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All Journal International Journal of Public Health Science (IJPHS) Media Kesehatan Masyarakat Indonesia BULETIN PENELITIAN SISTEM KESEHATAN Jurnal Vektor Penyakit Global Medical and Health Communication Jurnal Penelitian Kesehatan Suara Forikes Promotif: Jurnal Kesehatan Masyarakat Jurnal Kesehatan Vokasional Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Epidemiologi Kesehatan Komunitas Al-sihah: The Public Health Science Journal The Indonesian Journal of Infectious Diseases Biota Jurnal Kesehatan Ibu dan Anak Menara Ilmu J-KESMAS: Jurnal Kesehatan Masyarakat Jurnal Review Pendidikan dan Pengajaran (JRPP) Health Sciences and Pharmacy Journal Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Jurnal Ners Nusantara Science and Technology Proceedings Jurnal Cahaya Mandalika Jurnal Kesmas Jambi Jurnal EduHealth Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Riset Informasi Kesehatan Pro Health Jurnal Ilmiah Kesehatan Journal of Mandalika Literature Jurnal Info Kesehatan Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal) Preventif : Jurnal Kesehatan Masyarakat Jurnal Epidemiologi Kesehatan Indonesia Jurnal teknologi Kesehatan Borneo Prosiding Seminar Nasional Kesehatan Masyarakat Universitas Muhammadiyah Surakarta
Tri Yunis Miko Wahyono
Departemen Epidemiologi, Fakultas Kesehatan Masyarakat Universitas Indonesia, Kampus UI Depok, Indonesia
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Faktor-Faktor yang Berhubungan dengan Kematian Pasien TB MDR Selama Masa Pengobatan di Indonesia Tahun 2015-2017 Zulfa Ayuningsih; Tri Yunis Miko Wahyono
Pro Health Jurnal Ilmiah Kesehatan Vol. 1 No. 2 (2019): Pro Health Jurnal Ilmiah Kesehatan, Juli 2019
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (146.095 KB) | DOI: 10.35473/pro heallth.v1i2.244

Abstract

The incidence of TB cases in Indonesia in 2014 was 399 per 100,000 people with a mortality rate due to TB of 41 per 100,000 population. The incidence of MDR TB in Indonesia is 1.9% of new cases and 12% of cases are from previous treatment. This study discusses the factors associated with MDR TB patient deaths during treatment in Indonesia. This study used a retrospective cohort design. Data were obtained from 33 MDR TB Referral Hospitals in 2015-2017. The research subjects were data on patients who had ≥15 years of age, were diagnosed with positive MDR TB, and had complete data. Sample selection is done by total sampling method. The dependent variable is death, while the independent variables of this study are age, gender, discussion, treatment, sputum gradation at the beginning of treatment, sputum conversion in the first two months, and the number of resistance. The analysis carried out consisted of descriptive analysis, Kaplan Meier, and Cox regression. The probability of survival of MDR TB patients is 94.8% at 6 months of treatment; 91.2% at 12 months of treatment; 90% at 18 months of treatment; 87% at 24 months of treatment, 83.6% at 30, 36, 42, and 48 months of treatment. Multivariate analysis, obtained variables that support statistics with the death of MDR TB patients> old> 45 years the risk of death is 1.71 times faster with patients who increase ≤45 years. and the amount of OAT resistance> 2 risk of compensation is 0.71 times faster than patients who have OAT resistance 2. Efforts to find out early TB patients against drugs at the age of ≤45 years are expected to reduce the morbidity and mortality of MDR TB patients during treatment.
Training On Dengue Haemorrhagic Fever Surveillance System And Case Mapping For Public Health Center Level Dengue Hemorrhagic Fever Program Managers In Bogor City In 2022 Iska Beritania Sinulingga; Tri Yunis Miko Wahyono; Bai Kusnadi
Jurnal EduHealth Vol. 14 No. 02 (2023): Periode April-June, 2023
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (309.449 KB)

