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All Journal e-CliniC Medical Scope Journal (MSJ) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Fandy Gosal
Medical Faculty Universitas Sam Ratulangi, Manado
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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PROFIL PASIEN HIPERTENSI DI POLIKLINIK GINJAL-HIPERTENSI Tamburian, Marillyn M.; Moeis, Emma Sy.; Gosal, Fandy
e-CliniC Vol 4, No 1 (2016): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v4i1.11034

Abstract

Abstract : Hypertension is chrocnic medical condition which the blood pressure has elevated above 140mmHg systolic and 90 mmHg diastolic. Hypertension is one of top 10 of the causes of death worldwide. It is because hypertension affects in damaged of some organs like heart, brain, renal, retinal, ect.The purpose of this study is to give the information about profile of hypertensive patients and about antihypertensive drugs which most commonly used in Prof. Dr. R. D. Kandou General Hospital Manado.This is descriptive retrospective study. The data had been taken from medical records in Nephrology and Hypertension Clinic at Prof. Dr. R. D. Kandou General Hospital Manado.Keywords : Hypertension, Complication, Antihypertensive drugsAbstrak : Hipertensi merupakan kondisi dimana tekanan darah sistol diatas 140 mmHg dan tekanan darah diastol diatas 90 mmHg.Hipertensi menjadi salah satu penyebab kematian terbanyak didunia karena hipertensi dapat mempengaruhi kerusakan pada organ-organ target yang lain seperti organ jantung, otak, ginjal, mata dan lain-lain.Tujuan penelitian ini untuk memberikan gambaran tentang profil pasien hipertensi serta jenis obat antihipertensi yang digunakan di poliklinik ginjal-hipertensi RSUP Prof. Dr. R. D. Kandou Manado periode Oktober 2014 - Maret 2015.Penelitian ini merupakan jenis penelitian deskriptif retrospektif dengan data sekunder di poliklinik ginjal-hipertensi RSUP. Prof. Dr. R. D. Kandou Manado periode Oktober 2014 - Maret 2015. Sampel penelitian sebanyak 311 pasien.Kata Kunci : Hipertensi, Komplikasi, Obat Antihipertensi
Gambaran kadar bilirubin pasien tuberkulosis paru selama pengobatan di RSUP Prof. Dr. R. D. Kandou Manado periode Januari 2012 – Desember 2014 Pontoh, Livinia G.; Polii, Efata B.I.; Gosal, Fandy
e-CliniC Vol 4, No 1 (2016): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v4i1.10834

Abstract

Abstract: Indonesia still ranks as the third country in the world to have the most cases of tuberculosis (TB). For this reason, there is a needed treatment for TB, called the Anti-Tuberculosis Drugs (ATD) which comprises of isoniazid, ethambutol, pyrazinamide, rifampicin and streptomycin and this should be taken for 6-8 months. However, ATD has side effects mainly in disturbing the liver function that can be assessed by the serum levels checkup of SGOT, SGPT and bilirubin. This study aimed to determine the level of bilirubin pulmonary TB of patients during the treatment in RSUP Prof. DR. R.D. Kandou Manado for the period of January 2012 to December 2014. This was an observational descriptive study with a cross sectional design by using the medical records of patients of pulmonary TB hospitalization for the period of January 2012 to December 2014. There were 32 patients as samples. There has been an increase in total bilirubin levels during the ATD treatment. It has been discovered that as big as (47%) had an increase level of total bilirubin. The total of bilirubin levels had increased more in male patients. The increase in the total bilirubin occurred in the age of >35 and the more it increases with age. Meanwhile, the increase in direct bilirubin levels had been found in as many as (56%). The indirect bilirubin levels had been found to be normal in (91%). A total of (31%), with hyperbilirubinemia, had not had comorbidities and most had often occurred in the first month of ATD treatment.Keywords: pulmonary tuberculosis, bilirubin, antituberculosis drug, hepatotoxicityAbstrak: Indonesia masih menempati urutan ketiga negara penderita tuberkulosis (TB) terbanyak didunia. Untuk itulah, dibutuhkan pengobatan TB, yang dinamakan Obat Anti Tuberkulosis (OAT) yang terdiri isoniazid, etambutol, pirazinamid, rifampicin dan streptomisin yang harus dikonsumsi selama 6-8 bulan. Akan tetapi, OAT memiliki efek samping terutama menggangu fungsi hati yang dapat dinilai melalui pemeriksaan kadar serum SGOT, SGPT dan bilirubin. Untuk mengetahui kadar bilirubin pasien TB Paru selama pengobatan di RSUP Prof DR. R.D. Kandou Manado periode Januari 2012-Desember 2014. Desain penelitian yang digunakan adalah penelitian observasional deskriptif dengan pendekatan potong lintang (cross sectional) dengan memanfaatkan rekam medik pasien TB Paru rawat inap periode Januari 2012-Desember 2014. Jumlah sampel yang terpakai sebanyak 32 orang. Terjadi peningkatan kadar bilirubin total selama pengobatan OAT. Ditemukan sebesar (47%) terjadi peningkatan kadar bilirubin total. Kadar bilirubin total meningkat lebih banyak pada pasien laki-laki. Peningkatan bilirubin total terjadi pada usia >35 tahun dan semakin meningkat seiring bertambahnya usia. Sedangkan, kadar bilirubin direk ditemukan sebanyak (56%) terjadi peningkatan kadar bilirubin direk. Kadar bilirubin indirek ditemukan normal pada (91%). Sebanyak (31%) yang menderita hiperbilirubinemia tidak memiliki penyakit penyerta dan paling sering terjadi pada satu bulan pertama pengobatan OAT.Kata kunci: tuberkulosis paru, bilirubin, obat antituberkulosis, hepatotoksitas
Penyakit Crohn: Laporan Kasus Siwy, Paul V.; Gosal, Fandy
Medical Scope Journal Vol 2, No 1 (2020): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.2.1.2020.29630

