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All Journal e-CliniC Medical Scope Journal (MSJ) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Luciana Rotty, Luciana
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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HUBUNGAN TAPSE DENGAN GGT PADA PASIEN GAGAL JANTUNG KRONIK DI BAGIAN ILMU PENYAKIT DALAM RSUP PROF DR. R. D. KANDOU MANADO Patandean, Alvionita; Wantania, Frans E. N.; Rotty, Luciana
e-CliniC Vol 4, No 1 (2016): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.4.1.2016.10978

Abstract

Abstract: Right ventricular dysfunction is associated with chronic heart failure prognosis. TAPSE is one of the right ventricular systolic function tests which is routinely performed and adds prognostic information in patients with chronic heart failure (CHF). Gamma-glutamyl transferase (GGT) is a liver enzyme used to assess hepatobiliary dysfunction with high sensitivity. GGT is related to the severity of CHF and right ventricular dysfunction. This study aimed to determine the relationship of TAPSE and GGT in patients with CHF. This was an observational analytical study with a cross sectional design, conducted to CHF patients at Internal Medicine Department of Prof. Dr. R. D. Kandou Hospital Manado. The results showed 25 samples, aged 30-79 years. There were more males than females. The bivariate analysis showed the value of r = -0.212 and P = 0.156. Conclusion: There was no association between TAPSE and GGT in patients with chronic heart failure. Keywords: CHF, TAPSE, GGT, right ventricular dysfunction Abstrak: Disfungsi ventrikel kanan berhubungan dengan prognosis jangka panjang gagal jantung. TAPSE merupakan salah satu pemeriksaan fungsi sistolik ventrikel kanan yang rutin dilakukan dan menambah informasi prognostik pada pasien gagal jantung kronik (CHF). Gamma-glutamyl transferase (GGT) merupakan enzim hati untuk menilai fungsi hepatobiliaris dengan sensitifitas tinggi. GGT berhubungan dengan beratnya CHF dan disfungsi ventrikel kanan. Penelitian ini bertujuan untuk mengetahui hubungan TAPSE dan GGT pada pasien gagal jantung kronik. Jenis penelitian ialah observasional analitik dengan desain potong lintang terhadap pasien gagal jantung kronik di Bagian Ilmu Penyakit Dalam RSUP Prof. R. D. Kandou Manado. Hasil penelitian mendapatkan 25 sampel, usia 30-79 tahun. Jenis kelamin laki-laki lebih banyak daripada perempuan. Hasil analisis bivariat menunjukkan nilai r = -0,212 dan nilai P = 0,156 >0,05. Simpulan: Tidak terdapat hubungan antara TAPSE dan GGT pada pasien gagal jantung kronik.Kata kunci: gagal jantung kronik, TAPSE, GGT, disfungsi ventrikel kanan
Adenokarsinoma Kolon: Laporan Kasus Padang, Mersy S.; Rotty, Luciana
e-CliniC Vol 8, No 2 (2020): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v8i2.30539

