetahui apakah ekstrak etanol tunas rubung (Bambusa SP) memiliki aktivitas sebagai antiinflamasi pada tikus Jantan galur wistar dan berapa konsentrasi yang paling efektif dari ekstrak etanol tunas rebung (Bambusa SP) yang memberikan aktivitas antiinflamasi yang dilihat dari dari parameter penurunan edema pada kaki tikus. Metode penelitian secara eksperimental dengan cara tikus putih Jantan galur wistar sebanyak 15 ekor diinduksi dengan karagenan yang dibagi menjadi 5 kelompok, masing-masing kelompok terdiri dari 3 ekor. Kelompok control negatif diberikan Na-CMC dan control positif diberikan natrium diklofenak. Kelompok I diberikan ekstrak dengan konsentrasi 2%, kelompok II diberikan ekstrak dengan konsentrasi 4% dan untuk kelompok III diberikan ekstrak dengan konsentrasi 6%. Hasil penelitian menunjukkan bahwa : 1. Efek antiinflamasi dari ekstrak tunas rebung sangat kuat 2. Pemberian ekstrak etanol tunas rebung (Bambusa SP) berpengaruh terhadap penurunan edema pada kaki tikus Jantan galur wistar 2. Ada perbedaan pengaruh pemberiaan dosis terhadap penurunan edema pada kaki tikus Jantan galur wistar.
Formulation And Testing The Effectiveness Of Gel Extract Of Red Ginger (Zingiber officinale Var. Rubrum) As Antiinflamatory In White Male Rats (Rattus norvegicus). Nurjannah Bachri; Nielma Auliah; Sri Wahyuningsih; Husna Dewi
Proceeding International Conference Of Innovation Science, Technology, Education, Children And Health Vol. 3 No. 1 (2023): Proceeding of The International Conference of Inovation, Science, Technology, E
Publisher : Program Studi DIII Rekam Medis dan Informasi Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/icistech.v3i1.61

Abstract

Red Ginger is a type of rhizome that is widely used as an ingredient in traditional medicine in Indonesia. The efficacy of red ginger has been widely studied as an effective anti-inflammatory. One of the main components of red ginger is the gingerol class of compounds. This study aims to determine the anti-inflammatory effect that is applied to the red ginger extract gel (Zingiber officinale var. Ruburum) gel preparation with the HPMC gel-forming ingredient. The gel preparation was then tested for stability up to day 7 and evaluated for its anti-inflammatory power against white rats (Rattus norvegicus). The method used was the artificial inflammation ordering method, where the test was carried out by injection of carrageenan as a mediator for inflammation of the thighs of white rats, then topically giving Red Ginger extract gel with a concentration of 1%, 3% and 5%, HPMC as a negative control and diclofenac sodium as a Positive control. Measurements were carried out every 8 hours every day after being induced by carrageenan to use a caliper. The results showed that the reduction in inflammation to reduce the diameter of 1% after induction was 1.76 cm and decreased to 1.22 cm, the concentration of 3% after induction was 1.68 cm and decreased to 1.33 cm, the concentration of 5% after induction was 1 , 79 cm and decreased to 1.35 cm. Data were statistically analyzed using ANOVA showing that the negative HPMC controls did not show any anti-inflammatory effects. It can show that 1%, 3% and 5% Red Ginger ethanol extract gel has anti-inflammatory effects and the greatest effect is that the 5% concentration has an anti-inflammatory effect.
Formulation And Testing The Effectiveness Of Gel Extract Of Red Ginger (Zingiber officinale Var. Rubrum) As Antiinflamatory In White Male Rats (Rattus norvegicus). Nurjannah Bachri; Nielma Auliah; Sri Wahyuningsih; Husna Dewi
Proceeding International Conference Of Innovation Science, Technology, Education, Children And Health Vol. 3 No. 1 (2023): Proceeding of The International Conference of Inovation, Science, Technology, E
Publisher : Program Studi DIII Rekam Medis dan Informasi Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/icistech.v3i1.61

Abstract

Red Ginger is a type of rhizome that is widely used as an ingredient in traditional medicine in Indonesia. The efficacy of red ginger has been widely studied as an effective anti-inflammatory. One of the main components of red ginger is the gingerol class of compounds. This study aims to determine the anti-inflammatory effect that is applied to the red ginger extract gel (Zingiber officinale var. Ruburum) gel preparation with the HPMC gel-forming ingredient. The gel preparation was then tested for stability up to day 7 and evaluated for its anti-inflammatory power against white rats (Rattus norvegicus). The method used was the artificial inflammation ordering method, where the test was carried out by injection of carrageenan as a mediator for inflammation of the thighs of white rats, then topically giving Red Ginger extract gel with a concentration of 1%, 3% and 5%, HPMC as a negative control and diclofenac sodium as a Positive control. Measurements were carried out every 8 hours every day after being induced by carrageenan to use a caliper. The results showed that the reduction in inflammation to reduce the diameter of 1% after induction was 1.76 cm and decreased to 1.22 cm, the concentration of 3% after induction was 1.68 cm and decreased to 1.33 cm, the concentration of 5% after induction was 1 , 79 cm and decreased to 1.35 cm. Data were statistically analyzed using ANOVA showing that the negative HPMC controls did not show any anti-inflammatory effects. It can show that 1%, 3% and 5% Red Ginger ethanol extract gel has anti-inflammatory effects and the greatest effect is that the 5% concentration has an anti-inflammatory effect.
ANTIBACTERIA ACTIVITY ETHANOL EXTRACT OF ACHRAS ZAPOTA L. FRUIT AND LAGENARIA SICERARIA (MOLINA) STANDL. AGAINST SALMONELLA TYPHI Saldi Hapiwaty; Yuri Pratiwi Utami; Imrawati; Mahfuzun Bone; Nurjannah Bachri; Rahmah Mustarin; Ainun Jariah; Zahira Amody; Benedikta Winne Angela
JURNAL KATALISATOR Vol. 9 No. 2 (2024): Jurnal Katalisator Volume 9 No.2, Oktober 2024
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v9i2.3103

Abstract

The Synergistic of antibacterial is an interaction of two antibacterial agents that produces a greater inhibitory effect on bacteria, compared to the individual antibacterial effects of the two agents. The purpose of this study was to determine the synergistic effect of anti-bacterial extract of sapodilla fruit (Achras zapota L.) and water gourd (Lagenaria siceraria (Molina) Standl.) extract against Salmonella typhi bacteria. Extraction of sapodilla fruit and water gourd fruit was carried out by maceration method using 96% ethanol (1:10). Determination of the value of the minimum inhibitory concentration (MIC) of anti-bacterial sapodilla manila fruit and water gourd fruit was carried out by the checkerboard assay method using a 96 wells microplate by calculating the Fractional Inhibition Concentration Index (FICI) value. The results showed that the single MIC value of sapodilla manila fruit and water gourd fruit respectively are 50 mg/mL and 100 mg/mL. The interaction between the two is expressed as a Fractional Inhibitory Concentration Index (FICI) with a value of 1.5. The FICI values ​​indicate different antibacterial effects of the combination of sapodilla fruit and water gourd fruit against Salmonella typhi. Keywords: Synergistic, Salmonella typhi, Achras zapota L., Lagenaria siceraria (Molina) Standl., FICI