Abstract

Abstract: Crohn’s disease is an inflammatory transmural bowel disease with unspecific clinical characteritics. It could involve all parts of the digestive system. The exact cause of this disease remains unknown. Its manifestation depends on the location of involved intestinal mucosa, however, it could also occur extra intestinal. We reported a case of Crohn’s disease in a 54-year-old male. In this patient there was defecation with blood in stool, abdominal pain, nausea, and weight loss. Diagnosis was based on history, physical examination, endoscopic examination and colonoscopy, as well as histopathological examination. Colonoscopy EGD examination and tissue biopsy were performed on this patient and revealed esophagitis EGD classification of Los Angeles grade A and erosive gastritis. The results of colonoscopy suggested Crohn’s disease, and internal and external hemorrhoids. Pathology examination showed non-specific chronic gastritis, nonspecific chronic ileitis with datia cells, nonspecific pancolitis, and specific chronic proctitis. Disease activity measured by using CDAI (Crohn Disease Activity Index) score was 170 (mild disease). Moreover, based on the Montreal classification it was classified as A3 L3 B1 and SES-CD (Simple Endoscopic Scoring System in Crohn’s Disease) with value of 0 (not active). This patient was planned to be treated with 500 mg of mesalazine three times daily.Keywords: Crohn’s disease Abstrak: Penyakit Crohn adalah bagian dari penyakit inflamasi saluran cerna dengan karakteristik klinis yang tidak jelas, transmural, dan dapat mengenai semua bagian saluran cerna. Sampai saat ini etiologinya belum diketahui pasti. Manifestasi penyakit ini bervariasi tergantung kerusakan dari lokasi mukosa intestinal yang terkena. Manifestasi ini dapat juga terjadi di luar sistem saluran cerna. Kami melaporkan suatu kasus penyakit Crohn pada seorang laki-laki berusia 54 tahun. Pada pasien ini didapatkan buang air besar disertai darah, nyeri perut, mual dan penurunan berat badan. Diagnosis ditegakkan berdasarkan anamnesis, pemeriksaan fisik, pemeriksaan endoskopi dan kolonoskopi serta pemeriksaan histopatologik. Pemeriksaan EGD-kolonoskopi dan biopsi jarring-an dengan hasil EGD esofagitis klasifikasi Los Angeles grade A dan gastritis erosiva. Hasil kolonoskopi ialah kesan suspek penyakit Crohn dengan hemoroid interna dan eksterna. Hasil histopatologi mendapatkan gastritis kronik non spesifik, ileitis kronik non spesifik dengan sel datia, pankolitis non spesifik dan proktitis kronik non spesifik. Aktivitas penyakit diukur dengan skor CDAI sebesar 170 (aktivitas ringan) dan berdasarkan klasifikasi Montreal diklasifikasikan sebagai A3 L3 B1 dan SES-CD sebesar 0 (tidak aktif). Pasien ini direncanakan untuk diterapi dengan pemberian mesalasin 500mg tiga kali sehari.Kata kunci: penyakit Crohn
Asparaginase-Induced Acute Necrotizing Pancreatitis Resulting in Chronic Pancreatitis and Pseudocyst in an Adult with Acute Lymphocytic Leukemia Adiwinata, Randy; Waleleng, Bradley Jimmy; Haroen, Harlinda; Rotty, Linda; Gosal, Fandy; Rotty, Luciana; Hendratta, Cecillia; Lasut, Pearla; Winarta, Jeanne; Waleleng, Andrew; Tendean, Michael
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 1 (2023): VOLUME 24, NUMBER 1, April, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/241202398-101

