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Faktor Risiko Kejadian Demam Berdarah Dengue di Indonesia Sulfi Udi; Tri Yunis Miko Wahyono
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 14, No 1 (2023): Januari 2023
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf14103

Abstract

Dengue hemorrhagic fever is a health problem that is often experienced by tropical and subtropical countries throughout the world. Indonesia is a country with the greatest risk of dengue hemorrhagic fever in the world. This study aims to determine the risk factors for DHF in Indonesia. This study is a literature review involving the ScienceDirect and Google Scholar databases. The keywords used are “Risk Factor” of “Dengue Hemorrhagic Fever” in Indonesia and “Factor” of “Dengue Hemorrhagic Fever” in Indonesia, with inclusion criteria: articles 2021-2022; published between September 2021 to September 2022; speak Indonesian or English; original research; available in full text; discusses the causes of dengue hemorrhagic fever. Of the 8 articles that met the criteria, it was found that the risk factors for dengue hemorrhagic fever in Indonesia were: climate, environmental sanitation, knowledge and attitudes, 3M plus behavior, individual characteristics, and components of vulnerability.Keywords: Aedes aegypti; dengue hemorrhagic fever; risk factor ABSTRAK Demam berdarah dengue merupakan masalah kesehatan yang sering dialami oleh negara-negara tropis maupun subtropis di seluruh dunia. Indonesia merupakan negara dengan risiko kejadian demam berdarah dengue terbesar di dunia. Studi ini bertujuan untuk mengetahui faktor-faktor risiko kejadian DBD di Indonesia. Studi ini merupakan kajian literatur yang melibatkan database ScienceDirect dan Google Schoolar. Kata kunci yang digunakan yaitu “Risk Factor” of “Dengue Hemorrhagic Fever” in Indonesia dan “Factor” of “Dengue Hemorrhagic Fever” in Indonesia, dengan kriteria inklusi: artikel tahun 2021-2022; dipublikasikan dalam rentang September 2021 hingga September 2022; berbahasa Indonesia atau Inggris; original research; tersedia dalam full text; membahas faktor-faktor penyebab demam berdarah dengue. Dari 8 artikel yang memenuhi kriteria ditemukan bahwa faktor risiko kejadian demam berdarah dengue di Indonesia yaitu: iklim, sanitasi lingkungan, pengetahuan dan sikap, perilaku 3M plus, karakteristik individu, serta komponen kerentanan.Kata kunci: Aedes aegypti; demam berdarah dengue; faktor risiko
Faktor-Faktor yang Berhubungan dengan Kematian Pasien TB MDR Selama Masa Pengobatan di Indonesia Tahun 2015-2017 Zulfa Ayuningsih; Tri Yunis Miko Wahyono
Pro Health Jurnal Ilmiah Kesehatan Vol. 1 No. 2 (2019): Pro Health Jurnal Ilmiah Kesehatan, Juli 2019
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (146.095 KB) | DOI: 10.35473/pro heallth.v1i2.244

Abstract

The incidence of TB cases in Indonesia in 2014 was 399 per 100,000 people with a mortality rate due to TB of 41 per 100,000 population. The incidence of MDR TB in Indonesia is 1.9% of new cases and 12% of cases are from previous treatment. This study discusses the factors associated with MDR TB patient deaths during treatment in Indonesia. This study used a retrospective cohort design. Data were obtained from 33 MDR TB Referral Hospitals in 2015-2017. The research subjects were data on patients who had ≥15 years of age, were diagnosed with positive MDR TB, and had complete data. Sample selection is done by total sampling method. The dependent variable is death, while the independent variables of this study are age, gender, discussion, treatment, sputum gradation at the beginning of treatment, sputum conversion in the first two months, and the number of resistance. The analysis carried out consisted of descriptive analysis, Kaplan Meier, and Cox regression. The probability of survival of MDR TB patients is 94.8% at 6 months of treatment; 91.2% at 12 months of treatment; 90% at 18 months of treatment; 87% at 24 months of treatment, 83.6% at 30, 36, 42, and 48 months of treatment. Multivariate analysis, obtained variables that support statistics with the death of MDR TB patients> old> 45 years the risk of death is 1.71 times faster with patients who increase ≤45 years. and the amount of OAT resistance> 2 risk of compensation is 0.71 times faster than patients who have OAT resistance 2. Efforts to find out early TB patients against drugs at the age of ≤45 years are expected to reduce the morbidity and mortality of MDR TB patients during treatment.
Diagnosis Of Pulmonary Tuberculosis In Children Systematic Literature Review Sara Fadila; Tri Yunis Miko Wahyono
Jurnal EduHealth Vol. 14 No. 02 (2023): Periode April-June, 2023
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (309.425 KB)

