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Journal : annales bogorienses

Construction of Binary Vector With Wound Inducible Promoter for Hbsag Expression: Development of Plant-Based Edible Hepatitis B Vaccine from Indonesian Isolate Sony Suhandono; Ernawati A.Giri Rachman; Ima M. Zainuddin; Putri Dwi Utari; Apsari Supraba; Amy Estiati
ANNALES BOGORIENSES Vol 11, No 1 (2007): Annales Bogorienses
Publisher : Research Center for Biotechnology - Indonesian Institute of Sciences (LIPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3283.881 KB) | DOI: 10.14203/ann.bogor.2007.v11.n1.7-14

Abstract

Hepatitis B is a serious infectious disease In the third world countries including Indonesia . Vaccination is  the most effective way to prevent the spread of the disease;  therefore the demand for HBV vaccine is high.  In order to produce more vaccine at lower cost, transgenic plant can be chosen to express the vaccine with the above criteria. Several researches were successfully producing transgenic plants expressing HBsAg that formed virus-like particles and  induced  immune response  in  human.  However. HBsAg expression  in  transgenic plant needs to be  improved especially on gene  expression control system. Here, we describe the construction of HBsAg .  structural gene under the control of wound  inducible promoter, MeEFl promoter from  manihot esculenta Crantz. The HBsAg gene was amplified using PCR from HBV genome isolated from an  Indonesian patient. The gene was subsequently fused with VSPaS signal peptide, which targeted the reticulum endoplasm of plant cell . The construct was cloned into binary expression vector for Agrobacterium plant Transformation  in  near future.Keywords: HBsAg. VSPaS signal peptide and MeEFI promoter
Co-Authors . Anindyajati A'yun, Ramadhani Qurrota Afifah, Salma Aulia Afina Firdaus Syuaib Afina Firdaus Syuaib Agustiyanti, Dian Fitria Aluicia Anita Artarini Amy Estiati Anastasia Armimi Andri Wardiana, Andri Angga Fajriansyah Anita Artarini Apsari Supraba Arief Akhdestira Mustaram ARTARINI, ANITA ARUM PATRIATI Azzania Fibriani CATUR RIANI CHANDRA JINATA Chikako Ono David Virya Chen Debbie Retnoningrum, Debbie DEBBIE SOEFIE RETNONINGRUM Desriani Desriani Dessy Natalia Dessy Natalia DESSY NATALIA DYSHELLY NURKARTIKA PASCAPURNAMA Edi, Suryo Purnomo EDY GIRI-RACHMAN PUTRA Elfa Ali Idrus Elsa Gustianty Elvi Restiawaty Faizah, Nur Al FENRYCO PRATAMA Ferry Iskandar Hakim, Meutia Diva Hariyatun, Hariyatun Hotma Hutapea, Hotma Husna Nugrahapraja Ihsanawati Ihsanawati Ima M. Zainuddin Katherine Vanya Laurelia, Jessica Lia Dewi Juliawaty MAELITA RAMDANI MOEIS MAELITA RAMDHANI MOEIS Marissa Angelina Marselina Irasonia Tan Marselina Irasonia Tan Marselina Irasonia, Tan Marselina Tan Meutia Diva Hakim Muhammad Hamzah Syaifullah Azmi Muhammad Hamzah Syaifullah Azmi Neni Nurainy Noriko Yamano- Adachi Novia Syari Intan Nur AHM. Hasan Oktira Roka Aji Patricia Gita Naully Patriotika Muslima Permatasari, Fitri Aulia Popi Hadi Wisnuwardhani, Popi Hadi Putri Ayu Fajar Putri Dwi Utari RASI FITRIA RATIH ASMANA NINGRUM Rinto Sukoco RUKMAN HERTADI Shinta Stri Ayuda Nur Setyaningsih SONY HERU SUMARSONO Sony Suhandono SONY SUHANDONO Stephanie, Rebecca Suryohastari, Raden Rara Bhintarti Taharuddin, Audrey Angelina Putri Takeshi Omasa Tan, Marselina Irasonia Tina Rostinawati Wardono Niloperbowo Wicaksana, Dwi Nawang Wojciechowska, Gladys Emmanuella Putri Yamahoki, Nicholas Yana Rubiyana, Yana Yoshiharu Matsuura