Abstract

Abstract: Colorectal cancer (CRC) is a malignancy originated from the colon tissue which starts in the large intestine and rectum. In 2018, colorectal cancer was ranked fourth of the total malignancy in Indonesia with the number of cases of 30,017 (8.6% of the total cancer cases in Indonesia). We reported a case of colon cancer (adenocarcinoma) in a female aged 34 years. Diagnosis was based on anamnesis of the presence of liquid bowel movements along with blood, intermittent abdominal pain, and change of defecation pattern. Physical examination obtained tenderness in epigastric and hypochondriac right button regions. Colonoscopy was performed and revealed a colonic tumor suspicious of adenocarcinoma, suspected chronic colitis, and internal hemorrhoid. Pathological examination of the tumor tissue resulted in colonic adenocarcinoma (moderate differentiation). The management of this patient was extensive resection with anastomosis and was planned for adjuvant therapy.Keywords: adenocarcinoma colon cancer, colorectal cancer Abstrak: Kanker kolorektal (KKR) adalah keganasan yang berasal dari jaringan usus besar, yang menyerang usus besar dan rektum. Di Indonesia pada tahun 2018, kanker kolorektal menduduki posisi keempat dari keseluruhan diagnosis kanker dengan jumlah kasus 30.017 (8,6% dari seluruh kasus kanker di Indonesia). Kami melaporkan sebuah kasus kanker kolon (adenokarsinoma) pada seorang perempuan usia 34 tahun. Diagnosis ditegakkan berdasarkan anamnesis adanya buang air besar cair diserta darah, nyeri perut hilang timbul, perubahan pola defekasi. Pada pemeriksaan fisik didapatkan nyeri tekan epigastrium dan nyeri tekan bagian hipocondria kanan. Pada pemeriksaan penunjang dilakukan kolonoskopi dan didapatkan hasil tumor kolon curiga adenocarcinoma, kolitis kronik curiga kolitis ulseratif, dan hemoroid interna. Hasil patologi anatomi dari kolonoskopi yaitu kolitis kronis dengan displasia kolon ascenden dan hasil patologi anatomi jaringan tumor berupa adenokarsinoma kolon (diferensiasi sedang). Tatalaksana yang diberikan untuk pada pasien ini berupa tindakan reseksi luas dengan anastomosis dan direncanakan untuk terapi adjuvan.Kata kunci: adenokarsinoma kolon, kanker kolorektal
Peran Terlipressin pada Penyakit Hati Kronik Andrea, Decky; Rotty, Luciana
Medical Scope Journal Vol 3, No 1 (2021): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.3.1.2021.33784

Abstract

Abstract: Chronic liver disease is a progressive impairment of liver function. It is caused by non-alcoholic fatty liver, viral infection of the liver, excessive alcohol consumption, metabolic diseases such as galactosemia, autoimmune disease, and the influence of chemicals. Complications that are often found are esophageal variceal bleeding, hepatorenal syndrome, and refractory ascites. Terlipressin, which is a vasopressin analogue, is currently widely used in developed countries because it has been shown to improve survival of patients with esophageal varices, hepatorenal syndrome, and refractory ascites. Terlipressin is the current standard therapy for esophageal variceal bleeding in countries where it is available.Keywords: chronic liver disease; terlipressin  Abstrak: Penyakit hati kronis (PHK) adalah gangguan fungsi hati yang terjadi secara progresif. Peyakit hati kronis di sebabkan oleh non-alcoholic fatty liver, infeksi virus pada hati, konsumsi alkohol berlebihan, peyakit metabolik seperti galaktosemia, penyakit autoimun, dan pengaruh bahan kimia. Komplikasi yang sering ditemukan pada PHK ialah perdarahan varises esofagus, sindrom hepatorenal, dan asites refrakter. Terlipressin yang merupakan analog vasopressin saat ini banyak di pakai di negara maju karena terbukti dapat meningkatkan kelangsungan hidup pasien perdarahan varises esofagus, sindrom hepatorenal, dan asites refrakter. Dewasa ini terlipressin telah menjadi terapi standar perdarahan varises esofagus di negara-negara di mana obat ini tersedia.Kata kunci: penyakit hati kronik; terlipressin
Kolangitis Akut dengan Komplikasi Perdarahan Saluran Cerna Bagian Atas dan Peningkatan Ca 19-9: Laporan Kasus Irawaty, Agnita; Rotty, Luciana
Medical Scope Journal Vol 1, No 1 (2019): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.1.1.2019.26624

Abstract

Abstract: We reported a case of cholangitis in a 64-year-old-female associated with upper gastrointestinal bleeding. Diagnosis was confirmed by anamnesis, physical examination, and supportive investigation. This patient had a significant elevation of Ca 19-9 which often used to mark malignancy, especially in the pancreatic cancer. Albeit, in investigation we only found the obstruction of common bile duct stones. This case illustrates the fact that a markedly elevated CA 19-9 can be secondary to causes other than carcinoma.Keywords: cholangitis, Ca 19-9Abstrak: Telah dilaporkan sebuah kasus kolangitis pada seorang perempuan berusia 64 tahun, yang juga mengalami komplikasi berupa perdarahan saluran cerna bagian atas. Diagnosis ditegakkan berdasarkan anamnesis, pemeriksaan fisik, dan pemeriksaan penunjang. Pasien ini mengalami peningkatan bermakna Ca 19-9 yang sering digunakan untuk menandai adanya penyakit keganasan terutama kanker pankreas, namun pada pemeriksaan penunjang hanya didapatkan adanya batu di duktus koledokus. Kasus ini mengilustrasikan fakta bahwa peningkatan bermakna CA 19-9 secara sekunder dapat disebabkan oleh sebab-sebab lain selain karsinoma.Kata kunci: kolangitis, Ca 19-9
Asparaginase-Induced Acute Necrotizing Pancreatitis Resulting in Chronic Pancreatitis and Pseudocyst in an Adult with Acute Lymphocytic Leukemia Adiwinata, Randy; Waleleng, Bradley Jimmy; Haroen, Harlinda; Rotty, Linda; Gosal, Fandy; Rotty, Luciana; Hendratta, Cecillia; Lasut, Pearla; Winarta, Jeanne; Waleleng, Andrew; Tendean, Michael
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 1 (2023): VOLUME 24, NUMBER 1, April, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/241202398-101