Abstract

Tuberculosis (TB) is one of the top ten causes of death caused by infectious agents in Indonesia. In children, more than 96% of TB-related deaths are due not receiving anti-TB treatment, this is significant challenges to diagnosing TB in children. This study aims to analyze the methods of diagnosing TB in children. The research design used a systematic literature review which summarized and compared as many as 12 studies published through Pubmed and Sciencedirect in 2010-2022 concerning methods of diagnosing TB in children. Descriptive analysis showed that the subjects were male with an average age of 4.5 years. Diagnostic enforcement of TB in children found that the scoring system was the most widely used method to diagnosing TB in children with a high sensitivity and specificity, sensitivity and specificity using the modified Edwards Score was 93.3% and 95%. Furthermore, the PCR method by detecting the IS6110 gene using gastric lavage specimens showed sensitivity and specificity was 100% and 98.18%. The QFT-GIT diagnostic method showed a sensitivity of 82.6%, and Xpert MTB/RIF of 76%.
Effect of non-adherence to ARV therapy on 3-year life of HIV/AIDS patients: a cohort retrospective study Hendra Dhermawan Sitanggang; Tri Yunis Miko Wahyono; Ira Marti Ayu
Riset Informasi Kesehatan Vol 12 No 1 (2023): Riset Informasi Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30644/rik.v12i1.692

Abstract

Background: Antiretroviral drug Therapy (ART) has dramatically reduced the morbidity and mortality of People Living with HIV/AIDS (PLWHA). However, adherence to antiretroviral therapy has become a challenge due to a lifetime of therapy. Adherence to antiretroviral therapy is one determining factor in the success of treatment. Method: This study aimed to determine the influence of medication non-adherence on the 3-year survival of patients with HIV/AIDS. The study design used a retrospective cohort and calculated survival estimates using Cox regression. All HIV/AIDS patients in the RSPI-SS from 2010 – April 2012, totaling 164 patients, were obtained from medical records, a summary of treatment and ART (follow-up), pharmacy data, and ARV therapy monitoring books at the RSPI-SS. Data analysis using cox regression. Results: The cumulative survival probability of patients with HIV/AIDS at RSPI Prof. dr. Sulianti Saroso in the second year (24th month) was 95.6% and in the third year (in the 36th) was 91%. Multivariate analysis with Cox regression showed the factors that affected the 3-year survival of patients with HIV/AIDS are non-adherence to ART after being controlled by initial CD4 count (aHR = 7.608; 95% CI: 1.664 to 34.790) and non-compliance appointments after controlled by opportunistic infection, age and initial CD4 count (aHR = 2.456; 95% CI: 0.802 to 7.518). Among patients' non-adherence to ART, non-compliance appointments affected the 3-year survival of patients with HIV/AIDS after controlled by initial CD4 count, sex, CPT, modes of HIV transmission, WHO clinical stage, opportunistic infection, and age (aHR = 4.517; 95%CI: 0.729 to 27.987). Conclusion: Non-adherence to ART may cause a failure to suppress HIV viral, thus increasing the possibility of HIV mutations that can lead to drug-resistant and ultimately increase the risk of death. Patients who do not adhere to medication and do not adhere to their medication appointments show a higher risk of dying than those who adhere to HIV/AIDS. Non-adherence to taking medication in the first year can be used as a marker to monitor medication adherence and the patient's health condition in the future. Therefore, it is essential to monitor adherence to taking the medication regularly through ARV therapy surveillance activities.
Recent Findings in Malaria Emergence of Piperaquine-Resistant Plasmodium falciparum Genes in Malaria Endemic Areas of Indonesia: a Literature Review Ayu Nurdiantika Sari; Tri Yunis Miko Wahyono; Ayleen Alicia Kosasih; Yoshida Aussiana Samosir; Rania Rifdah Taufiq; Inge Sutanto
Jurnal Epidemiologi Kesehatan Komunitas Vol 8, No 2 : Agustus 2023
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jekk.v8i2.11803

