Article Per Year (5 Year)
p-Index From 2020 - 2025
0.92
P-Index
This Author published in this journals
All Journal Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Healthy Tadulako Journal (Jurnal Kesehatan Tadulako)
Nelwan, Berti Julian
Unknown Affiliation
Decision Sciences, Operations Research & Management Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

Published : 5 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 5 Documents
Search

 1 
HUBUNGAN EKSPRESI HYPOXIA INDUCIBLE FACTOR-1 ALFA (HIF-1a) DENGAN DERAJAT HISTOPATOLOGI PADA KARSINOMA PAYUDARA INVASIF Christinahadi, Agnes Dyah; Nelwan, Berti Julian; Cangara, Muhammad Husni; Miskad, Upik Anderiani; Arsyadi, Gunawan; Mardiati, Mardiati; Tawali, Suryani
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 10 No. 2 (2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v10i2.1109

Abstract

Karsinoma payudara merupakan salah satu penyakit keganasan terbanyak pada wanita di seluruh dunia. Tujuan penelitian ini adalah untuk mengetahui hubungan ekspresi HIF-1a dengan derajat histopatologi pada karsinoma payudara invasif. Penelitian ini merupakan suatu penelitian cross sectional dengan menilai ekspresi HIF-1a pada karsinoma payudara invasif derajat 1, 2 dan 3 yang dilakukan di Laboratorium Patologi Anatomik Rumah Sakit UNHAS Makassar mulai bulan April sampai Agustus 2023. Kami mengumpulkan dan mengelompokkan seluruh sampel yang memenuhi syarat berdasarkan pemeriksaan histopatologi sebagai karsinoma payudara invasif derajat 1, 2 dan 3. Kemudian mengumpulkan seluruh sampel yang memenuhi syarat untuk diambil blok parafinnya sesuai urutan berdasarkan nomor registrasi dan dilakukan pewarnaan imunohistokimia, kemudian mengelompokkan setiap kelompok tersebut berdasarkan skor ekspresi HIF-1a. Hasil penelitian yang didapatkan, dsimpulkan bahwa terdapat hubungan yang bermakna antara ekspresi HIF-1a dengan derajat histopatologi pada karsinoma payudara invasif, yaitu HIF-1a terekspresi lebih kuat pada karsinoma payudara invasif derajat 3 daripada derajat 1 dan derajat 2
STRATIFIKASI RISIKO HIPERPLASIA ENDOMETRIUM DAN KANKER ENDOMETRIUM TIPE ENDOMETRIOID BERDASARKAN FAKTOR DEMOGRAFI, GEJALA GINEKOLOGI DAN EKSPRESI BETA CATENIN Maulana, Aries; Masadah, Rina; Nelwan, Berti Julian; Ghaznawie, Mahmud; Miskad, Upik Anderiani; Tawali, Suryani
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 10 No. 2 (2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v10i2.1150

Abstract

Studi ini menganalisis hubungan antara faktor demografi, gejala ginekologi, dan ekspresi B-catenin di endometrium untuk mengembangkan stratifikasi risiko hiperplasia dan karsinoma endometrium. Studi ini menemukan bahwa distensi perut berhubungan dengan derajat patologi yang buruk, sedangkan peningkatan usia dan perdarahan uterus berhubungan dengan karsinoma. Namun, ekspresi B-catenin tidak dikaitkan dengan derajat patologis atau karsinoma. Penelitian ini juga mengembangkan model stratifikasi risiko pohon keputusan yang mampu membedakan antara hiperplasia non-atipikal dan hiperplasia/karsinoma atipikal dengan sensitivitas 80–94,8% dan spesifisitas 40,6–60%. Hal ini menunjukkan bahwa model stratifikasi risiko merupakan alat yang menjanjikan untuk mengidentifikasi wanita yang berisiko terkena hiperplasia dan karsinoma endometrium.
Leptin Expression in High-grade Serous Ovarian Carcinoma: The Controversy of Leptin Paradox in Ovarian Cancer Ham, Jonathan; Masadah, Rina; Nasser, Andi Sitti Halija Diawanti; Rauf, Syahrul; Nelwan, Berti Julian; Cangara, Muhammad Husni; Miskad, Upik Anderiani; Mardiati; Tawali, Suryani
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 1 January 2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i1.2373

Abstract

Objectives : To analyse the characteristics and expression patterns of Leptin in high-grade serous epithelial ovarian carcinoma (HGSC), and to compare them with the overall serous ovarian carcinoma population. Methods : This was a cross-sectional study. A total of 77 paraffin-embedded tissue samples were collected from patients at the Wahidin Sudirohusodo Hospital over a period of 3 years. Immunohistochemical staining was performed using a polyclonal Leptin antibody. Data were analyzed using SPSS version 22.0. Results: Among HGSC patients, the majority (64.3%) were over 50 years old, and a significant portion (39.3%) were obese. Leptin showed strong cytoplasmic expression in 69.6% of HGSC tumor cells and in 100% of LGSC tumor cells (p-value = 0.004). There was no correlation between lymphovascular space invasion and leptin expression. Interestingly, leptin expression in overall serous ovarian carcinoma patients exhibited a protective effect against metastasis (p-value = 0.047), suggesting a leptin paradox exists in this type of cancer. However, this association was no longer significant when the analysis excluded the LGSC group (p-value = 0.193). Conclusion : This study suggest that leptin expression may not be a significant prognostic factor in HGSC. The appearance of the pseudo-leptin paradox phenomenon in several previous studies was confounded by sample populations with heterogeneous tumor morphology. Keywords: high-grade serous carcinoma, leptin paradox, immunohistochemistry, leptin, obesity
Reducing Women’s Cancer Rates: Early Detection of Breast Cancer and Cervical Cancer Through Self-Breast Exams (SADARI) and Pap Smears in Pinrang Regency, South Sulawesi Masadah, Rina; Nelwan, Berti Julian; Ham, Jonathan; Raharja, Siska Putri Wulandari; Gosal, Steffy Rebecca; Rauf, Syahrul
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 11, No 1 (2025): March
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpkm.99065