Abstract

L-Asparaginase is one of the main chemotherapy regiments for acute lymphocytic leukemia (ALL) management. Acute pancreatitis is one of the serious side effects of l-asparaginase administration and may lead to interruption of chemotherapy cycle. Long term complications may be devastating for patients which include of pseudocyst pancreas and chronic pancreatitis. Asparaginase induced pancreatitis is rare among adult due to the nature of ALL which commonly occurred in children population. The pathophysiology of asparaginase induced pancreatitis is still unclear. Here we present 18-year-old male with ALL and asparaginase induced acute necrotizing pancreatitis which complicated to chronic pancreatitis and pseudocyst. 
The Prevalence and Risk Factors of Gastric Polyp in Endoscopy Unit at Prof. Dr. R.D. Kandou Hospital Adiwinata, Randy; Andriani, Janette; Soetanto, Raynold; Waleleng, Andrew; Winarta, Jeanne; Rotty, Luciana; Gosal, Fandy; Tendean, Nelly; Waleleng, Bradley Jimmy
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 1 (2023): VOLUME 24, NUMBER 1, April, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/241202335-40

Abstract

Background: Gastric polyps are usually asymptomatic; they are often incidentally discovered during an esophagogastroduodenoscopy (EGD) for other indication. Most of gastric polyps are benign, however, some have malignant potential. Therefore, identifying gastric polyp risk factors are crucial. This article aims to determine the prevalence and risk factor of gastric polyp in Endoscopy Unit at Prof. Dr. R.D. Kandou Hospital between April 2021-2022.Method: The retrospective study was using medical record data of all patients who underwent EGD between April 2021-2022. Data regarding patient’s characteristic, endoscopic finding, and risk factors were collected. Data was analyzed using SPSSv25.0 with Mann-Whitney, Chi-square-test, and logistic-regression.Results: There were 241 patients included, 56.4% were males. The median age was 53 years old. The most common symptom was epigastric pain (69.3%). The main indication of EGD was dyspepsia with alarm symptoms (79.25%). We found 24.1% of patients had gastric polyps. Most polyps were found in corpus (93.1%) and 70.7% were fundic gland polyp. We found that older age (p=0.001), female (p=0.003), gastritis (p=0.037), active-smoker (p=0.000), and one-year-PPI-usage (p=0.000) were significantly associated with gastric polyp. Logistic-regression analysis showed active smoking was the most significant risk factor (OR=9.3), followed by female gender (OR=6.4), and PPI-usage (OR=3.4). We found no significant association between esophagitis, bile-reflux, gastric ulcer, H. pylori infection, NSAID use, and alcohol abuse with gastric polyp.Conclusions: We found 24.1% gastric polyp prevalence with significant risk factors such as older age, female gender, gastritis, smoking, and long-term-PPI-usage.
Co-Authors Alvionita Patandean, Alvionita Andrea, Decky Andriani, Janette Bradley Jimmy Waleleng Fandy Gosal Frans E. N. Wantania, Frans E. N. Harlinda Haroen Hendratta, Cecillia Irawaty, Agnita Linda Rotty Padang, Mersy S. Pearla Lasut Randy Adiwinata, Randy Soetanto, Raynold Tendean, Michael Tendean, Nelly Waleleng, Andrew Winarta, Jeanne