Abstract

Background: In recent years, artemisinin and piperaquine (PPQ) resistance in the Greater Mekong Sub-region alarmed Southeast Asian countries, especially those relying on artemisinin- based combinations as antimalarial drugs. This study aims to review the current status of malaria research and examine the frequencies of piperaquine resistance in Plasmodium falciparum isolates originating from malaria-endemic areas in Indonesia.Methods: We undertook a review to identify empirical data on antimalarial piperaquine-inclusive artemisinin combination therapies (ACT) in Indonesia using studies conducted since 2015. Journal articles were searched using the keywords combination of malaria, piperaquine, Pfcrt, Pfmdr, Pfpm2, and Indonesia. The search was conducted in four databases. Trends in empirical data were summarised in a table and compared with emerging malaria prevalence and conditions in Indonesia.Results: Our study found that dihydroartemisinin-piperaquine (DHA-PPQ) is still effective in most area. Survey of PPQ resistance in regions using DHA-PPQ as the first-line treatment heavily depends on phenotypic tests of the given drug resistance. Molecular surveys exploring polymorphisms of Pfcrt, Pfmdr1, and Pfpm2 were not found.Conclusion: This study supports the use of dihydroartemisinin-piperaquine as the first-line antimalarial drug in malaria endemic areas of Indonesia. Further research examining efficacy is required to monitor piperaquine resistance in Indonesia.
THE EFFECTIVENESS AND SAFETY OF BEDAQUILINE-CONTAINING REGIMENS IN THE TREATMENT OF PATIENTS WITH MULTI-DRUG RESISTANT TUBERCULOSIS (MDR-TB): A SYSTEMATIC LITERATURE REVIEW Miptah Farid Thariqulhaq; Tri Yunis Miko Wahyono
Jurnal EduHealth Vol. 14 No. 03 (2023): Jurnal EduHealt, Edition September 2023
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54209/jurnaleduhealth.v14i3.2678

Abstract

Objective: MDR-TB is a life-threatening infectious disease. In recent years, RR/MDR TB sufferers have increased by 10% from 186,883 patients in 2018 to 206,030 in 2019. The success rate of treatment for RR/MDR-TB patients only reaches 57% globally. WHO has recommended bedaquiline for treatment of MDR-TB as the first drug in an all-oral regimen designed to maximize treatment outcomes. Purpose: to describe the efficacy and safety of a bedaquiline-containing regimen for the treatment of MDR-TB. Methods: Pubmed, Science Direct, and Embase online databases were used to obtain data published in the last five years where literature searches were carried out independently by researchers. The keywords used in this search are combined with the Boolean operator "AND", namely (bedaquiline) AND (multidrug resistant) AND (effectiveness). Results: Eight studies met the inclusion criteria, demonstrating a higher conversion rate of sputum cultures on the bedaquiline containing regimen between 74%-95.8% with a mean time to culture conversion between 39 days-3 months. The majority of studies reported an adverse effect of QT prolongation in patients treated with bedaquiline. Conclusion: This systematic review showed that bedaquiline is effective and safe for use in the treatment of MDR-TB. However, serious side effects of QT prolongation occurred in some respondents who were treated with bedaquiline, so an effective and efficient monitoring and surveillance system is needed to ensure best practice in the treatment of MDR-TB.
Hubungan Kepatuhan dan Riwayat Pengobatan Terhadap Keberhasilan PengobatanTuberkulosis Resistan Obat dengan paduan obat jangka pendek 9-11 bulan di Provinsi DKI Jakarta Budi Setiawan; Tri Yunis Miko Wahyono; Dwi Oktavia
Journal of Mandalika Literature Vol. 5 No. 3 (2024)
Publisher : Institut Penelitian dan Pengembangan Mandalika (IP2MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/jml.v5i3.3265

Abstract

Treatment success rate of drug-resistant tuberculosis (DR-TB) remains a challenge in DKI Jakarta. It is necessary to control adherence and the presence of treatment history that can affect treatment success. . The implementation of short-term combined treatment is expected to reduce the risk of treatment dropout (LTFU) and increase treatment success rates in patients undergoing treatment for DR-TB in Indonesia.(Ministry of Health, 2020). This study used a retrospective cohort design to look at the relationship of adherence and history to treatment success. The results showed that adherent patients had a potential treatment success of 9.14 times compared to non-adherent patients (RR = 9.14 (95%CI: 5.50-15.20)), The relationship between treatment history and the success of 9-11 month short-term combined DR-TB treatment can be seen in bivariate analysis which gives the results of no treatment history with an RR of 1.06 (95%CI: 0.90 - 1.24) but not statistically significant (p = 0.48). In stratification and multivariate analysis, there was no interaction or potential confounding from other variables on the association between adherence and history with treatment success.
Keberhasilan Pengobatan dan Karakteristik Pasien Tuberkulosis Sensitif Obat (TB SO) di Provinsi DKI Jakarta Wahyu Manggala Putra; Tri Yunis Miko Wahyono; Qonita Nur Salamah
Jurnal Penelitian Kesehatan SUARA FORIKES 2022
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf13nk401