Abstract

Background Behind : Bogor City has The incidence rate is 21.4 per 100,000 population, but the CFR is sufficient tall by 2.49%. So from That need exists enhancement knowledge about surveillance of DHF program holders in Bogor City in 2022. Method : Study design in research dengue operations is studies non-experimental pre-test and post-test design. Primary data begins from pretest-posttest results to DHF program manager with use questionnaire while Skills mapping taken from sheet observations that have made. While the secondary data obtained from results analysis Bogor City Health Office profile. Data analysis was performed in a manner univariate, bivariate and multivariate. Result: yes difference knowledge Community Health Center DBD program holders after done training in matter knowledge DHF surveillance (Pvalue < 0.05). There is difference enhancement Skills in do mapping DHF cases in DHF program holders at Puskesmas after done training in do mapping with use application ( Pvalue <0.05), and presence enhancement in do data interpretation and determine stratification area DHF cases (Pvalue <0.05). Conclusion: improvement knowledge and skills DHF program holders are carried out with use appropriate intervention , so DHF program holders can do system good surveillance in prevention and control DHF.
Diagnosis Of Pulmonary Tuberculosis In Children Systematic Literature Review Sara Fadila; Tri Yunis Miko Wahyono
Jurnal EduHealth Vol. 14 No. 02 (2023): Periode April-June, 2023
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (309.425 KB)

Abstract

Tuberculosis (TB) is one of the top ten causes of death caused by infectious agents in Indonesia. In children, more than 96% of TB-related deaths are due not receiving anti-TB treatment, this is significant challenges to diagnosing TB in children. This study aims to analyze the methods of diagnosing TB in children. The research design used a systematic literature review which summarized and compared as many as 12 studies published through Pubmed and Sciencedirect in 2010-2022 concerning methods of diagnosing TB in children. Descriptive analysis showed that the subjects were male with an average age of 4.5 years. Diagnostic enforcement of TB in children found that the scoring system was the most widely used method to diagnosing TB in children with a high sensitivity and specificity, sensitivity and specificity using the modified Edwards Score was 93.3% and 95%. Furthermore, the PCR method by detecting the IS6110 gene using gastric lavage specimens showed sensitivity and specificity was 100% and 98.18%. The QFT-GIT diagnostic method showed a sensitivity of 82.6%, and Xpert MTB/RIF of 76%.
Effect of non-adherence to ARV therapy on 3-year life of HIV/AIDS patients: a cohort retrospective study Hendra Dhermawan Sitanggang; Tri Yunis Miko Wahyono; Ira Marti Ayu
Riset Informasi Kesehatan Vol 12 No 1 (2023): Riset Informasi Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30644/rik.v12i1.692

Abstract

Background: Antiretroviral drug Therapy (ART) has dramatically reduced the morbidity and mortality of People Living with HIV/AIDS (PLWHA). However, adherence to antiretroviral therapy has become a challenge due to a lifetime of therapy. Adherence to antiretroviral therapy is one determining factor in the success of treatment. Method: This study aimed to determine the influence of medication non-adherence on the 3-year survival of patients with HIV/AIDS. The study design used a retrospective cohort and calculated survival estimates using Cox regression. All HIV/AIDS patients in the RSPI-SS from 2010 – April 2012, totaling 164 patients, were obtained from medical records, a summary of treatment and ART (follow-up), pharmacy data, and ARV therapy monitoring books at the RSPI-SS. Data analysis using cox regression. Results: The cumulative survival probability of patients with HIV/AIDS at RSPI Prof. dr. Sulianti Saroso in the second year (24th month) was 95.6% and in the third year (in the 36th) was 91%. Multivariate analysis with Cox regression showed the factors that affected the 3-year survival of patients with HIV/AIDS are non-adherence to ART after being controlled by initial CD4 count (aHR = 7.608; 95% CI: 1.664 to 34.790) and non-compliance appointments after controlled by opportunistic infection, age and initial CD4 count (aHR = 2.456; 95% CI: 0.802 to 7.518). Among patients' non-adherence to ART, non-compliance appointments affected the 3-year survival of patients with HIV/AIDS after controlled by initial CD4 count, sex, CPT, modes of HIV transmission, WHO clinical stage, opportunistic infection, and age (aHR = 4.517; 95%CI: 0.729 to 27.987). Conclusion: Non-adherence to ART may cause a failure to suppress HIV viral, thus increasing the possibility of HIV mutations that can lead to drug-resistant and ultimately increase the risk of death. Patients who do not adhere to medication and do not adhere to their medication appointments show a higher risk of dying than those who adhere to HIV/AIDS. Non-adherence to taking medication in the first year can be used as a marker to monitor medication adherence and the patient's health condition in the future. Therefore, it is essential to monitor adherence to taking the medication regularly through ARV therapy surveillance activities.
Recent Findings in Malaria Emergence of Piperaquine-Resistant Plasmodium falciparum Genes in Malaria Endemic Areas of Indonesia: a Literature Review Ayu Nurdiantika Sari; Tri Yunis Miko Wahyono; Ayleen Alicia Kosasih; Yoshida Aussiana Samosir; Rania Rifdah Taufiq; Inge Sutanto
Jurnal Epidemiologi Kesehatan Komunitas Vol 8, No 2 : Agustus 2023
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jekk.v8i2.11803

