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All Journal JURNAL KEDOKTERAN KOMUNITAS DAN TROPIK The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Bradley Jimmy Waleleng
Medical Faculty Universitas Sam Ratulangi, Manado
Medicine & Pharmacology

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Hubungan skor controlled attenuation parameter, nilai transient elastography, dan skor fibrosis-4 dengan nilai estimasi laju filtrasi glomerulus pada pasien non alcoholic fatty liver disease Siregar, Alfi Syahrin; Sugeng, Cerelia Esher Caroline; Waleleng, Bradley Jimmy
Jurnal Kedokteran Komunitas dan Tropik Vol 12 No 1 (2024): JKKT Volume 12 Nomor 1 (2024)
Publisher : UNIVERSITAS SAM RATULANGI

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Abstract

Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is one of the most common chronic liver diseases and has become a health burden throughout the world over the last two decades. Hypertension, dyslipidemia, obesity, and insulin resistance are considered risk factors for PGK that overlap with the metabolic comorbidity of NAFLD. Several studies reported that the prevalence and risk of PGK events increased significantly in NAFLD patients compared with patients without NAFLD. Aim: To determine the relationship between controlled attenuation parameter scores, transient elastography, and FIB-4 scores with eGFR values in NAFLD patients. Methods: This was an analytical study with a retrospective approach and used a cross-sectional design. The subjects were taken using consecutive sampling technique. Data collection on CAP scores, TE scores, FIB-4 scores, and eGFR was carried out by looking at the patients' medical records. In this study, the Pearson correlation statistical test was used. Result: Correlation test results between CAP scores and eGFR showed a significant positive correlation (r=0.296; p=0.031), between TE scores and eGFR showed a non-significant positive correlation (r=-0.093; p=0.509), and FIB-4 score with eGFR showed a significant negative correlation (r=-0.281; p=0.042). Conclusion: There is a significant positive correlation between the CAP score and eLFG, a non-significant positive correlation between the TE score and eGFR, and a significant negative correlation between the FIB-4 score and eGFR. Keywords: CAP score, TE score, FIB-4 score, eGFR
Association Between Esophagitis Severity and GERDQ Score, Sleep, Life Quality among GERD Patients Waleleng, Andrew; Richard, Timoteus; Rombot, Tisa; Waleleng, Bradley Jimmy; Wenas, Nelly
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 2 (2023): VOLUME 24, NUMBER 2, August, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2422023102-106

Abstract

Background: Gastroesophageal reflux disease (GERD) is characterized with acid reflux, therefore may lead to esophagitis. Acid reflux may cause night symptom of GERD, therefore resulting in decreased sleep and life quality. Gastroesophageal reflux disease questionnaire (GERDQ) is a simple and validated questionnaire for diagnosing GERD. This article aims to investigate association between esophagitis severity and GERDQ score, sleep, life quality among GERD patients at Prof. Dr. R.D. Kandou Hospital.Method: An analytic-cross-sectional study was conducted in gastroenterology clinic of Prof. Dr. R.D. Kandou Hospital between May–June 2021. We included all patients with reflux esophagitis that proven by esophagoduodenoscopy and the severity was graded using Los-Angeles criteria. The GERDQ score was calculated in all patients. The analysis of sleep and life quality was assessed using validated Indonesian version of Pittsburgh-Sleep-Quality-Index (PSQI) and WHO-quality-of-life-BREF (WHOQOLBREF) questionnaire. Independent T-test was used to compare GERDQ, PSQI, WHOQOLBREF score with esophagitis severity degree.Results: Among 30 patients with esophagitis, 70% was male. We found 22 patients with Los-Angeles-grade-A and 8 patients with Los-Angeles-grade-B. The analysis showed no significant different between GERDQ score with esophagitis grade (p = 0.753). There was no association between esophagitis grade with sleep quality (p = 0.125), physical health (p = 0.161), psychological health (p = 0.728), and environmental health (p = 0.133). But we found significant association between esophagitis grade with social relationship life quality (p = 0.028).Conclusion: Patients with higher esophagitis degree had lower social relationship, but not associated with another domain of WHOQOLBREF, sleep quality, and GERDQ score.
Asparaginase-Induced Acute Necrotizing Pancreatitis Resulting in Chronic Pancreatitis and Pseudocyst in an Adult with Acute Lymphocytic Leukemia Adiwinata, Randy; Waleleng, Bradley Jimmy; Haroen, Harlinda; Rotty, Linda; Gosal, Fandy; Rotty, Luciana; Hendratta, Cecillia; Lasut, Pearla; Winarta, Jeanne; Waleleng, Andrew; Tendean, Michael
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 1 (2023): VOLUME 24, NUMBER 1, April, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/241202398-101