Abstract

Tuberculosis is one of the infectious agents causing death in the world. This study aims to describe the success of treatment and its characteristics in TB SO patients in DKI Jakarta province. This study involved all confirmed positive cases of TB SO in DKI Jakarta Province in 2021 (24,001 cases), which were obtained from the TB 03 SO report from SITB, which were then analyzed descriptively. The results of the analysis show that the success rate for treating TB patients in DKI Jakarta province in 2021 was 82%. As for the patients whose treatment was unsuccessful, the majority were male (61.3%), elderly (44.7%), unemployed (38.3%), undergoing treatment at the hospital (71.7%). Central Jakarta (25%) with category 1 OAT treatment (90.1%). Research is needed regarding what factors influence the success of treatment in TB patients in DKI Jakarta province.Keywords: tuberculosis; treatment success; medical facility ABSTRAK Tuberkulosis menjadi salah satu penyakit infeksius agent penyebab kematian utama di dunia. Studi ini bertujuan untuk menggambarkan keberhasilan pengobatan serta karakteristiknya pada pasien TB SO di provinsi DKI Jakarta. Studi ini melibatkan seluruh kasus terkonfirmasi positif TB SO di Provinsi DKI Jakarta pada tahun 2021 (24.001 kasus), yang diperoleh dari laporan TB 03 SO dari SITB, yang selanjutnya dianalisis secara deskriptif.  Hasil analisis menunjukkan bahwa angka keberhasilan pengobatan pasien TB di provinsi DKI Jakarta tahun 2021 ialah 82%. Adapun pada pasien yang pengobatannya tidak berhasil mayoritas berjenis kelamin laki-laki (61,3%), lanjut usia (44,7%), tidak bekerja (38,3%), menjalani pengobatan di rumah sakit (71,7%) wilayah Jakarta Pusat (25%) dengan pengobatan OAT kategori 1 (90,1%). Diperlukan penelitian terkait faktor apa saja yang memengaruhi keberhasilan pengobatan pada pasien TB di provinsi DKI Jakarta.Kata kunci: tuberkulosis; keberhasilan pengobatan; fasilitas kesehatan
Human development index, geographic disparities and strategies to reduce maternal mortality in Indonesia : an ecological study Ramadhani, Ramadhani; Tri Yunis Miko Wahyono
Jurnal Kesehatan Ibu dan Anak Vol. 17 No. 2
Publisher : Poltekkes Kemenkes Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29238/kia.v17i2.2051

Abstract

Recent data shows disparities and setbacks in maternal health services. In Indonesia, there was an increase in maternal mortality in 2020 compared to 2019. Inequality is a powerful predictor of maternal mortality. This study aims to find whether inequality indicators, namely the Human Development Index and Geographic Units, can be predictors of maternal mortality. This research uses an ecological study design with a unit of analysis in 34 provinces in Indonesia. The data used in this study is secondary data from the Ministry of Health and Statistics Indonesia. Descriptive analysis and Poisson regression were used to determine whether the Human Development Index and geographic units could be predictors of maternal mortality. The increase in maternal mortality occurred in 21 (61%) provinces in Indonesia. The province's lowest maternal mortality rate was 48, and the highest was 565 per 100,000 live births. The Human Development Index and geographic units can significantly predict maternal mortality (P < 0.05). Human development indices and geographic units are significant predictors of maternal mortality. Strategies that can be done to reduce maternal mortality are improved education, health services, and specific and collaborative interventions according to provincial needs.
Penggunaan Prep Sebagai Upaya Pencegahan Penularan HIV Pada Kelompok LSL di Beberapa Negara Rahmi Marisa; Tri Yunis Miko Wahyono
Jurnal teknologi Kesehatan Borneo Vol 5 No 2 (2024): Jurnal teknologi Kesehatan Borneo
Publisher : POLTEKKES KEMENKES PONTIANAK

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30602/jtkb.v5i2.322

Abstract

Terapi Profilaksis Pra-Pajanan atau Pre-Exposure Prophylaxis (PrEP) merupakan antiretroviral (ARV) terapi yang dapat mengurangi resiko penularan HIV melalui hubungan seksual hingga lebih dari 90%. Lelaki Seks Lelaki (LSL) memiliki resiko penularan HIV tertinggi diantara kelompok risiko tinggi tertular HIV. PrEP diharapkan mampu menekan penularan HIV di Masyarakat. Penelitian dilakukan untuk mereview pengaruh kepatuhan penggunaan PrEP terhadap kejadian infeksi HIV pada LSL Pencarian literatur dilakukan dari artikel jurnal yang dipublikasi dan akses terbuka dalam rentang waktu tahun 2013-2023. Database yang digunakan dalam mengidentifikasi jurnal yang relevan dengan search engine PubMed, Embase, dan Scopus menggunakan kata pencarian men sex men, Pre-Exposure Prophilax (PrEP) dan penularan HIV. Hasil menunjukkan bahwa adanya efektifitas yang signifikan dalam menurunnya prevalensi HIV pada LSL yang patuh dalam menggunakan PrEP sehingga PrEP dapat menjadi alternatif pilihan terapi dalam pencegahan infeksi HIV tanpa meninggalkan upaya pencegahan lainnya.