Abstract

Background: In recent years, artemisinin and piperaquine (PPQ) resistance in the Greater Mekong Sub-region alarmed Southeast Asian countries, especially those relying on artemisinin- based combinations as antimalarial drugs. This study aims to review the current status of malaria research and examine the frequencies of piperaquine resistance in Plasmodium falciparum isolates originating from malaria-endemic areas in Indonesia.Methods: We undertook a review to identify empirical data on antimalarial piperaquine-inclusive artemisinin combination therapies (ACT) in Indonesia using studies conducted since 2015. Journal articles were searched using the keywords combination of malaria, piperaquine, Pfcrt, Pfmdr, Pfpm2, and Indonesia. The search was conducted in four databases. Trends in empirical data were summarised in a table and compared with emerging malaria prevalence and conditions in Indonesia.Results: Our study found that dihydroartemisinin-piperaquine (DHA-PPQ) is still effective in most area. Survey of PPQ resistance in regions using DHA-PPQ as the first-line treatment heavily depends on phenotypic tests of the given drug resistance. Molecular surveys exploring polymorphisms of Pfcrt, Pfmdr1, and Pfpm2 were not found.Conclusion: This study supports the use of dihydroartemisinin-piperaquine as the first-line antimalarial drug in malaria endemic areas of Indonesia. Further research examining efficacy is required to monitor piperaquine resistance in Indonesia.
THE EFFECTIVENESS AND SAFETY OF BEDAQUILINE-CONTAINING REGIMENS IN THE TREATMENT OF PATIENTS WITH MULTI-DRUG RESISTANT TUBERCULOSIS (MDR-TB): A SYSTEMATIC LITERATURE REVIEW Miptah Farid Thariqulhaq; Tri Yunis Miko Wahyono
Jurnal EduHealth Vol. 14 No. 03 (2023): Jurnal EduHealt, Edition September 2023
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54209/jurnaleduhealth.v14i3.2678