Abstract

Breast and cervical cancer constitute the two most prevalent cancer types globally, with a disproportionately high mortality rate among women. While cervical cancer ranks eighth in terms of incidence, it remains a significant public health concern. A common challenge is the community’s delay in seeking healthcare attributed to a dearth of information, consequently leading to delayed treatment. The Pinrang Regency Health Department and the Family Empowerment and Welfare Team (TP-PKK) of South Sulawesi identified a high incidence of breast and cervical cancer among women in the Pinrang region. A primary obstacle to addressing this issue is the absence of public awareness regarding breast and cervical cancer, including early warning signs, symptoms, and associated risks. This problem is compounded by the district’s lack of an anatomical pathology specialist, hindering public education efforts and diagnostic capabilities. The objective of this activity was to enhance awareness of early detection for these two gynecological cancers in order to reduce mortality and morbidity rates associated with cancer. The method comprised an educational session on breast and cervical cancer, practicing SADARI, attended by 145 participants, followed by Pap smear tests for 45 volunteers. Program effectiveness was evaluated through pretest and posttest. A Wilcoxon signed-rank test was conducted to compare pretest and posttest scores. The results revealed a highly significant increase in scores p = 0.000 (p<0.005), suggesting that the educational program was successful in improving participants’ knowledge. A significant proportion of participants (57.8%) reported undergoing a Pap smear for the first time, highlighting the need for enhanced awareness and knowledge-sharing efforts regarding early detection of cervical cancer. The Pinrang Regency Health Department and TP-PKK provided essential support and participation. The Institute for Research and Community Service (LPPM) funds this community service project. The project was executed under contract number 0031/UN.4.22/PM.01.01.2024.
Community-Based Sociodemographic Determinants of Chemotherapy Response in Breast Cancer: A Retrospective Study from Central Java, Indonesia Wijaya, Jauhari Deslo Angkasa; Peter, John Sammy Leids Alfawin; Smaradhania, Nilam; Nelwan, Berti Julian; Purnama, Imeldy Prihatni; Suwaryo, Putra Agina Widyaswara
Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Vol. 8 No. 8: AUGUST 2025 - Media Publikasi Promosi Kesehatan Indonesia (MPPKI)
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/mppki.v8i8.7498

Abstract

Introduction: Breast cancer remains a major global health concern, with disparities in treatment outcomes often rooted in social inequalities. Sociodemographic factors such as education, economic status, social support, and healthcare access play critical roles in influencing how patients respond to neoadjuvant chemotherapy (NAC). Understanding these determinants is essential for designing effective, community-based health promotion strategies that address health disparities. This study aimed to examine the influence of sociodemographic factors on breast cancer patients’ response to NAC and to explore implications for community health promotion. Method: A retrospective quantitative study was conducted on 144 breast cancer patients who received NAC at PKU Muhammadiyah Hospital Gombong, a secondary-level healthcare facility in Central Java, Indonesia. Statistical analyses were performed using SPSS version 28. Data on education level, economic status, social support (assessed via the MOS Social Support Survey), and healthcare access (measured by distance to facility) were collected. Treatment responses were categorized as complete, partial, or progressive. Statistical analysis involved chi-square, Mann-Whitney U, and multinomial logistic regression to determine significant predictors of response. Result: Patients with lower education levels were 2.50 times more likely to have a partial response (p = 0.031) and 4.20 times more likely to experience a progressive response (p = 0.004). Low economic status increased the likelihood of partial (OR = 3.30, p = 0.003) and progressive responses (OR = 6.40, p = 0.001). Each additional kilometre from a healthcare facility raised the risk of partial (OR = 1.20, p = 0.002) and progressive responses (OR = 1.50, p = 0.001). Higher social support decreased the odds of progressive response by 30% (OR = 0.70, p < 0.001). Social inequalities—particularly related to education, income, distance to care, and social support—significantly affect treatment response among breast cancer patients undergoing NAC. Consulasion: This study fills a gap in the existing literature by utilizing real-world, community-based data to examine chemotherapy response through a health equity lens, moving beyond biologically centered models. It contributes theoretically by aligning findings with the social determinants of health framework, offering insights into structural disparities in cancer care. These findings emphasize the urgent need for integrated health promotion interventions aimed at improving health literacy, strengthening community support systems, and reducing structural barriers to care. Empowering underserved populations through community-based strategies is essential for equitable cancer outcomes.
Co-Authors Arsyadi, Gunawan Cangara, Husni Christinahadi, Agnes Dyah Gosal, Steffy Rebecca Ham, Jonathan Mahmud Ghaznawie Mardiati Mardiati Mardiati Maulana, Aries Nasser, Andi Sitti Halija Diawanti Peter, John Sammy Leids Alfawin Purnama, Imeldy Prihatni Raharja, Siska Putri Wulandari Rina Masadah Smaradhania, Nilam Suwaryo, Putra Agina Widyaswara Syahrul Rauf Tawali, Suryani UPIK ANDERIANI MISKAD, UPIK ANDERIANI Wijaya, Jauhari Deslo Angkasa