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All Journal Jurnal Keperawatan Soedirman (The Soedirman Journal of Nursing) Indonesian Journal of Cancer Healthy Tadulako Journal (Jurnal Kesehatan Tadulako)
Mahmud Ghaznawie
Program Studi Biomedik Universitas Hasanuddin
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Deteksi Dini Karsinoma Sel Basal TAN, SUKMAWATI TANSIL; GHAZNAWIE, MAHMUD; REGINATA, GABRIELA
Indonesian Journal of Cancer Vol 10, No 2 (2016): April - June 2016
Publisher : Indonesian Journal of Cancer

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1248.004 KB)

Abstract

ABSTRACTBasal Cell Carcinoma (BCC) is a malignant neoplasm derived from nonkeratinizing cells that originate in the basal layer of the epidermis, which is locally invasive, aggressive, destructive, and rarely metastasize. BCC is more common in the elderly. Etiopathogenesis associated with BCC is genetic, environmental, and most often is exposure to ultraviolet light. Clinically, there are five types of BCC, which are nodular, superficial, morpheaform, pigmented, and fibroepitelioma Pinkus. Early detection of skin cancer can be done with self skin examination. Definitive diagnosis of malignancy is determined by anatomical pathology examination. However, for very early BCC lesion, it’s difficult to determine with hematoxylin eosin staining. Therefore, it is uses Ber-EP4 staining which is specific and highly sensitive for early BCC growing as budding in basal layer of the epidermis and follicles. This finding is particularly significant in the development of molecular pathology and clinical management of BCC lesions or suspected BCC. ABSTRAKKarsinoma Sel Basal (KSB) merupakan neoplasma ganas dari sel yang tidak mengalami keratinisasi pada lapisan basal epidermis, bersifat invasif lokal, agresif, destruktif, dan jarang bermetastasis. KSB lebih sering terjadi pada usia lanjut. Etiopatogenesis yang berkaitan dengan KSB adalah genetik, lingkungan, dan yang paling sering adalah paparan sinar ultraviolet. Secara klinis, terdapat lima tipe KSB, yaitu nodular, superfisial, morpheaform, pigmented, dan fibroepitelioma Pinkus. Deteksi dini kanker kulit dapat dilakukan dengan pemeriksaan kulit sendiri (SAKURI). Diagnosis pasti keganasan ditentukan dengan pemeriksaan patologi anatomi. Namun, untuk lesi sangat dini KSB sulit ditentukan dengan pewarnaan hematoksilin eosin. Oleh karena itu, digunakanlah pewarnaan Ber-EP4 yang bersifat spesifik dan sangat sensitif untuk KSB dini yang tumbuh sebagai tunas di lapisan basal epidermis dan folikel. Temuan ini sangat berarti dalam pengembangan patologi molekuler dan penanganan klinis lesi KSB atau yang dicurigai KSB.
Pengaruh Simulasi Kedaruratan Medik Terhadap Kompetensi Petugas Penanggulangan Bencana Daerah Provinsi Sulawesi Barat Nursana, I Made; Ghaznawie, Mahmud; Budu,
Jurnal Keperawatan Soedirman Vol. 08 No. 3 (2013)
Publisher : Jurusan Keperawatan FIKES UNSOED

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jks.2013.8.3.539

Abstract

Disasters almost always cause loss of property, destruction of ecosystems and causing human casualties both dead survivors in a state of emergency. The state of emergency is if not handled quickly and properly will lead to death and disability.This study aims to determine differences in the competence of emergency medical officer of the Regional. The method used is a quasi-experimental one group pretest-posttest design. Data analysis using Wilcoxon test test. There is a significant difference of knowledge, attitudes and skills of emergency medical personnel with a p value of 0.000. Significantly different attitudes emergency medical personnel before and after the simulation. Need to be implemented or simulated continuous exercise for officers to always be ready in a disaster can happen at any time.
STRATIFIKASI RISIKO HIPERPLASIA ENDOMETRIUM DAN KANKER ENDOMETRIUM TIPE ENDOMETRIOID BERDASARKAN FAKTOR DEMOGRAFI, GEJALA GINEKOLOGI DAN EKSPRESI BETA CATENIN Maulana, Aries; Masadah, Rina; Nelwan, Berti Julian; Ghaznawie, Mahmud; Miskad, Upik Anderiani; Tawali, Suryani
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 10 No. 2 (2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v10i2.1150

Abstract

Studi ini menganalisis hubungan antara faktor demografi, gejala ginekologi, dan ekspresi B-catenin di endometrium untuk mengembangkan stratifikasi risiko hiperplasia dan karsinoma endometrium. Studi ini menemukan bahwa distensi perut berhubungan dengan derajat patologi yang buruk, sedangkan peningkatan usia dan perdarahan uterus berhubungan dengan karsinoma. Namun, ekspresi B-catenin tidak dikaitkan dengan derajat patologis atau karsinoma. Penelitian ini juga mengembangkan model stratifikasi risiko pohon keputusan yang mampu membedakan antara hiperplasia non-atipikal dan hiperplasia/karsinoma atipikal dengan sensitivitas 80–94,8% dan spesifisitas 40,6–60%. Hal ini menunjukkan bahwa model stratifikasi risiko merupakan alat yang menjanjikan untuk mengidentifikasi wanita yang berisiko terkena hiperplasia dan karsinoma endometrium.
Co-Authors Budu, I Made Nursana Maulana, Aries Nelwan, Berti Julian REGINATA, GABRIELA Rina Masadah TAN, SUKMAWATI TANSIL Tawali, Suryani UPIK ANDERIANI MISKAD, UPIK ANDERIANI