Abstract

Objective: MDR-TB is a life-threatening infectious disease. In recent years, RR/MDR TB sufferers have increased by 10% from 186,883 patients in 2018 to 206,030 in 2019. The success rate of treatment for RR/MDR-TB patients only reaches 57% globally. WHO has recommended bedaquiline for treatment of MDR-TB as the first drug in an all-oral regimen designed to maximize treatment outcomes. Purpose: to describe the efficacy and safety of a bedaquiline-containing regimen for the treatment of MDR-TB. Methods: Pubmed, Science Direct, and Embase online databases were used to obtain data published in the last five years where literature searches were carried out independently by researchers. The keywords used in this search are combined with the Boolean operator "AND", namely (bedaquiline) AND (multidrug resistant) AND (effectiveness). Results: Eight studies met the inclusion criteria, demonstrating a higher conversion rate of sputum cultures on the bedaquiline containing regimen between 74%-95.8% with a mean time to culture conversion between 39 days-3 months. The majority of studies reported an adverse effect of QT prolongation in patients treated with bedaquiline. Conclusion: This systematic review showed that bedaquiline is effective and safe for use in the treatment of MDR-TB. However, serious side effects of QT prolongation occurred in some respondents who were treated with bedaquiline, so an effective and efficient monitoring and surveillance system is needed to ensure best practice in the treatment of MDR-TB.
Hubungan Kepatuhan dan Riwayat Pengobatan Terhadap Keberhasilan PengobatanTuberkulosis Resistan Obat dengan paduan obat jangka pendek 9-11 bulan di Provinsi DKI Jakarta Budi Setiawan; Tri Yunis Miko Wahyono; Dwi Oktavia
Journal of Mandalika Literature Vol. 5 No. 3 (2024)
Publisher : Institut Penelitian dan Pengembangan Mandalika (IP2MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/jml.v5i3.3265

Abstract

Treatment success rate of drug-resistant tuberculosis (DR-TB) remains a challenge in DKI Jakarta. It is necessary to control adherence and the presence of treatment history that can affect treatment success. . The implementation of short-term combined treatment is expected to reduce the risk of treatment dropout (LTFU) and increase treatment success rates in patients undergoing treatment for DR-TB in Indonesia.(Ministry of Health, 2020). This study used a retrospective cohort design to look at the relationship of adherence and history to treatment success. The results showed that adherent patients had a potential treatment success of 9.14 times compared to non-adherent patients (RR = 9.14 (95%CI: 5.50-15.20)), The relationship between treatment history and the success of 9-11 month short-term combined DR-TB treatment can be seen in bivariate analysis which gives the results of no treatment history with an RR of 1.06 (95%CI: 0.90 - 1.24) but not statistically significant (p = 0.48). In stratification and multivariate analysis, there was no interaction or potential confounding from other variables on the association between adherence and history with treatment success.
Evaluasi Sistem Surveilans Kematian Bayi di Provinsi Sulawesi Tengah tahun 202 Chaliq Setiawan, Dwi; Wahyono, Tri Yunis Miko; Apriani, Wayan
Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Vol 6 No 1 (2024): April
Publisher : Fakultas Kedokteran Universitas Alkhairaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31970/ma.v6i1.175

Abstract

Sebagai salah satu indikator kesejahteraan suatu daerah, kematian bayi menjadi salah satu aspek yang penting untuk dievaluasi. Pelaksanaan surveilans kematian bayi merupakan pendekatan yang efektif untuk merencanakan, melaksanakan, dan mengevaluasi program kesehatan bayi. Penelitian ini bertujuan untuk mengkaji sistem surveilans kematian bayi berdasarkan atribut surveilansnya. Penelitian ini dilakukan pada bulan April-Juni 2023 di tiga kabupaten/kota di Provinsi Sulawesi Tengah. Responden diwawancarai dengan menggunakan kuesioner terstruktur yang melibatkan pengelola kesehatan anak di Dinas Kesehatan Kabupaten dan Bidan Koordinator di Puskesmas. Atribut yang dievaluasi adalah akseptabilitas, kesederhanaan, ketepatan waktu, dan keterwakilan. Studi ini dilaksankaan dengan mengikuti Pedoman CDC untuk mengevaluasi sistem surveilans. Berdasarkan hasil studi ini menunjukan, 100% institusi menerima dan mampu menerapkan sistem surveilans. Identifikasi kematian bayi hanya didasarkan pada laporan di fasilitas kesehatan saja, sehingga berdampak pada aspek keterwakilan hasil sistem surveilans karena laporan tidak mewakili keadaan kematian bayi yang sebenarnya di ketiga kabupaten tersebut. Studi ini menunjukkan bahwa surveilans kematian bayi di ketiga kabupaten tersebut belum dilaksanakan secara optimal. Sistem surveilans juga harus dilaksankakan pada basis masyarakat sehingga diperlukan penguatan peran lintas sektora dalam pelaksanaannya.
Spatial study of the implementation of ivermectin, diethylcarbamazine citrate, and albendazole in an urban area Nafilata, Ikrimah; Supali, Taniawati; Wahyono, Tri Yunis Miko; Prihartono, Nurhayati Adnan; Hikmah, Kholisotul; Devi, Yuli Puspita
International Journal of Public Health Science (IJPHS) Vol 14, No 1: March 2025
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v14i1.24822

