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All Journal Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) Buguh: Jurnal Pengabdian Kepada Masyarakat Jurnal Info Kesehatan
Endah Setyaningrum
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Social Sciences

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Journal : Jurnal Info Kesehatan

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Phytochemical Composition, Antioxidant Activity, and Bioactive Compound Profiling of Sargassum sp. Ethanol Extract: Potential for Antimalarial Application Sulistianingsih, Eka; Huda, Misbahul; Endah Setyaningrum; Setiawan, Budi
JURNAL INFO KESEHATAN Vol 23 No 3 (2025): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol23.Iss3.2074

Abstract

Sargassum sp., a brown macroalga abundant in Indonesia's coastal ecosystems, has garnered attention for its diverse bioactive compounds with pharmacological potential. However, its application as a natural antimalarial and antioxidant agent remains underexplored. This study aimed to investigate the secondary metabolites in ethanol extracts of Sargassum sp. and evaluate their antioxidant and potential antimalarial activities. Ethanol extraction was conducted using the maceration technique, followed by phytochemical screening, FT-IR, and GC-MS analyses to characterize the extract. The results revealed the presence of saponins, terpenoids, tannins, alkaloids, and flavonoids. FT-IR and GC-MS confirmed compounds associated with antioxidant and antimalarial properties. The extract exhibited notable antioxidant activity with an IC₅₀ value of 26.16 ppm. These findings highlight the potential of ethanol-extracted Sargassum sp. as a promising source for the development of safer, resistance-limiting antimalarial and antioxidant agents.
Co-Authors Bambang Hermanto Bambang, Bambang Hermanto, M.Cs Budi Santoso Budi Setiawan Endang L Widiastuti Enna Aslina Isni Uswatun Khasanah jani master Misbahul Huda Nuning Nurcahyani Sulistianingsih, Eka Susanto, Gregorius Nugroho Tugiyono Tugiyono Wartariyus