Abstract

L-Asparaginase is one of the main chemotherapy regiments for acute lymphocytic leukemia (ALL) management. Acute pancreatitis is one of the serious side effects of l-asparaginase administration and may lead to interruption of chemotherapy cycle. Long term complications may be devastating for patients which include of pseudocyst pancreas and chronic pancreatitis. Asparaginase induced pancreatitis is rare among adult due to the nature of ALL which commonly occurred in children population. The pathophysiology of asparaginase induced pancreatitis is still unclear. Here we present 18-year-old male with ALL and asparaginase induced acute necrotizing pancreatitis which complicated to chronic pancreatitis and pseudocyst. 
The Prevalence and Risk Factors of Gastric Polyp in Endoscopy Unit at Prof. Dr. R.D. Kandou Hospital Adiwinata, Randy; Andriani, Janette; Soetanto, Raynold; Waleleng, Andrew; Winarta, Jeanne; Rotty, Luciana; Gosal, Fandy; Tendean, Nelly; Waleleng, Bradley Jimmy
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 1 (2023): VOLUME 24, NUMBER 1, April, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/241202335-40

Abstract

Background: Gastric polyps are usually asymptomatic; they are often incidentally discovered during an esophagogastroduodenoscopy (EGD) for other indication. Most of gastric polyps are benign, however, some have malignant potential. Therefore, identifying gastric polyp risk factors are crucial. This article aims to determine the prevalence and risk factor of gastric polyp in Endoscopy Unit at Prof. Dr. R.D. Kandou Hospital between April 2021-2022.Method: The retrospective study was using medical record data of all patients who underwent EGD between April 2021-2022. Data regarding patient’s characteristic, endoscopic finding, and risk factors were collected. Data was analyzed using SPSSv25.0 with Mann-Whitney, Chi-square-test, and logistic-regression.Results: There were 241 patients included, 56.4% were males. The median age was 53 years old. The most common symptom was epigastric pain (69.3%). The main indication of EGD was dyspepsia with alarm symptoms (79.25%). We found 24.1% of patients had gastric polyps. Most polyps were found in corpus (93.1%) and 70.7% were fundic gland polyp. We found that older age (p=0.001), female (p=0.003), gastritis (p=0.037), active-smoker (p=0.000), and one-year-PPI-usage (p=0.000) were significantly associated with gastric polyp. Logistic-regression analysis showed active smoking was the most significant risk factor (OR=9.3), followed by female gender (OR=6.4), and PPI-usage (OR=3.4). We found no significant association between esophagitis, bile-reflux, gastric ulcer, H. pylori infection, NSAID use, and alcohol abuse with gastric polyp.Conclusions: We found 24.1% gastric polyp prevalence with significant risk factors such as older age, female gender, gastritis, smoking, and long-term-PPI-usage.
Co-Authors Andriani, Janette Bradley Jimmy Waleleng Efata B.I. Polii, Efata B.I. Emma Sy. Moeis Harlinda Haroen Hendratta, Cecillia Linda Rotty Livinia G. Pontoh, Livinia G. Luciana Rotty, Luciana Marillyn M. Tamburian, Marillyn M. Pearla Lasut Randy Adiwinata, Randy Siwy, Paul V. Soetanto, Raynold Tendean, Michael Tendean, Nelly Waleleng, Andrew Winarta, Jeanne