Abstract

Studies on lymphatic filariasis (LF) in Indonesia have mostly focused on the disease determinants with limited focus on spatial-based and the determinants of implementing ivermectin, diethylcarbamazine citrate, and albendazole (IDA). This study aimed to identify the causes of program failure. A cross-sectional survey was conducted from November to December 2022 in nine urban villages with high endemic records and one sentinel village in Pekalongan City, Central Java, Indonesia. The analysis using Quantum Geographical Information System (QGIS) and Pearson correlation. Slum settlements were linked to the presence of open sewers (p=0.000; r=0.974) and overcrowding (p=0.033; r=0.672), while the first round of IDA medication adherence correlated with knowledge of medication (p=0.054; r=-0.623) and willingness to take the medication in the second round (p=0.051, r=0.603). Adverse effects of the treatment are strongly correlated with drug boredom from taking medication (p=0.003; r=0.828) and assistance from health workers (p=0.027; r=0.791). We identified gaps in slum settlements, open sewers, overcrowding and medication adherence, including low knowledge of medication, unwillingness to take second-round medication, adverse effects, and boredom with taking medication. We recommend effective strategies by engaging health education between health workers, local leaders, and private sectors as key to ensuring elimination program.
Probabilitas Kumulatif Survival Vaksin Covid-19 pada Populasi di Kota Depok Tahun 2021: Cumulative Probability of Vaccine Covid-19 Survival in the Population of Depok 2021 Helmi, Tri Amelia Rahmitha; Wahyono, Tri Yunis Miko
Promotif : Jurnal Kesehatan Masyarakat Vol. 12 No. 1: JUNE 2022
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (365.873 KB) | DOI: 10.56338/pjkm.v12i1.2412