Abstract

L-Asparaginase is one of the main chemotherapy regiments for acute lymphocytic leukemia (ALL) management. Acute pancreatitis is one of the serious side effects of l-asparaginase administration and may lead to interruption of chemotherapy cycle. Long term complications may be devastating for patients which include of pseudocyst pancreas and chronic pancreatitis. Asparaginase induced pancreatitis is rare among adult due to the nature of ALL which commonly occurred in children population. The pathophysiology of asparaginase induced pancreatitis is still unclear. Here we present 18-year-old male with ALL and asparaginase induced acute necrotizing pancreatitis which complicated to chronic pancreatitis and pseudocyst. 
The Prevalence and Risk Factors of Gastric Polyp in Endoscopy Unit at Prof. Dr. R.D. Kandou Hospital Adiwinata, Randy; Andriani, Janette; Soetanto, Raynold; Waleleng, Andrew; Winarta, Jeanne; Rotty, Luciana; Gosal, Fandy; Tendean, Nelly; Waleleng, Bradley Jimmy
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 1 (2023): VOLUME 24, NUMBER 1, April, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/241202335-40

Abstract

Background: Gastric polyps are usually asymptomatic; they are often incidentally discovered during an esophagogastroduodenoscopy (EGD) for other indication. Most of gastric polyps are benign, however, some have malignant potential. Therefore, identifying gastric polyp risk factors are crucial. This article aims to determine the prevalence and risk factor of gastric polyp in Endoscopy Unit at Prof. Dr. R.D. Kandou Hospital between April 2021-2022.Method: The retrospective study was using medical record data of all patients who underwent EGD between April 2021-2022. Data regarding patient’s characteristic, endoscopic finding, and risk factors were collected. Data was analyzed using SPSSv25.0 with Mann-Whitney, Chi-square-test, and logistic-regression.Results: There were 241 patients included, 56.4% were males. The median age was 53 years old. The most common symptom was epigastric pain (69.3%). The main indication of EGD was dyspepsia with alarm symptoms (79.25%). We found 24.1% of patients had gastric polyps. Most polyps were found in corpus (93.1%) and 70.7% were fundic gland polyp. We found that older age (p=0.001), female (p=0.003), gastritis (p=0.037), active-smoker (p=0.000), and one-year-PPI-usage (p=0.000) were significantly associated with gastric polyp. Logistic-regression analysis showed active smoking was the most significant risk factor (OR=9.3), followed by female gender (OR=6.4), and PPI-usage (OR=3.4). We found no significant association between esophagitis, bile-reflux, gastric ulcer, H. pylori infection, NSAID use, and alcohol abuse with gastric polyp.Conclusions: We found 24.1% gastric polyp prevalence with significant risk factors such as older age, female gender, gastritis, smoking, and long-term-PPI-usage.
Co-Authors Andriani, Janette Ari Fahrial Syam Fandy Gosal Harlinda Haroen Hendratta, Cecillia J Kairupan Linda Rotty Luciana Rotty, Luciana Marcellus Simadibrata Nelly Tendean Wenas Pearla Lasut Randy Adiwinata, Randy Rombot, Tisa Siregar, Alfi Syahrin Soetanto, Raynold Sugeng, Cerelia Esher Caroline Tendean, Michael Tendean, Nelly Timoteus Richard, Timoteus Waleleng, Andrew Wenas, Nelly Winarta, Jeanne