Abstract

Latar Belakang: Vaksin COVID-19 telah melalui uji tahap 1 hingga 3 dan digunakan selama satu tahun sebagai upaya memberikan kekebalan kepada individu di Kota Depok. Tujuan: Penelitian ini ingin mengetahui peluang untuk bertahan terhadap infeksi SARS-CoV-2 pada penerima setiap jenis vaksin. Metode: Penelitian menggunakan kohort retrospektif dengan analisis survival menggunakan metode Kaplan Meier. Subjek adalah penduduk di Kota Depok yang menerima vaksin COVID-19 dari tanggal 13 Januari 2021 sampai 12 Januari 2022. Hasil: Status Outcome di dapat dari data testing dan kasus di Kota Depok. Sebanyak 723.973 orang yang menerima vaksin, yang terdiri dari dosis tunggal, dosis ganda, dan dosis tambahan. Kelompok dengan risiko paling besar untuk terinfeksi adalah perempuan, kategori SDM kesehatan dan usia 19-35 tahun. Insiden terbesar ada pada kelompok umur pra lansia pada dosis tunggal (1,2%) dan kelompok umur lansia (>60 tahun) pada dosis ganda (1,6%). Probabilitas survival tertinggi terlihat pada dosis tunggal adalah Pfizer dan dosis ganda adalah Moderna. Probabilitas survival kumulatif terendah adalah 97,29% selama satu tahun pengamatan. Insiden rate lebih rendah, namun hazard ratio lebih besar pada dosis ganda dibandingkan dosis tunggal. Kesimpulan: Lima jenis vaksin yang digunakan seperti AstraZeneca, Sinopharm, Moderna, Pfizer, dan Sinovac memberikan kekebalan yang baik dalam mencegah terjadinya infeksi pada individu.
Co-Authors Abdulbar Hamid Adang Mulyana Adria Rusli Akira Ito Allisa Amelia Santoso Anggraini, Sely Apriani, Wayan Apriliyan, Afandi Setia Ariani, Novie Arkok, Hashem S. Arli Aditya Parikesit Aulia Habibi Ayleen Alicia Kosasih Ayu Nurdiantika Sari Azkia, Fara Irdini Bai Kusnadi Budi Setiawan Budiyani, Putri Immi Rizky Chaliq Setiawan, Dwi Chinta Novianti Mufara Damayanti, Elok Diani, Yuli Ayu Dipo Aldila Dumilah Ayuningtyas Dwi Handayani Dwi Oktavia Evi Martha Fajar Awalia Yulianto Fara Irdini Azkia Faralina, Mikyal Fardani, Sekar Astrika Farida Arriyani Ferizqo, Ferdian Akhmad Fitri Wahyuni Fitria Fitria Gayatri, Dwi Hadiono, Jennifer Irene Amorita Hairani, Lila K Harsheena Gobind Hartono, Pratiwi Ayuningtyas Helda Helda Helda Helda Helmi, Tri Amelia Rahmitha Hendra Dhermawan Sitanggang Hidayat, Ade Yanti Hikmah, Kholisotul Hutapea, Hotma Martogi Lorensi Ikrimah Nafilata Ikrimah Nafilata Imam Syahputra Yamin Inge Sutanto Inggariwati Inggariwati Inggariwati, Inggariwati Insani, Putri Novia Choiri Ira Marti Ayu Irzal, Mufti As Siddiq M. Iska Beritania Sinulingga Jasape, Muhammad Saleh Ketaren, Sonia Annisa Br Kusnadi, Bai Lhuri Dwianti Rahmartani Lila K. Hairani Loa, Welstin Wemi M. Insan Kamil Marisa Amelia Marisa, Amelia Marwanty Marwanty Melia Sari, Melia Miptah Farid Thariqulhaq Muhammad Farhan Dwi Yulianto Muhammad Nur Muslim Shidiq Muhammad Putra Kusuma MW, Oktarinda Nabilla Niken Widyastuti Nadia Putri Nafilata, Ikrimah Nasution, Helmi Suryani Nelda Aprilia Salim Ngetwa, Leopardo Alvalius Nimas Ayu Lestari Nurjanah Noerfitri, Noerfitri Nor Efendi Novia Indriani Sudharma Novie Ariani Nurcandra, Fajaria Nurjanah, Nimas Ayu Lestari Octaviani Octaviani Oktarinda MW Pratiwi Ayuningtyas Hartono Prihartono, Nurhayati Adnan Putri Bungsu Machmud Qonita Nur Salamah R Sutiawan R. Kince Sakinah Rahmah Hida Nurrizka Rahmartani, Lhuri Dwianti Rahmi Marisa Rahmi Marisa Ramadhani Ramadhani Rania Rifdah Taufiq Ratna Djuwita Renti Mahkota Renti Mahkota Rizal Subahar Rizaldi, Mohamad Rizka Maulida Rizka Maulida Ruth Tabitha Salam Salam Salam, Salam Sara Fadila Simanjuntak, Tri Damayanti Sri S. Margono Suardiyasa, I Made Sudaryo, Mondastri Korib Sulfi Udi Sutiawan, R. Suyanti Suyanti Suyanti Suyanti Syahrizal Syarif Syaputri, Nadhiratul Taniawati Supali Titi Sundari Tri Damayanti Simanjuntak Tri Wahyuningsih Wahyu Manggala Putra Wahyu Pudji Nugraheni Wawang Wawang Widarso H. S. Widarso Wijaya, Fikri Wilfried H. Purba Yoshida Aussiana Samosir Yovsyah Yovsyah Yuli Puspita Devi Yulianto, Muhammad Farhan Dwi Zulfa Ayuningsih